2020 Abstracts
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Benefits of Lyophilization of Cell Extract in Cell-Free Protein Synthesis
Bundy, Brad; Crop, Tyler (Brigham Young University)
Faculty Advisor: Bundy, Brad (Ira A. Fulton College of Engineering, Chemical Engineering)
Cell-free protein synthesis (CFPS) has proven to be a novel and effective method for recombinant protein production. However, one key disadvantage in this process is the need to store the requisite cell extract and energy source for the reaction at below-freezing temperatures. Our lab has developed a lyophilization-based system to overcome this problem. We have shown that lyophilization of the cell extract and energy system needed for the reaction are possible while still maintaining equivalent protein production capabilities of the reaction. This lyophilization-based system provides a solution to the high costs associated with the storage of these reagents, increases the shelf-life of the reagents, and, when mixed with water, allows for on-demand protein production in remote locations around the world.
Faculty Advisor: Bundy, Brad (Ira A. Fulton College of Engineering, Chemical Engineering)
Cell-free protein synthesis (CFPS) has proven to be a novel and effective method for recombinant protein production. However, one key disadvantage in this process is the need to store the requisite cell extract and energy source for the reaction at below-freezing temperatures. Our lab has developed a lyophilization-based system to overcome this problem. We have shown that lyophilization of the cell extract and energy system needed for the reaction are possible while still maintaining equivalent protein production capabilities of the reaction. This lyophilization-based system provides a solution to the high costs associated with the storage of these reagents, increases the shelf-life of the reagents, and, when mixed with water, allows for on-demand protein production in remote locations around the world.
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Design of Modular Dynamic Charging Primary Coils Compatible with SAE J2954 Secondary Coils
Zane, Regan; Kamineni, Abhilash; Nimri, Reebal (Utah State University)
Faculty Advisor: Kamineni, Abhilash (College of Engineering, Electrical and Computer Engineering Department); Zane, Regan (College of Engineering, Electrical and Computer Engineering Department)
Transportation electrification will bring a positive effect on sustainable environments and robust economies. Electric Vehicles (EV) are emerging in today's market as a solution. However, the battery technologies on EV cannot compete with fuel and diesel cars in terms of energy storage capacity, and time needed to recharge (equivalently refuel). These limitations directly reflect on the consumers' convenience, the max miles the Vehicle can perform for, and hence EV adoption. Wireless power transfer (WPT) systems are seen as a solution to ease consumers' transition to EV. A high-level diagram of WPT is shown in Figure (**).
Major advancements in WPT technology has enabled the commercialization of stationary WPT solutions — materials technology has been a major impediment. Hence, academia and industry are jointly considering more advanced solutions in WPT, namely Dynamic Wireless Power Transfer (DWPT). Implementing DWPT systems will permit on the go charging for EV the upper hand over present charging (equivalently fueling) methods and encourage EV adoption. This document reflects on some of the challenges of realizing an effective DWPT that maintains power transfer between the primary pad and secondary pad, and a proposed solution to allow dynamic charging. Also, the proposed DWPT offers compatibility with SAE J2954 (Wireless Power Transfer for Light-Duty Plug-in/Electric Vehicles and Alignment Methodology) WPT3Z3 pad.
A comprehensive approach was taken in the design of the primary pad to validate the power transfer requirements for the designed pads. The proposed solution consists of a custom primary pad and a custom secondary pad for dynamic charging. This document will refer to the custom primary pad and a custom secondary pad as DGA and DVA, respectively. DGA offers compatibility with WPT2Z3 for dynamic charging and DVA offers compatibility with the Universal Ground Assembly (UGA) for stationary charging.
Faculty Advisor: Kamineni, Abhilash (College of Engineering, Electrical and Computer Engineering Department); Zane, Regan (College of Engineering, Electrical and Computer Engineering Department)
Transportation electrification will bring a positive effect on sustainable environments and robust economies. Electric Vehicles (EV) are emerging in today's market as a solution. However, the battery technologies on EV cannot compete with fuel and diesel cars in terms of energy storage capacity, and time needed to recharge (equivalently refuel). These limitations directly reflect on the consumers' convenience, the max miles the Vehicle can perform for, and hence EV adoption. Wireless power transfer (WPT) systems are seen as a solution to ease consumers' transition to EV. A high-level diagram of WPT is shown in Figure (**).
Major advancements in WPT technology has enabled the commercialization of stationary WPT solutions — materials technology has been a major impediment. Hence, academia and industry are jointly considering more advanced solutions in WPT, namely Dynamic Wireless Power Transfer (DWPT). Implementing DWPT systems will permit on the go charging for EV the upper hand over present charging (equivalently fueling) methods and encourage EV adoption. This document reflects on some of the challenges of realizing an effective DWPT that maintains power transfer between the primary pad and secondary pad, and a proposed solution to allow dynamic charging. Also, the proposed DWPT offers compatibility with SAE J2954 (Wireless Power Transfer for Light-Duty Plug-in/Electric Vehicles and Alignment Methodology) WPT3Z3 pad.
A comprehensive approach was taken in the design of the primary pad to validate the power transfer requirements for the designed pads. The proposed solution consists of a custom primary pad and a custom secondary pad for dynamic charging. This document will refer to the custom primary pad and a custom secondary pad as DGA and DVA, respectively. DGA offers compatibility with WPT2Z3 for dynamic charging and DVA offers compatibility with the Universal Ground Assembly (UGA) for stationary charging.
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What does "Successful Aging" mean to you? A systematic review and cross-national comparison of lay perspectives of older adults in 12 countries, 2010-2017
Jensen, Afton; Claunch, Kelsie; Verdeja, Marco; Dungan, Matthew; Anderson, Shellie; Clayton, Colter K.; Goates, Michael, Thacker, Evan (Brigham Young University)
Faculty Advisor: Thacker, Evan (Life Sciences, Public Health)
The purpose of this paper is to provide a systematic review of lay perspectives on the meaning of successful aging from older adults across multiple cultures and countries. Furthermore, this article allows for a discussion of the complexity of older adults' perspectives on successful aging and how successful aging may be defined differently across cultures and countries. We conducted a systematic literature review to identify, summarize, and evaluate peer-reviewed studies of qualitative data on lay perspectives of older adults. This review included studies on elderly populations published from 2010 to 2017 that addressed older adults' lay perspectives on successful aging. Such studies involved primary research performed in the United States, Germany, Singapore, Lebanon, Mexico, Canada, and New Zealand. The key concepts that emerged from older adult responses across all studies included physical health, cognitive health, social engagement, attitude/coping, independence/security, and spirituality. The overall emerging themes from our data suggest that older adults were not as concerned with physical health as biomedical previous research of successful aging often suggest. Rather, older adults focused on maintaining positive attitudes in order to cope with life changes, valuing social engagement and contribution as more essential to successful aging. Respondents from Western Europe valued keeping positive attitudes about death and focusing on gratitude instead of worries. Additionally, respondents from the United States and Mexico placed importance on pursuing activities and interests and having strong involvement with family and friends respectively. Noting differences, respondents from the Middle East, Asia, and Oceania Region, as opposed to respondents from North America, moreso prioritized the absence of chronic disease and comfort in one's own environment over keeping active. By providing a more comprehensive organizational framework of older adults' qualitative responses to successful aging, we better understand what successful aging means across cultures.
