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2020 Abstracts

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Comparing the PCL-5 Item #20 and ISI in Veterans With PTSD

December 30, 0020 12:00 AM
Taylor Cline, Kent D. Hinkson Jr., Malisa M.Brooks, Craig J. Bryan (University of Utah)
Faculty Advisor: Hinkson, Kent (University of Utah, Psychology)

Abstract:

Post-Traumatic Stress Disorder is a debilitating and exhaustive disorder that has been under official observation since the first World War and has received attention from Psychologists in both research and clinic settings. In a study by Spoormaker and Montgomery (2008), they determined that disturbed sleep in PTSD is a core feature of the disorder rather than a secondary characteristic. Spoormaker et. al (2008) also indicated that treatment for insomnia for persons with PTSD would be beneficial by offering brief sleep hygiene education, and stimulus control methods in treatment with persons who have PTSD.

This study examines the scores from Item #20 of the PTSD Checklist (PCL-5; “How much were you bothered by trouble falling or staying asleep?”, rated from 0 – 4) and compares them with the Insomnia Severity Index (ISI) sum score to determine if Item #20 has a sufficiently strong relationship with respect to the ISI sum score so as to be useful in screening for insomnia in individuals with PTSD. Three hundred twenty-one (n = 321) student veterans participated in the nationwide study. Among the participants, 94.1% of those who marked “1”, “2”, “3”, or “4” on PCL-5 Item #20 met ISI criteria for insomnia, while those who endorsed “0” (“Not at all”) scored substantially below the criteria for insomnia on average. While the eight-item ISI gives more information on the nature of the sleep disturbances, Item #20 of the PCL-5 appears to do a good job at screening for those likely to meet diagnostic criteria for insomnia; this could allow clinicians and primary care staff to reduce the burden during routine mental health screenings among potentially traumatized individuals.
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Delay Discounting: State and Trait Influences

December 30, 0020 12:00 AM
Downey, Haylee; Odum, Amy; Haynes, Jeremy; Galizio, Annie (Utah State University)
Faculty Advisor: Odum, Amy (Emma Eccles Jones College of Education & Human Services, Psychology Department)

Impulsivity has been associated with a wide range of poor health behaviors including substance abuse and unhealthy eating. Delay discounting, the tendency for more remote outcomes to be devalued, has been used as a measure of impulsivity. Delay discounting is often measured by asking individuals to choose several times between smaller sooner outcomes and larger later outcomes. In delay discounting, the domain effect refers to the tendency for different outcomes to be discounted at different levels (e.g., people tend to be more impulsive about food, alcohol, and entertainment than money). Thus, some researchers have suggested that the different rates of delay discounting for different outcomes reflect different processes (i.e., delay discounting for different outcomes is not necessarily correlated for individuals). Others suggest that delay discounting is a trait. If delay discounting is trait-like, we would expect that individuals who are more impulsive about money are also more impulsive about food, drugs, and other outcomes (i.e., individual degree of delay discounting is correlated for different outcomes). We examined 53 studies using systematic review techniques to examine delay discounting of different outcomes. For the 29 studies included in Analysis 1, we found evidence to support that delay discounting is a trait. Out of the 86 correlations we examined, 83 showed non-zero, positive correlation between delay discounting of money and delay discounting of an alternative outcome. For the 28 studies included in Analysis 2, we also found support for the domain effect, a state influence: discounting of money was lower than discounting of alternative outcomes in most comparisons. In conclusion, delay discounting appears to be a generalizable, unified process, involving both state and trait influences, thus demonstrating its potential as a behavioral intervention target.
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Connecting with Complexity: The Physician's Perspective on Type 2 Diabetes and Patient-Provider Relationships

December 30, 0020 12:00 AM
Clark, Emilia (Utah State University)
Faculty Advisor: Glass-Coffin, Bonnie (College of Humanities and Social Sciences; Sociology, Social Work, and Anthropology Department)

