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Authors: Joshua Parmley, Acacia Overono. Mentors: Acacia Overono. Insitution: Utah Valley University. Since its founding over a century ago, the American Psychological Association has adopted several distinct roles in its ongoing pursuit of legitimacy, stability, and growth for the field of psychology. Two of its most important roles include the establishment and enforcement of an ethics code and the standardization and development of undergraduate education. These two goals are related; the best way to uphold an ethics code is to ingrain that code into future researchers and practitioners. The APA Guidelines for the Undergraduate Psychology Major 3.0, which lists the APA’s ideal learning objectives for undergraduate programs, attempts to do just that. In its section on ethics training, it places a great degree of responsibility on undergraduate programs to prepare students for a world of bad actors, exploitative systems, and ethical grey areas. To achieve this, the document recognizes that students must develop an ethical skill or proficiency, not just a knowledge of the codes and principles. Unfortunately, Guidelines recommendations for achieving that goal quickly become clouded, as the document wrestles with the various concerns about teaching ethics. Primarily, the Guidelines section on ethics seems conflicted about whether instructors should give students historical examples of psychologists and psychology systems engaging in unethical behavior The Guidelines expresses the concern that presenting students with examples of ethical failures by psychologists will distract students from the learning outcomes or lead them to view the field negatively and abandon it altogether. Accordingly, the APA tentatively recommends that negative examples be shared cautiously, alongside examples of the positive achievements of the field and ethical systems in place. Are the APA’s fears that blunt ethics courses could turn students away from the major valid? Or do the Guidelines recommendations put too little faith in their instructors and students? This study seeks to examine the validity of the APA’s concerns and the efficacy of their recommendations. One hundred and fifty Intro to Psychology students will be divided into three groups. Each group will be instructed in the principles of the APA ethics code using a) no historical examples, b) a balance of negative and positive examples, or c) several negative examples. Participants will then take a survey that measures their ethical proficiency, their memory of the material, and their confidence in the field of psychology. Measurement of ethical proficiency will be adapted from APA measurement tools. We predict that the group instructed with several negative examples, without balancing positive examples, will result in greater measurements of ethical proficiency, better recall, and a slightly lowered level of confidence in the field. We predict this based on the idea that reviewing negative examples in the instructional material will provide students with a specific model of ethical decision-making.

Authors: Ayana Srivastava, Gliceida Galarza Fortuna, Beverly Chigarira, Emre Dal, Chadi Hage Chehade, Georges Gebrael, Arshit Narang, Neeraj Agarwal, Umang Swami, Haoran Li. Mentors: Neeraj Agarwal. Insitution: University of Utah. The utility of ChatGPT in subspecialty consultation for patients (pts) with metastatic genitourinary (GU) cancer.Ayana Srivastava, Gliceida Galarza Fortuna, Beverly Chigarira, Emre Dal, Chadi Hage Chehade, Georges Gebrael, Arshit Narang, Neeraj Agarwal, Umang Swami, Haoran LiHuntsman Cancer Institute at the University of Utah, Salt Lake City, UT;University of Kansas Cancer Center, Westwood, KSBackground:Cancer management requires a multidisciplinary approach, often requiring medical consultation from subspecialists. With the advent of artificial intelligence (AI) technologies like ChatGPT, it is hypothesized that these tools may help expedite the consultation process. This study aimed to assess the efficacy of ChatGPT in providing guideline-based sub-specialty recommendations for managing pts with metastatic GU cancer.Methods:In this single-institution, IRB-approved, retrospective, proof-of-concept study, pts with metastatic GU cancer over the past 3 years were screened. Those with at least one consultation referral to subspecialty clinics were randomly selected. ChatGPT 3.5 was given the most recent clinic note that triggered sub-specialty consultation. The AI tool was then asked to provide an assessment and plan. Two physicians