2015 Abstracts

Jadyn Naylor, Michael Jensen, and Kevin Duncan, Utah State University Education From 2007-2008 the United States and the rest of the world suffered the largest economic downturn since the Great Depression, a period which has been termed the “Great Recession”. This occurred when, as a result of the subprime mortgage crisis, residential and business investment declined, leading to the collapse of several major financial institutions and significant disruption in the flow of credit to businesses and consumers. The contraction of GDP growth and record unemployment that followed inspired congress to pass TARP in 2008, authorizing the US government to purchase $700 billion worth of “troubled” assets. In 2009 President Obama passed the American Recovery and Reinvestment Act to boost demand for goods and services and create jobs. On top of these legislative measures, the Federal Reserve lowered the federal funds rate to nearly zero, to increase liquidity, and gave banks $7.7 trillion in emergency loans to promote market trust. These responses have been said to reflect the federal government’s faith in Keynesian economic theories, theories which encourage government manipulation of currency and interest rates to counteract fluctuations in the economy. Trust in markets to correct themselves is all but nonexistent at the federal level. Whether or not this distrust is justified is the subject of our research. Previous research has found that economic freedom is positively correlated with increases in wealth, education, health, and political freedom. With our research we hope to determine if and how economic freedom affects the speed and robustness with which an economy recovers from economic downturns. Because the United States government is based upon the ideas of federalism, economic policies vary from state to state. We will use this property to our advantage for our research, comparing each state’s level of economic freedom to various measures of that state’s economic health. These data will be analyzed before, during, and after the recession. Our hypothesis is that states with higher economic freedom rankings recovered from the financial crisis of 2007 and 2008 more quickly than states with lower economic freedom scores. To determine the level of economic freedom in each state, we will be using the Economic Freedom of North America ratings published by the Fraser Institute each year. The Fraser Institute measures the extent to which the policies in each state promote or limit economic freedom based on the state’s size of government, tax code, and labor market restrictions. The Fraser Institute does this at both a sub-government level and an all-government level, giving each state two rankings. We will be testing our hypothesis against both rankings. Our methodology is to compare these rankings to several economic variables: Real GDP, percentage unemployment, and number of jobs created per capita. We will be using periodic measurements of these data across time, from 2006 – 2013. In examining the relationship between these variables and the Fraser Institute’s economic freedom rankings we expect to determine whether there is any correlation, at the state level, between economic freedom and quality of economic recovery, and if there is, to determine the nature of the correlation.

Logan Carter, Southern Utah University Education Many students learn best from hands on activities. I myself have had several experiences that have led to deeper understanding and growth. I have participated in many scientific extra-curricular activities such as the SUU Science and Engineering fair, The International Science and Engineering fair, and NCSSSMST conventions. Throughout all of these I gained a deeper understanding of scientific concepts. To test the hypothesis that learning in elementary school students may be affected positively by experiential learning because it engages them in whole brain learning, I have designed an engaged learning set of activities. I will test these activities on approximately twenty students between the ages of nine and eleven at North Elementary School. I will measure how students respond to a set of experiential learning activities through pre and post-activity assessments. For example, we will learn about parental care in amphibians, specifically Alytes spp. -the midwife toads. Male midwife toads wrap the fertilized eggs on their legg’s and care for them until they hatch. The activity would be to split the students into groups and making one group gives the other group the eggs (balloons on a string) to the other group to simulate caring for them. That group would then race to a finish line with the balloons around their legs, making sure not to break any of the eggs. The students with the most unbroken eggs would be awarded a prize for parental care. Experiential learning is an effective way for students to gain knowledge.

Nicolette Parrish, Dixie State University Education In a world where it seems nearly impossible for American Indian people to succeed, this presentation will draw upon first-hand interviews with terminal degree-holding American Indian women to demonstrate their successes, failures, resiliency, determination, and strengths in the face of an educational system that has historically been a source of pain and trauma for their communities. Indeed, the relationship between American Indians and academia has not always been a pleasant one. In 1879, Carlisle Indian School was the first Indian boarding school to be opened in the United States. The first boarding schools took American Indian children thousands of miles away from their homelands and forced them to live a foreign lifestyle. They were not allowed to speak their language or live by their traditional and cultural values. A new life was forced onto them and for years American Indians struggled to cope with that cultural and geographical dislocation. 135 years later, American Indians are still struggling to make a connection with the modern world and with their cultural world. It is rare to see an American Indian with a doctorate degree and it is even rarer for that person to be a woman. The quality of education and lack of resources on reservations often leaves American Indian children behind. For this reason, the aim of this project, to collect the oral histories from those that have overcome these obstacles in the face of so much adversity, is especially valuable.

Are classic, young-adult novels set in the American west a dead genre in the American classroom? Despite its historical impact on popular culture, young-adult novels set in the American west have seen a considerable decline in relevance in American public schools. While classic young-adult literature receiving heavy rotation in current young-adult classrooms, as well as young-adult literature published in the current century, may have its place, Western, young-adult literature published in the 1960’s and 1970’s should still be read, taught, critiqued and celebrated. The general argument against including western, young-adult literature on the reading lists of public schools in the western states, where, arguably they should be the most prevalent, is that the texts are significantly passé and therefore not relevant to contemporary secondary students. While the majority of criticism in favor of western literature is also dated, this paper makes the argument that although the texts and various criticisms may seem behind the times, it should also be taken into account that present-day society is remarkably similar to society when the texts were initially published. Interestingly, not only is present-day society similar to society in the late 1960’s and 1970’s, but a recent interest in regionalism as opposed to vast commercialism also seems to be making an impact on society. By presenting literature that draws attention to the history of a local area, a literary gap created by an interest in who we were as a society and where we came from may be filled. The research conducted takes the classic, western, young-adult novel, True Grit by Charles Portis and that text with a more popular and more contemporary novel, The Outsiders by S.E. Hinton. It’s through this comparison we are able to appreciate and understand the relevance of classic Western literature in the contemporary classroom.

Erika Longino, University of Utah Education DesignbuildBLUFF is a development program wherein graduate architecture students apply custom designing and construction skills to make homes for Navajo families and individuals in need. 39% of the Utah reservation is under the poverty line and the whole Colorado Plateau is in an ecologically vulnerable position. There is clear evidence that water tables are dropping and native biodiversity is suffering because of anthropogenic climate change. Therefore, the human communities in the region are especially needful of proper infrastructure for sustainable development. DesignbuildBLUFF provides diverse services to many groups. The aim of this investigation is to map a framework for sustainable expansion and overall systematic improvement. The investigation will eventually produce a document outlining the inputs and outputs of DesignbuildBLUFF, environmentally and socially. Ecological components like soil quality, solar potential, rainfall, and plant inventory are noted and analyzed quantitatively. Social impacts are gathered using interviews and census data. The data is pulled together in a cohesive, aesthetic map and used to plan DesignbuildBLUFF’s trajectory. The document will provide a clear framework for acknowledging and eliminating unnecessary features, reducing the ecological footprint of the organization, and improving important social relations. This document is not a definitive “master plan”, rather it provides the necessary data and suggestions for growth that take into account whole systems thinking.

Shayla Miller, Dixie State University Education My research focuses on the positive side effects of using models and representations to facilitate student learning in the classroom. The science lesson was taught and recorded to a class of thirty students. The students made visual models/representations of their knowledge about ecosystems from the lesson taught. Test scores were improved, and the information was proven to stay in long term memory according to end of level testing.

