Health and Medicine

Liliana Bautista; Rachelle Clayson, Brigham Young University

Joseph Rich; Isaac Myres; Silvia Moncada; Matthew Hodgson; Beverly Roeder; Clayton Holding; Blaine Oldham; Rane Eskelsen, Brigham Young University

Nicholas Baker, Brigham Young University

Taylor Pack; Caden Duffy; Rachel Glew, Brigham Young University

Parker Howe; Adriana Vieira De Abreu; Rahul Agrawal, University of Utah

Bryson Dabney; Sean Pickard, Brigham Young University

Tess Armbrust; Canyon Neal; Ashli Hunter; Forest Eddy; Sumira Phatak; Korry Hintze, Utah State University

Annalyse Kofoed, Utah Valley University

Jamie Slade, Utah Valley University Health Electronic cigarettes (e-cigarettes) are gaining in popularity. Unfortunately, this increase is occurring at a time when we lack a definitive understanding of the health hazards. It is important for professionals to understand e-cigarette users’ experiences and satisfaction with the devices in order to determine what may entice users to begin and continue using these devices.

Paydon Newman and Joseph Rebman, Dixie State University Health Several studies (Shepley, 2012; Sherman-Bien, 2011; Walch, 2010) have found that sunlight has a stress-reducing effect on those who are exposed to it. An innovative new design of artificial lighting known as RaLight is proposed to reflect light with a color rendering index nearly identical to natural sunlight. This study will examine the relationship between exposure to RaLight (as a substitute for sunlight) and levels of stress. RaLight is predicted to decrease levels of stress in test subjects. In a commercial call center setting, test subjects will consist of an estimated 50 employees both male and female with ages ranging from 18 to 30 years. This research is designed as a single subject experiment (ABA). The initial control condition will be the common indoor environment which exposes patients to standard fluorescent lighting. Replacing light fixtures with RaLight will then establish both the second phase of the experiment and the independent variable. A follow up re-installment of the initial fluorescent lighting will be conducted post-RaLight phase. Throughout each phase, questionnaires regarding the overall well-being of employees will be completed.

Whittni O’Brien, Dixie State University Health St. George residents are currently at risk from poor indoor air quality. The objective of this study was to provide citizens with simple solutions to purify their indoor air and avoid the side effects of pollution. The rising threats include benzene, formaldehyde and trichloroethylene. These carcinogens are directly linked to heart disease, birth defects, asthma and premature deaths in individuals. The study was conducted to see just what could be done to combat these hazards and provide the necessary information to resolve the levels of indoor air pollution to residents. A standardized questionnaire was issued to find out how educated locals were about the pollution levels and air quality within the community. Questions covered a variety of aspects including exactly what the threats were to specific methods of indoor air purification. To reduce the number of carcinogenic related health issues, participants were provided with a pamphlet including easy to follow steps to cleaner indoor air and outdoor air pollution. The objective result yielded plants to be the best solution. Aloe vera plants are not only grown locally, but are easy to propagate. These plants are known for their ability to remove formaldehyde from the air and therefore an inexpensive and readily available resource that will assist residents. Other solutions found included greenery such as moth orchids, snake plants and the ficus tree. All of these plants are easy to maintain with local climate conditions. By providing residents with the proper education and resources, the overall health of the population will rise. The conclusion of the study offers vital knowledge to the community and a progressive approach to cleaner indoor air for a healthier living space.

Kalene Mears, Brigham Young University Health The purpose of this project is to compile a learning history for a hospital unit, documenting patterns of past adaptation within a clinical microsystem that can be magnified to help the system continue to improve. The goal in healthcare is to create an adaptable system, where changes are continuously made as problems are identified to prevent harm from care. Through a learning history, a hospital unit can identify how they have already solved problems in the past and identify patterns of adaptation that can be replicated to increase reliability within the organization. This project has the potential to help a hospital unit improve its reliability in providing quality patient care and reduce preventable patient harm. To obtain the information about the unit’s history, key team members will be interviewed using an appreciative approach to identify strengths and patterns of successful adaptation. Interviews will highlight positive features of this team to foster feelings of success and achievement, promoting desire to continue improvement. Clinical data will supplement the interviews to show a full picture of how the unit adapted to its situation. The transcribed interviews will then be distilled to highlight the critical, meaningful points in the plot line where learning and adaptation took place. This resulting manuscript is the tangible learning history. Internal dissemination will involve sharing the learning history with the organization and facilitating group discussions about the findings with members of the organization. Through this process, we anticipate the unit will be able to promote more effective interventions to improve patient care.