independently assessed the accuracy of diagnoses made by ChatGPT and subspecialty physicians. The primary outcome was the consistency of ChatGPT recommendations with those of subspecialty physicians. Secondary Outcomes included potential time saved by using ChatGPT and comparison of medical decision-making (MDM) complexity levels between ChatGPT and subspecialty physicians.Results:A total of 39 pts were included. Their primary diagnoses included prostate cancer (51.3%), bladder cancer (23.1%) and kidney cancer (15.4%). The referred subspecialty clinic included cardiology (33.3%), hematology (17.9%), hepatology (2.6 %), hospice (10.3%), neurology (12.8%), pulmonary (15.4 %), and rheumatology (7.7%). The average waiting time for pts to be seen in subspecialty clinics was 44.9 days (SD = 42.4). Of 39 patient’s charts reviewed by ChatGPT, 30/39 (76.9%) had the same diagnosis with consultant sub-specialties. The average diagnoses made by ChatGPT were 8.2, compared with 3.4 made by sub-specialty physicians (p < 0.0001). The accuracy of diagnoses made by ChatGPT was the same, higher, and lower than human physicians in 10 (33.3%), 3 (10%), and 17 (56.7%) cases, respectively. Consistency of treatment plans between ChatGPT and physicians was found in 18 cases (46.2%). ChatGPT recommended additional workup in 32 cases (85.1%). The average number of words written in consultation notes by ChatGPT was 362.7 (SD = 72.9), which was significantly greater than subspecialty physicians (n = 224.7, p < 0.0001).Conclusions:These hypothesis-generating data suggest the potential utility of ChatGPT to assist medical oncologists in managing increasingly complex pts with metastatic cancer. Further studies are needed to validate our findings.

Authors: Danielle Alvarado, Kasidy Weber, Shannon Buckley. Mentors: Shannon Buckley. Insitution: University of Utah. The ubiquitin-proteasome system (UPS) plays a critical role in cancer by regulating the degradation of key proteins involved in cell cycle control, DNA repair, apoptosis, and signaling pathways, making it a crucial mechanism for maintaining cellular homeostasis and preventingtumor development and progression. The expression levels of F-box ubiquitin E3 ligase, FBXO21, correlates with patient survival in several types of cancer, suggesting a role in tumorgenesis. We have previously shown silencing FBXO21 in acute myeloid leukemia (AML) cell lines and patient samples leads to differentiation, slowed tumor progression, increased chemotherapy sensitivity, and altered cytokine signaling. Further, we found that FBXO21 ubiquitinates p85Î±, a regulatory part of the phosphoinositide 3-kinase (PI3K) pathway, for degradation resulting in altered PI3K signaling. Although PI3K inhibitors are used in cancertreatment, issues like off-target effects, dose-limiting toxicities, and resistance necessitate further research and development for optimized efficiency and minimal negative effects in targeting the PI3K pathway. To further understand the role of FBXO21 in cancer, we utilized shRNAs targeting FBXO21 in various cancer cell lines to identify the role of FBXO21 in cellular proliferation, apoptosis, and alteration of the PI3K pathway. The PI3K signaling pathway is initiated through p85Î± binding to the catalytic subunit, p110, leading to downstream AKT and mTOR activation. We found knockdown of FBXO21 stabilizes p85Î±, leading to dimerization of free p85 and decreased PI3K pathway activation. Therefore, we hypothesize that FBXO21 may function as a novel regulator of PI3K signaling, offering an alternative approach to PI3K inhibitors. Our findings suggest that FBXO21 may represent a novel therapeutic target acrossvarious cancer subtypes to target the overactive PI3K pathway. Targeting FBXO21 may enhance the efficacy of current therapies and provide potential benefits for improving patient outcomes in the treatment of cancer, including but not limited to AML