Lauren Ezzell and Lauryn Chapman, Snow College Education Most secondary level public schools have school counselors. However, the actual responsibilities of counselors are seen differently by people. There are studies demonstrating the perspective of principals’, teachers’, and counselors’. Yet, little attention is paid to the parents’ perspective and no attention to the students’. That’s why the research, Perceptions of School Counselor’s Responsibilities, is important. Surveys were distributed to high school students and parents throughout Utah. Surveys asked what were the counselors’ three main jobs. The majority of responses were: scheduling, ACT prep, graduation requirements. Participants were asked if there were jobs their counselor was supposed to do, but wasn’t, and what service they would like them to provide. Data was analyzed using SPSS to determine correlative trends then compared to the Utah Model for Comprehensive Guidance and Counseling. College students were also surveyed to determine their understanding of the counselors’ job. Students were asked two questions: What is the job of the college counselor? and What is the job of the college advisor? Responses were coded into five categories: knew job of counselor, knew job of advisor, unaware of difference, knew both, and didn’t know either. Results show when problems arise students confide in teachers instead of counselors, although parents thought differently. When asked what job counselors should do, the majority said emotional/wellness counseling. Results compared to the Utah Model, showed ‘Guidance Curriculum’ was given 3% (students) and 2% (parents) but the state gives 22%. Responses of college students showed only 5% knew the jobs of both the counselor and advisor, and only 15.1% of students knew the job of counselor. As a result, individuals are unsure of the school counselors’ job, which leads to the counselors being viewed as glorified registrars. This research could have lasting impacts on not only schools, but also individual students.

Mercedes Sanford, Ryan Pearson, Kate Summers, and Brigid Crotty, Utah State University Education Deficits in complex syntax may not be apparent in stories that children with Autism Spectrum Disorders (ASD) create on their own. That is, in self-generated stories, complex syntactic forms are not obligatory in order to get the “message across.” However, in order to create complex stories, those that contain complicating actions and events, complex sentences are unavoidable. Although children with ASD have been said to have typical syntactic skills, it is possible, that this is due to a preference for syntactically simple utterances. The purpose of this study was to examine the syntactic complexity of stories created by 5 children with ASD as they participated in an intervention to improve their narrative skills. Stories were elicited once weekly from single scene picture prompts; recorded, transcribed and then coded for narrative proficiency and syntactic complexity. Results indicated that during baseline when children were not receiving instruction, their self-generated stories contained more simple sentences (75-100%) that contained one main verb as compared to complex sentences (0-25%) that contained two or more main verbs. Their narrative skills during baseline were judged to be below average. Over the course of instruction, children’s narrative skills and their use of complex sentences increased in a similar pattern. Individual differences were observed in the impact that this pattern of change had on children’s verbal fluency and grammaticality. These differences will be discussed in terms of a cognitive load hypothesis.

Kristine Jolley, Brigham Young University Education This research-in-progress examines the role of action research in teacher movement toward reform-based mathematics education during a sustained professional development initiative. This initiative, which provided coursework for the Utah Elementary Mathematics Endorsement (UEME), was implemented as a Brigham Young University/Alpine School District partnership collaboration. Although the UEME is offered at several sites across Utah as a major state professional development initiative in mathematics education, our collaboration was unique in incorporating action research as a major component. We pose and seek to answer the following question: What happens to teachers’ knowledge and theories regarding reform-based mathematics education as they engage in action research on a reform-based mathematics education practice of their choice in their classrooms? We have examined data collected from three cohorts of participants over the 4-year duration of the grant; each participant was involved for 2 years. Of the 53 participants, 12 (4 from each cohort) were purposefully selected according to pre- and post-measures of participants’ mathematics beliefs, knowledge, and practice as well as the dimensions of gender, ethnicity, professional assignment, and years of teaching experience. Qualitative analysis of relevant data from these participants is contributing to our understanding of the role of action research in teacher movement toward reform-based mathematics education. We are currently writing the analysis section of a manuscript based on these data. Recognition of the need for improvement in mathematics teaching and learning is not new, yet implementing the Common Core State Standards for Mathematics adds a new layer of challenge. This in-depth study of action research as a professional development practice should inform decision-making regarding the inclusion of action research in subsequent Endorsement programs as well as in other professional development initiatives. Further, this study should add its own unique contribution to the research conversation on a broader scale.

Amber Christensen, Weber State University Education Session Title Women and nutrition in the back country: How their calorie intake and calorie expenditure affect their body composition while backpacking Summary Abstract This study examines the factors that influence change in women’s body composition while backpacking through a mountainous terrain. To see the changes and why they happened, pre- and post- data was collected to measure body composition while participants filled out food logs to generate calorie intake and calorie expenditure. Full Abstract Women are becoming more frequent in the back country as the benefits of nature are becoming more known. Since men have dominated the outdoor world, there is more research conducted on men in the outdoors than there are on women. Nutrition research in the back country is also a new research subject that is gaining interest. Adding women, nutrition, and the back country for research is a topic that not many have touched on. Why is this all relevant and what could it mean? From looking into women and their nutrition in the back country, we can get an inside look at what changes their bodies are making and what factors are causing these changes. During this study women over the age of 18 enrolled in a National Outdoor Leadership School (NOLS) course of their choice went into the back country of Wyoming for thirty days. Before they left for the back country, pre-tests were recorded of their body composition using Weber State University’s Bod Pod which recorded lean muscle masses and body fat masses. During their expedition they were asked to keep a food log. Their leaders recorded their distance traveled during each day which was then calculated into energy expenditure. Upon returning, post-tests were recorded using the Bod Pod to compare results between before and after. Measurements and data have been collected on these women as well as their food logs. A conclusion will be made from analyzing the data from both Bod Pod measurements and the food and nutritional intake vs energy expenditure. Currently the process of entering this data is underway and will be completed within the coming months. Once this data is entered and analyzed with the results from the Bod Pod, conclusions can be made to determine if these women received adequate calorie intake to at least match calorie expenditure and what affects their nutrition intake had on changes to their body composition. Measurable Outcomes 1. Changes in body composition; lean muscle mass vs fat mass. 2. If calorie intake was sufficient to support calorie expenditure. 3. Nutritional value of the foods consumed and how they affected performance.

Raschelle Davis, Dixie State University Education The general populace in America has many misconceptions concerning space; this is due to lack of explicit, clear education. As children grow and observe the world around them they can create misconceptions about how things work. Research shows that this is particularly true when children are learning about space (Brunsell and Marcks, 2007). Many of these misconceptions can be corrected or avoided if the teacher has specific knowledge of the science content and how to teach it (Bulunuz and Jarrett, 2009). As a mother of a young boy I have been asked many questions about space and how it all works. I was never sure how I should answer those questions, since I did not fully understand how it worked myself. This past year I became involved in a NASA astronomy project in my teacher education program that teaches space science to students using a hands-on approach. During my first astronomy event I could not help but be amazed with the questions and the confusion that some of the students had about space while looking through the telescopes. This gave me the desire to learn more about space and teaching children about space. This research project explores children’s misconceptions about space, the problems with how children are currently being taught about space, and how students could more effectively be taught about space in order to reach clear understanding.

Emily Kunz, Shea Long, Melany Reeder, and Brigid Crotty, Utah State University Education It has been proposed that asking a child to make up their own story, rather than to retell a story, is a more stringent test of narrative ability and may tax the linguistic system revealing weaknesses not apparent in less difficult contexts (eg., retelling stories). At least one study has shown that children with Autism Spectrum Disorders (ASD) experience content-form tradeoffs as they master narrative discourse (DeLucchi, Fricke, Kaye, Crotty and Gillam, 2015). The content-form tradeoff was observed when children with ASD with typical grammatical skills and poor narrative proficiency were shown to experience significant grammatical difficulties as they mastered narrative discourse. The purpose of this study was to determine whether content-form trade-offs were observed in stories children with ASD were asked to retell. Five children with ASD ranging in age from 9-12 were asked to retell stories weekly, during a baseline and narrative treatment period over the course of 12-16 weeks. The stories were scored for grammaticality and narrative proficiency. Story retells were observed to be grammatical whether elicited during baseline, early, mid or later treatment sessions. Children with lower language skills experienced times when they were completely unable to recall a story, particularly early on in instruction, although when they did, they experienced good grammatical accuracy. Children with higher language skills were always able to remember parts of the story and were highly grammatical. The story model (retell) may make it less difficult for students with ASD to focus on and remember content while also maintaining grammatical accuracy.