Type 2 diabetes (T2D) affects roughly 1 in 10 Americans with as many as 1 in 4 Americans suffering from pre-diabetes, which often leads to full-blown T2D within five years. The role of the physician in managing diabetes is especially crucial, as this is a chronic illness. Because of its long-term impacts and comorbidities, successful treatment of the condition requires the development of effective and on-going provider/patient partnership. The physician must not only thoroughly and accurately assess the patient's condition and recommend the appropriate treatment options, but also guide and motivate patients in ongoing lifestyle changes relevant to each patient's individual circumstance. And, they must do this while working in a system that creates significant barriers and obstacles for creating and maintaining these physician/patient partnerships. Although there is no shortage of research on T2D, there are very few studies that focus on physician insights about these barriers nor are there many studies that analyze the specific strategies, aims, perspectives, and challenges physicians face when juggling the many dimensions of managing T2D over a patient's lifetime. This study adds to what we know about diabetes care by conducting in-depth interviews with a local physician at the Logan Clinic who has been treating T2D for 20 years. Developed in the context of an Ethnographic Methods class in the Anthropology program at Utah State University, this study thus provides new insights on the challenges of approaching type 2 diabetes from the physician perspective.
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Cosmology Episode in HEALAfrica Hospital, Goma: An interview study of sense-losing following trauma

December 30, 0020 12:00 AM
Roy, Taylor; Nguyen, Richard; Moffitt, Drew; Bonsrah, Dicken; Fannin, Austin; Yirenya Tawiah, Daniel (Brigham Young University)
Faculty Advisor: O'Grady, Kari (Brigham Young University, Psychology)

Outline:
- Anticipating a cosmology episode
- Sense-losing in different levels of trauma
- Outcomes of certain sense-losing methods
Abstract: With significant life-changing events occurring throughout the world on a daily basis--on an individual, societal or organizational level--BYU's Organizational Psychology and Societal Resilience Lab studied the aspects concerning how people have prepared for and maneuver their way through losing a sense of their identity, beliefs, and relationships following a traumatic event. Using O'Grady & Orton's model (2016), we explored different ways that individuals anticipate a cosmological episode and how they react in the sense-losing process. Using 40 interviews with employees from the organization HEALAfrica, we attempted to outline possible methods of sense-losing used by these individuals to attempt to cope with the traumatic event on losing their beloved Co-Founder, Lyn Lusi, who was deemed a mother figure to the organization. We discovered that there are two broad categories of sense-losing that play a factor in how these individuals lose sense of this traumatic event--whether it is on the level of the individual or the organization: Rigid Sense-Losing and Resilient Sense-Losing. The outcomes that each of these two pathways take end in significantly opposite directions, one leading to suicidal ideations, alienation, and hopelessness, while the other leads to improvising, sense-remaking, and a sense of renewing.
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Does LDS Affiliation Lead to Shame in LGBT+ Members

December 30, 0020 12:00 AM
Nielson, Madison; Salas, Jessica; Baird, Todd (Weber State University)
Faculty Advisor: Baird, Todd (Weber State university, Psychology)

The reason for shame stems from feelings of inadequacy and that conflicts have become too overwhelming for an individual to handle. This creates emotional dysfunction because the conflict is not aligning with the individual feelings of what is appropriate on a societal level (Kilborne, 2019). Shame is created by an individual thinking about another's perception of them, it is a highly socially involved emotion. Religion is a large cultural proponent adding to an individual's feeling of shame, there are rigid structures of what behaviors are found acceptable and lifestyle standards to achieve the highest level of being and what happens to an individual after death. LGBTQ+ individuals who are religious have unique struggles. They face more internalized heterosexism which reduces self-esteem and life satisfaction and increases distress (Foster et. al., 2017). Religion intermixed with same-sex attraction or gender identification can be linked to shame proneness which leads to lower self-esteem (Green & Britton, 2013) because the nature of the beliefs is strongly against their identification. This is an extremely problematic issue that affects their familial relationships, many do not feel comfortable coming out to their parents in fear that they will be judged. The Church of Jesus Christ of Latter-day Saints has stringent policies about same-sex attraction. Policy 21.4.6 the LDS Church states that "homosexual behavior violates the commandments of God, is contrary to the purposes of human sexuality, and deprives people of the blessings that can be found in family life and in the saving ordinances of the gospel". We predict that individuals who are LGBTQ+ and LDS will have more shame, have lower self-esteem, will have greater difficulty in identifying as LGBTQ+, will conceal their sexuality more, and have lower pride in being LGBTQ+ than those who are LGBTQ+ and non-LDS.
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Emerging Consequences from Transgenerational Trauma in Haiti, DR Congo, and the United States