Faculty Advisor: Thacker, Evan (Life Sciences, Public Health)
The purpose of this paper is to provide a systematic review of lay perspectives on the meaning of successful aging from older adults across multiple cultures and countries. Furthermore, this article allows for a discussion of the complexity of older adults' perspectives on successful aging and how successful aging may be defined differently across cultures and countries. We conducted a systematic literature review to identify, summarize, and evaluate peer-reviewed studies of qualitative data on lay perspectives of older adults. This review included studies on elderly populations published from 2010 to 2017 that addressed older adults' lay perspectives on successful aging. Such studies involved primary research performed in the United States, Germany, Singapore, Lebanon, Mexico, Canada, and New Zealand. The key concepts that emerged from older adult responses across all studies included physical health, cognitive health, social engagement, attitude/coping, independence/security, and spirituality. The overall emerging themes from our data suggest that older adults were not as concerned with physical health as biomedical previous research of successful aging often suggest. Rather, older adults focused on maintaining positive attitudes in order to cope with life changes, valuing social engagement and contribution as more essential to successful aging. Respondents from Western Europe valued keeping positive attitudes about death and focusing on gratitude instead of worries. Additionally, respondents from the United States and Mexico placed importance on pursuing activities and interests and having strong involvement with family and friends respectively. Noting differences, respondents from the Middle East, Asia, and Oceania Region, as opposed to respondents from North America, moreso prioritized the absence of chronic disease and comfort in one's own environment over keeping active. By providing a more comprehensive organizational framework of older adults' qualitative responses to successful aging, we better understand what successful aging means across cultures.
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Reliability of Shear Wave Elastography Measurements in the Gastrocnemius of Senior Athletes
Preece, J Caleb; Seibold, Tanner; Hutchison, Cortland (Brigham Young University)
Faculty Advisor: Feland, J. Brent (Life Sciences, Exercise Science)
BACKGROUND: The recent development of shear-wave elastography (SWE) allows for the quantification of muscle elasticity/stiffness without complex biopsy or dynamometry. To date SWE information is available in younger subjects (typically <30 yrs). Variables such as temperature, joint position, ultrasound probe position and pressure can affect the SWE measurement.
PURPOSE: The purpose of this study was to determine the reliability of SWE measurements of both the medial and lateral heads of the gastrocnemius muscle using 3 different trained ultrasound users.
METHODS: Data was collected from 118 volunteers (participants in the Huntsman World Senior Games) in St. George, Utah, 2019. Subjects (62 males: mean age = 68.9 ± 7.8 yrs, Ht = 177.4 ± 8.1 cm, Wt= 85.4±20 kg; 54 females: mean age = 66.9 ± 8.5 yrs, Ht = 164.4 ± 7.2 cm, Wt= 69.8±18 kg) signed an approved consent form and then lay prone on a treatment table for 3 repeated ultrasonic measurement of SWE of both heads of the gastrocnemius using all three trained research assistants.
ANALYSIS: The three SWE measurements were analyzed using SPSS ver25 for medial and lateral gastrocnemius separately using the reliability analysis function and calculating a two-way mixed model of Intraclass Correlation Coefficient (ICC).
RESULTS & CONCLUSION: Overall, the measurements of SWE were very reliable with both the lateral gastrocnemius (ICC = .985) and the medial gastrocnemius (ICC = .991). Based on our experience in learning SWE measurements there is a significant learning curve to probe positioning and pressure as well as waiting for a stable elastography signal on the ultrasound screen. The high ICC values for these repeated measurements demonstrate that SWE measurement of the gastrocnemius can be reliable and repeatable. These results may not apply to other muscles since size and depth of muscle can also affect SWE signaling.
Faculty Advisor: Feland, J. Brent (Life Sciences, Exercise Science)
BACKGROUND: The recent development of shear-wave elastography (SWE) allows for the quantification of muscle elasticity/stiffness without complex biopsy or dynamometry. To date SWE information is available in younger subjects (typically <30 yrs). Variables such as temperature, joint position, ultrasound probe position and pressure can affect the SWE measurement.
PURPOSE: The purpose of this study was to determine the reliability of SWE measurements of both the medial and lateral heads of the gastrocnemius muscle using 3 different trained ultrasound users.
METHODS: Data was collected from 118 volunteers (participants in the Huntsman World Senior Games) in St. George, Utah, 2019. Subjects (62 males: mean age = 68.9 ± 7.8 yrs, Ht = 177.4 ± 8.1 cm, Wt= 85.4±20 kg; 54 females: mean age = 66.9 ± 8.5 yrs, Ht = 164.4 ± 7.2 cm, Wt= 69.8±18 kg) signed an approved consent form and then lay prone on a treatment table for 3 repeated ultrasonic measurement of SWE of both heads of the gastrocnemius using all three trained research assistants.
ANALYSIS: The three SWE measurements were analyzed using SPSS ver25 for medial and lateral gastrocnemius separately using the reliability analysis function and calculating a two-way mixed model of Intraclass Correlation Coefficient (ICC).
RESULTS & CONCLUSION: Overall, the measurements of SWE were very reliable with both the lateral gastrocnemius (ICC = .985) and the medial gastrocnemius (ICC = .991). Based on our experience in learning SWE measurements there is a significant learning curve to probe positioning and pressure as well as waiting for a stable elastography signal on the ultrasound screen. The high ICC values for these repeated measurements demonstrate that SWE measurement of the gastrocnemius can be reliable and repeatable. These results may not apply to other muscles since size and depth of muscle can also affect SWE signaling.