Authors: Natalia Rubio, Madison Farrer. Mentors: Christopher Anderson. Insitution: Utah Valley University. Functional Near-Infrared Spectroscopy (fNIRS) is a neuroimaging technique used to monitor brain activity by measuring the changes in blood oxygenation levels, especially when presented with stimuli or given tasks. This is due to the principle that active brain regions require more oxygen, resulting in changes of blood flow and concentrations of hemoglobin. These observable results are achieved by diodes placed on the surface of the scalp that emit near-infrared (NIR) light into the skull. The absorption of this light by the hemoglobin in the brain’s blood vessels is then detected, localizing neural activity. Due to its portability and cost-efficient nature, fNIRS is being widely used across various fields of research and clinical applications whereas other neuroimaging methods might be less feasible or practical. Psychologists and neuroscientists are able to utilize fNIRS to understand how different regions of the brain are involved in various cognitive processes. It has been used in studying conditions like Alzheimer's disease, stroke, traumatic brain injury, autism, schizophrenia, mood disorders, and dementia. In the context of dementia research, fNIRS has emerged as a promising tool . While fNIRS has a low spatial resolution with measurements restricted to the outer cortex of the brain, it enables the study of the progression of dementia by providing real-time data and offering relative tolerance to subject motion. In fact, a neuro-clinic in Provo, Utah (Cognitive FX) has been studying the use of this fNIRS technique on patients with dementia while they perform language tasks. Although no patient data will be used in this study, the use of fNIRS as a technique to learn about the progression of dementia is noteworthy. Therefore, following IRB approval I will perform semi-structured qualitative interviews with two neuro-technicians using fNIRS in this clinic. Items will focus on the strengths and challenges of using fNIRS with dementia patients. Additionally, I will shadow these technicians to gain hands-on experience. Qualitative results will be analyzed and presented. It is anticipated that this research project will raise awareness of the use of fNIRS as a technique in neuroscience as well as its potential to benefit those with dementia.

Authors: Ellie P. Evans, Mmadili Ilozumba, Sheetal Hardikar, Neli Ulrich, Jennifer Ose. Mentors: Mmadili Ilozumba. Insitution: Utah Valley University. Cachexia is a complex syndrome characterized by severe weight loss and muscle wasting. It is also a prevalent complication in various chronic diseases, including cancer and acquired immunodeficiency syndrome. Recent research has underscored the pivotal role of the gut microbiome in systemic well-being. Furthermore, it has been shown that cancer patients suffering from cachexia have unique bacteria composition in the gut compared to that of non-cachectic patients. In the absence of stool samples, there are a few metabolites in the circulatory system that can be directly linked to gut microbiota. Examples include bile acids, and short chain fatty acids as metabolites produced by specific Phylum. The presence of these gut microbiota derived metabolites (GMDM) in the circulation indicate a compromise in the integrity of tight junctions in the intestines. These results prompted an investigation of GMDM as an indicator of gut permeability. Our hypothesis is that an increased concentration of GMDM in the circulation is linked to gut permeability, leading to the development of cachexia in patients with colorectal cancer.  This literature review provides a comprehensive analysis of the relationship between gut permeability and cachexia, seeking to identify which GMDMs are the most accurate indicators of specific bacteria linked to gut permeability, and subsequently, are accurate projectors of cachexia.  Acetic acid, a short chain fatty acid (SCFA) is a GMDM detected in the plasma of patients with gut permeability. Acetic acid makes up about 60% of the SCFAs produced by a healthy gut flora and 90% of it is produced by the genus Bifidobacterium. Our literature review will cover how closely a measurement of acetic acid and other GMDMs measured in plasma can be linked to gut permeability and to Bifidobacterium levels in the gut. Similarly, Indole is a GMDM produced by Escherichia coli and other indole-producing bacteria. Indole isn’t produced naturally anywhere else in the body. When it is naturally absorbed into the liver through the portal vein, it’s mostly converted into indoxyl sulfate. The heightened presence indole in plasma in sulfate-free forms could indicate that indole is being absorbed through holes in the tight junctions of the intestines, rather than through the portal vein. This information would allow cohorts that have collected plasma samples in the past to measure gut permeability by proxy, even if they’re unable to investigate the gut microbiota and metabolites present from stool samples. These connections found could further help us to use-already collected samples to find accurate biomarkers for early cachexia development in cancer patients. If an oral presentation is unavailable, a poster presentation would be great.