December 30, 0020 12:00 AM
James, Marissa; Stevens, Colton; Johnson, Jannea; Gonzalez-Lishman, Diego (Brigham Young University)
Faculty Advisor: O'Grady, Kari (Brigham Young University, Psychology)

The awareness of significant global traumas and their impact on future generations has been acknowledged by the scientific community. The degree of consequences from trauma transmission between generations is only recently finding light, and the potential areas for trying to alleviate these consequences is yet to be explored. BYU's Organizational Psychology and Societal Resilience Lab conducted a qualitative meta-analysis on interview data from locals during the Ferguson events, Haiti & China earthquake survivors, and DR Congo sexual trauma victims. Survivors of these traumas carry an altered perception of their trauma and lives in general that distorts their self and cultural place in the world. Patterns of time distortion, poor familial interactions, and faulty processing are major patterns among these cross-cultural samples. The emotionally haunted parent(s) passes on an uncommunicated ghost on to his/her offspring that manifests in ways that often still keep the true, original trauma buried. Each family exists within a community system that often has parallel transmission cycles as well as communal historical experience that creates a large-group transgenerational trauma crisis. The silence becomes the story, and the effects of the trauma lives on. The cyclical transmission can carry on infinitely, without recognition or awareness. Observations of these experiences suggest that there is a critical role for addressing and grounding trauma before, during, and after the time that it becomes transgenerational.
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Exploring the Sexual Experience and Habits of Latter-Day Saints

December 30, 0020 12:00 AM
Barton, Melissa. (Utah Valley University)
Faculty Advisor: Anderson, Chris (Utah Valley University, Behavioral Science Department)

Sex is an important element in the building and maintenance of a successful marriage. The subject of marital sexual relations from a national perspective has been studied (Kinsey, 2010). There also exists much research data specific to conservative Christian populations on this subject (Crosby, 2008). Little research that looks specifically at the sexual beliefs, experiences, and expectations within the community of the active members of the Church of Jesus Christ of Latter Day Saints has been conducted. This research provides a baseline and will aid individuals and their clinicians in the support of the health and healing of marriages. This researcher will be presenting what has been discovered in regards to the sexual attitudes and practices among-st the active LDS population.

This research is intended to begin the process of creating a baseline of data that could ultimately change the conversations and even the conventions of the LDS community surrounding elements of sexuality in marriage. This data could assist Marriage Counselors and Sex Therapists in understanding the true nature of sex inside this culture, particularly in regards to LDS women.

This research will be conducted anonymously and with high regard to confidentiality utilizing a Qualtrics survey. This is the first step in a process this researcher is interested in exploring. This report illuminates the sexual attitudes, beliefs and behaviors of active LDS women ages 35-55, it is anticipated that 100 individuals will participate.

Crosby, Cindy. "The Best Sex (Survey) Ever!" Today's Christian Woman, 12 Sept. 2008, www.todayschristianwoman.com/articles/2008/september/best-sex-survey-ever.html.

Kinsey,"FAQs And Sex Information." Historical Report: Diversity of Sexual Orientation, Indiana University, 2010, kinseyinstitute.org/research/faq.php.
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Does My Child's Educational Success Depend on Me? A Qualitative Field Study of the Attitudes and Beliefs on Parental Involvement in Education throughout Malawi.

