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2013 Abstracts

Computing for a Cure: Why Mammogram Rates in Utah are Lower than the National Average

January 01, 2013 12:00 AM
Computer Science and Information Systems Breast cancer is the leading cancer killer among women in the state of Utah. According to the Center for Disease Control (CDC’s) Behavioral Risk Factor Surveillance System (BRFSS), Utah has the second lowest mammogram rate in the nation. Mammograms reduce breast cancer mortality rates by increasing early detection of the disease when it is still curable. A quick binary logistic regression of the data completed for this presentation suggests that there at least three factors that are statistically significant for not receiving a mammogram: lack of a health plan, infrequent dentist visits, and age. Some counties including Millard, Summit, Tooele, Sanpete, and Uintah appear to be statistically significant factors. Other counties have low mammography rates, but too little data to be statistically significant including Beaver, Wayne Garfield, Paiute, Daggett, and Rich. By identifying patterns and analyzing correlations between variables, we may begin to understand why Utah women are not taking advantage of early detection in the form of mammography screenings. Our research has the potential to improve the attitude with which the topic of mammography is approached, and in doing so, save lives.

Differential Equations for the Construction of Novel Kernels in Machine Learning

January 01, 2013 12:00 AM
Alexandra Pasi, Brigham Young University Mathematics Significant research in Machine Learning has been directed at the application and implementation of kernel-based learning methods. However, few studies have focused on the problem of kernel construction. This paper introduces a novel method for generating new kernels by solving differential equations for kernel functions. We examine specific kernels generated using this method. These kernels are applied to various data sets and compared against state-of-the-art kernels.

Neural Correlates of Gender Differences in Distinguishing Malware Warnings and Legitimate Websites: A NeurolS

January 01, 2013 12:00 AM
Dixon Brown, Brigham Young University Information Systems Despite being a problem for more than two decades, malicious software (or malware) remains a serious threat to the information security of organizations. Increasingly, attackers target the computers of end users to gain a beachhead from which the network of a user’s organization can be surveilled and exploited. Given the growing threat of malware to end users and their or- ganizations, there is a need to understand how malware warnings can be made more effective to alert end users of potential threats. We address this need by performing a NeuroIS study to examine whether men and women process malware warnings in the brain differently (or whether men process them at all?). We conducted a laboratory study that employed electroencephalography (EEG), a proven method of measuring neurological activity in temporally sensitive tasks. We found that the amplitude of the P300, an ERP event-related potentialcomponent indicative of decision making ability, was higher for all participants when viewing malware warning screenshots relative to legitimate website shots. Additionally, we found that the P300 was greater for women than for men, indicating that women exhibit higher brain activity than men when viewing malware warnings. Our results demonstrate the value of applying NeuroIS methods to the domain of information security and point to several promising avenues for future research.

The Role of Nup153 in Nuclear Lamina Assembly

January 01, 2013 12:00 AM
Merima Beganovic, Westminster College Molecular Biology Nuclear Pore Complexes (NPC) create aqueous channels embedded in the nuclear envelope and are made from a network of proteins called nucleoporins (nups). The nucleoporin Nup153 has previously been found to be required for proper assembly of the nuclear lamina. In this study, a fragment of Nup153 was overexpressed in order to impede Nup153 function in T-Rex HeLa cells. After inducing the expression of the dominant negative fragment, I examined the localization of lamins A, B1 and B2, as well as SUN1, Emerin, and BiP, three proteins that mark cell membrane compartments. Lamins B1, B2, SUN1, and Emerin were found to mislocalize to the cytoplasm of the cells, and colocalization among the proteins was observed. Lamin A also had an abnormal phenotype unlike that seen with the B lamins, but indicative of a problem with integration of Lamin A into the nuclear lamina. Colocalization of the various lamin isoforms with membrane proteins such as SUN1 and Emerin indicates a problem with membrane assembly. The distinct localization of BiP, however, suggests that there is a “nuclear-like” membrane in the cytoplasm that either does not incorporate normally into the nuclear envelope as it forms or is newly-recruited to mislocalize the lamin proteins.

Isolation of Hydrocarbon Metabolizing Microorganisms in the Great Salt Lake

January 01, 2013 12:00 AM
Natalie Batty, Westminster College Biology Hydrocarbon metabolizing microbes play a critical role in bioremediation and bio-augmentation projects. In 1978, Brock et al. identified microbes in the Great Salt Lake (GSL) capable of metabolizing hydrocarbons, but since then these microbes have gone unstudied. This research has isolated and identified bacterial species capable of hydrocarbon metabolism from GSL. Though capable of survival in the high salt concentration of the Great Salt North Arm, we have demonstrated that these species are also capable of thriving in low salt concentrations. This research will continue with the characterization process to identify what hydrocarbon sources each species is capable of degrading.

Assessing the Impact of Urbanization on Stream Health

January 01, 2013 12:00 AM
Morgan Anderson, Westminster College Environmental Studies Emigration Creek, part of the Salt Lake City watershed, runs through Westminster campus at two points: by Garfield school and through main campus. We assessed several measures of water quality, to understand the impacts of anthropogenic activities and urbanization on this stream ecosystem. Additionally, we identified areas for restoration with the ultimate goal of reintroducing the endangered native Bonneville Cutthroat trout. Beginning in June 2012, we monitored the creek monthly, and will continue for a full year’s time. We assessed the structure and stability of the stream along with dissolved oxygen, pH, temperature, and turbidity. The macroinvertebrate community composition was analyzed also as a biological indicator of stream health. Along both reaches lack of vegetative cover, lack of large rocks to support the lower banks, and scouring and deposition along the steam bottom were common. We found that for all water quality measures monthly average levels were in acceptable limits for trout populations except for dissolved oxygen. Dissolved oxygen dropped below optimal levels in July and August, most likely due to an increase in water temperature. We found that both reaches have moderate species diversity of macroinvertebrates, though the community is dominated by species that thrive in water highly polluted with organic waste. Preliminary results suggest that the current condition of Emigration Creek is not optimal for cutthroat trout, largely due to seasonally low dissolved oxygen levels and lack of preferred food. Continued monitoring, along with a comparative study of nearby creeks, will further our understanding of the impacts of urbanization and the restoration efforts needed to support native fish populations in the Salt Lake Valley.

Establishing Two-point discrimination of Cranial Nerve V

January 01, 2013 12:00 AM
Kristie Williamson, Weber State University Athletic Training Context: Cranial Nerve V (CN V; Trigeminal nerve) is responsible for facial sensation. CN V has three separate branches which include ophthalmic, maxillary and mandibular. The ophthalmic nerve (V1) carries sensory information from the forehead; the maxillary nerve (V2) carries information from the cheek; and the mandibular nerve (V3) carries information from the chin. It is important to test all three areas of cranial nerve V to accurately assess full nerve function. Previous research has indicated that pressure threshold is not affected by age, however, normative values for two-point discrimination for CN V have not yet been established and may prove useful in concussion evaluation. Objective: Initial investigation aimed at determining gender-specific normative values for CN V two-point discrimination. Design: Prospective repeated-measures design. Setting: This study was performed in the athletic training facilities on the campus of a large Division I institution. Patients or Other Participants: Convenience sample of 106 healthy students enrolled at our institution (43 females, average age: 23.2; 63 males, average age: 22.1). Participants had no history of concussion within the last year, no facial scaring or plastic surgery and not a current smoker. Interventions: Measurement was taken using a two-point discriminator (Disk-Criminator) on the mid-forehead, mid-cheek, and mid-chin. Participants closed their eyes while each measurement was taken. Light pressure was applied (force equal to approximately 10-15 grams to produce blanching of the skin). Measurements were taken three times on each of three facial locations, sequentially. The smallest number in millimeters (mm) to correctly discriminate one/two points was recorded. The two pressure points were applied at exactly the same time. Main Outcome Measure: Discrimination score for each test location (mid-forehead, mid-cheek, mid-chin). Nested average was calculated within subjects for each test location; average was calculated between subjects for each test location. One-way between-subjects ANOVAs were conducted to evaluate potential differences in gender for each test location. Results: Between-subjects average for mid-forehead was 7.8mm (+/2.9), for mid-cheek was 10.4mm (+/2.6), and for mid-chin was 5.9mm (+/1.9). There was a significant effect for gender for cheek normative value (p<0.01); average discrimination score for males was 11mm, average for female was 9.7mm.