Mary Ann Hammon, Sydney Sneddon, Madeline Williams and Brigid Crotty, Utah State University Education Children diagnosed with ASD often experience marked difficulty in the comprehension and production of narrative discourse that extends well into their adolescent and adult years (7, 8, 9, 10). These narrative difficulties appear to be linked directly to the core symptoms of ASD that manifest in failure to plan using information from multiple sources, a hyper-focus on details at the expense of gist-level propositions and limited use of mental state and causal language to encode goals and motivations of characters (11). Theory of Mind (ToM) accounts propose that a core deficit in ASD is an inability to infer the emotional or mental states of others. Deficits in ToM have been shown to significantly impair one’s ability to engage in ongoing social interactions and to develop the linguistic knowledge (e.g., mental state and causal language) necessary for understanding the relationship between events in discourse (9). Mental state and causal language is necessary for the establishment of a causal framework to link story grammar elements together. The overarching goal of this project was to test whether a program designed to teach narrative language skills was effective for increasing the use of mental state and causal language for children with high functioning autism (ASD). A multiple baseline across participants study was conducted with 5 children with ASD (ages 8-12). Intervention was provided for two 50-minute individual sessions per week for a total of 21-33 sessions (depending on the student). Children’s spontaneous stories and story retells, collected weekly, were analyzed for the use of mental state and causal language before, during and after intervention. All of the children made clinically significant gains after participating in the instruction, with clear changes in the use and complexity of mental state verbs during both types of narrative production tasks (story retell, spontaneous generation). The gains were maintained after intervention was discontinued.

Kassandra Sqrow, Weber State University Education Opportunities for children to interact and connect to the natural environment through play are declining. The benefits of outdoor play are well documented (Little and Wyver, 2008) and show the important role it contributes to healthy child development. Yet, fears and anxieties parents have about the outdoor environment are the most potent forces that prevent parents from allowing their children to play outdoors (Furedi, 2002; Louv, 2006). Identifying the beliefs and attitudes parents have about outdoor-based play can provide valuable insights for recreation and youth professionals to understand how to encourage outdoor play in families. Therefore, the purpose of this study was to explore parents’ perceptions on factors that constrain or facilitate the level of outdoor play that they encourage in their children. Parents with children ages 4 to 10 years old were recruited through a local school to participate in focus groups. Research participants were asked about their perceptive on the role outdoor-play has on their child’s development and characteristics of outdoor play spaces that influence the level of outdoor play their children engage in. Data will be analyzed by identifying recurring themes and patterns of parents’ perceptions and factors that influence the level of outdoor-based play in their child’s life. The data for this study is currently being collected and will be analyzed by November 2014. Implications for practice will be discussed.

Claudy Eckardt, Weber State University Education Obesity is a growing epidemic in the United States. Statistical facts show that one third of U.S. children, between the ages of 2-19, are obese. A common health risk found in children who are overweight is that they will continue to stay overweight throughout the course of their lifespan. Long-term health consequences of obesity only to be found in adults have become more prevalent in children as well. Prevention is the key to reducing this dangerous epidemic and its consequences. The purpose of this study was to investigate children’s knowledge on the causes and consequences of being overweight. This study used a qualitative research method. Two participants were interviewed for case studies. Both participants were between the ages of 8 and 11 and were from different ethnic backgrounds. Each child was given nine questions to answer. Each child was given an adequate amount of time to thoroughly understand each question and respond. Interviews lasted between five to ten minutes. Parental consent was given before the interview process. Results showed that the participants were exposed to the risk factors of obesity. Each child demonstrated a clear understanding that obesity has negative health consequences and expressed preventative measures as well. Furthermore the participants proved that obesity was not only limited to the school or home environment but multiple environments.

Samantha DeLucchi, Telesha Fricke, Kamilla Okey and Brigid Crotty, Utah State University Education Children with ASD often experience marked difficulty achieving proficiency in narration, and often require explicit instruction to learn this important discourse skill. The present study was designed to extend the work of Colozzo et al., 2011 by examining the relationship between content and form in the narratives of school-age children with ASD as they participated in a narrative intervention program to improve their knowledge of story structure and ultimately, to improve their ability to create coherent, organized narratives. Children received two, individual, 50-minute intervention sessions weekly for a period of about 7 – 11 weeks. Children were asked to make up their own stories once weekly. These stories were scored for narrative proficiency and for grammatical accuracy. Findings revealed that prior to beginning narrative treatment, all of the children’s grammatical accuracy was high while their narrative proficiency scores were low. In the first weeks of treatment, all children experienced a significant decrease in grammatical accuracy (<70%), however their narrative scores were observed to increase. Narrative proficiency scores continued to increase and become stable for all children. Interestingly, grammatical accuracy returned to normal (90% or greater) during the last weeks of intervention as children’s narrative proficiency became stable. The findings from this study support the presence of a content-form tradeoff, as children learn difficult linguistic skills, other skills that are ordinarily stable, may fluctuate until the new skill is mastered. The absence of grammatical errors may not be taken as an indication that the student is proficient in constructing a coherent, organized narrative. Further implications are discussed.

Taylor Anderson, Megan Israel Sen, Amy Nielsen, and Brigid Crotty, Utah State University Education Children with Autism Spectrum Disorders (ASD) have been shown to use substantially more simple sentences as compared to complex sentences in their spontaneously generated narratives (Sanford, Pearson, Summers, Crotty and Gillam, 2015). However, Sanford et al., showed that children with ASD began to use substantially more complex sentences in their stories during and after narrative treatment (>50%). It is possible that children with ASD may experience greater difficulty using complex sentences in stories they must generate than in retelling stories they have heard. The purpose of this study was to examine story retells of 5 children with ASD before, during and after narrative intervention for syntactic complexity. Results indicated that during baseline when children were not receiving instruction, their story retells contained more simple sentences than complex sentences. The use of complex sentences was observed to increase as children became more proficient in their narrative production skills. When compared to stories children generated on their own (spontaneous stories), the story retells contained more complex sentences overall, but were often associated with less verbal fluency particularly as children were mastering narrative skills. The findings will be discussed in terms of trade-offs in verbal fluency, grammaticality and the use of complex sentences during different stages of narrative proficiency as a function of initial language knowledge.

James Newton, Scott Anjewierden, and Sasha Luks-Morgan, University of Utah Engineering Oxytocin (OXT), a neuromodulatory peptide produced by the hypothalamus, is involved in a variety of physiological and behavioral phenomena. Exogenous OXT and drugs that mimic OXT signaling are potential treatments of a number of neurological disorders. The canonical mechanisms of OXT function are neuroendocrine in nature, as the peptide is released into circulation through the neurohypophysis. However, OXT has also been shown to exert some of its effects through direct synaptic release within the central nervous system. Using the larval zebrafish as a model, we seek to identify targets of these directly projecting OXT neurons and study what role they play in the modulation of behavior. Critical to this analysis are computer programs which enable precise quantification of anxiety, social behavior, and reward learning. Our custom-written software automatically identifies and tracks free- swimming fish, using measured positions over time to evaluate behavior in a variety of paradigms. In combination with molecular, cellular, and optogenetic manipulation of OXT networks, this project will allow a fuller understanding of the relationship between these neurons and behavior.

Jordan Eatough, Jeremy Struk, Andrew Priest, Brady Vance, Brielle Woolsey, Steven Balls, Camille

Adam Herron, Jared Thomas, Shawn Coleman, Douglas Spearot, and Eric Homer, Brigham Young University Engineering For many years, x-ray diffraction and electron diffraction have served as effective means to understand and classify the molecular structure of many materials. Diffraction, as a physical phenomenon, is well known and theoretical diffraction simulation is relatively simple for perfect crystalline structures of known orientation. Prior methods of diffraction simulation, however, are insufficient to predict experimental diffraction patterns of unknown crystal structures or of crystal structures with high defect density. Recent advancements in computing capability and development of atomistic simulation software have greatly enhanced our ability to predict material properties and behaviors under various conditions. Atomistic simulation has become an extremely useful tool in the analysis of dynamic chemical and mechanical systems. It can only be truly effective, however, when it models a real-world application, can be interpreted coherently, and can accurately predict future conditions. Thus, we are developing new tools that bridge the gap between electron diffraction through real materials and simulated diffraction through atomistic simulations. We present a method of generating Kikuchi Diffraction Patterns from atomistic simulation data with no a priori knowledge of the crystal structure or crystallographic orientation. Our research was inspired by the recent work of Coleman et. al. 2013 and builds on their methods of calculating diffraction intensity at discrete locations in the reciprocal domain. We improve on their method by introducing an integration of the structure factor to ensure complete capture of diffraction intensity peaks while maintaining a relatively low density of sample points. This allows us to significantly reduce the required computation time on the analysis of atomistic simulation data. We use this diffraction data to generate simulated Kikuchi Diffraction Patterns.