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A Preliminary Paleomagnetic Test for Incremental Pluton Emplacement
Parsons, Travis; Lippert, Peter; Bartley, John (University of Utah)
Faculty Advisor: Lippert, Peter (University of Utah - College of Mines and Earth Science, Geology & Geophysics); Bartley, John (University of Utah - College of Mines and Earth Science, Geology & Geophysics)
Field observations and geochronological measurements of plutons in Yosemite Valley suggest that plutons grow incrementally as a series of stacked sheets of smaller intrusions (i.e., dikes and sills) (Coleman et al., 2004; Glazner et al., 2004; Bartley et al., 2006). This interpretation is in contrast to the traditional view of pluton emplacement through crystallization of a single, massive magma chamber. Most of the observations supporting incremental pluton emplacement use the relationship between zircon U-Pb dating of pluton sections and estimated granitic magma cooling rates to argue that a single magmatic event would crystallize significantly faster than the geochronologic data permit. Incremental pluton emplacement also predicts specific relationships between the age of intruded sheets of magma and the original orientation of these sheets, such that older sheets are expected to be tilted or deformed more than younger sheets. Here we test this prediction of differential tilting by measuring the paleomagnetic inclination preserved in well-dated and structurally characterized sheets of the Tuolumne Intrusive Suite. Magnetic inclination provides a tilt-meter with respect to the Earth's magnetic field direction at the time of pluton emplacement; the reference inclination assuming an untitled pluton is known from independent data sets. We also present rock magnetic data (temperature-dependent magnetic susceptibility, magnetic remanence characteristics) and results from petrographic investigations to characterize the mineralogy and stability of the magnetization. Our results suggest that the low-titanium magnetite remanence carriers are primary and are not biased by secondary magnetizations. The distribution of magnetic inclinations in our sample set — in which older sheets on the periphery of the pluton are shallower than those in younger, more interior sheets, and with respect to the reference inclination — is consistent with predictions from the incremental pluton emplacement hypothesis.
Faculty Advisor: Lippert, Peter (University of Utah - College of Mines and Earth Science, Geology & Geophysics); Bartley, John (University of Utah - College of Mines and Earth Science, Geology & Geophysics)
Field observations and geochronological measurements of plutons in Yosemite Valley suggest that plutons grow incrementally as a series of stacked sheets of smaller intrusions (i.e., dikes and sills) (Coleman et al., 2004; Glazner et al., 2004; Bartley et al., 2006). This interpretation is in contrast to the traditional view of pluton emplacement through crystallization of a single, massive magma chamber. Most of the observations supporting incremental pluton emplacement use the relationship between zircon U-Pb dating of pluton sections and estimated granitic magma cooling rates to argue that a single magmatic event would crystallize significantly faster than the geochronologic data permit. Incremental pluton emplacement also predicts specific relationships between the age of intruded sheets of magma and the original orientation of these sheets, such that older sheets are expected to be tilted or deformed more than younger sheets. Here we test this prediction of differential tilting by measuring the paleomagnetic inclination preserved in well-dated and structurally characterized sheets of the Tuolumne Intrusive Suite. Magnetic inclination provides a tilt-meter with respect to the Earth's magnetic field direction at the time of pluton emplacement; the reference inclination assuming an untitled pluton is known from independent data sets. We also present rock magnetic data (temperature-dependent magnetic susceptibility, magnetic remanence characteristics) and results from petrographic investigations to characterize the mineralogy and stability of the magnetization. Our results suggest that the low-titanium magnetite remanence carriers are primary and are not biased by secondary magnetizations. The distribution of magnetic inclinations in our sample set — in which older sheets on the periphery of the pluton are shallower than those in younger, more interior sheets, and with respect to the reference inclination — is consistent with predictions from the incremental pluton emplacement hypothesis.
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Binding Trends of simple hosts and guests with CB5, CB6, and Mc5
Dearden, Heravi, Shen, Arslanian, Shrestha, Mismash, Tinsley, Pay (Brigham Young University)
Faculty Advisor: Dearden, David (Brigham Young University, Chemistry)
Using the Spartan and Ion Molecular Spectrometry Suite (IMoS), we use the 3D modeling to predict stability and molecule favorability. Previously in our experimentation we have seen and proper capping of a host molecule with cucurbit[5]uril. This was different than cucurbit[6]uril as the cap in some cases didn't bond to all the upward oxygens because on the molecular symmetry, thus host enclosure was less favorable in cucurbit[6]uril than cucurbit[5]uril. We also observed in our lab the energy differences using the Extensible Computation Chemistry Environment (ECCE) of cucurbit[5]uril host transfer based on cap and host interactions. These studies show that cucurbit[5]uril with methane as a host is more favorable than outside the cavity. It also shows that methane inside cucurbit[5]uril is more favored than in decamethylcucurbit[5]uril. The studies using computational study will be testable using mass spectrometry, and we predict that the same behavior trend will show using other caps and hosts with cucurbit[5]uril and decamethylcucurbit[5]uril.
Faculty Advisor: Dearden, David (Brigham Young University, Chemistry)
Using the Spartan and Ion Molecular Spectrometry Suite (IMoS), we use the 3D modeling to predict stability and molecule favorability. Previously in our experimentation we have seen and proper capping of a host molecule with cucurbit[5]uril. This was different than cucurbit[6]uril as the cap in some cases didn't bond to all the upward oxygens because on the molecular symmetry, thus host enclosure was less favorable in cucurbit[6]uril than cucurbit[5]uril. We also observed in our lab the energy differences using the Extensible Computation Chemistry Environment (ECCE) of cucurbit[5]uril host transfer based on cap and host interactions. These studies show that cucurbit[5]uril with methane as a host is more favorable than outside the cavity. It also shows that methane inside cucurbit[5]uril is more favored than in decamethylcucurbit[5]uril. The studies using computational study will be testable using mass spectrometry, and we predict that the same behavior trend will show using other caps and hosts with cucurbit[5]uril and decamethylcucurbit[5]uril.
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Using the Moral Foundation Theory to Improve Vaccine Hesitancy in Utah
Cromar, Zachary J.; Findlay, Matthew; Turner, Elizabeth; Mills, Ammon (Utah Valley University)
Faculty Advisor: Gazdik-Stofer, Michaela (College of Science - Utah Valley University, Biology); Sylvester, Steven (College of Humanities and Social Sciences - Utah Valley University, Political Science)
The World Health Organization has included vaccine hesitancy in the top ten threats to global health in 2019. Studies done in the United States have shown that the Moral Foundations Theory (MFT) can be used to identify why individuals are more vaccine-hesitant (VH) than others. Counterintuitively, the dichotomous moral foundations (MF) of care vs. harm, traditionally used in pro-vaccine messaging interventions, or fairness vs. cheating, were not found to be the foundations on which VH parents based their decision not to follow the CDC recommended vaccination schedule. It was discovered that the purity vs. degradation and liberty vs. oppression foundations are more important to VH individuals than all other foundations. Highly VH individuals are twice as likely to emphasize purity and liberty. Concerningly, in 2018, Utah ranked in the bottom ten states for child vaccination rates in 11 of the 19 vaccines reported by the Utah Department of Health. We plan on testing a broader messaging intervention than the current, traditional vaccine messages. Our messaging interventions will emphasize the MFs of liberty vs. oppression and purity vs. degradation to see if they will be more effective than our more traditional messaging intervention emphasizing care vs. harm, or an unrelated control message not related to vaccines. We hypothesize that messages emphasizing the purity and liberty foundations will resonate better with the VH and decrease their vaccine-hesitancy relative to the other groups. If our data supports that the MFs of liberty vs. oppression and purity vs. degradation significantly decrease vaccine-hesitancy than current general vaccine education messaging interventions should be broadened to include these MFs. However, if results do not demonstrate that the liberty vs. oppression MFs are more effective at decreasing vaccine hesitancy, then more research should be performed on the subject.
