Spencer Waters and Hannah Page, Brigham Young University
Social and Behavioral Sciences
Variations in the μ-opioid-receptor (OPRM1) gene have been shown to affect most mammalian species mother-infant relationships and more recent studies show it may also modulate it in at least some primates Macaca mulatta (rhesus monkeys). Research shows that variation in the OPRM1 SNPs in rhesus macaques (C77G) is linked to relational behavioral differences, specifically within mothers and infants. Individuals homozygous for the ancestral C allele exhibit more “normal” behaviors, attachment, and oxytocin (OT) levels, whereas individuals heterozygous for the G allele exhibit greater variation in OT levels, as well as the type and quality of bonding1. Behavioral data was collected by the National Institute of Health (NIH) between 1996 and 2005. Individual monkeys in the study were genotyped for the previously characterized OPRM1 genotype. Repeated measures analyses were run using weekly measures of mother-infant behaviors across the first 24 weeks of the infants’ lives, using the mother’s genotype and infant’s sex as between-subject factors. A second series of analyses were performed using the infant’s genotype and infant sex as between-subject factors. Leave by mother (LVMO) and Reject by mother (REJM) was associated with mother genotype and infant sex at p<0.05. Passivity (PASS) was associated with infant genotype and infant sex at p=.04. Four other behaviors (Restraint, receive groom by mother, receive groom by infant, and approach by mother) were found to be nearly significant (p> 0.05