Identification of Novel Invertebrate Neurokinin Receptor Gene Sequence

January 01, 2013 12:00 AM
Chelsie Thomas, Weber State University Zoology The invertebrate ribbon worm, Paranemertes peregrina, serves as a unique model in that it thrives in an environment exposed to drastic fluctuations in salinity during tidal interchange. Its ability to sustain homeostatic integrity is not well understood. With an aim to clarify this phenomenon, total RNA was isolated, and reverse transcription with polymerase chain reaction allowed us to serendipitously clone and elucidate a 488 base pair region of a gene coding for a Tachykinin Receptor (TKR), a subtype of G-protein coupled receptor (GPCR). This region shows 79% homology to the mouse TKR-2 mRNA sequence, and 44% homology to human Neuromedin-K receptor’s amino acid sequence. Specifically, we have isolated a portion containing a cytosolic carboxy-terminus that has classically been associated with palmitoylation or otherwise hydrophibicity-enhancing interactions. This process facilitates the docking of cytosolic subunits to the membrane in the assembly of GPCRs, acting as a regulatory component. In vertebrate models, much of these proteins are conserved. Given that only a few of these genes have been reported for invertebrates, this suggests a critical need for investigation of the evolution of TKRs as they relate to stress response. Additionally, this receptor poses questions about its potential role in pain, with the prospect of revealing insight about the long-elusive pain perception in invertebrates.

Antimicobial Properties of Phytochemicals Against Multi-Drug Resistant Bacterial Pathogens

January 01, 2013 12:00 AM
Alisha Ryan, Weber State University Microbiology One of the major challenges facing U.S. military caregivers is the presence of multidrug resistant organisms in extremity wounds. The most frequently identified drug resistant strains of bacteria found in these wounds are Acinetobacter baumanni, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. Due to these organisms rapid increase in resistance to the commonly used drugs, it is crucial to discover and establish alternative methods for treating these microbial infections. Antibiotics are currently the most common treatment for infections by these pathogens, and there is little data on the evaluation of phytochemicals as potential chemotherapeutic agents that could take their place. We have screened 24 individual compounds from 9 major compound families to determine if plant-based phytochemicals could be explored further for use in treating bacterial infections in patients with military wounds. All compounds were tested to determine the minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC). Of the 24 compounds tested, 21 (87.5%) inhibited at least one strain used in this study, with only 1 of the 24 (4.2%) inhibiting all strains. There were 10 (41.7%) of the compounds that displayed MIC values less than 100 _g/ml. For compounds displaying MLCs, they ranged from 2.5 mg/ml to 78.13 g/ml. While there is much more research that needs to be done with each of these compounds, this work is a crucial first step in the drug discovery process. We believe that several of these may serve as potential novel inhibitors of these drug-resistant bacteria.

Effects of Natural Stimuli on Attention in Children

January 01, 2013 12:00 AM
Amanda Snow, Utah State University Psychology Past studies investigating attention have found that exposure to natural scenes have a restorative effect on attention in adults, allowing for the occurrence of effortless, involuntary attention. This is in contrast to exposure to urban scenes which do not show the same restorative effect on attention (Berto et al., 2005, 2008). The present study investigates the potentially restorative effects on childhood attention of exposure to natural scenes. In this study, 58 children ages 4 to 11 participated in a task which was attentionally taxing. Next, they were instructed to attend to pictures belonging to one of three conditions: “high fascination” (natural scenes), “low fascination” (urban scenes), or a control group (geometric shapes). Finally, the participants performed the initial attentionally taxing task once again. While accuracy remained constant across conditions, children demonstrated a greater decreased reaction time when exposed to high fascination natural scenes as opposed to low fascination urban scenes or the geometric shapes of the control group. Between the pre and post tests, mean differences of 37.7 milliseconds for the natural condition, 24.4 milliseconds for the urban condition, and 22.7 milliseconds for the control group was found. This suggests that exposure to high fascination natural scenes has a restorative effect on attention in children as it does in adults. This finding is important because it provides a mechanism by which the attentional capacities of children may be improved.

Comparing Family Conflict and Additional Care Responsibilities across Spouse and Adult Offspring Caregivers of Persons with Dementia

January 01, 2013 12:00 AM
Heather Sheffer, Utah State University Family Consumer and Human Development Background:

Chronic Administration of Selective Serotonin Reuptake Inhibitor Fluoxetine Changes Neuronal Activation During Anxiety-Inducing Distractors in an Interval Timing Task

January 01, 2013 12:00 AM
Lauren Miller, Utah State University Psychology Affective disorders such as depression, phobias, schizophrenia, and post-traumatic stress disorder impairs the ability to time in the seconds-to-minutes range, i.e., interval timing. We investigated the effect of chronic administration of selective serotonin reuptake inhibitor fluoxetine (FLX) when anxiety-inducing task-irrelevant distracters are presented during an interval timing task. Given that some anti-depressants have beneficial effects on attention and working memory, e.g., decreasing emotional response to negative events, we hypothesized that FLX would decrease activation of amygdala and increase activation of prefrontal cortex. Our results revealed differential activation of amygdala and prefrontal cortex in FLX and vehicle treated rats corresponding to the expected changes in behavior. Results are discussed in relation to the brain circuits involved in interval timing and emotional processing, and the pharmacological management of affective disorders.

LDS Attitudes Towards Female Gender Roles

January 01, 2013 12:00 AM
Laura Steffen, Brigham Young University Psychology There is a wide spectrum of opinion on female gender roles, or what behaviors are appropriate for women. Attitudes towards gender roles can hypothetically be influenced by a variety of factors, including religion. Sexist views have been found to be held by members of many faiths, including Catholics, Muslims, and Evangelical Christians (Glick, Lameiras, & Castro, 2002; Maltby, Hall, Anderson & Edwards, 2010; Tasdemir & Sakalli-Ugarlu, 2010). To our knowledge, this phenomenon had not yet been studied among members of the Church of Jesus Christ of Latter-day Saints (LDS). Our measure, the LDS Attitudes Towards Female Gender Roles Scale, (LDS-AFGR) was created in the hopes of accurately assessing opinions of female gender roles among the LDS population, in regards to both religious social contexts. All questions on the LDS-AFGR yielded superior to moderate content validity, and two components were yielded by factor analysis. This suggests that our scale has initial promise, and could be further revised to obtain more accurate data about opinions on female gender roles among LDS church members.

Mu Opioid Genotype x Rearing x Sex Effects on Aggression and Antisocial Behavior During Social Challenge in Rhesus Macaques (Macaca Mulatta)

January 01, 2013 12:00 AM
Trenton Simmons, Brigham Young University Psychology Endogenous opioids are believed to modulate social sensitivity and aggression. The mu-opioid receptor gene in rhesus macaques has two common variants thought to be orthologous to human variants: C77G (CG) and C77C (CC). Based on previous studies, we predicted that rhesus macaques with the CG variant would exhibit higher rates of antisocial and aggressive behavior during social challenge. To test this hypothesis, we subjected mother-reared (MR) and nursery-reared (NR) subjects to an intruder challenge. 130 subjects were genotyped for the mu-opioid receptor gene variant. Behaviors were recorded after an unfamiliar intruder of the same sex and age was placed adjacent to the subjects’ home cage. CG, MR males received more non-contact aggression from group members than any other condition (p range<0.012), instigated more contact aggression than any other condition (p range<0.018), and received more contact aggression from the intruder than all other conditions except CC, NR males. In contrast to high rates of aggression, male, CG, MR subjects exhibited the lowest time in social affiliation when compared to all other genotype, sex or rearing conditions (p<0.026) except for CG, NR females. Our findings suggest that the mu-opioid receptor gene modulates aggression and antisocial behavior but only in the context of rearing and sex. These findings suggest one potential pathway for antisocial aggressive behavior development in men.