Conner Earl, Brigham Young University Engineering The emerging field of Cell-free protein synthesis enables the efficient production of complex proteins for a number of exciting applications such as medicines that better interact with the body, vaccines, antibodies, and renewable, sustainable biocatalysts. However, progress is hampered by high costs and low yields of necessary proteins. This project is designed to improve protein yields and drive down costs by studying techniques of optimization of protein yields in Cell-Free protein synthesis. Our main area of focus is the inhibition of naturally occurring ribonucleases (RNAses) which are enzymes that degrade essential elements for protein synthesis- specifically, the mRNA used to transcribe protien. One of the techniques we intend to use for inhibition of these RNAses is by complexing the RNAse with an appropriate RNAse inhibitor protein thus limiting or eliminating its function of degrading mRNA. The aims of this research project is to: (1) Identify appropriate RNAse inhibitors (2) Design and synthesize inhibitor genes (3) Express, purify and assay RNAse inhibitors (4) Improve Cell-free protein synthesis yields utilizing RNAse inhibitors for analysis of activity and effectiveness as well as the enhancement of cell-free protein synthesis yields. Accomplishing these goals will result in more efficient systems and more accurate analysis that may lead to cheaper, more readily available vaccines and pharmaceuticals produced through Cell-free protein synthesis.

Dan Barfuss, Brigham Young University Engineering Shale oil has long been seen as a source of energy that can be incorporated into existing infrastructure. It consists of kerogen (or organic matrix) bound to inorganic rock. This kerogen can be released as an oil-like substance by heating it up to high temperatures without the presence of oxygen (i.e., pyrolysis). Due to advances in NMR (Nuclear Magnetic Resonance) we were able to make an accurate structural based model that can predict the relative tar and light gas yields[1]. We modified the Chemical Percolation Devolatilization Model (CPD) of coal to fit with the more aliphatic nature of oil shale. The CPD model describes the aromatic regions as clusters and aliphatic regions as bridges. As these bridges are broken the model releases groups of clusters that will form tar. In coal the bridge breaking gives off light gases, whereas in shale oil the bridges are much heavier and mostly form tar. We built two models that accounted for this. We also used the composition of the tar and the gas found by Fletcher et. al. [2] to predict what elements would be left and the aromaticity of the carbons. We found that throughout the reaction new aromatic regions were formed. With information from this model,- we are able to better predict the products of oil shale pyrolysis, and describe what happens chemically.

Nandini Deo, University of Utah Engineering Air quality in the United States has come under scrutiny in recent years. Many pollutants are trapped in the air we breathe in the form of photochemical smog. The aim of this research is to aid the breakdown of these pollutants. Peroxyacetyl Nitrate (PAN) is a predominant smog species; the research conducted aims to decompose this molecule and capture the resulting particles using the photocatalytic properties of Titanium Dioxide Nano tubes. The research conducted thus far has focused on the following questions:What molecules does the thermal decomposition of PAN produce? Is there a metal substrate to attach to TiO2 Nano-materials that aids the breakdown of PAN and its decomposition products? Can a sustainable process/device be identified to functionalize these materials? Literature research shows that PAN thermally decomposes into CO_2, NO_2, methyl nitrate, and formaldehyde. Methyl Nitrate and CO_2 may be eliminated using specific experimental conditions. Hence, it can be determined that the substrate attached to TiO2 must decompose PAN, NO_2 and formaldehyde. Using the molecular modeling programs Avogadro and MOPAC, 50 metals were optimized in relation to Formaldehyde, NO_2, and PAN. To find each metal’s reactivity to each target compound, HOMO/LUMO (Highest Occupied Molecular Orbital/Lowest Occupied Molecular Orbital) energies were calculated and used to find the common reactive metals between the target compounds: Cobalt, Silver, Iridium, and Niobium. To test whether the most complex product of the PAN decomposition (Formaldehyde) will break down, a device was created using a 3-D printer and Cobalt functionalized nanotubes. Pure formaldehyde, a blank sample (no tubes), and a sample with functionalized tubes were run through the device in the form of vapor, in front of a solar simulator. The captured vapor’s GC/MS results show an almost complete breakdown of Formaldehyde with the use of the device containing the functionalized tubes.

Carlton Reininger and John Salmon, Brigham Young University Engineering Electric Vehicles (EV) are a rising alternative to standard combustion vehicles because of their energy cost savings and reduced carbon emissions. However, EVs come with limitations such as limited driving range and potentially long recharge times. The purpose of this study is to determine the feasibility of implementing an electric vehicle system into an urban environment. Using data provided by the New York City Taxi and Limousine Commission, models are developed and generated to simulate driver shifts and analyze system level impacts from EVs on driver behavior. The models evaluate the number of charge events over the course of a shift and calculate the potential revenue lost to missed fares during charge intervals. Across the system, the results indicate that for a majority of NYC taxi drivers, EVs can be implemented without significant changes in driver behavior, while providing an economic and environmental advantage over current combustion vehicles. These preliminary findings can be used to support implementing such a system in urban environments and these models could be used as a template toward analyzing EV taxi potential in other cities.

Scott Anjewierden, James Newton and Joshua Barrios, University of Utah Engineering Organisms in their natural environment are constantly presented with sensory stimuli. These stimuli must be filtered by the brain to select an appropriate behavioral response. A significant example of this filtering process is audiomotor prepulse inhibition (PPI). In PPI, the startle response to a loud noise is suppressed by a preceding stimulus of lower intensity. This ability to optimize behavior in response to environmental context is an essential brain function. Defects in PPI are associated with neurological disorders such as obsessive- compulsive disorder, Tourette syndrome, and schizophrenia. This project demonstrates the development of new software to analyze swim kinematics in a restrained, larval zebrafish model of PPI. Our programs automatically extract several kinematic parameters from image sequences of behaving animals and use them to classify behavior into one of three, stereotyped categories. Correct classification is reported in 96.32% of trials (n = 162). This automated analysis will now permit a more robust study of PPI in these animals, where the brain’s experimental accessibility will allow us to discover the cellular bases of sensory filtering.

Hayley Ford, Kristen Wilding and Matt Schinn, Brigham Young University Engineering Therapeutic proteins are specially engineered proteins used to treat many large profile diseases. Such diseases include cancer, diabetes, hepatitis B/C, hemophilia, multiple sclerosis, and anemia. The use of these proteins is specific and highly successful and the demand for these proteins in rapidly increasing. One of the largest problems with the use of therapeutic proteins is the cost of making them. The cost of producing these proteins amounts to hundreds of billions of US dollars every year. There is a growing need to find better, faster, and cheaper ways to create them. As specific therapeutic proteins are coming off patent, research labs are able to explore the processes of making these drugs that have become such a large part of the pharmaceutical industry. Here we report the use of cell-free synthesis as a more cost-effective way to produce these therapeutic proteins. Cell-free protein synthesis is faster and allows for direct manipulation and control of the protein creating environment. Cell-free synthesis can produce proteins in a matter of days as opposed to the weeks it takes to produce them in vivo. The increased manipulation and control of the environment that comes with cell-free synthesis allows improved accuracy in creating the desired proteins and is more adaptable to changes if they need to be made.

