2020 Abstracts

Westover, Jonathan; Hardy, Danielle; Arvizu, Annie; Johnson, Jace; Powell, Spencer (Utah Valley University)
Faculty Advisor: Westover, Jonathan (Woodbury School of Business, Academic Director, Center for Social Impact)

Purpose - The purpose of this presentation and paper is to explore work-life balance predictors of job satisfaction across various generations, using international sample of workers across 37 countries. The four generational cohorts included in the analysis include Silent Generation, Baby Boomers, Generation X, Millennial.

Design/methodology/approach: This study provides a comparative analysis of work-life balance indicators of overall job satisfaction across generational cohorts, utilizing data from the 2015 Work Orientations IV Wave of the International Social Survey Program (including stratified random samples of employees across 37 different countries).

Findings: Initial analyses indicate statistically significant differences in work-life balance related indicators of employee job satisfaction across generational cohorts. Additional analyses will be performed to clarify these relationships and further explore the causes behind the differences.

Originality/Value: While many studies have been performed on job satisfaction, very few studies have explicitly examined job satisfaction levels and its indicators across generations. Additionally, while many studies have examined the role of work-life balance saliency on job satisfaction across generational cohorts, and no research has previously been done examining these relationships cross-nationally.

Keywords Job satisfaction, Generational Differences, Work-life Balance, Cross-national

Purpose/Hypothesis:

We hope to supply statistical evidence that there are differences in the saliency and impacts of work-life balance variables on job satisfaction across generational cohorts. Specific hypotheses include:

H1: There are statistically significant differences in the mean scores of job satisfaction and work-life balance variables across generational cohorts.

H2: One's age (generational cohort grouping) has a positive statistically significant impact on job satisfaction.

H3: One's age cohort has a statistically significant impact on the determinants of job satisfaction.

H4: There are statistically significant cross-national differences in the impact of generational cohort on job satisfaction.

Calzado Real, Tamara; Blair, Ariel; Tenney, Elizabeth (University of Utah)
Faculty Advisor: Blair, Barbara "Ariel" (David Eccles School of Business, Management)

The purpose of this study is to understand how racial dissimilarity affects people of color's voice behavior in a student or class group. In a group where a person's social category is underrepresented, they become more aware of that social identity and their ability to perform at their full potential reduces because they are more focused on monitoring their performance and suppressing negative thoughts and feelings than improving group performance. However, in situations where people are more identified with the group, they are more likely to feel committed to or express themselves in a group. Additionally, in groups where people of color don't perceive themselves as different from all or most of the other group members, subgroups and division among team members is less likely to occur. In order for people of color to contribute in meaningful and innovative ways, having the confidence to speak up and express new ideas is crucial. We will run a survey where participants recall groups that they have been a part of and rank their voice (participation) in the group, their perceived racial dissimilarity of the group, and the importance of race on their personal identity. Afterwards, they will placed in an online student group chat with high or low dissimilarity and will be asked to reflect on their experiences. In line with previous research we expect that the importance of race on their personal identity will be positively related to perceived racial dissimilarity and therefore, we expect peoples' voice behaviors to decrease when they are in a group where racial dissimilarity is high.

Nye, David; Winner, Langdon (Utah State University)
Faculty Advisor: Edenfield, Avery (College of Humanities and Social Sciences, English Department)

The purpose of this research project is to examine the interplay between psychotherapeutic mobile applications, such as Calm and Headspace, and the people that use them. Using Langdon Winner and David Nye's discussions on technologies and the discourses surrounding them, I aim to synthesize the existing literature, which primarily investigates the effectiveness of these mobile technologies as forms of psychotherapy, with the concept of technology as an identity-forming tool. I hope to address how these psychotherapeutic technologies can both enable and disallow users, and how users, through their engagement with these mobile applications, are challenging prevailing definitions of psychotherapy and technology. Through a thorough analysis of current literature, together with Winner and Nye's work and my own evaluations of public online reviews of psychotherapeutic mobile applications, I intend to advance the research that considers how technologies affect people and how people affect technologies.