A Meta-Analytic Comparison of Individual and Group Treatment Formats

January 01, 2013 12:00 AM
Jyssica Seebeck, Brigham Young University Psychology Until recently, there were very few meta-analytic comparisons between individual and group formats to determine if reliable outcomes were produced. However, Burlingame, Strauss, and Joyce (2013) recently identified a dozen diagnosis specific meta-analyses (bipolar disorder, schizophrenia, etc.) and twenty-three new studies published over the last decade that test for differential format efficacy/effectiveness. This meta-analysis builds upon these by selecting the most rigorous studies drawn from these meta-analyses. More specifically we selected studies that tested equivalent treatments enabling us to make strong causal conclusions about differential efficacy/effectiveness. We began with published meta-analyses that tested for format differences, went to each and determined whether individual studies summarized in these meta-analyses compared treatments that were equivalent. If they did, the study was included herein. We also conducted a literature search to identify studies that tested individual and group treatments not included in the aforementioned meta-analyses. Computed effect sizes tested differential outcomes (group versus individual) and also estimated the effectiveness of format compared to waitlist controls. Moderator variables of outcomes, such as group type and theoretical orientation were also tested. Results are reviewed with reference to treatment recommendations, feasibility of implementation, and evidence based recommendations.

Efficacy of Small Group Treatments for Patients with Schizophrenia: A Meta-Analysis

January 01, 2013 12:00 AM
Brian Redford, Brigham Young University Psychology Small group treatment is a well-recognized as an effective intervention for persons diagnosed with schizophrenia. The most frequently used and efficacious types of small group treatment include psychoeducational, multifamily and skills groups. These groups are second only to psychopharmacology and frequency of use (Burlingame, Strauss & Joyce, 2013). Using the following search terms (group psychotherapy OR group counseling OR group treatment AND schizophrenia from 1990-2000) 62 studies were identified that used the aforementioned small group treatments. Of these, 29 were excluded based on strict inclusion criteria (i.e., sample size, study design, statistical methodology). 26 studies produced active group comparisons with controls, 3 studies produced single group pre-post comparisons and 5 studies produced waiting list control comparisons studying 2,248 patients. We conducted a meta-analysis using several descriptive (e.g. setting, ethnicity) and moderator (e.g. age of onset, group type) variables examining outcomes on key dimensions (e.g. relapse, hospitalization, medication adherence). Effect sizes estimated treatment effects (pre to post) and if these effects were maintained (post to follow up). Findings are examined in reference to treatment recommendations, feasibility of implementation and evidence based recommendations with respect to illness, protective, mechanisms of action and risk factors.

Rearing Conditions and CSF Monamine Influence in Alcohol Consumption

January 01, 2013 12:00 AM
Nickolal Mullen, Brigham Young University Psychology Previous studies have shown that the monoamines are related to risk for alcoholism, and that both are affected by early rearing experiences. This study builds on previous research in examining the effect of alcohol on monoamine neurotransmitter systems, by exposing macaques to a set dose of alcohol and measuring CNS monoamine metabolites. We explored

Pairing Success in Rhesus Macaques

January 01, 2013 12:00 AM
Adrianne Miller, Brigham Young University Psychology Recent studies in rhesus macaques suggest that social competence and sociality, as measured by ease of forming new relationships, is modulated by genetic and behavioral factors. In research centers that study primates, pairing unfamiliar subjects is the most costly and difficult problem that researchers face. We investigated several factors believed to influence social competence: rearing condition, serotonin transporter genotype (5HTT), temperament, and stress responsiveness, as measured by infant plasma cortisol levels. We assessed 354 pairings from subjects housed at the California National Primate Research Center (n=177 male and n=177 female adult pairings). Temperament and plasma cortisol was assessed at three to four months of age. Analyses showed that males were more difficult to pair than females. High cortisol, nursery rearing, and temperament ratings for high emotionality during infancy was predictive of adult pairing failures. Intriguingly, our data showed that the high risk 5HTT genotype was also predictive pairing failures, and that 5HTT genotype interacted with sex, with pairs of males where one or more of the subjects in a pair possessed the high risk 5HTT allele were more likely to be unsuccessful in their pairings. To the extent that our results generalize to humans, our data suggest that early temperament, perhaps modulated by the serotonin transporter genotype, as well as sex and early experiences lead to social competence and success in social relationships.

A Measure for Body Image and Social Comparisons in Women

January 01, 2013 12:00 AM
Paige McAllister, Brigham Young University Psychology Negative body image among younger women has grave ramifications including eating disorders, depression, anxiety, and low self-esteem. In order to more accurately detect negative body image among women, we created the Body Image and Social Comparison Survey (BISCS). The BISCS is a 10 item self-report measure using a 4-point Likert scale. Our two domains were attitudes about personal body image and social comparisons. We took a convenience sample of 115 women between the ages of 18 and 30 and administered our survey to establish psychometrics for the BISCS. It was discovered that the BISCS has high internal consistency, and 43 out of 45 of the Pearson correlations between items were significant. Factor analysis revealed two primary factors. All questions loaded onto the factors we expected them to except there was one question that loaded onto both factors. Content validity ratios ranged from .48 to .81. Future applications and improvements for the BISCS are discussed.

Sarrus-Based Passive Mechanism for Robotic Perching

January 01, 2013 12:00 AM
Kay (Beau) Freckleton, University of Utah Mechanical Engineering Current quad-rotors provide excellent maneuverability and opportunity for data collection in large scale areas such as agriculture, but lack the capability to maintain flight for an extended period of time. This is due primarily to a lack of energy supply, requiring operators to replace the battery source before the quad-rotor completes its designated purpose [1]. In this paper, we introduce a mechanism to enable flying robotic rotorcraft, such as quadrotors and helicopters which utilize vertical takeoff and landing, to perch similar to a bird. The mechanism is passive, using only the weight of the rotorcraft for actuation. Such a mechanism will dispel the need for multiple batteries by allowing the quadrotor to perch amid its designated flight course, recharge using solar energy, and complete data collection over large scale areas in less time. In previous research to this same end, biomimetic approaches were pursued, resulting in designs that looked similar to the legs and feet of birds. The design in this paper utilizes a Sarrus mechanism to convert rotorcraft weight into perch grip. We began by designing the mechanism for a range of cylindrical perch sizes. Using MATLAB, we developed a program to optimize the various mechanism dimensions needed to perch within this range while also maximizing the mechanical advantage of grip force. Using SolidWorks, a 3-dimensional model was created and manufactured with these dimensions. In testing, the mechanism successfully allowed a small RC helicopter to perch on a 4cm diameter rod with some resistance to external forces. However, in crash tests, the mechanism was unable to withstand certain moment forces and developed large fractures. Further research will focus on decreasing these moment forces’ ability to weaken the mechanism while optimizing perching capability.

Insects of Capitol Reef National Park

January 01, 2013 12:00 AM
Matthew Ethington, Utah Valley University Biology Although the insect fauna of the Colorado Plateau region are somewhat well known, our specific understanding of the diversity in Capitol Reef National Park is sparse. Here we present an overview of the insect diversity of the park based on a number of undergraduate student-led excursions to collect specimens. The collections will contribute to an increased understanding of the parks insect diversity and will result in an appropriately curated natural history museum collection. Furthermore, an insect field guide for the park will be created in order to serve as an educational tool for visitors to the park. Field collecting efforts, consisting of traditional insect collecting methods (aerial nets, aquatic nets, light traps, etc.) will be used. The collected material will be curated, photographed, and stored in a natural history museum (Brigham Young University ML Bean Museum). This presentation will be a summary of material gathered in the last three years.

Creating Claudin-16 Reporter Assays for Studying Epithelial Ovarian Cancer

January 01, 2013 12:00 AM
Miguel Cuevas and Joseph Wilkerson, Utah Valley University Biology Ovarian cancer is the leading cause of death from gynecologic malignancies in the United States and is the fifth leading cause of cancer death among American women. It is estimated that over 22,000 women in 2012 will be diagnosed with ovarian cancer in the United States and approximately 15,500 women will succumb to the disease. This is due to the fact that only 20 percent of cases are diagnosed before the cancer has spread to the peritoneal cavity. Currently, there are no reliable, standard screening tests; the only diagnostic test currently available is the CA125 tumor antigen blood test. This test is inadequate and not available as a general screening tool; additional diagnostics are required to effectively diagnose this disease. It has been previously shown that the tight junction protein Claudin-16, found only in normal kidney, is aberrantly expressed in epithelial ovarian tumors. Therefore, this protein is a good candidate for ovarian cancer diagnostics and targeted therapy. By identifying the promoter region that controls cldn-16 gene expression in ovarian tumors, we can create a luciferase reporter assay to identify cells that express Claudin-16 in culture. To do this, PCR-amplify of various upstream regulatory elements previously identified in kidney cell lines were subcloned into the pGL3 luciferase reporter vector. A higher amount of luminescence is present if the promoter sequence successfully up-regulates the luciferase gene in the vector. This is measured using a Dual Luciferase Assay to determine which promoter region is responsible for the over-expression of Claudin 16. Promoter activity was verified in kidney cell lines that normally express Claudin-16. Next, the assays will be repeated in ovarian cancer cell lines known to express Claudin-16 compared to cell lines that do not express the protein. The promoter assay will then be tested on a collection of ovarian cancer cell lines to determine if luciferase activity correlates with Claudin-16 expression. Once validated, we can test our construct as a cell based assay for identifying therapeutics that can lower Claudin-16 expression in ovarian cancer cells.