Theo Stoddard-Bennett and Steven Christiansen, Brigham Young University Engineering Damage to the human retina is often irreversible and so currently there are no established treatments of diseases such as dry age related macular degeneration (AMD). Dry AMD results in a loss of sight because of cell death in the macula, a centralized part of the retina which contains a high concentration of photoreceptor cells. One possible treatment would be to limit the rate of cell death within the macula, however this is not a comprehensive solution. Rather, regeneration of the photoreceptors within the retina is necessary to restore sight. In current research, Müller glia cells, a major glial component of the retina, can potentially be used as sources for photoreceptor regeneration in order to combat dry AMD due to their homeostatic regulation of retinal injury. Directed reprogramming would occur through a five step process. The Müller glia would need to undergo de-differentiation to Müller glia-derived progenitor cells (MGPCs), proliferation of MGPCs, migration of MGPCs, neuronal differentiation, and integration in order to generate retinal neurons. Müller cells can be isolated and cultured by dissociating retinal tissue in optimal media. Here we present the dissection and dissociation of rat retinal tissue to obtain purified proliferating Müller cell cultures. Our lab has tracked and modelled the rates of proliferation and phenotypically characterized the stages of proliferation. Using immunofluorescence and PCR tests to confirm purity, we will then expect to run a series of assays to identify growth factors, Wnt signals and cytokines to test the effects of retinal extracellular matrix proteins on Müller cell de-differentiation to MGPCs. The focus of our current research is the identification of reprogramming mechanisms that may possess beneficial data leading to both unique strategies for promoting retinal regeneration in mammals and clinical applications for those living with dry AMD.

Takami Kowalski, Warren Robison, Anton Bowden, and Brian Jensen, Brigham Young University Engineering Using a coronary stent to expand a blocked blood vessel as a way to treat coronary heart disease has proved effective in the past. However, there are risks, such as thrombosis, that are a natural side effect of inserting a foreign object into the body. Creating a stent out of a hemocompatible material such as carbon-infiltrated carbon nanotubes could potentially resolve these issues and also make unnecessary treatments such as dual antiplatelet therapy as a way of decreasing the risk of adverse side effects. Previous research done in this lab has shown that carbon-infiltrated carbon nanotubes can be grown in a pattern defined by photolithography on a planar surface. The present work demonstrates preliminary results from patterning a flat, flexible substrate and rolling it into a cylindrical shape before growing carbon-infiltrated carbon nanotubes as a way to fabricate cylindrical stents, fulfilling all necessary specifications for a stent with the added benefit of hemocompatibility. We also demonstrate growth on curved substrates and explore process parameters for achieving good-quality CNT forests.

Benjamin Buttars, Jeffrey Nielson, Spencer Baker, Jonathon Thibaudeau, Angela Nakalembe, Tim

Steven Stanley, Brigham Young University Engineering The genetic code has long been restricted to a set of 20 fundamental building blocks called amino acids. Recent research has expanded the genetic code through unnatural amino acids (uAA), thus adding enormous possibilities to the potential chemistries of proteins. Because nature is highly selective in the protein translation process, it has proven extremely difficult to successfully insert multiple uAAs simultaneously. The incorporation of an uAA with in vitro methods typically relies on the use of the amber stop codon as a mutated insertion site. A stop codon placed at the middle of a gene can code for either the uAA or termination, thus, protein synthesis may often terminate prematurely instead of inserting the desired uAA. This inefficiency inhibits the possibility of inserting multiple uAAs simultaneously. We propose a novel method that will allow for multiple uAAs to be inserted simultaneously. Our method involves isolating a minimal set of tRNA for in vitro protein synthesis, allowing for uAA insertion to occur at codons other than the amber stop codon. My work has focused on the production of 4 versions of uAA-tRNA synthetase, a protein that charges tRNA with the uAA. We are currently growing these 4 different proteins in bulk and testing their activity. We will test them for compatibility, confirming that they do not interfere with one another and other synthetases native to our in vitro protein synthesis system. These uAA-tRNA synthetases, in conjunction with specialized tRNA, will provide the basis to efficiently incorporate multiple uAA simultaneously. The success of this project will have many practical applications ranging from new therapeutics to new methods of medical diagnosis.

Sam Katz, University of Utah Fine Arts “Tom Stockham: The Father of Digital Audio Recording” is a 30-minute documentary film about former University of Utah professor Thomas Greenway Stockham, Jr., who developed the first commercially viable method of recording sound digitally with extremely high fidelity and made it possible to edit sound and music using a hard drive. Despite the limitations of 60s and 70s computing technology, as well as a number of audio professionals who opposed to the shift to digital audio, Stockham believed in his ideas, persevered, and changed the way we listen to music forever. To this day, these innovations have dramatically altered the shape of the audio recording industry in music, television, and film. Despite Dr. Stockham’s many achievements, his story remains relatively unknown outside of the audio engineering world, even here at the University of Utah and in Salt Lake City, where much of his pioneering work was done. This film brings well-deserved attention to Dr. Stockham’s story. Sadly, Dr. Stockham passed away from early-onset Alzheimer’s in 2004, therefore I portray him by interviewing those who knew him best: his wife, his four children, and his colleagues. I situate Stockham’s life and work in a larger historical context by interviewing historians, musicians, and audio industry professionals, and by mining archival footage, family photos, voice memos, and magazines for relevant material. I travel from Seattle, to Boston, to Lake Powell, to Moab, to Salt Lake City. In homage to Stockham, I use the sound and music of the film, rather than images, as the locus from which meaning and emotional power are derived. The finished film serves as an important educational and historical resource and helps to preserve an important piece of the history of the University of Utah, Salt Lake City, and the State of Utah in general.

Kelly O’Neill, University of Utah Fine Arts After studying the formal qualities of photographic production and the canonic narratives of art history for over three years at the U, I am still left with a pressing question: how can this medium of artistic self-expression also be considered evidence admissible in the court of law powerful enough to elicit felony convictions? How can these mechanical images which I have been trained to see as subjective representations of artistic sentiment in their contrast, tonality, and composition simultaneously be objective records of fact in judicial and scientific discourses? If the medium of photography does exist how is this single operation able to function in such heterogeneous and contradictory discourses? Through my works and research I investigate these and other questions concerning the photographic medium’s ambiguous nature as a simultaneously aesthetic and empirical object. By combining a vast assortment of photographic forms from contemporary GIFs to historical processes such as the Cyanotype, my work reveals the multiplicity of the photographic form and its dubious ability to function within seemingly contradictory systems of knowledge production. Interrogating the processes by which photography has been used and abused, my project does not propose to reveal the truth of photography, but rather underlines the importance of seeing photography in a new and radicalized fashion. The images that I create contemplate the liminal spaces of photography in which its factual, emotional, institutional, and narrative truths commingle; fragmenting not only the solidity of the photograph but also the cultural and institutional systems it predominates. More than just a series of art works, my research seeks to bring a broader discourse on photographic meaning into a serious academic engagement which does not treat it as a simple device for conveying meaning but as a specific and complex subject in its own right.

Steven Saline, Dixie State University Fine Arts Electronic Dance Music or EDM has grown from its underground club origins in the late 70’s to early 80’s to become a widespread phenomenon in pop music. Through out those years, EDM has been categorized in previous terms such as Techno, and Electronica. Today EDM can be heard in music festivals through out the world and is now widely experienced in the US. Much of the genres within EDM such as Dubstep, Hardcore,Trance, etc… were created and have evolved outside the US, however; House and Techno originates here in the US. In this presentation I will discuss the history of some of the popular genres in EDM, present how each of the genres started whether they were created on their own or their evolution from previous electronic music, the history of its origins, how the music evolved in Europe, and its move to the US as we hear the music today. I will present how wide-spread EDM has become and how diverse the various forms are within the genre. I propose that if EDM continues in the direction that it is moving now, EDM will continue to grow among all other forms of music in the world for years to come.