Faculty Advisor: Gazdik-Stofer, Michaela (College of Science - Utah Valley University, Biology); Sylvester, Steven (College of Humanities and Social Sciences - Utah Valley University, Political Science)
The World Health Organization has included vaccine hesitancy in the top ten threats to global health in 2019. Studies done in the United States have shown that the Moral Foundations Theory (MFT) can be used to identify why individuals are more vaccine-hesitant (VH) than others. Counterintuitively, the dichotomous moral foundations (MF) of care vs. harm, traditionally used in pro-vaccine messaging interventions, or fairness vs. cheating, were not found to be the foundations on which VH parents based their decision not to follow the CDC recommended vaccination schedule. It was discovered that the purity vs. degradation and liberty vs. oppression foundations are more important to VH individuals than all other foundations. Highly VH individuals are twice as likely to emphasize purity and liberty. Concerningly, in 2018, Utah ranked in the bottom ten states for child vaccination rates in 11 of the 19 vaccines reported by the Utah Department of Health. We plan on testing a broader messaging intervention than the current, traditional vaccine messages. Our messaging interventions will emphasize the MFs of liberty vs. oppression and purity vs. degradation to see if they will be more effective than our more traditional messaging intervention emphasizing care vs. harm, or an unrelated control message not related to vaccines. We hypothesize that messages emphasizing the purity and liberty foundations will resonate better with the VH and decrease their vaccine-hesitancy relative to the other groups. If our data supports that the MFs of liberty vs. oppression and purity vs. degradation significantly decrease vaccine-hesitancy than current general vaccine education messaging interventions should be broadened to include these MFs. However, if results do not demonstrate that the liberty vs. oppression MFs are more effective at decreasing vaccine hesitancy, then more research should be performed on the subject.
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Water Consumed From Total Fluid Intake Influences Metabolic Syndrome Parameters
Tilisa Howell; David Aguilar-Alvarez (Weber State University)
Faculty Advisor: Aguilar-Alvarez, David (Moyes College of Education, Athletic Training & nutrition)
Abstract:
Background:
Recent studies show that water intake plays a major role in the development of chronic diseases such as type 2 diabetes, cardiovascular disease, and kidney disease. The aim of this study was to determine if the percentage of total fluid intake from water influences Metabolic Syndrome (MetS) and identify significant associations between water, dairy, soft drinks and juice consumption with MetS parameters in college students.
Methods:
We measured MetS parameters and collected diet records from 364 college students, ages 18-65 years. Participants were grouped by gender (Male: 112; Female: 252) and by percentage of total fluid consumption from water. Groups were defined as high (>70%) percentage of total fluid intake from water (HPW) and Low percentage (<30%) of total fluid intake from water (LPW). T-test was used to determine mean differences in MetS parameters between HPW and LPW, and Pearson correlations to determine associations between MetS and specific fluids.
Results:
HPW participants showed lower diastolic blood pressure when compared with their LPW counterparts (µ=78. 51±8. 28 vs µ=81. 2± 9. 28, p=0. 05). Men dairy fluid consumption was associated with increased fasting blood glucose (r=0. 242, p=0. 01. In women, Juice consumption was associated with increased LDL-Cholesterol (r= 0. 205, p=0. 02).
Conclusion:
Consuming non-water fluids showed negative effects on blood pressure. Contrary to previous studies, dairy fluid consumption in men was associated with increased blood glucose. It is possible that high-glycemic foods tied to dairy consumption modulate this association. Our results in women are consistent with previous studies were juice consumption increases triglyceride production and VLDL-Cholesterol.
Faculty Advisor: Aguilar-Alvarez, David (Moyes College of Education, Athletic Training & nutrition)
Abstract:
Background:
Recent studies show that water intake plays a major role in the development of chronic diseases such as type 2 diabetes, cardiovascular disease, and kidney disease. The aim of this study was to determine if the percentage of total fluid intake from water influences Metabolic Syndrome (MetS) and identify significant associations between water, dairy, soft drinks and juice consumption with MetS parameters in college students.
Methods:
We measured MetS parameters and collected diet records from 364 college students, ages 18-65 years. Participants were grouped by gender (Male: 112; Female: 252) and by percentage of total fluid consumption from water. Groups were defined as high (>70%) percentage of total fluid intake from water (HPW) and Low percentage (<30%) of total fluid intake from water (LPW). T-test was used to determine mean differences in MetS parameters between HPW and LPW, and Pearson correlations to determine associations between MetS and specific fluids.
Results:
HPW participants showed lower diastolic blood pressure when compared with their LPW counterparts (µ=78. 51±8. 28 vs µ=81. 2± 9. 28, p=0. 05). Men dairy fluid consumption was associated with increased fasting blood glucose (r=0. 242, p=0. 01. In women, Juice consumption was associated with increased LDL-Cholesterol (r= 0. 205, p=0. 02).
Conclusion:
Consuming non-water fluids showed negative effects on blood pressure. Contrary to previous studies, dairy fluid consumption in men was associated with increased blood glucose. It is possible that high-glycemic foods tied to dairy consumption modulate this association. Our results in women are consistent with previous studies were juice consumption increases triglyceride production and VLDL-Cholesterol.
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The Power of Wind on Rock: Yardang Formation in Argentina
Sevy, Jonathon; Radebaugh, Jani; McDougall, Dylan; Kerber, Laura; Rabinovitch, Jason (Brigham Young University)
Faculty Advisor: Radebaugh, Jani (Brigham Young University, Geology)
Yardangs are wind-carved linear ridges that are found selectively on Earth and extensively on Mars. The history of the morphologic development of yardangs is not well known. In the Puna high plateau of Argentina there are ignimbrite deposits, many of which have been eroded into yardang fields, commonly called fleets. Yarding fleets are evenly spaced forms, facing into the wind, that resemble a fleet of boats sailing. A prominent fleet, known as Campo de las Piedras Pomez (CCP) was studied to more fully understand their formation and morphology, including field research in December 2018 and 2019. Some physical characteristics looked at in the field included: dedos direction and lengths; heights and lengths of yardangs; structural features; wind and gravel ripple direction. In addition, relationships between yardang organization and structural control have been analyzed. The dedos on the fronts of yardangs averaged 4.0cm in length, while the reverse dedos were 3.3cm. From this it was determined that: Two wind directions, with one dominant, are present; Structural features can shape morphology of yardangs.