Chronic Administration of Selective Serotonin Reuptake Inhibitor Fluoxetine Reduces the Effect of Anxiety-Inducing Distractors on Interval Timing

January 01, 2013 12:00 AM
Chance Christensen, Utah State University Psychology Affective disorders such as depression, phobias, schizophrenia, and post-traumatic stress disorder impairs the ability to time in the seconds-to-minutes range, i.e., interval timing. We investigated the effect of chronic administration of selective serotonin reuptake inhibitor fluoxetine(FLX) when anxiety-inducing task-irrelevant distracters are presented during an interval timing task. According to the Relative Time-Sharing (RTS) model, presentation of task-irrelevant distracters during a timing task results in a delay in responding suggesting a failure to maintain subjective time in working memory, possibly due to attentional and working memory resources being diverted away from timing. Given that some anti-depressants have beneficial effects on attention and working memory, e.g., decreasing emotional response to negative events, we hypothesized that FLX would improve maintenance of information in working memory in trials with distracters, resulting in a decrease of the disruptive effect of emotional events on the timekeeping abilities. Our results revealed independent effects of FLX on timing and resource allocation. Acute administration of FLX delayed timing, but this effect was eliminated after chronic administration. FLX reduced the detrimental effect of the distracters only when the distracters were anxiety-inducing, but not when they were neutral. Results are discussed in relation to the brain circuits involved in RTS of resources, and the pharmacological management of affective disorders.

A Preliminary Assessment of Mercury Concentrations in a Terrestrial Songbird on Antelope Island

January 01, 2013 12:00 AM
Heather Reynolds, Westminster College Biology The presence of mercury in a food chain can have harmful effects, including altering behavior, on organisms. Mercury is typically found in aquatic ecosystems, however recently is also recognized as a potential problem in terrestrial ecosystems. High levels of mercury have been found in the Great Salt Lake in a form able to bioaccumulate up the food chain. If the aquatic ecosystem is linked to the terrestrial ecosystem, then some of the highest predators included in this food chain may be songbirds that eat spiders. We quantified mercury in the blood of the Loggerhead Shrike, Lanius ludoviciaus, on Antelope Island. Upon being caught, the birds were measured, color banded, and a blood and feather sample taken from each of the 15 shrikes to be tested for mercury. Mercury concentrations ranged from 0.96 to 4.00 ppm, with a mean 1.14+/0.31 ppm. Sub-lethal effects in songbirds from another study were seen with concentrations ranging from 2.0-3.5 ppm. Two shrikes we tested exceeded that range. There was high variability in concentrations of mercury, which might be related to distance from shore. These preliminary data demonstrate that some mercury from the aquatic ecosystem is bioaccumulating in the terrestrial ecosystem on Antelope Island, and there may be harmful levels in the birds which could lead to change in behavior, and eventually decline in population. Future studies will investigate the costs of mercury contamination.

Frequency Characteristics of Urban House Finch Songs

January 01, 2013 12:00 AM
Dakota Hawkins, Westminster College Arts and Sciences Abstract. Previous studies have documented effects of urbanization on the behavior, reproduction and survival of wildlife. Specifically, noise pollution in urban areas has been known to mask communication among several avian species. In a previous study in Mexico City, House Finches increased the frequency (pitch) of their songs to help mitigate the effects of low frequency urban noise. To document the average minimum frequency of House Finch song in Utah, we recorded House Finches singing from May 2012 to August 2012. Three sample sites with 1 km radii were established in Salt Lake City, Utah while a fourth site was sampled in Logan, Utah. Ambient sound was recorded at locations where songs were recorded to measure urban noise. Average minimum song frequencies and ambient noise were calculated for three sites. Frequency measurements were not significantly different among the three urban populations. Future studies will compare the minimum frequency of these urban populations to nonurban populations and investigate syllable structure and use.

Exploring the Population Genetics of Artemia Franciscana in the Great Salt Lake

January 01, 2013 12:00 AM
Graham Doherty, Westminster College Biology The Great Salt Lake is home to Artemia Franciscana, a species otherwise known as brine shrimp. These halophiles are able to live in extreme environments that have higher than average salt concentrations. Brine shrimp live their entire life cycles in the Great Salt Lake and can be found in both the north and south arm of the lake. Currently, the genetic information regarding the brine shrimp populations at different locations in the lake is underdeveloped. The Artemia populations live in different microenvironments throughout the lake with different physical characteristics and barriers between one another. The physical environment also affects the salt concentration in each microenvironment. Other studies have shown that the increased salinity of an environment accelerates the rate of change in the mitochondrial genome. We feel that different salinity levels in each microenvironment will create different amounts of genetic variation. Our goal is to determine if the distribution of genetic variation is different at different sites in the Great Salt Lake Artemia population.

Total Mercury and Methylmercury in Water and Brine Flies from Two Distinct Sites at the Great Salt Lake

January 01, 2013 12:00 AM
Jeff Collins, Westminster College Biology The Great Salt Lake (GSL) has some of the highest mercury concentrations ever measured in surface waters. The accumulation of high levels of mercury, particularly its more toxic and readily biomagnified form, methylmercury, has been recorded in many species that inhabit or feed directly in the GSL, including waterfowl. However, no studies at the GSL, and very few studies elsewhere, have investigated the transfer of mercury from aquatic ecosystems to terrestrial ecosystems. We hypothesized that brine flies are able to accumulate mercury during their larval stages in the lake, then transfer this mercury to adjacent terrestrial ecosystems when they become flying adults. Concentrations of total mercury (HgT) and methylmercury (MeHg) were measured in samples of surface water and brine flies (larvae, pupae, and adults) collected once each month between February and July at Antelope Island, in the GSL. Samples were collected from two distinct sites: one along Gilbert Bay on the west side of the Island, and the other along Farmington Bay on the east. On average, HgT concentrations are greater in water samples from Farmington Bay (19.3 ± 9.0 ng/L unfiltered; 13.5 ± 10.1 ng/L filtered) compared to Gilbert Bay (8.5 ± 7.5 ng/L unfiltered; 9.2 ± 9.6 ng/L filtered). MeHg and HgT levels in brine flies displayed the opposite trend, with higher levels at Gilbert Bay (567 ± 123 ppb HgT; 425 ± 12 ppb MeHg) than at Farmington Bay (270 ± 60 ppb HgT; 208 ± 35 ppb MeHg). Potential explanations for the trends observed will be discussed.

Impact of Cations on the Aggregation,Dissolution,and Phytotoxicity of Metal Oxide Nanoparticles in a Sand-Wheat Growth System

January 01, 2013 12:00 AM
Trevor Hansen, Utah State University Biology The use of metallic nanoparticles (NPs) in various applications presents the possibility for environmental contamination by these NPs. CuO and ZnO NPs have dose-dependent phytotoxicity. However, NPs are modified by different environmental factors such as salts: chlorides of Na, K, and Ca are used on roads for de-icing, dust control, irrigation, water treatments, and fertilizer production. At low concentrations these salts promote plant growth, but elevated concentrations become phytotoxic. This study examines the impact of Na, K and Ca chlorides on the phytotoxicity of CuO and ZnO NPs for wheat grown in sand. Atomic force microscopy and dynamic light scattering showed dose-dependent aggregation of the NPs in the wheat rhizosphere. The salts also caused NP-aggregation, but the degree of dissolution of the NPs was salt specific. Release of Cu from CuO NPs in the planted sand was reduced by all salt treatments whereas Zn release from ZnO NPs was reduced by Na and K but not Ca. Overall, a phytotoxic synergistic effect was seen at lower salt concentrations, but at higher salt levels, toxicity was mediated mainly by the salts. Therefore, effects upon plant growth of NPs and salts will vary according to concentrations.