Delena Hanson, Dixie State University Health Debate in diagnostic imaging over the effectiveness of shielding the patient from the incident (primary) beam compared to shielding from the scattering beam once it has hit the image receptor is ongoing. Because radiation in any amount can cause long term effects, it is the ethical obligation of those in the profession to keep the dose of radiation to the patient as low as reasonably achievable. Backscatter is radiation that goes through the patient, contributes to the diagnostic image, then still has enough energy to hit the image receptor and scatter back toward the patient. While previous studies indicate that dose to the gonads from the primary beam during chest x-ray exams are low, this additional research assesses the amount of backscatter that happens during a chest x-ray to determine at what point patient size is a factor that increases patient dose. As more technique must be used for larger patients, increased interactions will occur and therefore present a higher probability of backscatter that can add to the patient’s gonadal dose. This research quantifies whether and at what point placing a lead shield between the patient and the image receptor will reduce dose to the patient by measuring the thickness of a patient receiving chest x-ray and using a pocket dosimeter to measure the amount of radiation scattering back from the patient to compare with data from the incident beam.

Diana Carter, Brigham Young University Health Purpose:

Abigail Harris, Brigham Young University Health Purpose:

Trey Esplin, Alathia Burnside, Sean Madill, Marquelle Funk, Sean Kiesel, Kaisey Margetts,

Rebekah Goodrich, Leenalitha Panneerseelan Bharath, Ting Ruan, Tetyana Forostyan, Ashot Sargsyan,

Erika Brown and Stacie Hunsaker, Brigham Young University Health Health care professionals are often challenged with starting an intravenous (IV) line in patients who are dehydrated, have suffered trauma, or are in shock. Nurses and physicians can become frustrated by the multiple attempts and patients can lose valuable time. An alternative route to deliver the needed fluids and medications to these critical patients can be achieved by accessing the blood supply inside the bone. Intraosseous (IO) access is a safe, rapid, and an effective alternative method to deliver medications and fluids to these critical patients (Hunsaker and Hillis, 2013). I was mentored in the practice of qualitative research and interview process in a study related to difficult IV access. A qualitative research study was performed at Hospital Luis Vernaza in Guayaquil, Ecuador, to determine the complications faced in providing timely care to critical patients, and to assess their knowledge and use of IO therapy. Interviews were performed, and, because of my fluency in the Spanish language, I was the primary interviewer. These interviews were analyzed to assess the need of interventional IO therapy. Through the interviews, preliminary results demonstrated a need for an organized IV algorithm in this large hospital. The difficult IV algorithm has been developed and will be presented to the health care professionals at Hospital Luis Vernaza in the spring of 2015 on a Brigham Young University College of Nursing Global Health stay in Guayaquil, Ecuador.

Daisha L. Cummins, Kodey Meyers, and Breanna E. Studenka, Utah State University Health Children with Autism Spectrum Disorder (ASD) exhibit rigidity of motor plans and difficulties planning and executing movements (Eigsti et al., 2013). Those with ASD may also have difficulty formulating new or switching between different motor plans. In typically developing individuals, sequential actions exhibit hysteresis, a phenomenon where a specific motor plan is influenced by recent, similar motor actions. We sought to determine if hysteresis was stronger in children with ASD. A rotation motor task measured the rigidity of motor planning (hysteresis) of five ASD children, and 5 control participants. A stick was placed in one of 24 different orientations around a circle. The researcher moved the stick counterclockwise or clockwise in subsequent trials. A participant grasped the stick and returned it to the home position. Researchers measured the position at which the child switched from a thumb up to a thumb down grasp in each direction. The peak counterclockwise switch occurred later for children with ASD. The grasp also changed less frequently for the ASD than for the control group. Our results suggest that changing a grasp was more costly than being comfortable, and that hysteresis was more prevalent in children with ASD than in the control group.

Cody Craig and Charles Yeager, Snow College Health Logically, a rise in income should lead to a healthier population. Diseases like malaria, cholera, and HIV/AIDS are associated with poverty, low rates of education, and poor infrastructure in many parts of the world. In populations with higher per capita income (or “wealth”), these diseases are not as common. However, while our higher socioeconomic classes have fewer poverty linked diseases, is the overall health of people across Utah as high as we might expect it to be? Diseases like obesity, heart disease, and diabetes (known as diseases of affluence) are becoming more and more common, even though advanced health technology and healthcare availability increase. This project will examine the relationship between income level, diseases of poverty, and diseases of affluence. Data will be aggregated from a number of sources and mapped using a geographic information system. A regression analysis will be conducted to determine if variables are positively or negatively correlated with diseases of poverty and affluence in Utah.