Faculty Advisor: Radebaugh, Jani (Brigham Young University, Geology)
Yardangs are wind-carved linear ridges that are found selectively on Earth and extensively on Mars. The history of the morphologic development of yardangs is not well known. In the Puna high plateau of Argentina there are ignimbrite deposits, many of which have been eroded into yardang fields, commonly called fleets. Yarding fleets are evenly spaced forms, facing into the wind, that resemble a fleet of boats sailing. A prominent fleet, known as Campo de las Piedras Pomez (CCP) was studied to more fully understand their formation and morphology, including field research in December 2018 and 2019. Some physical characteristics looked at in the field included: dedos direction and lengths; heights and lengths of yardangs; structural features; wind and gravel ripple direction. In addition, relationships between yardang organization and structural control have been analyzed. The dedos on the fronts of yardangs averaged 4.0cm in length, while the reverse dedos were 3.3cm. From this it was determined that: Two wind directions, with one dominant, are present; Structural features can shape morphology of yardangs.
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A Yarrowing Experience: The Tumor Inhibition and Toxicity of Utah's Native Achillea millefolium
Parada, Michelle (Weber State University)
Faculty Advisor: Schramm, Katharina (Weber State University, Botany)
This research focuses on anti-tumor and the biotoxicity of A. millefollium (yarrow).
Yarrow is an interesting plant with a long history of medicinal uses, but very little has been done to research and prove the different beneficial properties claimed. There are two simple bench-top assays performed in this study, the potato disc assay which inoculates potato slices with Agrobacterium tumefaciens as well as different concentrations of yarrow extracts and assesses the resulting tumor formation and the brine shrimp toxicity assay to assess the LD-50 of the extracts. My results will indicate whether or not the native yarrow extracts inhibit or do not inhibit tumor formation and its toxicity level. The results of this research could lead to further studies of the phytochemicals in the plant to be used for cancer treatments.
Faculty Advisor: Schramm, Katharina (Weber State University, Botany)
This research focuses on anti-tumor and the biotoxicity of A. millefollium (yarrow).
Yarrow is an interesting plant with a long history of medicinal uses, but very little has been done to research and prove the different beneficial properties claimed. There are two simple bench-top assays performed in this study, the potato disc assay which inoculates potato slices with Agrobacterium tumefaciens as well as different concentrations of yarrow extracts and assesses the resulting tumor formation and the brine shrimp toxicity assay to assess the LD-50 of the extracts. My results will indicate whether or not the native yarrow extracts inhibit or do not inhibit tumor formation and its toxicity level. The results of this research could lead to further studies of the phytochemicals in the plant to be used for cancer treatments.
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γ-T3 and ɑ-TEA reduce the amount of docetaxel required to decrease cell viability in human prostate cancer cells and enhance the efficacy of docetaxel in the treatment of drug-resistant cells
Asay, Spencer; Graham, Andrew; Burke, Lexady; Barnes, Brad; Oblad, Richard; Kenealey, Jason (Brigham Young University)
Faculty Advisor: Kenealey, Jason (Life Sciences; Nutrition, Dietetics, and Food Science)
Prostate cancer is the second most commonly diagnosed cancer in men, and metastatic prostate cancer is currently incurable. Prostate cancer frequently becomes resistant to standard of care treatments. Moreover, the administration of conventional chemotherapeutic drugs, such as docetaxel (DOC), poses the risk of debilitating toxic side effects. Combination therapy, in which several compounds targeting multiple cellular pathways are administered jointly, is one tool that can be used to combat therapeutic resistance and drug toxicity. Vitamin E (VE) compounds and analogs have been proposed as potential non-toxic chemotherapeutics. We modeled combination therapy using mixture design response surface methodology (MDRSM), a statistical technique designed to optimize mixture compositions, to determine whether combinations of three chemotherapeutic agents (γ-tocotrienol (γ-T3), γ-tocopherol ether acetate (ɑ-TEA), and DOC) would prove more effective than DOC alone in the treatment of PC-3 human prostate cancer cells. A response surface was generated for cell viability, and the optimal treatment combination for reducing cell viability was calculated. We found that a combination of 30 µM ɑ-TEA, 20 µM γ-T3, and 25 nm DOC was most effective in the treatment of PC-3 cells. We also found that combining γ-T3 and ɑ-TEA with DOC decreased the dose of DOC required to significantly reduce cell viability in PC-3 cells. Finally, we found that combining γ-T3 and ɑ-TEA with DOC enhanced treatment efficacy in DOC-resistant PC-3 cells.
Faculty Advisor: Kenealey, Jason (Life Sciences; Nutrition, Dietetics, and Food Science)
Prostate cancer is the second most commonly diagnosed cancer in men, and metastatic prostate cancer is currently incurable. Prostate cancer frequently becomes resistant to standard of care treatments. Moreover, the administration of conventional chemotherapeutic drugs, such as docetaxel (DOC), poses the risk of debilitating toxic side effects. Combination therapy, in which several compounds targeting multiple cellular pathways are administered jointly, is one tool that can be used to combat therapeutic resistance and drug toxicity. Vitamin E (VE) compounds and analogs have been proposed as potential non-toxic chemotherapeutics. We modeled combination therapy using mixture design response surface methodology (MDRSM), a statistical technique designed to optimize mixture compositions, to determine whether combinations of three chemotherapeutic agents (γ-tocotrienol (γ-T3), γ-tocopherol ether acetate (ɑ-TEA), and DOC) would prove more effective than DOC alone in the treatment of PC-3 human prostate cancer cells. A response surface was generated for cell viability, and the optimal treatment combination for reducing cell viability was calculated. We found that a combination of 30 µM ɑ-TEA, 20 µM γ-T3, and 25 nm DOC was most effective in the treatment of PC-3 cells. We also found that combining γ-T3 and ɑ-TEA with DOC decreased the dose of DOC required to significantly reduce cell viability in PC-3 cells. Finally, we found that combining γ-T3 and ɑ-TEA with DOC enhanced treatment efficacy in DOC-resistant PC-3 cells.
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Serotonergic Hallucinogens' Antidepressant Potential: A Comparative Review of Serotonergic Hallucinogens and Ketamine
Ouzts, Ethan (Brigham Young University)
Faculty Advisor: Matheson, Rebekka (BYU Family, Home, and Social Sciences; Psychology)
Ketamine was recently approved by the U.S. Food and Drug Administration as a therapeutic approach to treat individuals with treatment-resistant depression. This approval opens the door for other hallucinogens to be approved for psychiatric use. This review compares the antidepressant efficacy and safety of ketamine to serotonergic hallucinogens, such as lysergic diethylamide acid (LSD). Ketamine acts as the standard of comparison in this review. Serotonergic hallucinogens demonstrate similar short to mid-term responses in patients with depression and compares well to ketamine's safety. Researchers should conduct additional randomized, controlled experiments to better establish serotonergic hallucinogens' antidepressant potential. Despite this limitation, serotonergic hallucinogens warrant serious consideration for potential antidepressant treatment.