Authors: Ana Paulina Medellin-Alvarez, Jared Almazan, Tursun Turapov, David A. Kircher, Karly A. Stanley, Gennie L. Parkman, MiKaela N. Field, Katie M. Culver, Silvia Coma, Jonathan A. Pachter, Howard Colman, Sheri L. Holmen. Mentors: Sheri Holmen. Insitution: University of Utah. Despite promising results from recent FDA-approved therapies, many advanced melanoma patients develop resistance to both immunotherapy and targeted therapy. A common resistance mechanism to targeted therapy is upregulation of the PI3K/AKT signaling pathway, which has also been shown to promote the development of melanoma brain metastases. Historically, AKT inhibitors have failed in the clinic due to their limited efficacy or intolerable toxicity. Proteomic analysis comparing non-metastatic vs brain metastatic primary tumors in mice revealed focal adhesion kinase (FAK) as an AKT1 specific effector and a potential alternative therapeutic target. FAK is a non-receptor tyrosine kinase that localizes primarily to focal adhesions to regulate cell migration. To determine whether targeting FAK alone or in combination with the RAF/MEK inhibitor avutometinib reduces brain metastases and prolongs survival, we utilized both autochthonous and syngeneic melanoma mouse models. Mice with either subcutaneous tumors or established brain metastases were treated with FAK inhibitor, RAF/MEK inhibitor, or the combination of FAK and RAF/MEK inhibitors. Each cohort was assessed for tumor onset, growth, metastasis, and survival. Our results show that combined RAF/MEK/FAK inhibition significantly delays tumor onset, causes regression of established tumors, prevents the development of brain metastases, promotes the regression of established brain metastases, and prolongs survival. In addition, patient-derived BRAF V600E melanoma xenograft mouse models resistant to the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib, were sensitive to combined RAF/MEK/FAK blockade. The addition of the BRAF inhibitor encorafenib to these models further enhanced the effect on tumor growth. These results support the initiation of a clinical trial evaluating the efficacy of the RAF/MEK inhibitor avutometinib in combination with the FAK inhibitor defactinib in patients with brain metastases from cutaneous melanoma. Additionally, we are assessing non-canonical roles of FAK in modulating the tumor microenvironment to determine whether avutometinib and defactinib also enhance the efficacy of immune checkpoint inhibition in this disease.

Authors: Corin Marsh, Acacia Overono. Mentors: Acacia Overono. Insitution: Utah Valley University. A variety of memorization techniques have been shown to enhance the ability to recall important information. While many of these techniques focus on repetition and retrieval of verbal information, the drawing superiority effect (DSE, Wammes et al., 2016) is a phenomenon where drawing leads to better recall compared to re-writing. The present study investigates the extent of these findings by combining the DSE with retrieval practice. This experiment utilized a within-subjects, single-blind design consisting of 32 undergraduate students ranging in age from 18 to 42. Participants were tasked with learning 20 vocabulary terms through a guided slideshow, then studied terms through; reading definitions (verbal restudy), viewing images of the definitions (visual restudy), writing definitions (verbal retrieval), and drawing definitions from memory (DSE with retrieval). After a brief distractor task, participants were tested on their recall of the definitions. Finally, subjects completed a shortened version of the Vividness of Visual Imagery Questionnaire (VVIQ) and a funnel debrief. Preliminary analyses using a repeated measures ANOVA revealed that re-reading was the study method that resulted in the highest recall scores (M = .57) compared to all other conditions (F (3, 93) = 14.9, p < .001, ηp2 = .324). Further — VVIQ ability showed no significant correlation with participant scores for any of the study methods. These results indicate that re-reading was a more effective study strategy for memorizing vocabulary terms with a short delay when compared to viewing images, writing definitions, and drawing definitions from memory. Future work will examine how longer delays and providing feedback influence may modulate the benefits of re-reading, drawing, and retrieval as study strategies. Keywords: drawing superiority effect, retrieval practice, memory, VVIQ