Harrison, Jake; Bartkus, Kenneth; Marlowe, Byron (Utah State University)
Faculty Advisor: Bartkus, Kenneth; Marlowe, Byron

The use of genetically modified organisms in the production of food products in the U.S. appears to be pervasive. For example, it is reported that 90 percent of corn, soy and other crops grown in the U.S. are currently genetically modified and 75 to 80 percent of food products contain GMOs or GMO components. Unfortunately, a gap exists between what scientists and consumers believe with regard to the health safety of GMO foods. Specifically, it has been reported that while "Nearly 9 out of 10 scientists from the American Association for the Advancement of Science say GMOs are 'generally safe' to eat, more than half of general public believe it is not a good idea." This presents a challenge for restaurants. That is, should they continue to use GMO food products given assurances from the scientific community or should they respond to consumer concerns and begin the process of adopting a non-GMO policy? The purpose of this research is to address this question by proposing a framework that helps explain why a restaurant might decide to adopt (or not adopt) a non-GMO policy. Based on an adaptation of Roger's Characteristics of an Innovation, the framework has five constructs: (1) Relative Advantage, (2) Compatibility, (3) Complexity, (4) Trialability, (5) Observability. An exploratory application of the model to U.S. restaurants suggests that the framework can provide meaningful and systematic insights into the perceptions of U.S. restaurants with regard to the adoption or non-adoption of a non-GMO policy. Recommendations for further application of the framework, along propositions for additional analysis are provided. Implications for decision making are also presented.

Mary Daly, Tina Fey, Erin A. Frost (Utah State University)
Faculty Advisor: Colton, Jared (College of Humanities and Social Sciences, English Department)

The TV show 30 Rock has been described as many things; laugh-out-loud funny, immature, witty... but is it feminist? The show's main character makes claims to feminism in almost every episode, and several episodes cover the topic in various ways. However, she often falls short in her feminism, and the argument can be made that this is intentional. For my presentation, I'll be analyzing the show through the rhetorical lens of Mary Daly's theory on foreground/background spaces. Spaces where women are oppressed and free of oppression, respectively; for example, in the show, the characters are creating a sketch comedy TV show, a place where women have traditionally been marginalized by mainstream media - in contrast, the writers' room is a place where they can speak their minds freely about any topic of their choosing. Through my analysis, I'll also be looking to see if this can be a space for second and third wave feminists to meet. Many third wave feminists are doing things that would be considered "traditionally feminist" without identifying themselves with the term "feminist". There are a few characters in the show who identify as such, and the main character, considered to be a traditional second wave feminist, learns to work together with them. As a result of my analysis, I want to be able to present 30 Rock and other similar spaces as a middle ground for all feminists to meet and agree on, in order to be able to move forward as a movement.

Alder, Jacob (Utah State University)
Faculty Advisor: Tainter, Joseph (S.J. & Jessie E. Quinney College of Natural Resources, Enviroment and Society Department); Robert, Davies (College of Science, Physics Department); Fjeldsted, Paul (Jon M. Hunstman School of Business, Economics and Finance Department)

Abstract: Have you ever wondered why economists always talk about a growing economy? Modern economists today rely on several fundamental assumptions in the same way physicists rely on laws governing energy and motion. Economists use growth—ideally unrestricted growth—as the key assumption upon which we build models and policy recommendations. The central economic theory explains that growth will enhance individual well-being over time. However, every known physical system has boundaries beyond which it will collapse, and the observed reality is that economic growth cannot be separated from physical resource consumption. As a result, many societies are overshooting physical, ecological boundaries.

This project focuses on outcomes generated by a few of those complexities in a growth-oriented economy in Northern Utah. It analyzes the ways traditional economic models prioritize growth as the primary means of improving quality of life. It explores several positive and negative impacts of limits to growth, whether they are elective policy measures (like paying a carbon tax) or reactions to a collapsed system (like depleted natural gas deposits). It draws on electricity data from two electricity utility providers and compares trends with interconnected behavioral and technological changes.

Ultimately, this project develops a case study to assess ways in which society could thrive without traditional economic growth. By using axioms from physics, primarily the first and second laws of thermodynamics (energy and entropy) this project assesses population projections and increased resource consumption, drawing connections between a growing population, a growing economy, and growing energy use.

Johnson, Hayden Allen; Harris, Laurie (Southern Utah University)
Faculty Advisor: Harris, Laurie (Southern Utah University, College of Science and Engineering)

Rural communities in Utah may be an excellent place for technology companies to expand. Many rural Utah communities face major problems with declining economies. Adding to the problem, median incomes in nine rural counties is $48,306 while the statewide median income is $62,961 (US Census Bureau, 2017). Rural areas seem to be an untapped well of potential to help both the state’s economy and tech companies themselves. This research explores how to effectively use that potential.