Faculty Advisor: Matheson, Rebekka (BYU Family, Home, and Social Sciences; Psychology)
Ketamine was recently approved by the U.S. Food and Drug Administration as a therapeutic approach to treat individuals with treatment-resistant depression. This approval opens the door for other hallucinogens to be approved for psychiatric use. This review compares the antidepressant efficacy and safety of ketamine to serotonergic hallucinogens, such as lysergic diethylamide acid (LSD). Ketamine acts as the standard of comparison in this review. Serotonergic hallucinogens demonstrate similar short to mid-term responses in patients with depression and compares well to ketamine's safety. Researchers should conduct additional randomized, controlled experiments to better establish serotonergic hallucinogens' antidepressant potential. Despite this limitation, serotonergic hallucinogens warrant serious consideration for potential antidepressant treatment.
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An Aperture Correction for GeMS MCAO SBF Distance Measurements
Sundstrom, Rebecca; Jensen, Joseph B. (Utah Valley University)
Faculty Advisor: Jensen, Joseph (Utah Valley University, Physics)
We will measure Surface Brightness Fluctuations (SBF) in three galaxies (ESO137-G006, NGC 3309, and NGC 5128) using images from two cameras: the GeMS Multi-Conjugate Adaptive Optics (MCAO) system and the FLAMINGOS-2 (F-2) near-infrared imaging spectrograph, at the 8-meter Gemini South Telescope in Chile. To make an accurate measurement we need to first determine a photometric calibration for the MCAO system by comparing flux, or captured light, from both detectors. This is necessary because MCAO collects crisp, sharp images but omits some of the total incoming flux from the stars in the galaxies. F-2 takes broader images but includes more measurable flux. By finding the ratio of the flux collected by MCAO to the flux collected by F-2 we can take this "missing" light into account without compromising the crisp, sharp resolution MCAO provides.
Faculty Advisor: Jensen, Joseph (Utah Valley University, Physics)
We will measure Surface Brightness Fluctuations (SBF) in three galaxies (ESO137-G006, NGC 3309, and NGC 5128) using images from two cameras: the GeMS Multi-Conjugate Adaptive Optics (MCAO) system and the FLAMINGOS-2 (F-2) near-infrared imaging spectrograph, at the 8-meter Gemini South Telescope in Chile. To make an accurate measurement we need to first determine a photometric calibration for the MCAO system by comparing flux, or captured light, from both detectors. This is necessary because MCAO collects crisp, sharp images but omits some of the total incoming flux from the stars in the galaxies. F-2 takes broader images but includes more measurable flux. By finding the ratio of the flux collected by MCAO to the flux collected by F-2 we can take this "missing" light into account without compromising the crisp, sharp resolution MCAO provides.
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Vaping: Not a Safe Alternative to Smoking
Morgan Howard, Corinna Trujillo Tanner, Boyd Tanner, Brandon Thatcher, Janelle Macintosh (Brigham Young University)
Faculty Advisor: Trujillo Tanner, Corinna (Nursing, Nursing)
Purpose/Aims: The purpose of this Review of Literature is to present the most current and accurate information about e-cigarette use, or vaping, with recommendations for nursing practice.
Rationale/Conceptual Basis/Background: According to the CDC, to date over 1300 individuals have developed severe lung injury, associated with vaping, including 216 fatalities. Most of these cases involved young people in their teens or twenties. There are concerns that marketing for vaping specifically targets young people and leads potential users to consider the practice relatively safe. On the contrary, vaping is associated with several serious health risks, including lipoid pneumonia, acute respiratory distress syndrome and popcorn lung. Little is known about the effects of the 60+ compounds identified in vaping aerosol, which is inhaled directly into the lungs. Nurses are often the first point of contact for patients in primary care and urgent/emergent settings. Nurses provide valuable patient education, health assessment, and referral. It is important for nurses to have access to the latest information about this developing problem.
Methods: We conducted a review of literature. We reviewed and summarized information from the Food and Drug administration, Centers for Disease Control, American Medical Association, American Academy of Pediatrics, and other reputable sources. All information reviewed had been published within the last six months. Research questions which guided this review sought to identify important considerations for nursing assessment, and nursing interventions.
Findings/Clinical Implications:
Nursing Assessment: An important part of nursing assessment should include documentation of a patient's history of vaping. When a patient presents with respiratory symptoms and has a history of vaping, a detailed vaping history covering the previous 90 days should be obtained. When acute lung injury, caused by vaping is identified, it must be reported to local and state health departments, per the new CDC guidelines.
Nursing interventions should include patient education as follows: 98.7% of "vape juice" assayed by the FDA contained the addictive substance nicotine (even if labeled "nicotine free") Nicotine is highly addictive and damages developing brain tissue in fetuses, infants, children and teens Inhaled "second hand" vape aerosol is dangerous for pregnant women, infants, children and those with lung disease The inhaled solution is not "water vapor" but rather an aerosol created by an electric heating element within the vaping device The inhaled solution contains up to 60 + chemicals including heavy metals
There is no established standard for vaping safety
Flavorings in vape juice, although considered safe for ingestion, have not been approved for inhalation and are not known to be safe
Additional information and recommendations will be forthcoming as our understanding of the risks associated with vaping is rapidly evolving.
Faculty Advisor: Trujillo Tanner, Corinna (Nursing, Nursing)
Purpose/Aims: The purpose of this Review of Literature is to present the most current and accurate information about e-cigarette use, or vaping, with recommendations for nursing practice.
Rationale/Conceptual Basis/Background: According to the CDC, to date over 1300 individuals have developed severe lung injury, associated with vaping, including 216 fatalities. Most of these cases involved young people in their teens or twenties. There are concerns that marketing for vaping specifically targets young people and leads potential users to consider the practice relatively safe. On the contrary, vaping is associated with several serious health risks, including lipoid pneumonia, acute respiratory distress syndrome and popcorn lung. Little is known about the effects of the 60+ compounds identified in vaping aerosol, which is inhaled directly into the lungs. Nurses are often the first point of contact for patients in primary care and urgent/emergent settings. Nurses provide valuable patient education, health assessment, and referral. It is important for nurses to have access to the latest information about this developing problem.
Methods: We conducted a review of literature. We reviewed and summarized information from the Food and Drug administration, Centers for Disease Control, American Medical Association, American Academy of Pediatrics, and other reputable sources. All information reviewed had been published within the last six months. Research questions which guided this review sought to identify important considerations for nursing assessment, and nursing interventions.