Activation of Transient Receptor Potential Ankyrin-1 by Wood Smoke Particulate Material

January 01, 2013 12:00 AM
Darien Shapiro, University of Utah Pharmacology and Toxicology Exposure to wood smoke particulate matter (WSPM) has been linked to exacerbation of asthma, development of chronic obstructive pulmonary disease (COPD), and premature death. Combustion-derived PM (cdPM) such as cigarette smoke (CS), diesel exhaust (DEP), and WSPM, activate transient receptor potential ankyrin-1 (TRPA1) which promotes neurogenic inflammation/edema and airway irritation/cough. The mechanism of TRPA1 activation by DEP and CS involves the electrophilic/oxidant binding (3CK) and menthol-binding (ST) sites, and a novel mechanosensitive site. We hypothesized that WSPM would activate TRPA1 through one or more of these sites similar to other cdPM. Pine and mesquite PM were generated in the laboratory. Both types of WSPM particles activated TRPA1 in human TRPA1 over-expressing HEK-293 and primary mouse trigeminal (TG) neurons. WSPM also activated TRPA1 in A549 cells, a human alveolar adenocarcinoma cell line, which has recently been shown to express TRPA1. HC030031, a TRPA1 specific antagonist, attenuated the calcium flux due to WSPM treatment in both human A459 cells and mouse primary TG neurons. Differential activation of TRPA1, as a function of particle size, demonstrated that PM2.5 m were most potent. Several known chemical components of WSPM, including 3,5-ditert-butylphenol and agathic acid were TRPA1 agonists. Both WSPM and agathic acid activated TRPA1 primarily via binding the 3CK site, based on inhibition of calcium flux by glutathione and mutation of the 3CK site. Conversely, 3,5-ditert-butylphenol activated TRPA1 through the ST site. This study established the mechanism by which WSPM and associated chemical components activated TRPA1 which may help tailor effective therapeutic treatments for WSPM pneumotoxicity. Support: NIEHS ES017431 and the University of Utah Undergraduate Research Opportunities Program.

A Retrospective Analysis of Vehicular Accidents Involving Emergency Medical Service and Fire Vehicles

January 01, 2013 12:00 AM
Jacqueline Rodriguez, University of Utah Health Promotion and Education This is the second phase of an anticipated multistage research study. The first phase was completed Spring of 2012 and data showed that drivers of personal vehicles were having a difficult time hearing Emergency Medical Service (EMS) vehicles when driving with their radio on or while operating a hands-free cell phone which may be a leading factor in many of the estimated 9,000 EMS accidents a year. Information will be collected from accident reports and personal interviews will be conducted with EMS personnel who have been involved in a vehicular accident while driving an EMS vehicle. Similarities found in the interviews and accident reports that may explain why vehicular accidents involving EMS occur will be recorded. The accident reports which will be analyzed will have occurred in the past five years and will have transpired within the State of Utah. One-on-one interviews will be conducted about the accident in the State of Utah and with EMS personnel that have been in a vehicular accident in the past 5 years while driving an EMS vehicle. It is hypothesized that many of the vehicular accidents involving EMS drivers occur due to drivers in personal vehicles not noticing EMS vehicles in enough time to clear the way. It is believe the results gathered from the interview and accident reports will show that drivers do not see/hear EMS vehicles very well when distracted. In the cases where the EMS driver was found at fault for the accident, it may be due to having to resort to unsafe driving practices because they are responding to an emergency and the drivers in personal vehicles are not moving out of the way in a timely manner or simply not at all. It is anticipated that the results of this study should be available late December.

Measuring Nitric Oxide Production by Endothelial Cells Using Electron Paramagnetic Resonance Spectroscopy

January 01, 2013 12:00 AM
Jennifer Nhan, University of Utah College of Health, Division of Endocrinology, Metabolism, and Diabetes The overall goal of our laboratory is to elucidate mechanisms whereby endothelial nitric oxide (NO) synthase (eNOS) enzyme function and NO bioavailability are impaired in individuals with diet-induced obesity (DIO), type 2 diabetes (T2DM), and insulin resistance. This is a clinically relevant issue because all of these conditions are associated with poor vascular function that might be precipitated by disrupted eNOS enzyme function and NO bioavailability. To study this issue we use model systems including cell culture, isolated arteries, and rodents. It is important to have an accurate, reproducible, and sensitive method to detect NO in each of these systems. The purpose of my work was to optimize the technique of electron paramagnetic resonance spectroscopy (EPR) to assess NO in bovine aortic endothelial cells (BAECs). NO contains an unpaired electron. This structural feature facilitates the measurement of NO via EPR. NO is detected with a spin trap of FeSO4 and diethyldithiocarbamate trihydrate (DETC). In the presence of NO, the spin trap forms a NO-Fe(DETC) complex which is detected by EPR. BAECs were grown to 70-80% confluency in six-well plates, and treated with: (i) vehicle (buffer only), (ii) 600 uM of insulin (an NO agonist), (iii) 10 uM of NG-monomethyl-L-arginine acetate salt [LNMMA, an NO synthase (NOS) inhibitor], and (iv) three doses (1, 10, 100 uM) of diethylammonium (DEA) NONOate (an NO donor) to serve as a positive control. All treatments contained L-arginine [the substrate for endothelial NOS (eNOS)] and FeSO4 (the spin trap). After a 60-min incubation with treatments (i) (iv), cells were dislodged from each plate, collected, frozen in liquid nitrogen, and NO was detected using EPR. Relative to vehicle treatment, 1uM, 10uM, and 100uM DEA NONOate increased NO production by 50±8%, 150±2%, and 700±26% (p<0.05) respectively. Insulin increased (p<0.05) NO production by 73±4% vs. vehicle, and this response was prevented in cells treated with insulin + LNMMA. These results indicate EPR is a suitable method to detect cellular NO production. My next project is to optimize this technique for use in isolated arteries from experimental animal models.

Family Caregivers in Home Hospice

January 01, 2013 12:00 AM
Edie Kieu-Mi Nguyen and Cassandra Nguyen, University of Utah Nursing Home hospice care is a growing area within the health care system. However, because of the difficulty in gaining access to these patients and caregivers in the home, research findings have been slow to keep pace with this growth. While hospice has been at the forefront of family-centered care, explicitly stating that the unit of care is the family, there has been little empirical research to show who is actually involved in this care in the home on a regular basis. Hypothesis: Our goal of this project was to describe who is present at the nurse home visit with the patient. Research Method: This research, part of a larger intervention study, involved reviewing audio recordings of home hospice visits to set up a coding system for future communication coding. During this review, we also identified and documented those present during the visit. Results: In our sample of 115 home hospice visits, 12 nurses caring for 13 patients spent an average of XXX minutes each (SD=XXX) in the home. We have found that caregivers are present 80% of the time. Our data shows that a spouse is present in 28% of visits. In 58.3% of visits, a daughter is present, while sons are present in only 3.1% of visits. Implications: It is important to know who is present at the visit and how long they spent with the patient to increase our understanding of what goes on in home hospice care. This research has implications for improving patient care. For example, in order to promote a more family orientated home care; more family members should participate in nurse visits. This descriptive research can be used in practice for hospices to know who to expect during patient home visits, as well as to incorporate the family members better into the patient care plan.