Authors: Kaycie A Melville, Ashley N Egan, Yu Ya Liang. Mentors: Ashley N. Egan. Insitution: Utah Valley University. Phaseolus vulgaris (common bean) and P. lunatus (lima bean) provide protein and nutrition for millions of people across the globe. Native to the New World, these cultivated species present unique histories of multiple and independent domestications in Mesoamerica and the Andes. Brazil is the leading producer globally of these beans. With both wild and cultivated landraces present, Brazil may act as a secondary center of domestication for these two economically significant leguminous crops. Brazil's indigenous populations’ cultivation efforts may include both wild and cultivated germplasm, potentially contributing to the continued domestication of these crops to create novel shapes, sizes, and colors that are grown and hand-selected by the natives in these regions. To investigate Brazil as a secondary domestication center of beans, this research addresses several key questions: Are signals of past and current domestication processes discernible in current Brazilian cultivars of these species? Can we unravel the relationships between these Brazilian crops and their primary centers of domestication? What genetic differences are underpinning domestication? How diverse are Brazilian cultivars? How do they relate to wild and related material and species? This work focuses on 48 accessions of P. lunatus and P. vulgaris from Brazil, including wild material and two accessions from two related species, P. polystachios and P. filiformis from North America. Whole genomes were resequenced using Illumina sequencing and compared against the published genome of Phaseolus vulgaris to identify SNPs in each accession. Whole chloroplast genomes were also assembled and compared. Phylogenetic analyses, network analyses, population structure, and tests for neutral and positively selected mutations were conducted, revealing distinct clades for both P. vulgaris and P. lunatus with clear links to their Andean and Mesoamerican origins. Genetic diversity was assessed both within (cultivated vs wild) and between P. vulgaris and P. lunatus, demonstrating significant variations, not only between species but also within each species, suggesting the influence of diverse selection pressures and local adaptation during the domestication process. McDonald-Kreitman tests analyze and locate possible domestication genes from the library of SNP’s between outgroups (Phaseolus filiformis and Phaseolus polystachios) and between species. Overall, this research advances our understanding of the intricate process of domestication in P. vulgaris and P. lunatus, highlighting potential ongoing domestication in Brazilian cultivars, unraveling their genetic relationships, and shedding light on the complex interplay of genes that underpin domestication and diversity. These findings contribute to the broader understanding of crop evolution and have practical implications for crop improvement and conservation.

Authors: Joshua Stubbs, Annette Lewis, Kendall Holcomb, Barbara Suassuna Schincariol. Mentors: Geoffery Zhan. Insitution: Utah Valley University. Does Greater Phylogenetic Distance Affect Competition Outcomes in Fungal Communities?Annette Lewis, Kendall Holcomb, Bárbara Suassuna Schincariol, Josh Stubbs, Geoffery Zahn PhDFungi play a critical role in decomposition, affecting nutrient cycling at a global scale. Saprotrophic fungi competitively decompose dead organic matter. However, the role of phylogenetic relatedness on interspecific competition in fungal communities has not received much attention. The theory of phylogenetic over-dispersion suggests that species within a community tend to be less related than expected by chance, therefore limiting competition due to functional redundancy. Similarly, Darwin’s naturalization hypothesis suggests that taxonomically distinct invaders might experience reduced competition and resistance. In this study, we chose three different saprotrophic fungal species with varying relatedness: Aspergillus niger and Fusarium keratoplasticum (from the same family), and Pleurotus ostreatus (from a different phylum). These species were chosen based on decomposition abilities and phylogenetic distances. These species were cultured and placed in seven combinations to assess their ability to decompose and compete as individual fungal populations and as combined communities (e.g., A, B, A+B, B+C, and A+B+C). Each species was placed near a sterilized piece of paper such that competition was evaluated by analyzing the paper coverage in Petri dishes over three weeks. Each Petri dish was analyzed individually based on the average percentage of paper covered and, within combined communities, the percentage of paper each species covered. Interactions between each species and the percentage of the paper covered was recorded for further analysis. Assessing paper coverage allows for the observation of any potential competitive inhibition of decomposition. We hypothesize that decomposing and competitive abilities would be the strongest with A. niger. Despite the fast growth rate of A. niger individually, preliminary results suggest that it was outcompeted when paired with other species. This research highlights the potential nuances in fungal community interactions influenced by phylogenetic relationships, shedding light on the principles of phylogenetic overdispersion and Darwin’s naturalization hypothesis.