Amanda Salgado, Weber State University Humanities In 1983, Rigoberta Menchu, the first indigenous Mayan-Quiche Nobel Peace Prize recipient, shared the terror and the abuse that she and millions of other indigenous people in Guatemala were experiencing during the country’s 36-year Internal Armed Conflict. In her book Me llamo Rigoberta Menchu y así me nació la conciencia, she discusses how the indigenous population was frequently viewed and treated as inferior by the Ladinos (those of mixed indigenous and European heritage), and was therefore subjected to a great deal of discrimination, which was reflective of the legacy of the country’s colonial past. The purpose of this research was to examine within a Postcolonial framework, if postcolonial structures were still in force in Guatemala, and if and how they continued to affect the indigenous population, particularly Mayan women living in rural areas. Methodology included analysis of newspaper articles, journals and documents, as well as a two-week field experience, talking to Mayan women. The result shows that while the political situation of Guatemala has improved since the time of the publication of Menchu’s book, many of the conditions and practices that promote discrimination against the indigenous population have continued and are still visible today, reflective of a Postcolonial society that values European descendants more than their neighbors. For instance, the educational system now takes into account indigenous languages, and Mayan spirituality is not persecuted, a first since the Spanish Conquest. Nevertheless, indigenous women continue to experience a triple discrimination because based on their sex, social status, and ethnicity. The goal of this research is to promote greater awareness of these issues.

Natasha Mickelson, Brigham Young University Humanities Young adult contemporary realistic fiction is a genre which attempts to portray real life. Young adult readers of these novels should be able to find themselves in the characters and relate to their backgrounds, experiences, and perspectives on life. While many young adult novels deal with controversial topics such as sexuality, drug use, physical abuse, suicide, and other difficult subjects in an attempt to be realistic, one aspect of life still largely considered a literary “taboo” is religion.Through examining studies done and looking at a sample of novels in the young adult contemporary realistic fiction genre I found that most of these books mention nothing about the religious beliefs or backgrounds of their characters. In the few novels which do bring up religion, Christian beliefs and characters are more common than minority religions. However, those novels depicting Christian characters are more likely to show them in a negative light. These novels frequently portray religious characters (especially leaders) as bigoted, fanatical, or gullible. Often the main adolescent character is trying to break free from cultish groups, and their eventual loss of faith is celebrated. Since contemporary realistic fiction attempts to portray the real world and real teenagers, I researched recent studies surveying American teenagers’ views on and involvement with religion. The results of these studies show that most teenagers identify with and willingly participate in religious groups and practices. In my research I found that this disparity between real life and realistic YA fiction exists due to the aversion of writers and publishers to possible censorship issues and alienating potential readership. However, scholars agree that both the lack of religion and the negative religious stereotypes in these novels can leave teenage readers incorrectly feeling as though their beliefs in or questions about God and religion are uncommon or wrong.

Thomas Aguila, University of Utah Humanities “A Tide Just West” is a book arts project that conceptually adopts the theories of Hélène Cixous– and to an extent Julia Kristeva and Luce Irigaray– and concerns itself with investigating narratological schemas, as the book experimentally utilizes photographic imagery (alongside the text) to constitute a story of écriture féminine. Ecriture féminine, translated from French as “woman’s writing,” is a type of writing characterized by its tendency to subvert the narrative conventions and the pragmatism within books, poetry, language, and the genres in between. Hélène Cixous used this conceptual term in her 1975 essay, “The Laugh of Medusa,” and considered the difficulty of definitively putting into words such a category: “It is impossible to define a feminine practice of writing, and that impossibility will remain, for this practice can never be theorized, enclosed, coded.” In this project, écriture féminine takes form– and subverts form– through the book’s incorporation of photographic images. The narrative’s images act as areas that are not reliant on words but visual experiences that contradict, unify, and break apart the text alongside it. Such visual components allow new narratives to form. Instead of illustrations, the visual images act as indefinite, experiential moments for the reader to expand upon (to pass through), as the reader’s literal relationship to the characters, scenarios, and overall thematics of the book turns more toward conflicting, potent, and vague contradictions. The images fracture and destabilize the logocentrism of the book, destabilizing that expectation and faith upon the written word; they act as an in-definitude to the text, the narrative, the body, and the metaphors between the three.

Jennifer Melvin and Wendy Schatzberg, Dixie State University Physical Sciences The general chemistry laboratory can be a dangerous place, and the possible danger is amplified by the fact that general chemistry is frequently a student’s first chemistry laboratory experience. College students come from a variety of backgrounds with only some having had chemistry in high school, and therefore many students will not know beforehand what kind of precautions to take or what kind of action to take in case of an accident in the lab. Safety information is given briefly at the beginning of the semester, but the efficacy of this is uncertain. An online survey was conducted to gauge first- and second-semester general chemistry students’ knowledge about chemistry laboratory safety and the data gathered was analyzed. This survey was conducted at two secondary schools in two different countries. Statistical analysis will be presented. Results will allow discernment of misconceptions held by students over two semesters and between countries, and conclusions can be made about the effectiveness of current laboratory safety instruction methods.

Brett Barton, Dixie State University Physical Sciences Dissolution using ionic liquids has been shown to be an efficient analytical method of dissolving keratin fibers. Using wool and hoof material from livestock, chloride-based ionic liquids were used to break down the hydrogen bonds important for keratin structure, making the extraction of constituent material much easier. Efficient methods of extraction allow for small samples to be analyzed while still providing high yields; efficient dissolution of keratin in a small sample size will be utilized to prevent any harmful effects on the animals. Ionic liquids are nondestructive solvents which allow for the safe extraction of organic substances. Denaturing keratin would help in the process of identifying any constituent radioactive materials. Efficient identification of radioactive material in livestock is crucial for maintaining health and quality of life.

Brandon Davies, Utah Valley University Physical Sciences Epithelial ovarian carcinoma (EOC) is the sixth most common cancer in US women. The long-term cure rates are low due to the lack of reliable biomarkers for early disease detection, resulting in advanced stage diagnosis. Approximately 75%-80% of ovarian cancers are diagnosed at stages IIIV with a 10% 5-year survival rate despite aggressive treatments. Claudin proteins are being studied as possible biomarkers as they are aberrantly overexpressed in EOC tumors. The Claudin family of proteins are a main component of tight junctions in the upper region of epithelial cells that act as gateways for the exchange of water and solutes while also helping determine the cell’s polarity and function. Changes in these proteins cause changes in phenotype and function of normal epithelial cells, such as proliferation control, trans-epithelial resistance, polarity, and solute transport. Claudin-16 is often aberrantly expressed in breast and ovarian cancer, while Claudins 3- and 4 are highly overexpressed in EOC. The location of these proteins is also correlated with oncogenic transformations and cell proliferation. Determining the specific characteristics of these Claudin proteins can prove to be of incredible benefit in cancer treatments. As these proteins are targeted during these therapies, these tight junctions may then send normal signals, which in turn can regulate the cell normally. The C-termini of the Claudins, which are cytoplasmically located, contain a known PDZ-binding motif and may interact with other junction proteins or with proteins involved in interesting signaling pathways. To identify these interacting proteins, we will use the Expresso T7 Cloning System (Lucigen Corp., Middleton, WI) to purify the Claudin-16, -3, and -4 C-terminal tails to use in pull-down assays. This process includes using affinity tags to capture the Claudin tails by FPLC, which can then be analyzed by SDS-PAGE and, ultimately, the corresponding genes cloned and sequenced. This study can potentially provide crucial information in relation to how members of the Claudin family interact with other proteins that are commonly found in tissues that are misregulated in cancer. With this data treatments can be improved to increase the responsiveness of ovarian cancer patients.

Tim Beach, Utah State University Physical Sciences Successful management of the arid West requires a basic knowledge of available water resources, withdrawals, and existing management efforts. Utah, the second driest state in the country, is continuing its efforts to restore impaired water systems and teach the next generation to conserve water. Because of a fast-growing population, the diversity of Utah’s landscape, and strict regulations that govern water throughout the state, understanding the region’s current water condition can be difficult. Historically, the majority of this information has been stored in databases, represented by only numbers and statistics. In an effort to better conceptualize this data and increase the spatial understanding of Utah’s water, a set of maps have been produced. These maps were created using ESRI’s ArcMap software and Adobe Illustrator. Included are major lakes and rivers, average annual precipitation, average annual streamflow, total urban withdrawals per county, total agricultural withdrawals per county, and water management. Viewing visual representations of this information in multiple maps can aid in creating spatial inferences, and raise additional questions regarding aquatic restoration and management throughout the state. This set of maps can also be used to supplement physical science education at all school levels. Future work includes distributing these maps as posters to schools and water managers, as well making it a resource for teachers via websites and fact sheets.