The object of this research is to identify needs and limitations that currently exist in rural communities that would prevent or could be seen as obstacles for technology industry to grow in these areas. Ongoing research being conducted is looking into the viability of technology companies being able to expand and/or start up in rural Utah by exploring if those areas are ready for the technology industry. Specifically, the research examines:

1. Current educational opportunities related to technology in rural area school systems.

2. Interest among potential workforce in technological fields.

3. Presence of skilled workforce in these rural areas.

4. Potential to form partnerships between higher education and high schools to offer better education and generate interest.

5. Infrastructure of rural areas to support growing technology industry.

Additionally, obstacles that are preventing these areas from being able to support technology industry are found and examined. This research constitutes the first step in helping bolster rural economies through an increase of jobs and industry into those areas. By conducting extensive research and getting in on the “front-lines” of the problem, current situations are more understood and potential suggestions are being developed.

Kaneshiro, Alma; Jordan, Adam; Crompton, Rhees; Brailsford, Samantha; Spencer, Jonathan (Weber State University)
Faculty Advisor: Clark, Daniel (Science, Microbiology Department and Neuroscience Center); Chaston, John (Life Sciences, Plant & Wildlife Sciences)

Antibiotic resistance is of great concern in the medical community, with bacterial resistance increasing proportional to their use. Staphylococcus aureus, such as methicillin resistant S. aureus (MRSA), can cause fatal infections. Problems due to this resistance are compounded when the infecting bacteria form a biofilm, thick sticky layers of bacterial secretions, which are difficult for antibiotics to penetrate. Biofilm formation is common in hospital settings on stents, catheters, and IV lines. Biofilms make antibiotic treatment risky due to incomplete killing—the most resistant survive exposure. There is evidence that bacteriophage can break up biofilms, possibly making them more susceptible to antibiotics. We induced a S. aureus biofilm formation using chemicals that mimic a skin wound. Using bacteriophage K, we inoculated the biofilm and observed clearance. Samples of cell pellets and liquid supernatant were collected, and DNA was extracted. Real-time PCR was used to quantify the levels of bacteriophage K replication, representing clearance of the bacteria. This research can be used to find efficient ways to treat an infection caused by a S. aureus biofilm. Bacteriophage used in combination with antibiotics may be able to better clear a biofilm infection and reduce antibiotic resistance risk due to more complete infection clearance.

Townsend, Jessica; Freitas, Claudia; Weber, Scott; Cardon, Dallin (Brigham Young University)
Faculty Advisor: Weber, Scott (Brigham Young University / Life Sciences, Microbiology and Molecular Biology)

The World Health Organization reported in 2016 that oral diseases affected half of the world's population. Oral diseases are due to poor oral hygiene and tobacco use which can develop into periodontal disease. Periodontal disease is caused by an immune response to microbial challenge, which initiates an invasion of lymphocytes and other single-nucleated cells to the site of inflammation in the mouth that can cause tooth loss and is a risk factor for heart and lung disease. Patients with severe periodontitis have increased auto-reactive B lymphocytes that express the CD5 co-receptor and these cells are influenced by T cells. We propose to investigate the relationship between oral inflammation, CD5, and the T helper immune response. This will be done by comparing oral inflammation in mice with and without CD5. CD5 is a T cell co-receptor that regulates T cell development and function and we hypothesize CD5 plays an important role in periodontal disease. We will test this hypothesis by co-culturing T cells expressing or lacking CD5 with oral mucosal or gingival epithelial cells that have been exposed to LPS (lipopolysaccharide, a major component of gram-negative bacteria's wall) and will exam differences in cell number, T cell subtype, and cell function.

Stoneham, Lisa; Brasso, Dr. Rebecka (Weber State University)
Faculty Advisor: Brasso, Rebecka (Weber State University, Zoology)

Mercury is a toxic heavy metal that poses significant health threats to people and wildlife. The organic form of mercury, methylmercury, is converted from its inorganic form via microbial methylation. Methylmercury is dangerous because it attaches to proteins in the blood, muscle, and other tissues and can cross the blood-brain and placental barriers. Microbial methylation is enhanced in anoxic environments such as wetlands, which are increasingly being classified as mercury hotspots where animals accumulate elevated concentrations relative to those in terrestrial systems. This is concerning for the wetlands of the Great Salt Lake due to its history of anthropogenic inputs of pollutants and its importance as a breeding ground and rest stop for migrating avian species. Previous research has shown significant mercury methylation occurring within the Deep Brine Layer of the GSL. The purpose of this project was to investigate potential spatial variation in mercury concentration in different portions of the GSL. With a focus on invertebrates, we collected insects including brine flies, midges, damselflies, and crane flies from three sites of varying salinity around Antelope Island State Park: Farmington Bay, White Rock Bay, and the Antelope Island Marina. Mercury concentrations in insects were determined using a Nippon MA-3000 Direct Mercury Analyzer. Our results will provide a preliminary assessment of mercury concentrations in flying insects from different habitats around the island. This will help in determining differential risk to insectivorous songbirds, waterfowl, and shorebirds foraging on these common prey species in the GSL.