Authors: Kendra Johnson. Mentors: Dannelle Larsen-Rife. Insitution: Utah Tech University. This study's objective is to examine how sleep quality is related to attachment and any moderating effect from social support. Sleep quality affects multiple aspects of life including physical and mental health. About 40% of the population is affected by sleep complaints (Palagini et al., 2018). Over time, disturbed sleep can become a risk factor for mental illness and substance use disorders (Adams et al., 2014). According to Gur-Yaish et al., (2020), negative interactions related to attachment disturbances negatively affected sleep quality. Individuals with insecure attachment may be more prone to insomnia and sleep disturbances (Palagini et al., 2018). People with anxious attachment have difficulty trusting that others will be there for them when they are in need. Insecure attachment is measured on two scales: anxious and avoidant. Because of this fear, people with insecure attachment may engage in behaviors intended to reassure them of the other person’s trustworthiness. An individual with avoidant attachment tends to resist close relationships, fearing that others are not reliable (Bowlby 1982). Adults in romantic relationships tend to behave similarly to children and mothers when it comes to attachment pairing (Fraley & Shaver, 1998). When people have insecure attachment, they may be highly activated by relationship ruptures, leaving them anxious and vulnerable to poor sleep quality. The resulting poor sleep quality may be moderated by high levels of outside social support, though with high attachment avoidance, the benefits of social support are less influential. Participants (N = 94) completed the Experiences in Close Relationships-Revised (ECR-RS) scale to measure attachment, the Pittsburgh Sleep Quality Index (PSQI), and the Social Support Questionnaire-Short Form (SSQ6). Findings reveal that though the correlation between insecure attachment and sleep was small, the addition of social support revealed some interesting patterns that give insight to the relationship between attachment, sleep, and the effects of social support.

Authors: Hunter Mitchell, Grace Carsey, Maria Balaceanu, Peg Bird, Bridger Lisonbee, Dannelle Larsen-Rife. Mentors: John Jones. Insitution: Utah Tech University. Early experiences in the home have long-term effects on health and well-being. This study will examine the connections between parenting styles and coping mechanisms, shedding light on their implications for child development and adult mental health and well-being. Parenting styles looked at in this study, specifically authoritarian has varied views on expectations, discipline, and rewards (Doepke & Zilibotti, 2017). Parenting styles have been shown to impact how children express themselves, and more specifically their expression of anger (Radomir-Beliţoiu, 2019). The expression of anger may indicate a deficiency in healthy coping skills. When individuals are found without healthy ways of coping, they become increasingly vulnerable to mental health disorders and poor relationship satisfaction. Based on our current understanding we believe that an authoritarian parenting style will be positively correlated with unhealthy coping mechanisms such as avoidance, substance use, and self-criticism. Adult participants (N = 100) varying in ethnicity and age will be recruited to complete the Brief Cope Questionnaire (Carver, 1997) and an adaptive version of the Parenting Styles and Dimensions Questionnaire (PSDQ; Robinson, Mandleco, Olsen, & Hart, 2001) to assess their parent's style of parenting and their ability to cope with challenges. We will run an ANOVA on the collected data using SPSS. We expect to see a correlation between parenting styles and children’s coping skills. It is anticipated that there will be a strong positive correlation in unhealthy coping skills and parental strategies. This study may suggest the importance of educating children and young adults in healthier coping skills and adults in healthy parenting strategies. This education may aid in reducing the frequency and intensity of mental health crisis in adults.