The Impact of Geography on the Burden of Care for Pediatric Oncology Patients and Their Families

January 01, 2013 12:00 AM
Deborah Nelson, University of Utah Pediatrics Families of pediatric cancer patients are presented with significant emotional, social, and financial challenges. Most children with cancer are treated in pediatric oncology centers located in urban areas and many must travel great distances for therapy. This study aims to evaluate the burden of care associated with pediatric cancer care and to determine the impact of the location of patients’ residence on those burdens. We administered a n=310 (48-item, English) and n=46 (72-item, Spanish) survey to the primary caregiver of patients, ages 0-18 years, diagnosed with a cancer between three to six months prior to the survey. Survey domains included measures of rurality, time from first symptoms to diagnosis, financial burden (travel costs and time, missed work, relocation) and missed school. Survey analysis suggests rural families and those traveling >2 hours to a pediatric oncology center took longer to obtain diagnosis, missed more work days, paid more in travel expenses and relocated more often than families living closer. Of the respondents, 18% were considered “rural” with 38% reporting greater than one-hour travel time and 25% reporting greater than two-hour travel time. Mean onset of initial symptoms to diagnosis was 11.4 weeks for rural and 7.6 weeks for urban patients. Mean out of pocket costs per clinic visit for rural were over three times that of urban patients. Twenty-nine percent (n=102) moved since diagnosis; of that 33% reported moving was directly due to cancer. Fifty-six percent of school-aged patients discontinued school; of those 28% were unable to “keep up” and 10% repeated a grade. Caring for a child with cancer places a significant number of burdens on the patient’s family. This burden appears greater for patients living in rural and distant areas and could effect patient care and access to treatment.

Dynamics of Vascular Development with Conotruncal Banded Heart in Chick Embryo

January 01, 2013 12:00 AM
Mikaelyn Miles, University of Utah Pediatrics Altering myocardial growth interferes with hemodynamic parameters such as blood flow or pressure, and subsequently alters vascular development. We hypothesized that experimentally increasing hemodynamic stress by conotruncal banding during early heart development would result in a remodeling of the arterial wall. The outflow tract of a stage-21 (3_-d) chick embryo was constricted with an overhand knot of a 10-0 nylon suture, and the embryo was returned to the incubator. Normal embryo was not operated. We harvested the embryo at stage-34 (8-d), and fixed the heart in diastole with 0.025 μg/Kg diltiazem in 4% paraformaldehyde. Transverse sections of the carotid artery were stained with H&E staining, and the dorsal aorta was treated with rhodamin-phalloidin-smooth muscle antibody staining. En face sections of the aorta were examined under confocal microscopy. Morphometric analysis was quantitated using customized MatLab software for filament-actin alignment and density. Data are presented as mean±SEM, and analyzed by Student’s t test and ANOVA with statistical significance defined as a p value of less than 5%. Both right and left carotid arteries in the conotruncal banded heart had a thinner vessel wall when compared to the arteries of the normal embryos. Some vessels in the conotruncal banded hearts displayed dilation and variation in size between the right and left coronary arteries. The overall filament length in the dorsal aorta between the normal and banded hearts (39.8±4.3 vs. 29.6±2.7 μm, respectively) was statistically different (p<0.05). The filaments were also widely spaced in the conotruncal banded hearts. Altered growth in the developing heart caused by altering the hemodynamics results in secondary abnormalities in development due to abnormal vascular architecture. These factors may be important in the understanding of myocardial development with defects such

Procedural Violations That Could Cause Hospital Acquired Infections

January 01, 2013 12:00 AM
Nicole Kelbert, University of Utah Nursing Introduction:

Continuous-Flow Left Ventricular Assist Device does not Impair Coronary Arterial Function After Implantation

January 01, 2013 12:00 AM
Elizabeth Johnson, University of Utah College of Health, and Division of Endocrinology, Metabolism, and Diabetes Constant-flow left ventricular assist devices (LVAD) are implanted in heart failure patients to assist the heart in pumping blood through the body either temporarily as a “bridge” mechanism until a heart transplant or permanently as a destination therapy. The blood flows constantly with an LVAD contrary to the natural pulsatile flow of the human heart. We wanted to determine if this constant flow attenuated the function of the arteries. A transmural biopsy was taken from seven male patients (52±6 years old) when the LVAD was implanted (pre) and again 142±2 days later upon LVAD explant (post). Arteries were obtained from the pre and post tissue biopsies. Vessel function was assessed using isometric tension techniques. After Lmax tension was determined for each vessel, the contraction-response curve of each vessel was tested using potassium chloride (KCl, 10-100 mM). Next the vessels were pre-contracted to ~65% maximal tension and treated with bradykinin (BK, 10-6 to 10-10 M) and sodium nitroprusside (SNP, 10-4 to 10-9 M) to determine, respectively, endothelium-dependent and -independent vasorelaxation. Maximal KCl-evoked contraction (0.99±0.22 and 0.69±0.14 mg tension development / μm vessel length), maximal BK-evoked vasorelaxation (64±13% and 80±7%), and maximal SNP-evoked vasorelaxation (92±3% and 92±4%), was similar in arteries obtained from pre (n=13 arteries, 206±40 μm i.d.) and post (n=14 arteries, 288±24 μm i.d.) transmural biopsy samples, respectively. These preliminary data indicate that coronary vascular function is not attenuated by LVAD implantation.

Production of Biofuel Methyl-butenol in Cyanobacteria

January 01, 2013 12:00 AM
Israel Worthington, Utah Valley University Science and Health The Nation and world’s dependency on fuels has steadily grown over the last several decades. The world’s consumption of oil dramatically increases in the United States and peaks at approximately 20 million barrels of oil each day. Predictions of decreasing fuel reserves and increasing costs have made the development of a renewable fuel source increasingly appropriate. Much research has been done using the fermentative process to produce biofuels as an alternative fuel source, but the research attempting to utilize photosynthetic bacteria as a producer of alternative fuels is relatively undeveloped. In this research, it was attempted to transform cyanobacteria with the gene necessary to produce the enzyme methyl-butenol synthase, which catalyzes the production of the biofuel methyl-butenol. The gene for methyl-butenol was successfully transformed into cyanobacteria on a plasmid, and production of the enzyme methyl-butenol synthase was successfully detected via western blotting. The production of an alternative fuel source using photosynthetic bacteria could create a cheap, renewable, and more environmentally friendly source of fuel.

PP2A Activation is Required for Lipid-Induced Arterial Dysfunction in Mice

January 01, 2013 12:00 AM
Xin Wan, University of Utah College of Health, and Department of Endocrinology, Metabolism, and Diabetes We hypothesized that PP2A activation is required for lipid-induced, ceramide-mediated arterial dysfunction. Mice haploinsufficient for dihydroceramide desaturase (des1+/-) and their wild-type littermates (des1+/+) were infused (iv) for 6 h with lard-oil (LO) or vehicle (veh). Subgroups of LO and veh mice were treated (1.5 mg/kg IP) for 3 days prior to infusion with the PP2A inhibitor LB1 (Lixte Biotechnology, NY). LO increased ceramide accrual in arteries from des1+/+ but not des1+/mice. Palmitate (3 h x 500 uM) increased (p<0.05) PP2A activity, and impaired (p<0.05) insulin-stimulated p-eNOS(S) 1177 to eNOS in endothelial cells, and these responses were negated by LB1 (4 uM; n=5-8). Endothelium-dependent and -independent relaxation of femoral arteries (~ 150 um i.d.) was assessed using acetylcholine (ACh) and sodium nitroprusside (SNP), respectively (n=3 mice / group, 3 vessels / mouse). ACh-mediated (2×10-8, 3×10-8, and 6×10-8 M) relaxation (%) was less (p<0.05) in LO des1+/+ (30±2, 41±3, and 61±4, respectively) vs. veh des1+/+ mice (48±4, 67±6, and 73±6, respectively). Endothelial dysfunction observed in LO des1+/+ mice was less severe when ceramide accrual (i.e. LO des1+/mice) or PP2A activation (i.e., LB1 +LO des1+/+ mice) were prevented. SNP-evoked vasorelaxation was intact among groups. LO-induced ceramide accumulation induces endothelial dysfunction that is dependent upon PP2A activation. ADA1-12-BS-208, 2R15HL091493

Relationships Between Symptoms and the Hospital Care Environment in Children and Adolescents with Cancer