December 30, 0020 12:00 AM
Foster, Kathryn (Brigham Young University)
Faculty Advisor: Child, Curtis (Brigham Young University, Sociology)

Parental involvement in a child's schooling is vital in the academic performance of a child. Malawi, a country in sub-Saharan Africa, passed a law in 1994 stating primary education would be free for the public. However, there are extenuating circumstances that prohibit a child from attending primary school. Currently less than half of children in Malawi finish primary school.

In a qualitative study conducted in Malawi, over 30 parents were randomly selected from different districts throughout the country. Parents were interviewed about their beliefs and attitudes regarding their children's education, and what they believed their role was, or if they had a role in the child's educational success. These parents were also questioned about their own educational journey, such as if their parents helped them with their education and what factors either prevented or facilitated their success as a student.

Over 30 teachers were also randomly selected throughout Malawi to be interviewed about parental involvement in education. These teachers were asked about what they observe with respect to parents in their children's education, as well as what they believe to be important in a student's academic performance.

Through analysis of the data collected, one sees a discrepancy between parents and teachers and their beliefs about a child's education. Of the parents interviewed, it seemed as if their involvement in education revolved more around providing their children with the materials they needed for school rather than caring about their grades and or attendance. Parents seemed to believe that success would not come from education, but rather farming. Teachers believed that parents caring about attendance and grades would improve the performance of students. These findings are important to show where there are discrepancies in parental involvement in a child's education and how this can be changed to improve a child's academic performance.
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Exploring consumer travel mode decision making

December 30, 0020 12:00 AM
Garrison, Mackenzie; (Utah State University)
Faculty Advisor: Graul, Antje (Jon M. Huntsman School of Business, Marketing and Strategy Department); Thompson, Greg (Brigham Young University, Anthropology)

The means of transportation is forever changing and just recently multiple means of electric transport have emerged in our cities. People are taking full advantage of all means of transportation but the framework for decision making has not adapted to include all means of transport. Current frameworks are largely utilitarian based and do not account for a large portion of travel mode choice behaviors. The goal for this project was to identify alternate decision frameworks for understanding and modeling consumers' personal travel mode choices and determine the appropriateness of a non-compensatory Maslow-like framework for explaining consumers decision making processes for travel mode choice. To complete this goal, we followed two objectives:
1) Qualitatively determine the structure and contents of consumers' pre-consumption perceived satisfaction of needs for understanding the personal transportation mode choice decision-making process and consumers' intention to engage into a particular mode of transport from a consumer behavior perspective, and
2) Quantitatively validate the proposed framework by taking both pre-consumption perceptions and post-consumption evaluations into consideration.
To collect data, we used two means of research: conducting focus groups and collecting surveys. This allowed us to collect both quantitative and qualitative data. From this data we concluded that travel mode decisions are influenced by a number of factors ranging from convenience to environmental concern. Depending on the type of transportation, some factors were considered more than others. Some factors included health when bicycling, traffic when driving an independent vehicle, and relationship building with bicycle and scooter share. As we predicted, there are many factors, both utilitarian and non-utilitarian, that drive transportation decision making.
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Early Plasma Cortisol Concentrations are Associated with Later Parenting Behaviors in Female Rhesus Macaques (Macaca Mulatta)

December 30, 0020 12:00 AM
Halter, Colt; Jacobsen, Natalia; Wood, Elizabeth; Capitanio, John; Higley, James (Brigham Young University)
Faculty Advisor: Higley, James (Brigham Young University, Psychology)