Tianne Pierce, Utah Valley University Health Since Mario and Zelda (Nintendo video games), video interactive games have been a favorite babysitter for the past two generations of children, simulation is no stranger to this population. Portions of this population became nursing students. Simulation in health care is second to none in the ‘hands on’ teaching of skills; thus, it would be the natural order of things to include interactive figures and scenario during teaching and learning in nursing. Utah Valley University’s nursing department employs the use of human simulators in the delivery of content to the students. It is no surprise that these students relate well to simulation in the classrooms. The purpose of the research study will be to compare students’ responses to learning in a teaching environment void of simulation vs. a teaching environment which uses simulation. Although simulation has long been used in aviation and the military, it has become more integrated in the health care profession over the last 20 years. These study results were congruent with national and international landmark studies where the use of simulation in nursing has been supported by the world of healthcare.

Ashley Havlicak and Joanna Beachy, University of Utah Health Background:

John Rossi, Julie Valentine, Leslie Miles, Linda Maybe, and Julie Melini, Brigham Young University Health The purpose of this study is to explore the effects of sexual assault on memory and consciousness in 314 victims in a Mountain West community using retrospective chart review. Altered mental awareness and/or loss of consciousness during a sexual assault are widely unexplored phenomena. A majority of assaulted individuals experience a varying degree of loss of consciousness during an assault – resulting in memory loss and conflicting evidentiary reports creating challenges during an investigation and prosecution. Statements written by a forensic nurse based on patients’ telling of the sexual assault (analyzed in Nvivo10) were placed within the following categories: memory loss; decreased feelings of mental alertness or awareness; symptoms of tonic immobility; detachment from self, environments and/or situation; reports full loss of consciousness; and/or awoke to assault. Quantitative data from patients’ answers to questions related to their memory of the nature of the assault was analyzed through descriptive statistics in SPSS, resulting in the following statistics: 58.3% reported having a loss of consciousness or awareness, 54.2% reported “unknown” to 1 or more questions about the nature of the assault, 37.8% reported “unknown” to 4 or more questions, 17.3% reported “unknown” to all questions. Additionally, a Chi square test for independence found patients with memory loss/altered consciousness were associated with the following variables: patients with mental illness and/ or use of psychotropic medications (p=0.025) and use of alcohol prior to assault (p=0.000). Medical teams, law enforcement, and judicial representatives must understand the impediments associated with a victim suffering from altered mental status caused by neurobiological and psychophysical effects of sexual trauma; thus, creating an atmosphere that avoids re- traumatizing a patient and providing for optimal care. This research will supplement other studies focusing on neurobiology/sexual assault trauma and foster greater understanding of the effects of sexual assault on memory and consciousness.

Matthew Wood, Brigham Young University Health Anatomy Academy (AA) is a recently developed school based educational program for fifth graders that uses college age students as small group mentor educators. This program aims to combat child obesity by improving the children’s understanding of nutrition, anatomy, exercise, and healthy behaviors. Our study specifically aimed to evaluate the impact of this mentoring opportunity on student nurses. As the largest population of healthcare workers, nurses play an essential role in patient and family education, especially in well populations. As healthcare costs increase, it will be increasingly important for nurses to actively participate in prevention efforts that empower individuals to develop healthy lifestyles. Currently, there exists a paucity of opportunities for student nurses to practice providing this health teaching to well populations and a lack of research literature on the subject. Anatomy Academy is one of these opportunities and our hypothesis is that there will be positive changes in the self-perceived abilities of the student nurses. After identifying undergraduate nursing students engaged in AA, we collected pre and post (5 scale Likert) surveys asking the nurses to rate their self-perceived ability of their skills to 1) adapt the message to the level of audience understanding, 2) communicate basic physiological concepts, 3) teach and model the link between concepts and health behaviors, 4) empower children toward healthy decisions, and 5) collaborate with organizations, like elementary schools, toward a common goal of helping children maintain healthy BMI and habits. A demographic survey and weekly reflective journals were also collected. Our results found statistically significant results in every perceived skill and we conclude that mentoring opportunities for student nurses in programs like AA improve their confidence and ability to communicate in a nursing role. We recommend that similar opportunities be included in the curriculum of all undergraduate nursing programs.