January 01, 2013 12:00 AM
Kara Vickers, University of Utah Nursing Symptoms related to cancer and its treatments are a significant source of distress for children and adolescents with cancer. Although children and adolescents may receive interventions aimed at alleviating symptoms, the hospital care environment itself may be one that adds to the overall symptom burden. The purpose of this study is to investigate relationships between symptoms experienced by hospitalized children and adolescents with cancer and the care environment on an inpatient pediatric oncology unit. This prospective, descriptive study uses use a repeated measure, within-group design to identify relationships between symptoms and the nursing care environment that can be used to guide future interventions. Participants are 50 children and adolescents (7 to 18 years of age) with cancer. Data collection is occurring over a 3-day and 3-night period. Children and adolescents’ symptoms are measured each shift using the Memorial Symptom Assessment Scale for patients aged 7-12 years. Participants also answer two open-ended questions about what has bothered them about the hospital environment and what they perceive could improve the hospital environment. Sound and light levels are measured continuously using a sound pressure level meter and data logger placed approximately 48 inches from the child’s bedside. Nursing care activities are measured through counts of care activities occurring during room entries by nursing staff. Room entries are identified using an Axis pan-tilt-zoom (PTZ) dome camera. A member of the research team reviews the child’s nursing flow sheet, medication administration record, acuity level, laboratory values, and medical orders each day. Data is presently being collected and will be analyzed using hierarchical mixed effects statistical models. Long-term goals of this project include improving symptom management in the inpatient setting, minimizing modifiable factors in the care environment that cause greater symptom burden, and lastly use the findings to inform hypotheses for a larger intervention studies. Hopefully these studies will target structuring the hospital care environment to minimize the symptom burden experienced by hospitalized children and adolescents with cancer and, ultimately, promote their quality of life.

Sentimentality Preserves Our Past

January 01, 2013 12:00 AM
Hanna Higginson, University of Utah Anthropology The study, “Sentimentality Preserves Our Past” focuses on two branches of nostalgia: sentimentality and historical utility and their relationship to cultural relics. Our approach assumes we can recognize similarities and differences between cultural communities by describing the extent to which individuals are sentimental or utilitarian with regard to their possessions. We are currently collecting data from the northern Utah community and Utah Tongan community. We set up a preliminary exercise asking participants to free list the items they have a difficult time throwing away for sentimental reasons. So far we have collected 40 questionnaires and 13 interviews that focus on the five most referenced items. Our target is to conduct about 45 questionnaires and 45 interviews for each community. For the Utahan population we have enough data to identify an S:U RANK – the ratio between a participant’s measure of sentimentality to the measure of utility. For the 25 questions where a respondent’s answer could be classified as appealing to sentimentality (s) or historic utility (h), we summed the totals then divided it by the sum of the answers appealing to utility (u). All totals above 1 indicate that the respondent prefers protecting items for nostalgic purposes; all answers below 1 indicate the respondent prefers items of utility. The S:U RANK gives a general view into a particular population. From this we can discuss the effect of variables such as age, marital status, children, age of children, and years in Utah on an individual’s preference. Currently, the pattern from the S:U RANK suggests that marital status and children are having the greatest effect on the ratio, but this will become clearer as the interviews progress. The research began as an effort to understand the presence of nostalgia as applied to five common relics among a particular diaspora, in light of the incoming data, this question is developing into an attempt to understand nostalgia in a cultural and universal sense as well.

The Influence of L1 and L2 on Perceptual VOT Boundaries in Initial-Stage L3

January 01, 2013 12:00 AM
Jeffrey Green, University of Utah Linguistics Although learning a second language can be difficult, especially for adults, many people believe that once an individual has acquired a second language, it will be easier to learn a third. Individuals may utilize strategies learned from studying a second language (L2) to their study of a third, but this does not necessarily mean that learning a third language (L3) will be easier. As individuals study an L3, their knowledge of both their native language (L1) and their L2 will compete with their developing knowledge of the L3. Previous research has shown that during early stages of L3 acquisition, both L1 and L2 phonology (that is, the underlying sound system of a language) influence the phonology of their L3. This is evident, for example, in learners’ production of some word-initial consonants, such as d, p, and k. Languages differ in the timing between the articulation of the consonant and the beginning of vibration of the vocal folds (voicing) associated with a following vowel sound. This timing is known as Voice Onset Time (VOT). Studies suggest a stronger influence from L2 than from L1 in L3 VOT production. However, learners in these studies had some (if limited) knowledge of the L3, and the influence of this knowledge is unclear. In addition, previous studies have addressed L3 production, but not L3 perception. Research has yet to investigate (i) the influence of L1 and L2 phonology in the very initial stages of L3 acquisition (when the language is totally unfamiliar), and (ii) the influence of L1 and L2 phonology on the perception of VOT boundaries. This study investigates (i) and (ii) by presenting English and Spanish bilinguals with stimuli representing a range of VOT in their L1 and L2, as well as from a third, unfamiliar language in a series of tasks designed to elicit evidence of VOT boundaries in each language. The results of these tasks will be examined to determine whether learners rely more on their L1 or their L2 for processing a third, unfamiliar language. Preliminary results and analyses will be available by February 2013. This research will give important insights into the process of acquisition of a third language.

Dendroclimatology of Range Creek Canyon

January 01, 2013 12:00 AM
Melanie Cooke, University of Utah Geography Range Creek is a small deeply incised canyon located in south central Utah. It is a remote canyon that has experienced minimal impact to its rich archaeological heritage by European-American settlers during the last two hundred years. The canyon contains hundreds of important archaeological sites and thousands of artifacts from the Fremont culture that inhabited the area from around 800 A.D. to 1350 A.D. Though work has been done on the archeological sites in the canyon, a better understanding of the paleoclimate and environment are needed to help understand why the Fremont culture disappeared so abruptly around 1160 A.D.Dendrochronology has been shown to provide excellent data for reconstruction of climatic conditions. Conifer tree species, including Douglas fir (Pseudotsuga mensiezii), are well-suited for studying past climate through the analysis of their tree rings. In this study, I use increment cores from Douglas fir to build a local history of tree-ring growth rates through time and will compare these results to regionally available climate records. By comparing changes in ring widths with weather station data, including monthly and seasonal temperature and precipitation records, I hypothesize that Douglas fir will provide a sensitive indicator of past changes in winter precipitation. Twelve tree cores collected from climatically sensitive locations during the 2012 summer are being analyzed from Range Creek Canyon. Preliminary analyses of the tree ring series suggests this study will provide a climatic history spanning the past ~300 years. Although this analysis cannot provide direct observation on climate conditions during the period of the Freemont occupation and abandonment of Range Creek, it will provide insights into the natural climate variability occurring within the Range Creek Canyon. All tree cores are being analyzed with ARSTAN and COFECHA software, commonly used by dendrochronologists, and results will be made available at the time of presentation.

Forte! Forte! Sound the Syllogism! Question the Composition! The Relation of Reason and Music in Nietzsche

January 01, 2013 12:00 AM
Duke Cruz, Westminster College Philosophy This research focuses on the nineteenth-century philosopher Friedrich Nietzsche, his philosophy, and how that relates specifically to what he thinks about music. In general this presentation will consist of three main parts: 1) analyzing passages on music in a few of Nietzsche’s works, specifically, “The Birth of Tragedy”, “Beyond Good and Evil”, and “Twilight of the Idols’” with supplementary material relating to his philosophy taken from “The Anti-Christ”, and Walter Kaufmann’s biography of Nietzsche “Nietzsche: Philosopher, Psychologist, Antichrist”; 2) showing the relation of music and reason in each example; 3) postulating the importance of this relation. Throughout my research on Nietzsche and his thoughts surrounding music, it is apparent that whenever he discusses music, it is never about the specific score, keys, melodic content, etc. Instead, I found that in most of the passages that I have ran across, Nietzsche’s thoughts on music collide directly and importantly to his philosophy. In this presentation I aim to elucidate what the importance of this relation between music and reason could be for Nietzsche.

Creating a Sense of Home: Examining the Personal Belongings of World War II Servicemen

January 01, 2013 12:00 AM
Paul Greenhalgh, Weber State University History Much has been written about the tactics and strategies of World War II, as well as the effects of the war on the world. Far less, however, has been written about the cultural aspect of the war experience, and in particular about the day-to-day culture of the servicemen during the war. Archival research at the Library of Congress and The Institute on WWII and the Human Experience at Florida State University yielded the bulk of the primary sources while a review of the literature on WWII and the culture of U.S. servicemen during the war provided context. Additionally, a cross-disciplinary review of psychological literature on pets and their importance to well-being, as well as why it is important for people to create a sense of home, has nuanced the research. This study looks at the personal effects that servicemen had during the war and how their possessions contributed to the creation of a sense of home while they were deployed. Servicemen carried a vast variety of possessions with them that were not Government Issue. These possessions included diaries, pictures of, and letters from, loved ones, Bibles, pets, musical instruments, and talismans. Moreover, in letters and in diaries, these servicemen have described why they personally have carried these objects with them. This study adds to the body of knowledge on the cultural aspect of WWII servicemen, and therefore adds to the overall understanding of WWII and the culture of war in general.