Studies show that early parent-infant attachment categorization is not only predictive of child outcomes, but also second-generation parenting behavior. Few studies, however, have longitudinally assessed how infant behavior inhibition affects future adult parenting styles. Studies show that behavior inhibition is interindividually stable across time and situation, with elevated plasma cortisol levels serving as a marker of anxious temperament. In this study, we investigate the relationship between infant cortisol concentrations and later parenting behavior. We hypothesized that high cortisol levels in infancy would predict deficits in maternal behaviors later in adulthood. Due to their biological and behavioral similarities to humans, rhesus macaques (Macaca mulatta) were used. The subjects were 123 females, first studied when they were 3-4 months of age, underwent a 25-hour mother-infant separation, during which four blood samples were obtained: one at 2-hours, 7-hours, 11.5-hours, and 12-hours post-separation. 3-5 years later, these same subjects were observed as mothers, and four 300-second observations of maternal behaviors that are traditionally associated with the quality of the mother-infant attachment relationship were obtained—infant approaches and leaves, and mutual-ventral contact. Other behavioral measures that characterize rhesus monkey anxiety, including self-directed behaviors, were also recorded. Controlling for infant age and sex, results showed that infant cortisol predicted adult maternal deficits, with high cortisol concentrations predicting high rates of infant approaches and leaves (p<.03) and low rates of mutual ventral contact (p<.03). High cortisol concentrations also predicted mothers' anxiety-like self-directed behaviors (p=.04). These results suggest that females with high cortisol as infants show anxiety-like behaviors as adults and exhibit deficient parenting behaviors, leading their infants to drive the mother-infant relationship. To the extent that these results generalize to humans, this study lends empirical evidence to the proposed relationship between early life anxiety and deficits in later parenting behaviors.
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Different Sources of Sex Education: The Effects on Attitudes and Knowledge

December 30, 0020 12:00 AM
Martin, Shay; Beesley, Karissa (Utah Valley University)
Faculty Advisor: John, Cameron (Utah Valley University, Behavioral Science)

Sex education's purpose is to facilitate healthy behaviors. Research suggests that sex education should focus on things that influence behavior among youth: life skills; self-efficacy; attitudes; beliefs; and social norms (Born, Wolvaardt, & Mcintosh, 2015). The purpose of this study is to learn where people are getting the majority of their sex education and how it is affecting these behaviors. We are still gathering data for this study. We predict the data will be skewed in Utah because of the high population of religious affiliation. We are interested to see the differences in behaviors based on sources of sex education.
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Baseline effects of lysophosphatidylcholine and nerve growth factor in a rat model of sciatic nerve regeneration after crush injury

December 30, 0020 12:00 AM
Boatright, Greggory; Medrano, Braxton; Goeckeritz, Joel (Brigham Young University)
Faculty Advisor: Roeder, Beverly (Brigham Young University, Life Sciences)

Schwann cells play a major role in helping heal injured nerves. They help clear debris, produce neurotrophins, upregulate neurotrophin receptors, and form bands of Büngner to guide the healing nerve. But nerves do not always produce enough neurotrophins and neurotrophin receptors to repair themselves. Nerve growth factor (NGF) is an important neurotrophin for promoting nerve healing and lysophosphatidylcholine (LPC) has been shown to stimulate NGF receptors (NGFR). This study tested the administration of a single intraneural injection of LPC (1 mg/mL for single LPC injection and 10 mg/mL for multiple LPC injections) at day 0 and one (day 7), two (days 5 and 7), or three (days 5, 7, and 9) injections of NGF (160 ng/mL for single injections and 80 ng/mL for multiple injections) to determine baseline effects on crushed sciatic nerves in rats. The rats were randomly divided into four groups: control, crush, crush-NGF, and crush-LPC-NGF. The healing of the nerves was measured weekly by monitoring gait; electrophysiological parameters: compound muscle action potential (CMAP) amplitudes; and morphological parameters: total fascicle areas, myelinated fiber counts, fiber densities, fiber packing, and mean g-ratio values at weeks 3 and 6. The crush, crush-NGF, and crush-LPC-NGF groups statistically differed from the control group for all six weeks for the electrophysiological parameters but only differed from the control group at week 3 for the morphological parameters. The crush, crush-NGF, and crush LPC-NGF groups did not differ from each other over the course of the study. Single injections of LPC and NGF one week apart or multiple treatments of NGF at 5, 7 and 9 days post-injury did not alter the healing rate of the sciatic nerves during weeks 1-6 of the study. These findings are important to define the baseline effects of NGF and LPC injections, as part of a larger effort to determine the minimal dose regimen of NGF to regenerate peripheral nerves.
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Correlation between Chronic Pain Symptoms and Brain Structure