Findings/Clinical Implications:
Nursing Assessment: An important part of nursing assessment should include documentation of a patient's history of vaping. When a patient presents with respiratory symptoms and has a history of vaping, a detailed vaping history covering the previous 90 days should be obtained. When acute lung injury, caused by vaping is identified, it must be reported to local and state health departments, per the new CDC guidelines.
Nursing interventions should include patient education as follows: 98.7% of "vape juice" assayed by the FDA contained the addictive substance nicotine (even if labeled "nicotine free") Nicotine is highly addictive and damages developing brain tissue in fetuses, infants, children and teens Inhaled "second hand" vape aerosol is dangerous for pregnant women, infants, children and those with lung disease The inhaled solution is not "water vapor" but rather an aerosol created by an electric heating element within the vaping device The inhaled solution contains up to 60 + chemicals including heavy metals
There is no established standard for vaping safety
Flavorings in vape juice, although considered safe for ingestion, have not been approved for inhalation and are not known to be safe
Additional information and recommendations will be forthcoming as our understanding of the risks associated with vaping is rapidly evolving.
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Supplemental treatment options for diabetes: how flavanol metabolites improve β-cell function
Barlow, Andrew; Beales, Joseph; Ekpo, Idongesit; Krueger, Emily; Lloyd, Trevor; Ross, Mimi; Sheets, Jared; Tessem, Jeffery; (Brigham Young University)
Faculty Advisor: Tessem, Jeffery (Brigham Young University; Nutrition, Dietetics, and Food Science)
One in eleven people worldwide suffer from diabetes, and 12% of the global health expenditure is attributed to its treatment. Despite spending over $300 billion on the treatment of diabetes, none offer curative therapies. Diabetes is characterized by the loss of pancreatic β-cell function, but research has shown changes in diet are beneficial in treating Type 2 Diabetes. Phytochemicals are commonly utilized in these diets, and recent studies show diets high in derived flavanols exert beneficial bioactivity for β-cells. However, given that these phytochemicals are rarely found in circulation, the direct mechanism of action is still under investigation. Gut bacteria metabolize flavanols into smaller, absorbable metabolites, which can be found in circulation. We hypothesize that these gut bacteria derived flavanol metabolites are absorbed and have direct effects on β-cell function. We test this hypothesis by feeding rats control diets or diets rich in the flavanol monomers catechin hydrate and epicatechin or grape seed extract. Here we present data regarding the in vitro effects of these absorbed gut bacteria derived flavanols on β-cell function. This study sheds further light on flavanols and their potential to promote insulin secretion and, ultimately, glucose homeostasis.
Faculty Advisor: Tessem, Jeffery (Brigham Young University; Nutrition, Dietetics, and Food Science)
One in eleven people worldwide suffer from diabetes, and 12% of the global health expenditure is attributed to its treatment. Despite spending over $300 billion on the treatment of diabetes, none offer curative therapies. Diabetes is characterized by the loss of pancreatic β-cell function, but research has shown changes in diet are beneficial in treating Type 2 Diabetes. Phytochemicals are commonly utilized in these diets, and recent studies show diets high in derived flavanols exert beneficial bioactivity for β-cells. However, given that these phytochemicals are rarely found in circulation, the direct mechanism of action is still under investigation. Gut bacteria metabolize flavanols into smaller, absorbable metabolites, which can be found in circulation. We hypothesize that these gut bacteria derived flavanol metabolites are absorbed and have direct effects on β-cell function. We test this hypothesis by feeding rats control diets or diets rich in the flavanol monomers catechin hydrate and epicatechin or grape seed extract. Here we present data regarding the in vitro effects of these absorbed gut bacteria derived flavanols on β-cell function. This study sheds further light on flavanols and their potential to promote insulin secretion and, ultimately, glucose homeostasis.
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Use of Computer Tomography Imaging for Analyzing Bone Remodeling Around an Osseointegrated Implant
Wankier, Zakary; Sinclair, Sarina PhD; Drew, Alex PhD; Taylor, Carolyn MS; Kubiak, Eric MD; Agarwal, Jayant MD (University of Utah)
Faculty Advisor: Sinclair, Sarina (School of Medicine, Orthopaedics)
Introduction:
Osseointegration (�OI�) technology is the direct skeletal attachment of a prosthetic limb to bone using an intramedullary stem. For OI to be effective and secure, bone in-growth and remodeling around the implant must be achieved. Physicians need an effective way to measure bone remodeling in order to make informed decisions on treatments. This work describes methodology that was developed that utilizes computed tomography (CT) imaging as a tool for analyzing bone remodeling around an OI implant.
Method:
Subjects implanted with a new Percutaneous Osseointegrated Prosthesis (POP) had CTs taken of their residual femur at 6 and 52-weeks post-op. The CT images were used to segment and create three-dimensional models of the femur.
Following segmentation, models were aligned to a common world coordinate system. STLs of the aligned medullary cavity and femur volume were entered into custom Matlab code to calculate cortical and medullary morphology measurements. Morphology data from 6 and 52-week scans were compared in order to determine if bone remodeling around the POP implant could be detected.
Results:
Comparing data from post-operative visits suggests that important indicators of bone remodeling around the device could be detected. One year after implantation of the POP device the medullary parameters had minimal % differences (-1.5 and 2.2) compared to 6-weeks, validating that consistent alignment was achieved between scans from different time points. Cortical area, perimeter, and thickness around the POP implant showed positive percent changes at 12-months of 19.44%, 4.04% and 14.36% respectively. Increases in cortex morphology values indicate bone remodeling around the implant, with largest increases observed at the distal end for each parameter.
Discussion:
This pilot study utilized CT imaging as a tool for quickly and accurately analyzing bone remodeling around a new osseointegrated device. Additional work will further validate and optimize these methods for clinical use.
This study described an investigational device, limited by federal law to investigational use. No long-term data exists about its performance.
Faculty Advisor: Sinclair, Sarina (School of Medicine, Orthopaedics)
Introduction:
Osseointegration (�OI�) technology is the direct skeletal attachment of a prosthetic limb to bone using an intramedullary stem. For OI to be effective and secure, bone in-growth and remodeling around the implant must be achieved. Physicians need an effective way to measure bone remodeling in order to make informed decisions on treatments. This work describes methodology that was developed that utilizes computed tomography (CT) imaging as a tool for analyzing bone remodeling around an OI implant.
Method:
Subjects implanted with a new Percutaneous Osseointegrated Prosthesis (POP) had CTs taken of their residual femur at 6 and 52-weeks post-op. The CT images were used to segment and create three-dimensional models of the femur.
Following segmentation, models were aligned to a common world coordinate system. STLs of the aligned medullary cavity and femur volume were entered into custom Matlab code to calculate cortical and medullary morphology measurements. Morphology data from 6 and 52-week scans were compared in order to determine if bone remodeling around the POP implant could be detected.