Haynie, Christopher; Freitas, Claudia M. Tellez; Whitley, Kiara V.; Weber, K. Scott (Brigham Young University)
Faculty Advisor: Weber, K. Scott (Life Sciences, Microbiology and Molecular Biology)

T cells play a critical role in the adaptive immune response and undergo significant metabolic changes upon activation. T cell co-receptors influence T cell activation and function, yet their influence on T cell metabolism remains unclear. CD5, an inhibitory co-receptor expressed on the surface of T cells, is known to regulate thymocyte selection and T cell receptor (TCR) signaling. We previously observed that CD5 plays a critical role in calcium signaling in naïve helper T cells. As calcium signaling influences metabolic changes in cells, our current work focuses on understanding the role of CD5 in T cell metabolism. To understand how CD5 regulates metabolism in T cells, we used CD5 deficient T cells and compared them to wildtype CD5 sufficient T cells. We have characterized their metabolic activity using glycolytic and mitochondrial respiration assays. Interestingly, CD5 deficient naïve T cells have increased glycolysis, mitochondrial respiration, and spare respiratory capacity in comparison to wildtype T cells. We hypothesize that this is due to CD5 altering mitochondrial membrane potential and mass, gene regulation, and the influence of different cellular fuels. Understanding how CD5 regulates T cell metabolism will provide critical insights for improved immunotherapeutic strategies.

Lidgard, Audrey; French, Susannah; Hudson, Spencer (Utah State University)
Faculty Advisor: Lidgard, Susannah (College of Science, Biology Department)

Ectothermic organisms, such as reptiles, rely on the external environment for regulating internal temperatures necessary for vital physiological processes. When faced with environmental challenges, temperature may differentially affect how allostatic mediators (e.g., glucocorticoid hormones) are released to mediate energy allocation for handling stressors. Subsequent differences in energy mobilization and circulating metabolites during a stress response may ultimately influence self-maintenance processes such as immunity. The aims of this research were to determine how stress sensitivity varies with diurnal temperatures in the Plateau Side-blotched Lizard (Uta stansburiana uniformis) and to assess the potential implications for immune function. Both baseline and stress-induced levels of glucocorticoids (corticosterone) and energy metabolites (glucose) were compared to body temperature and the thermal environment. Variation in innate immune function (bactericidal ability) was then compared to both temperature and physiological parameters at baseline and stress-induced levels. Stress reactivity via glucocorticoid release positively corresponded with body and environmental temperatures, although glucose release did not. Bactericidal ability subsequent to a stressor negatively corresponded with body temperature and glucocorticoid release. Such findings provide further insight on how stress sensitivity and self-maintenance can vary across the thermal environment, posing potential fitness consequences for an ectothermic organism.

Edwards, Jeffrey; Friend, Lindsey; Weed, Jared; Sandova, Philipl; Nufer, Teresa; Ostlund, Isaac Ostlund (Brigham Young University)
Faculty Advisor: Edwards, Jeffrey (Life Sciences, Physiology and Developmental Biology)

Substance abuse is a widespread problem in the United States. Although there are some existing treatments for addiction, the neural mechanisms of addiction are not deeply understood. This study quantifies the expression of GAD65 and GAD67 in GABAergic cells in the VTA of adolescent mice to shed light on the subtypes of cells involved in learning and addiction pathways.

The ventral tegmental area (VTA) of the brain, a critical part of the dopamine reward system, has many dopamine cells that are inhibited by nearby GABAergic neurons. Formation of memories and addiction involve long-term potentiation (LTP) and long-term depression (LTD) of these inhibitory GABA cells. We studied potential pathways of learning and addiction by measuring levels of expression of GAD 65/67 proteins and quantifying the cells that express one or both of these proteins.