December 30, 0020 12:00 AM
McQuinn, Sophie; Love, Tiffany (University of Utah)
Faculty Advisor: Love, Tiffany (University of Utah, Psychiatry)

Chronic pain is a major health crisis, and is considered the second major cause of disability in the world. People with chronic pain that lasts 6 months or longer often experience other symptoms as well, including depression. While the causes of chronic pain are often unknown, it has been shown that people with chronic pain exhibit brain structure differences compared to those who do not. It is important to know how chronic pain and brain structure are interconnected so that we can find a better way to treat patients. Gaining more knowledge of this connection can lead to a better understanding of the underlying causes. Brain structure goes hand in hand with neuroplasticity, which plays a key role in normal brain development. While it has been shown that chronic pain can have a significant effect on brain structure, it is unknown whether different symptoms affect different areas of the brain. The effects of chronic pain on the brain have only been looked at in a holistic sense and have not been quantified according to symptoms. Because chronic pain can have a variety of causes, this makes it difficult to determine a good method of treatment for individuals. Our aim was to determine how different symptoms of chronic pain affect the brain individually and evaluate possible overlap. The categories we tested were sensory, affective, unpleasantness, intensity, and depression. We used MRI scans from both healthy individuals and participants experiencing chronic lower back pain. The relative levels of each symptom that the participants were experiencing were determined via the McGill Pain Questionnaire and the Center for Epidemiologic Studies Depression Scale. Having a better understanding of how different symptoms of chronic pain affect the brain can aid in finding more personalized treatment for those experiencing it.
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Genetic engineering of cells for treatment of autoimmune disorders

December 30, 0020 12:00 AM
Passey, Abigail; Domyan, Eric (Utah Valley University)
Faculty Advisor: Domyan, Eric (Utah Valley University, Department Of Biotechnology/Biology)

In the United States approximately 3 million people are living with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Approximately 75,000 of those patients represent pediatric cases. We aim to create a new drug delivery system with the intention of establishing a more feasible, stable, and effective form of administering treatments to those with the aforementioned autoimmune diseases, specifically attempting to provide a more ideal treatment for juvenile patients. We are focusing on first providing a rudimentary proof of concept. For the project, we will attempt to engineer mammalian cells that will produce the fusion protein CTLA4-Ig, commonly known as abatacept, a current treatment for RA, and a potential treatment for SLE. Thus far, we have completed and verified success of the molecular cloning necessary to create the recombinant molecule. We have successfully induced expression of the fusion protein in mammalian cell lines COS-7 and B16F10 via lipofections. We are currently working to optimize lipofection conditions and test for successful cellular production of CTLA4-Ig. Ideally, we aim to engineer red blood cells (RBCs) to produce the molecule. If we can complete our proof of concept, we will then attempt to reprogram myeloid and lymphoid progenitors into induced hematopoietic stem cells (iHSCs), and culture the cells ex vivo to allow for massive expansion of these iHSCs, which can then be genetically engineered. Additionally, the iHSCs will be cultured in such a way that, once in vivo, will result in them committing explicitly to erythroid lineages, and secreting the target protein as they mature into fully functional, adult RBCs. Causing RBCs to secrete CTLA4-Ig throughout the body would eliminate the need for regular injections of the drug, and thus potentially improve the quality of pediatric patients' lives.
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Effect of dietary blueberry on vascular function in aged C57BL/6J mice

December 30, 0020 12:00 AM
Petersen, Chrissa; Velaytham, Anandh; Saldivar, Miguel (University of Utah)
Faculty Advisor: Velayutham, Anandh (Integrative Physiology and Nutrition)