Zachary Coffman, Utah Valley University Physical Sciences Breast density describes the proportion of connective tissue versus the fat tissue in the breast. Studies have shown that women with higher breast density are four to five times more likely to develop breast cancer than women with lower breast densities, (www.women.org/BreastCancer). Higher breast densities have proven to make current breast cancer imaging and detection more difficult. A pilot study done at the Huntsman Cancer institute showed that the ultrasonic parameter peak density, generated by high-frequency (HF) ultrasound (20-80 MHz), was sensitive to breast tissue pathology. The objective of this study was to determine the effect of breast density on ultrasound wave propagation from high frequency ultrasound using phantoms that mimic the histology of breast tissues. Phantoms were created from a mixture of distilled water, agarose powder, and 10X TBE stock solution. In order to simulate breast tissue histology and breast density, polyethylene microspheres were embedded into the phantoms in layers, totaling 4 layers per phantom. The polyethylene microsphere size (90-106 μm diameter) was kept constant within each phantom while the weight percent concentration of the microspheres varied (0.00g to 0.06g). Pitch-catch and pulse-echo measurements were acquired using 50-MHz transducers (Olympus NDT, V358-SU, 50 MHz, 0.635-cm diameter active element), a HF pulser-receiver (UTEX, UT340), and a 1-GHz digital oscilloscope (Agilent DSOX3104A). Glycerol (Genesis Scientific) was used as a coupling agent between the transducers and the phantoms. Spectra were derived from the data, giving peak density (the number of peaks and valleys in a specified spectral range), velocity, and attenuation values. The results showed that peak density did not start to show a trend until phantoms of 0.03g concentrations, where it increased from a value of 14.0 peaks (0.03g) to 18.7 peaks (0.06g). Velocity showed a statistically significant increase with greater polyethylene microsphere concentration, from 1508 m/s for 0.00g to 1536 m/s for 0.06g. No trends were observed for attenuation. These results indicate that higher levels of scattering centers in dense breast tissues will be detectable with high frequency ultrasound. This additionally shows that high frequency ultrasound may also be sensitive to greater amounts of connective tissue present in dense breast pathologies. High frequency ultrasound is sensitive to the weight percent of polyethylene microspheres. Future research is planned to further understand this relationship, including repeat studies and studies of phantoms containing chopped polyethylene fibers and triple the polyethylene microsphere concentrations to more closely simulate dense breast tissues.

Melinda Hurlbut, Dixie State University Physical Sciences A newly discovered plant fossil locality in the Chinle Formation (Upper Triassic) in Washington County broadens the distribution of known Late Triassic plant fossil localities to include southwestern Utah. Previously reported plant localities in the Chinle Formation are known from southeastern Utah, Arizona, New Mexico, and equivalent strata from the Dockum Group in Texas. The majority of the known plant fossil localities are from higher stratigraphic units of the Chinle Formation. However, the new Washington County locality is from the older, basal unit, the Shinarump Member. The plant fossils identified from the new locality include fronds of the fern Phlebopteris sp., fertile leaves of the fern Cynepteris sp., and leaves of the bennettitalean Zamites sp. Undetermined species of conifers are represented by a partial branch and a three- dimensionally preserved cone containing well preserved seeds. The diversity of species found at the Washington County plant fossil locality correlates with other known floral assemblages from the Chinle Formation, suggesting general homogeneity of Chinle Formation floras. These plant fossil assemblages support interpretations of basal Chinle Formation paleoclimates as humid and warm.

Amy Fair Brother, Utah Valley University Physical Sciences Results from a 2010 pilot study indicated that multiple parameters in high-frequency (HF) ultrasound spectra (20-80 MHz) correlate to a range of tissue pathologies in surgical margins from breast conservation surgery (BCS). One of these parameters, peak density, was particularly effective at discriminating between normal, atypical, and malignant patholUtah Conference on Undergraduate Research 2015 100 ogies. Subsequently, Utah Valley University and the Huntsman Cancer Institute initiated a follow-up study to further investigate this approach. Objectives: The purpose of this study was to determine the sensitivity and specificity of HF ultrasound for differentiating malignant tissue from normal tissue in BCS surgical margins. Methods: A 73-patient blind study was conducted with conventional pathology used as the gold standard for assessing the HF ultrasound method. Specimens were delivered by the surgeon’s team immediately following resection and ultrasonically tested outside the surgical suite. The margins were approximately 3x20x20 mm, and were oriented using a small staple inserted by the surgeon in one corner and a stitch on one side. The margin was tested at 2-5 locations on the specimens using our methodology and then sent to pathology for their analysis. 498 specimens were tested from 73 patients. That corresponded to 1112 positions collected from the margins. The data was then analyzed for malignancy using peak density, and then correlated with the traditional pathology. Results: Results from the current study indicate that peak density can differentiate between malignant and nonmalignant pathologies with an accuracy of 73.8%. The correlation between pathology and peak density has a high level of statistical significance compared to random chance, with p = 0.000078 (Fisher’s Exact test). The results also provide data for improving the technique. For example, approximately 3 times more false positives were observed than false negatives, indicating the peak density threshold used for identifying malignant pathology is most likely too low and should be adjusted to a higher value. Conclusions: Results from this study showed that HF ultrasound has the potential to provide rapid, intraoperative evaluation of surgical margins, thereby decreasing the number of additional surgeries for patients and thus increasing the quality and efficacy of surgical treatment for breast cancer.

Eric Johnson, University of Utah Physical Sciences The ability to reduce O2 in mild conditions holds many important implications such as: use as an economical fuel cell, pharmaceutical synthesis, biomass degradation and conversion of small molecules to fuels. We are building the [M(μ-OH) (oxapyme)M(H2O)]+ molecules and symmetrical counterparts for use in O2 reduction reactions (M = Cobalt, Nickel, Iron). The precursors to the [M(μ-OH)(oxapyme)M(H2O)]+ have been synthesized as follows. 2-[5-(2-Nitro-phnyl)-[1,3,4]oxadiazol- 2-yl]-phenylamine serves as the backbone of the complex, allowing for two distinct ligands to be attached to each side. Initial yields for this synthesis averaged at 6%. To be able to complete the synthesis this needed to be significantly raised. The literature procedure was modified in various ways until new reaction conditions were found that allowed for 40% yield. Other precursors include 2,2’-(1,3,4)Oxadiazole-2,5-diyl-bis-aniline which also serves as a ligand backbone but differs in that it allows for preparation of a symmetrical ligand have been synthesized with a 51% yield. The first ligand Bis-pyridine-2-ylmethyl-amino has been produced with a 60% yield. The second ligand Methyl-pyridine-2-ylmethyl-amino has been synthesized with an approximate yield of 75%. These yields are high enough to finish the synthesis of the ligand and subsequently coordinate the metals. Upon completion, the electrochemical properties of the compounds that differ in the metal composition and the ligand (symmetrical versus asymmetrical) will be determined using studies such as cyclic voltammetry. Once the metal and ligand that are most apt at oxygen reduction is determined, more advanced studies will be undertaken to identify the reaction mechanism and intermediates.

Kyle Marcus, Cami McKellar, Riley Pearce, Shay Beck, and Zenja Draca, Dixie State University Physical Sciences Invasive marine and freshwater species have a detrimental impact on aquatic ecosystems and are easily transferred between bodies of water as a result of unregulated settlement and attachment to commercial and recreational watercraft. This results in infestation of waterways and disruption of native organisms throughout an ecosystem. The quagga mussel (Dreissena rostriformis bugensis) is one example of such invasive species that has called for a focus on cross-contamination prevention. The goal is to use aquatic paint suitable for watercraft that prevents the settlement and/or attachment of various aquatic species such as algae, snails (Physa sp.), anemones (Aiptasia sp.), and quagga mussels. The paint is integrated with newly developed surfactants that act as an inhibitor to the adherence ability of invasive aquatic species. The surfactants are added to provide a barrier between the paint surface and the organisms creating an undesirable surface area for the organisms to attach. This barrier disrupts the specific naturally occurring chemical and physical processes that allow organisms to adhere to surfaces. The most innovative characteristic of the surfactant-based paint is its effectiveness on adherence inhibition without degradation, dissociation, or toxicity to the environment. Preventing adherence of invasive organisms to surfaces could have significant positive effects on the efficiency and cost of operations in marine environments and waterways.