Our results will provide insight about which GABAergic neurons are involved in the addiction pathway, furthering our understanding of the cellular mechanism of addiction. This will pave the way for more educated, effective treatment of drug addicts in clinical settings.

Pehkonen, Eliza (Salt Lake Community College)
Faculty Advisor: Seaboch, Melissa (Salt Lake Community College, Anthropology)

Precipitation-associated behaviors have been observed in several species of primate including bonobos (e.g., building leafy shelters), chimpanzees (e.g., drinking, rain dancing displays), and mantled howler monkeys (e.g., licking rain from the air, altering typical behavior based on weather and season). The purpose of this study is to determine if mantled howler monkeys (Alouatta palliata) exhibit precipitation-associated vocalizations. A. palliata is well known for its vocalizations, which are the loudest sound made by any terrestrial mammal and are used for a wide variety of communicative purposes, such as attracting mates, defending territory, and deterring predation. Given the purpose with which A. palliata vocalizes and the existence of precipitation-associated behaviors within primate species, including A. palliata, it was hypothesized that A. palliata would vocalize in association with climatic events (precipitation and thunder). To test this hypothesis, 41.75 hours of data were collected on A. palliata over a two-week time period during the rainy season at La Selva Biological Station in Costa Rica. All-occurrence sampling was used to record the timing and duration of all A. palliata vocalizations, precipitation, and thunder events. Events were considered accompanied if they occurred within five minutes of one another. Of the 59 observed vocalization events 53% were associated with climatic events. Of the 20 observed precipitation events 90% were accompanied by vocalizations and of the 37 observed thunder events 57% were accompanied by vocalization. Associated vocalizations occurred before, during and after climatic events, however, during or after were most common. The data indicate an association between A. palliata vocalization and precipitation, confirming the hypothesis. Further research is warranted to investigate a possible purpose of precipitation-associated vocalizations, an understanding of which could provide further insight into A. palliata's behavioral interaction with climatic events.

Smith, June; Mishra, Niharika (Weber State University)
Faculty Advisor: Oberg, Craig (Weber State University, Microbiology); Culumber, Michele (Weber State University, Microbiology)

Non-dairy food options have become a growing cultural necessity, however, providing fermented or probiotic supplemented non-dairy alternatives is difficult. Little is known about the activity and survival of probiotic cultures in dairy alternatives. We evaluated the activities of several probiotics at various concentrations and in different combinations in oat, almond, and coconut beverages. Probiotic culture strains of Streptococcus thermophilus (YFLO1), Lactobacillus rhamnose (LGG), L. casei (Casei 431), and Bifidobacterium animalis subsp. lactis (BB12), and commercial probiotic mixtures, YFLO2, and Fresh Q, were inoculated in MRS broth, transferred to MRS agar plates, and incubated anaerobically for 24 hours at 37_. BB12 was grown anaerobically in MRS + cystine broth and agar. Isolated colonies were assayed on API 50 CH panels, and a carbohydrate use panel was developed for each organism. Oat, almond, and coconut beverages were inoculated in duplicate with the isolated strains and incubated in a water bath at 40_. The pH was recorded at regular intervals for up to 41 hours. The oat beverage had the most rapid and significant pH change, when incubated with either YFLO1, casei431, and LGG, dropping between 1.5 to 3 pH units over 3 hours depending on the culture. The almond and coconut beverages did not show rapid pH change with the organisms tested. Due to the quick decrease in pH change, further tests on the oat beverage. It was inoculated with Lactobacillus casei 431, LGG, and YFLO1. Organisms were tested at 0.5%, 1.0%, and 2.0% concentrations in oat beverage in triplicate. These inoculations were again incubated at 40°C and pH monitored after 5 hours, then plated on MRS agar plates after 24 hours. Final ranged between 1.0 x 109 - 1.8 x 109 for the 1% inoculum. It appears that these organisms survive, and may even grow in the oat beverage. This research demonstrates that probiotic cultures can grow in non-dairy beverages and can ferment the available carbohydrates and decrease pH. These results provide insights that can be used for beverages, yogurt, ice cream, and other fermented food production.

Armitstead, Annie; Grether, Lara; Creech, Kealani (Brigham Young University)
Faculty Advisor: Watt, Richard (Brigham Young University, Biochemistry)

Lateral Flow Immunoassays (LFI) are simple tests that detect specific levels of antigens or antibodies in patient samples. Requiring only a few minutes, small sample sizes and no read-out equipment, LFI�s are an invaluable and time efficient testing technique. Made up of multiple layers they facilitate the capillary flow of a sample through protein detection zones and can be developed to detect virtually any disease or condition.