Authors: Willow Norton, Kaleb Cox, Jaycen Sunderman, Jessalyn Warhurt. Mentors: Kirsten L. Graham. Insitution: Southern Utah University. Positive awe is a feeling of wonder, insignificance, reverence, etc., that is stimulated by man-made or natural events, objects, or circumstances. Monroy & Keltner list the five primary domains of awe as nature, spiritual engagement, music, dance, and psychedelics, but a scale determining the exact origin points of awe has not yet been developed. Upon researching awe more and determining that it is a universally felt emotion, we started looking at where awe may stem from, or what causes it. We have found that there are different types of awe, or that different populations may be able to feel it differently, but we could not find a measure of where it originates. In our study, we attempted to determine the sources from which people experience positive awe by developing the Positive Awe Origin Scale (PA-OS). While developing the PA-OS, we delivered our scale to five peers who tested the face value of our scale about readability and subject matter, and we then edited our scale based on the feedback we received. In the present study, participants will be recruited through social media and MTurk to complete an online survey, via Qualtrics. This survey will include likert scale items rated 1 to 5, with 1 being “strongly disagree” and 5 being “strongly agree.” Psychometric evaluation of results will include a confirmatory factor analysis and an internal consistency measure using Cronbach’s alpha. Discriminant validity will be measured as we correlate our scores with other, unrelated, scales included in the Qualtrics survey, which measure different constructs. Convergent validity will be measured as participants complete an awe subscale of the Dispositional Positive Emotion Scale (DPES). We anticipate that the PA-OS will help further identify the various sources of awe and lead to improvements in the research.

Authors: Peg Bird, Maria Balaceanu, Grace Carsey, Tiffanee Suhaka, Hunter Mitchell, Ives Hong, Tara Caplin, Ed Wu, John T Jones, Dannelle Larsen-Rife. Mentors: John T Jones. Insitution: Utah Tech University. This study examines the relationship between perfectionism and self-compassion. Perfectionism may be beneficial, but often promotes unrealistically high self-imposed standards, a preoccupation with making mistakes, and a compulsivity toward order, leading to self-criticism and self-loathing. Perfectionism results in persistent feelings of failure, indecision, procrastination, and shame, which negatively impact relationships, work-life satisfaction, and overall well-being (Enns et al., 2001; Frost et al., 1993). Self-compassion is directing warmth and care toward oneself during times of suffering and comprises three core components: self-kindness (offering oneself warmth during adversity), common humanity (acknowledging shared suffering), and mindfulness (approaching the experience of pain with presence and curiosity) (Neff, 2003). Self-compassion is associated with mental health and well-being, including a stable sense of self-worth, increased resilience, life satisfaction, and perspective-taking. Furthermore, self-compassion negatively correlates with anxiety and depression, reduced fear of failure, perfectionism, and self-criticism (Barnard et al., 2011; Neff, 2003; Neff et al., 2006). This correlational study will recruit approximately 100 adult participants to evaluate associations between perfectionism and self-compassion. Participants will complete the Frost Multidimensional Perfectionism Scale and the Self-Compassion Scale (Frost et al., 1990; Neff, 2003). We anticipate a negative correlation between self-compassion and perfectionism, with higher levels of self-compassion corresponding with lower levels of perfectionism. If this prediction is supported by the data, the study’s outcomes will extend existing research on the potentially deleterious effects of perfectionism and pave the way for the development of interventions aimed at improving mental health outcomes among individuals adversely impacted by this trait.