Mattie Jones, Dixie State University Physical Sciences Current techniques for isolating components of samples found at crime scenes by their unique chemical properties are lengthy and often destroy important forensic evidence. New methods aimed at forensic analysis of sensitive, minute samples are critical to the intelligence community. In particular, successful extraction of dyes from materials found at crime scenes will provide innumerable benefits for matching, identifying, and finding origins of these materials and dyes. Ionic liquids possess the necessary chemical properties to ensure efficient extractions while maintaining the forensic signatures of the original materials. Ionic liquids, which are organic salts that are room temperature, provide a versatile solvent to achieve single-component extraction-separation-identification of forensic analytes. Following extraction, successful identification by infrared, absorption, and fluorescence spectroscopy has provided evidence of preserved quality and complete separation of material and dye. This novel approach to forensic analysis is advantageous particularly when sample sizes are extremely limited, but it can be readily scaled to larger applications. Developing a simple and affordable method of achieving specific molecular interactions provides a solution for often unidentifiable evidence in crimes. Harnessing the versatility of ionic liquids in a high-yielding recovery and efficient single-pot methods will enhance forensic abilities for the intelligence community and forensic investigators.

Madeline Parson, Travis Bulloch, and Tyler Argyle, Southern Utah University Physical Sciences Lipid bilayers have many important purposes in living cells. A lipid bilayer forms a barrier which separates the fluid inside the cell from the fluid surrounding the cell. The arrangement of components within cell membranes can be extremely important, particularly in cell communications. For example, when our immune system attacks certain pathogens, it recognizes them by specific proteins in the inner and outer regions. This can be thought of as forming a “bull’s-eye” shape. The ability to generate such patterns in bilayers might see applications in many areas of biology. Our goal is to take an initially un-patterned supported lipid bilayer (model cell membrane) and use magnetic tweezers as a delivery system to generate patterns. We hope to show pattern formation using fluorescent-labeled lipids within our bilayer. In the past, we have used streptavidin and biotinylated lipids with Oregon Green. Currently, we are pursuing a fluorescein/anti-fluorescein system that has been yielding much more promising results. We are currently using a fluorescent microscope to confirm that patterns are forming within the bilayer.

Michael Kutschke and Niccolo Fiorentino University of Utah Measurements of joint angles, moments, and forces can be sensitive to positional changes in the center of a joint. Due to its deep location, the hip joint center (HJC) can be difficult to determine. Regression equations and functional methods use skin markers and are commonly used to measure the HJC, yet introduce sources of error such as bony landmark identification, soft tissue artifact, and system resolution. Additionally, the accuracy of said methods cannot be established in-vivo without a reference standard. The purpose of this study was to implement a dual fluoroscopy (DF) and model-based tracking technique to quantify the subject-specific HJC position in-vivo. This reference standard (DF-HJC) was then compared to the HJC defined by regression equations (CODA) and a functional method (FHJC) using skin markers. Five subjects with normal hip anatomy provided informed consent to participate in this IRB approved study. A gait marker set was applied to the subject’s skin. The subject performed various activities involving the inferior limb while a 10-camera Vicon system measured the position of the skin markers. From these data, the CODA and FHJCs were identified. Simultaneously, the hip was visualized using a DF system, and the DF-HJC was identified using model-based tracking. The DF-HJC was then transformed to the Vicon coordinate system for comparison with the CODA and FHJCs. The average Euclidean distance (and standard deviation) for the five subjects from the DF-HJC was 2.0 (0.6) cm for CODA and 1.3 (0.4) cm for the FHJC. To our knowledge this is the first study to use DF and model-based tracking to measure the in-vivo position of the HJC. This technique affords greater accuracy in determining subject-specific bone geometry and visualization of deep hip anatomy, thus may be considered a reference standard for identifying the HJC.

Michaelle Cadet, Utah Valley University Physical Sciences Breast cancer is the most common cancer among women in the United States. Tumor angiogenesis and its inhibition is an important aspect of oncology and the treatment of cancer. High-frequency ultrasound (10-100 MHz) is particularly sensitive to small vascular structures that are close in size to the ultrasound wavelength (15-150 _m). The ability to rapidly determine the degree of vascularization in small animals in vivo would provide a useful characterization tool for breast cancer studies. The objective of this study was to determine if direct ultrasonic measurements in the 10-100 MHz range could be used as a vascularization assay for breast tumors and other tissues. To accomplish this, six mice from the Huntsman Cancer Institute (Salt Lake City, Utah) with grafted breast cancer tumors (three control and three treated with an angiogenesis inhibitor called Avastin) were tested in vivo using through-transmission ultrasonic measurements. A second study was also performed at the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (Vienna, Austria), where the femoral artery in one hind leg of each of sixteen mice was ligated and tested over the time period of eight days. Eight of the ligated limbs were treated with vascular endothelial growth factor (VEGF) while the remaining eight ligated limbs were allowed to grow ischemic. The unligated limbs were controls. Results from the Huntsman Cancer Institute study indicated that breast tumors in Avastin-treated mice showed higher ultrasound velocities than control tumors. This can be ascribed to the vasculature in the nontreated tumors creating greater wave scattering in the tissue, thus decreasing the velocity. Results from the Boltzmann Institute study indicated that in mice with ligated femoral arteries, ultrasonic signals from ischemic limbs displayed a decrease in wave velocity over the test period as compared to the VEGF-treated limbs. However, both the ischemic and VEGF-treated limbs showed decreases in ultrasonic attenuation during the entire test period. Results from Avastin-treated mouse tumors and mouse limbs with ligated femoral arteries revealed that high-frequency ultrasound holds potential for measuring angiogenesis in vivo.

Nicole Cowan, Utah Valley University Physical Sciences Breast cancer is the second most prevalent cancer among women, affecting one out of eight women in their lifetime. The ability to differentiate between malignant and normal tissues during breast cancer surgery would enable the surgeon to remove all of the cancer from the affected region in the breast, thereby reducing the risk of recurrence and the need for subsequent surgeries. A pilot study conducted at the Huntsman Cancer Institute showed that high-frequency ultrasound (20-80 MHz), and in particular the ultrasonic parameter peak density, was sensitive to breast tissue pathology. The objective of this study was to determine the effect of tissue microstructure on peak density using phantoms that mimic the histology of breast tissue. Phantoms were created from a mixture of distilled water, Knox gelatin, and Metamucil fiber. In order to simulate breast tissue histology and terminal ductal lobular units, polyethylene microspheres were embedded into the phantoms in layers, totaling 4 layers per phantom. The volume percent of polyethylene microspheres was kept constant in each phantom while varying microsphere sizes (58-925 μm diameter). Pitch-catch and pulse-echo measurements were acquired using 50-MHz transducers (Olympus NDT, V358-SU, 50 MHz, 0.635-cm diameter active element), a HF pulsar-receiver (UTEX, UT340), and a 1-GHz digital oscilloscope (Agilent DSOX3104A). Glycerol (Genesis Scientific) was used as a coupling agent between the transducers and the phantoms. Spectra were derived from the data, giving peak density (the number of peaks and valleys in a specified spectral range) and attenuation values. In a previous study, histology- mimicking phantoms were fabricated where the weight percent of polyethylene microspheres was kept constant, but the microsphere diameter was varied. The former study showed a clear trend of higher peak density values for smaller diameters, but no trend for attenuation. In contrast, the phantoms from this study showed no trend in peak density, but a clear trend of higher attenuation values for larger microspheres. The results show that specific changes in tissue microstructure affect the parameters of peak density and attenuation differently. Changes in the number of scatterers and in their size, as in the previous study, affected peak density most significantly. In contrast, changes solely in the size of the scatterers, but not in their number, affected attenuation most significantly. These results are consistent with attenuation results for lobular carcinoma in the pilot study. These results show that peak density and attenuation are complementary parameters, and could be used together to characterize a variety of tissue pathologies