Despite the attractive attributes of these tests, the assembly of an LFI strip requires expensive machines, trained personnel, and materials not easily accessible to low-resourced labs or clinics. Developing an innovative point-of-care platform designed to be streamlined, low-cost, and intelligible to the unskilled would open the door of medicine to even the most underprivileged clinics in the world.

We are currently developing a paper LFI that uses a single sheet of copy paper with the ability to filter whole blood as well as replacing high-priced machines with stencils and pens which can still deliver detection proteins to the designated test zones. This avenue of testing is supported by previous experiments we have done with protein pens and tagged antibodies. Using anti-mouse and anti-hCG antibodies as our control and test lines respectively, we spike our sample with hCG mouse antibodies tagged with nanoparticles, and we are able to see binding of both proteins with their respective antibodies. We have seen results in our new testing technique that is easily comparable with currently commercialized LFI's: visual results of binding within 1 min, successful transformation of printer paper into a functional binding platform, and consistent protein binding at a 1/10^5 concentration. Once this concept can be translated to different inks in order to diagnose a plethora of varying conditions, we'll be able to detect diseases and other important biomarkers no matter the limiting low-resource circumstances.

Davis, Morgan; Edvalson, Logan; Busath, David (Brigham Young University)
Faculty Advisor: Busath, David (Life Science, Physiology and Developmental Biology)

Influenza infection, and subsequent pneumonias, are the cause of over fifty thousand deaths in the United States per year, and, according to the CDC, influenza is the 8th leading cause of death in this country. Research into the pathogenesis of influenza elucidates critical interactions that take place during different phases of infection which can be targeted by novel drug therapies. Our lab has focused on discovering the role of of PDGFR and VEGFR and other Receptor Tyrosine Kinases (RTKs) in aiding viral infection. RTK activation is reported to be important for successful viral infection, and our project has focused on three different RTKs: VEGFR, PDGFR, and endothelial growth factor receptor (EGFR). In these experiments, Madin Darby Canine Kidney (MDCK) cells were bathed in growth medium containing a specific RTK inhibitor, and then infected with the influenza virus. The vitality of the cells was measured using crystal violet staining and spectrophotometer results. The data showed that using a drug called imatinib—a potent PDGFR inhibitor—resulted in the highest cellular vitality while VEGFR inhibitors developed here at BYU also showed anti-influenza activity. This suggests that the influenza virus is at least partially dependent on PDGFR and VEGFR activation to enhance its life cycle. Future experimentation will study which of the many branches of these receptor's phosphorylation cascades are being utilized by the virus.

Edwards, Taylor; Ram, Akila; McCarty, Ashley; Bobeck, Erin N (Utah State University)
Faculty Advisor: Bobeck, Erin (College of Science, Biology Department)

First-line chemotherapies against solid tumors are highly efficacious in reducing the tumor burden, but have many adverse side-effects including nerve damage, leading to chronic pain. Non-addictive, efficacious pain relievers are an area of active interest, and we propose a novel target to address this pressing issue. GPR171 is a G-Protein Coupled Receptor that was recently deorphanized and was identified to be expressed in the brain in regions that regulate reward, anxiety, and pain. Within the pain circuit, it was shown previously that systemic administration of the GPR171 agonist enhances morphine antinociception in acute pain tests. Preliminary data from our lab has shown that GPR171 activation can also alleviate persistent inflammatory pain. However, the role of this receptor has not been investigated in other chronic pain models. Given these findings in acute and inflammatory pain, we hypothesize that GPR171 can reduce neuropathic pain. To test this hypothesis, we investigate the role of GPR171 in chronic neuropathic pain. We tested the efficacy of a GPR171 agonist in a chemotherapy-induced neuropathy mouse model. Neuropathic pain was induced by injecting paclitaxel (16 mg/kg) followed by assessment of the pain-relieving effects of activating GPR171 receptors. Mechanical pain thresholds were assessed using Von Frey filaments. We observed an increase in mechanical thresholds following GPR171 agonist treatment. Further, using immunofluorescence we observed that there is a decrease in GPR171 receptors in the periaqueductal gray (PAG) of these mice that have neuropathic pain, indicating that the agonist can bind to the available receptors to produce pain relief. Overall, this study proposes that GPR171 may be a novel target for the treatment of neuropathic pain.