Finding Social Values from Social Outcasts

January 01, 2013 12:00 AM
S. Geneva Balin, Weber State University Anthropology In the past, mythology served as a guide to how life should be lived and provided a context for the condition in which people found themselves. As the sacred gave way to the secular, mythology lost its power to influence and guide the people as it did in the past. Rather than myths, people turned to literature for guidance. These stories have been told and retold through different eras in history. They have also been shared in contemporary forms such as books and movies which now reach a large audience. This paper will examine stories of social outcasts in an interpretive exploration into culture through the lens of literature. The multiple versions “The Phantom of the Opera” and “The Hunchback of Notre Dame” reflect the cultures in which they were produced as well as the contemporary cultures that love them. A basis for comparison will be established by first recounting, in summary, the plotline for each of the novels. Then theories relevant to exploring meaning will be approached, notably those of Claude Levi-Strauss, Émile Durkheim, Dame Mary Douglas and Carl Jung. From here, variations of the stories and the history surrounding them can be examined to discover potential social meaning and show the importance of stories as a way to bind a culture together.

The “Slave Morality” of the Working Class Promise and the “Domination” of the American Dream

January 01, 2013 12:00 AM
Betty Stoneman, Utah Valley University Philosophy The “American Dream” and the “Working Class Promise” are ubiquitous ideologies in American culture. For this paper, I will argue these ideologies are social constructs which perpetuate and reinforce discrimination, the social hierarchy and the domination of the American working class. First, I will define the key concepts of this paper: ideology, stereotyping, domination, discrimination, the ideologies of the American Dream and the Working Class Promise. Secondly, I will argue these ideologies, as defined by communications professor Kristen Lucas, lead to discrimination and domination of the working class. I will argue the Working Class Promise is an example of philosopher Frederick Nietzsche’s slave morality, where a lower status group attaches positive values to themselves which only serves to perpetuate discrimination against them. Further, I will argue domination arises from such discrimination by examining a study by psychologists Shannon K. McCoy and Brenda Major regarding positive stereotyping, self-stereotyping, discrimination and domination. Next, I will argue, using sociologist Pierre Bourdieu’s concept of habitus, both the Working Class Promise and the American Dream are structured and structuring social concepts which reinforce discrimination and domination through exclusion. In line with Bourdieu, I will use social philosopher Louis Althusser’s arguments to show how the Working Class Promise and the American Dream reproduce the roles of the social hierarchy and domination. I will support this demonstration with evidence from McCoy and Major’s study showing how various forms of discrimination are reproduced in society when individuals believe in the American Dream. Having accepted the social insights of these scholars, I would propose, based on the arguments of philosopher Immanuel Kant regarding the intrinsic worth of rational beings and contrary to elitist or socialist views, the solution is for Americans to reject these ideologies.

Look Who’s Talking: Exploring Writing Conference Interactions and Subsequent Revision

January 01, 2013 12:00 AM
Ryan Krage, Utah Valley University English and Literature Within Freshman Composition Studies, little research has been produced on writing conferences between students and teachers since Laurel Johnson Black’s Between Talk and Teaching: Reconsidering the Writing Conference in 1998. Most published research has not included any systematic information about the nature of the writing conference, a consultation between the student and teacher designed to discuss the student’s paper in order to make changes. Student feedback and involvement in this study is of crucial importance because there is no existing data whether teacher-student conferences are working from a student perspective. The major research question is “What is the relationship between types of teacher-student conference interaction and subsequent revision of students’ papers?” The purpose of the research is to discover what the writing conference between teacher and student accomplishes in terms of better writing outcomes, what the expectations of the student are, and what and how the power dynamics between student and teacher affect the quality and quantity of revision from both student and instructor perspectives. We will examine the connection of students’ perceptions about the writing conference to their final scores and other data. During the spring 2012 semester, we drafted three surveys designed to capture students’ perspectives and expectations regarding the conferences (a pre-conference, post conference, and post final grade). The methodology includes transcribing voice recordings of conferences, collecting student surveys before and after conferences, and collecting students’ rough and final drafts for two papers during the semester. This raw data will be coded into usable data, which will then be analyzed to identify behaviors that facilitate or impede the conference and determine its overall effectiveness. We hypothesize that a dialogic conference will occur when the power dynamic between student and teacher is more equitable, resulting in more student-ownership over the revision process. The extent of student ownership within the revision process will be determined by both the quantity and quality of revision. These findings will, in turn, enable teachers to take a closer look at the nature of their own writing conferences in order to develop better consultations with their students.

Cold War to Holy War: The Soviet-Afghan War and Jihad

January 01, 2013 12:00 AM
Nina Cook, Utah Valley University History As events of the 1978 April Revolution in Afghanistan played out during the Cold War, U.S. policy makers became concerned about the Soviet sphere of influence and began to fund the Mujahedeen-rebel groups that formed in Pakistan. The Mujahedeen, inspired by jihad, remained divided across ethnic lines, began a religiously inspired struggle against Communist usurpers and oppressors. The United States saw the Mujahedeen as a useful Cold War tool in order to contain Soviet expansion and therefore throughout the 1980’s the United States continued to head the effort to supply the rebels with money and weapons. This aid was crucial in the Soviet decision to withdraw from Afghanistan and contributed to the eventual breakup of the Soviet Union. Yet, many of the Arab Mujahedeen saw this outside the Cold War context, as a victory for concepts of militant Jihad. Thus, the Soviet-Afghan war became a catalyst for the ideas of Radical Jihad, which would lead to a global holy war against the U.S and the West by the al Qaeda network, created during the Soviet-Afghan war, beginning in the 1990s. The significance of the Soviet-Afghan War, then, lies in some unintended consequences for the U.S.: Cold War containment of the Soviets in Afghanistan fueled Jihad, which in turn targeted American interests in an entirely new war.

Guerrilla Warfare Theory and Praxis: The Case of Revolutionary Leader Ernesto ‘Che’ Cuevara

January 01, 2013 12:00 AM
Anna Maria Guadarrama, Utah State University Languages, Philosophy, and Communication Studies Guerrilla warfare is an ancient style of armed conflict that continues to be practiced throughout the world today. Many countries and peoples have either taken part in guerrilla warfare or have sought to counteract irregular war with counterinsurgency methods (e.g. United States). This thesis project consists of an analysis of the guerrilla warfare theories and battlefield strategies utilized by Ernesto ‘Che’ Guevara—the Argentine-born Cuban revolutionary considered by most people as the premier thinker on the nature of guerrilla warfare. Guevara developed his foco theory of guerrilla warfare based on the model of warfare used successfully during the Cuban Revolution, and then sought to replicate this achievement in The Congo and Bolivia. After a brief introduction on the nature of guerrilla warfare in general, the thesis proceeds to analyze the theoretical writings on guerrilla warfare by Ernesto ‘Che’ Guevara, as seen in his seminal treatise Guerrilla Warfare: A Method (1963). The thesis then proceeds to analyze Guevara’s application of his foco theory as an on-the-ground guerrilla leader to evaluate the praxis of Guevara’s foco theory during his guerrilla campaigns in Cuba, The Congo, and Bolivia.

English-Mainly Language Policy: Improving Language Proficiency through Self-Regulated Learning

January 01, 2013 12:00 AM
Kendra Williamson, Brigham Young University Linguistics and English Language Questions regarding language policy have persisted in Intensive English Programs nationwide. BYU’s English Language Center has revoked an English-only policy in favor of an English-mainly policy. In this environment, a two-month study has been initiated in which four experimental-group classes are provided tools for self-regulated learning to encourage English use during the lunch break. Students record goals and perceived actuals daily, reflect and respond to their individual progress, and receive weekly printed progress charts. As students use tools designed for self-regulated learning, it is expected that their daily efforts to speak English and their speaking proficiency test scores will improve.