Results:
Comparing data from post-operative visits suggests that important indicators of bone remodeling around the device could be detected. One year after implantation of the POP device the medullary parameters had minimal % differences (-1.5 and 2.2) compared to 6-weeks, validating that consistent alignment was achieved between scans from different time points. Cortical area, perimeter, and thickness around the POP implant showed positive percent changes at 12-months of 19.44%, 4.04% and 14.36% respectively. Increases in cortex morphology values indicate bone remodeling around the implant, with largest increases observed at the distal end for each parameter.
Discussion:
This pilot study utilized CT imaging as a tool for quickly and accurately analyzing bone remodeling around a new osseointegrated device. Additional work will further validate and optimize these methods for clinical use.
This study described an investigational device, limited by federal law to investigational use. No long-term data exists about its performance.
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Characterizing the grain size distribution of geomorphic units along the Yampa River in Dinosaur National Monument, Colorado.
Schmidt, Jack; Leonard, Christina; Jukes, Thomas (Utah State University)
Faculty Advisor: Schmidt, Jack (S.J. & Jessie E. Quinney College of Natural Resources, Watershed Sciences Department)
Abstract: Western rivers are impounded by a suite of water resource infrastructure that supports human life and has fueled western development. These rivers also support a unique ecosystem for endemic endangered species, whose habitat has been degraded by water resource development that has disrupted the flow and sediment delivered to the system. Channel morphology, and within-channel habitat are the consequence of sediment deposition and erosion. One way to measure the amount of sediment deposition or erosion is by measuring the amount of sediment transported into and out of a river segment to calculate the mass-sediment budget. Such analyses, however, cannot identify the locations within the river segment where aggradation or degradation has occurred, or predict how habitat has changed. In this study, we aim to correlate field-based measurements of channel and habitat change with flux-based sediment budgets. We propose that in order to predict detailed channel response and habitat change, flux-based sediment budgets must be partitioned by grain size class, because different grain size classes are eroded and deposited in different parts of the channel. As part of this study, we have collected samples and observations throughout the study area to analyze and characterize the grain size distribution of the channel and floodplain in units identified as eroding or aggrading. By obtaining information about where different grain size classes of sediment are deposited and eroded, we are working to link the partitioned mass-sediment budget to channel change to understand where and why channel change occurs.
Faculty Advisor: Schmidt, Jack (S.J. & Jessie E. Quinney College of Natural Resources, Watershed Sciences Department)
Abstract: Western rivers are impounded by a suite of water resource infrastructure that supports human life and has fueled western development. These rivers also support a unique ecosystem for endemic endangered species, whose habitat has been degraded by water resource development that has disrupted the flow and sediment delivered to the system. Channel morphology, and within-channel habitat are the consequence of sediment deposition and erosion. One way to measure the amount of sediment deposition or erosion is by measuring the amount of sediment transported into and out of a river segment to calculate the mass-sediment budget. Such analyses, however, cannot identify the locations within the river segment where aggradation or degradation has occurred, or predict how habitat has changed. In this study, we aim to correlate field-based measurements of channel and habitat change with flux-based sediment budgets. We propose that in order to predict detailed channel response and habitat change, flux-based sediment budgets must be partitioned by grain size class, because different grain size classes are eroded and deposited in different parts of the channel. As part of this study, we have collected samples and observations throughout the study area to analyze and characterize the grain size distribution of the channel and floodplain in units identified as eroding or aggrading. By obtaining information about where different grain size classes of sediment are deposited and eroded, we are working to link the partitioned mass-sediment budget to channel change to understand where and why channel change occurs.
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The Homeless Population and End of Life Care
Trumble, Tanner; Jensen, Francine (Utah Valley University)
Faculty Advisor: Jensen, Robert (Utah Valley University, Nursing)
Background: Individuals who experience homelessness lack the necessary components needed receive end of life care (EOL). However, due to personal and structural barriers such as cost of care, lack of insurance, addiction, and many who experience mental health and intellectual disabilities, homeless individuals are unable to receive palliative or hospice care. Because homeless individuals lack the necessary components of basic living such as food, water and shelter, their quality of life is significantly lower than that of the general population, and this affects their EOL experiences.
Purpose: To explore the factors that affect the homeless population and the barriers they face when accessing health care, including their needs at the EOL, and to provide recommendations for better EOL care.
Methods: A focused literature review was performed using the databases PubMed, Google Scholar and Science Direct using the keywords homeless, end of life, and palliative care covering the years 1985 to 2018.
Findings: Homeless individuals want to experience a "good death". Unfortunately, homeless individuals who seek medical treatment feel deterred due to unfair treatment and belittlement from previous health care experiences and the social stigma surrounding homelessness. This can delay their treatment of chronic or acute conditions and lead to long-term health consequences. One effort to aid in EOL care for homeless individuals is the Social Model Hospice, which provides holistic EOL care in home like setting. Social model hospice overcomes barriers to lack of insurance, social support and a location where EOL care can be delivered for homeless individuals.
Significance: Many barriers are limiting medical care for the homeless that should be available to them at the EOL. It is evident that healthcare providers need to be more aware of the needs of this population to help improve and provide the EOL care homeless individuals deserve.
Faculty Advisor: Jensen, Robert (Utah Valley University, Nursing)
Background: Individuals who experience homelessness lack the necessary components needed receive end of life care (EOL). However, due to personal and structural barriers such as cost of care, lack of insurance, addiction, and many who experience mental health and intellectual disabilities, homeless individuals are unable to receive palliative or hospice care. Because homeless individuals lack the necessary components of basic living such as food, water and shelter, their quality of life is significantly lower than that of the general population, and this affects their EOL experiences.
Purpose: To explore the factors that affect the homeless population and the barriers they face when accessing health care, including their needs at the EOL, and to provide recommendations for better EOL care.
Methods: A focused literature review was performed using the databases PubMed, Google Scholar and Science Direct using the keywords homeless, end of life, and palliative care covering the years 1985 to 2018.
Findings: Homeless individuals want to experience a "good death". Unfortunately, homeless individuals who seek medical treatment feel deterred due to unfair treatment and belittlement from previous health care experiences and the social stigma surrounding homelessness. This can delay their treatment of chronic or acute conditions and lead to long-term health consequences. One effort to aid in EOL care for homeless individuals is the Social Model Hospice, which provides holistic EOL care in home like setting. Social model hospice overcomes barriers to lack of insurance, social support and a location where EOL care can be delivered for homeless individuals.
Significance: Many barriers are limiting medical care for the homeless that should be available to them at the EOL. It is evident that healthcare providers need to be more aware of the needs of this population to help improve and provide the EOL care homeless individuals deserve.
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