Aging is a major risk factor for cardiovascular diseases such as atherosclerosis, which are major causes of disability and mortality in the elderly. Endothelial dysfunction plays a major role in aging-associated vascular complications. Dietary change may be one of the novel strategies to ameliorate endothelial dysfunction and aging-associated complications. Our lab recently showed that dietary supplementation of blueberries improves vascular inflammation and dysfunction in diabetic mice. In our present study, we investigated the effect of dietary blueberries on vascular function in aged mice. Adult male mice (two months old) and old male mice (17 months old) were fed a control rodent diet (Y and O respectively). The subgroups of Y and O mice were fed a diet supplemented with 3.8% freeze-dried blueberries (Y+BB, O+BB respectively) for 15 weeks. Based on normalization to body surface area, this dose in mice is equivalent to ~1.5 servings of blueberries (~240 g) in humans. Mesenteric arteries were collected and used to assess vascular function using a wire myograph system. After arteries were precontracted to ~65% of maximal phenylephrine-induced contraction and tension was stable, responses to acetylcholine (ACh, 10-8-10-6 M) were evaluated to determine endothelium-dependent vasorelaxation. In our study, there is no difference existed between Y vs. O and O vs. O+BB indicating the vascular function was similar among the groups. Our ongoing studies are focused on identifying the effect of dietary blueberries on vascular inflammation in aged mice and the possible molecular mechanisms involved.
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Engineering Cell-free Protein Synthesis as a Biosensor for Endocrine Disrupting Chemicals

December 30, 0020 12:00 AM
Nelson, Andrew; Foutz, Isaac; Hunt, Porter; Wood, David; Bundy, Bradley; (Brigham Young University)
Faculty Advisor: Bundy, Bradley (Brigham Young University, Chemical Engineering)

Cell-free Protein Synthesis (CFPS), an in vitro system for producing recombinant protein, is a rapidly expanding field. To date, applications of this technology, among others, include unnatural amino acid incorporation, protein microarray fabrication, genome engineering, and the production of therapeutics, vaccines, and biocatalysts. Here, we further engineer cell-free protein synthesis as a biosensor for endocrine-disrupting chemicals (EDCs), compounds that mimic hormones and thus disrupt endocrine system physiology in the body.
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Daily Experiences of Children with Cancer Reported Through a Game-Based App

December 30, 0020 12:00 AM
Linder, Caitlin; Linder, Lauri (University of Utah)
Faculty Advisor: Linder, Lauri (College of Nursing, Nursing)

Childhood cancer disrupts children's day-to-day experiences. The purpose of this study was to analyze children's responses to two questions included in a daily symptom reporting app: "What is the best thing about today?" and "What is bothering you the most today?" Responses were part of a larger study evaluating the feasibility and acceptability of the app. Children used the app to record daily symptoms and answer short questions about their day.

Children completed a trial of the app between visits at the hospital for chemotherapy. Daily responses to each question were analyzed using descriptive qualitative content analysis with each response serving as a unit of analysis. Coding was completed by each author and reviewed together to reach agreement. Children's responses were organized into categories and subcategories.

Participants were 19 children 6-12 years of age (median 8 years) (12 boys) receiving chemotherapy who used the app for a total of 83 days (median 4.5 days/child). Children provided 72 responses about the best thing about their day that were organized into nine categories: Activities (n=22), People (n=14), Food (n=9), Well-Being (n=9), School (n=7), Nothing (n=5), Object (n=4), Going Home (n=3), and Don't Know (n=1). Children provided 60 responses about the most bothersome aspect of their day that were organized into six categories: Nothing (n=22), Symptoms (n=17), Port (n=7), Cancer Treatment (n=5), Day-to-Day Stuff (n=5), and People (n=4).

Children's responses provide perspective of the impact of cancer on their daily lives. Their responses indicate the importance of maintaining developmentally normal activities and family relationships. Children's responses further indicate the pervasiveness of the cancer experience, such as symptoms, even on days when children are away from the hospital. Mobile health apps can help children not only track symptoms but also reflect on their day. Clinicians can use children's information to better understand children's experiences.
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Determining Potential Abuse Liability of a Novel Pain Therapy

December 30, 0020 12:00 AM
Bobeck, Erin; McDermott, Max (Utah State University)
Faculty Advisor: Bobeck, Erin (College of Science, Biology Department)

TBD - Updated for publication
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