Breanne Woodbury, Dixie State University Health In this paper I will be discussing the health impacts of immunizations and how it affects the individual, the family, the community, and society. I will present information from both sides of the argument of immunizations, as well as my own conclusion on this controversial subject. Findings from leading experts in the medical field will be cited, including Dr. Paul Offit, co-inventor of vaccines and one of the most trusted advocates for vaccine safety, as well as award-winning scientific writer Seth Mnookin. Their research on vaccines, specifically the ingredients included in vaccines, possible side effects, and the nonexistent correlation between vaccines and autism, will support my thesis of vaccine safety and the need for immunizations. I will include current scientific studies which reveal the very serious results of a vaccine-free society and discuss the desperate need to change the anti-vaccine mindset. In conclusion, I will re-state, with supporting evidence, why immunization is absolutely crucial and why it plays a key role in the health of our society and in our personal daily living.

Kristin Walker, Utah State University Health The purpose of this study was to quantify the efficacy of a six-week aquatic treadmill exercise program on measures of pain, balance, mobility, and muscle thickness. Three participants (age = 64.5 ± 10.2) with knee OA completed a six-week exercise training intervention. Outcome measures, collected before (pre) and after (post) the six-week intervention, included visual analog scales for pain, posturography for balance, a 10 m walk test for mobility, and ultrasound for muscle thickness. The exercise protocol included balance training and high-intensity interval training (HIT) in an aquatic treadmill using water jets to destabilize while standing and achieve high ratings of perceived exertion (14-19) while walking. Expected results include, reduced joint pain (pre = 50.3 ± 24.8 mm versus post = 15.8 ± 10.6 mm), improved balance (equilibrium pre = 66.6 ± 11.0 versus post = 73.5 ± 7.1), and mobility (walk pre = 8.6 ± 1.4 s versus post = 7.8 ± 1.1 s) after participating in the exercise protocol (p = 0.03-0.001). We expect that aquatic treadmill exercise that incorporates balance and HIT training will be well tolerated by patients with OA and may be effective at managing symptoms of OA.

Jorgen Madsen, Utah State University Health The gold standard in purification of influenza virus is by means of ultracentrifugation. Although effective, this process is very expensive and thus impractical for developing countries. We hypothesize that column chromatography can be a cost efficient alternative that is as effective as ultracentrifugation. If correct, this method of purification could revolutionize vaccine production in third world countries. We tested the purification ability of column chromatography by comparing two different chromatography resins. The Capto Q resin separates proteins on the basis of protein charge. The Capto 700 resin separates proteins on the basis of both size and charge. Samples following chromatography were collected, and evaluated for virus specific proteins as well as total protein content. After chromatography selected samples were evaluated by electrophoresis to determine protein separation. Although it is evident that some protein separation occurred, the results are inconclusive and suggest more testing.

Nathan Bliss, Utah Valley University Health High-frequency (HF) ultrasound in the 20-80 MHz range has recently been found to be sensitive to pathology in tissue margins from breast cancer surgery. In order to improve the resolution and sensitivity of this method, however, transducers need to be employed that have piezoelectric elements that are smaller than those currently in use. The purpose of this study was to determine if similar results can be obtained from small element transducers (Blatek pachyometer, 50 MHz, element diameter < 2 mm) as compared to large element immersion transducers (Olympus NDT, V358-SU, 50 MHz, 6.35-mm diameter active element). Ultrasonic tests were performed on 10 bovine heart specimens of varying surface structure (myocardium, endocardium, and epicardium). Pulse-echo and through transmission measurements using a HF square-wave pulser/receiver (UTEX, UT340) and a digital storage oscilloscope (Agilent, DSOX3104A, 1 GHz, 4 analog channels) were acquired from a total of 2 sites per bovine specimen, first testing all specimens with the large transducers then again with the small transducers. Specimens were marked with India ink for location and accuracy of testing. The density of peaks in the ultrasonic spectra of the large transducers paralleled those of small transducers. Results from HF ultrasonic measurements of bovine heart tissue obtained from large transducers compared to the small transducers indicate that they produce statistically comparable peak densities.

Talmage Wood, University of Utah Health One of the challenges facing emergency room physicians is the number of tests and procedures to be performed on patients who present with chest pain but had negative initial findings. Since heart disease ranks as the leading cause of death in the United States, hospitals have protocols to monitor patients for a period of time before discharging them. At the University Of Utah’s Emergency Department our monitoring protocol was adjusted over a year ago to mandate consultation with a cardiologist for any and all chest pain patients being observed due to negative findings, whereas prior to the adjustment patients were monitored and consulted by normal emergency room physicians or advanced care providers.

Tyler Harris, Brigham Young University Health Background

Tyler Harris, Brigham Young University Health Background

Percy Segura, Utah Valley University Health High frequency (HF) ultrasound has been investigated for the detection of breast cancer in surgical samples, and has shown correlations to histology including precursors to cancer development. It is hypothesized that the sensitivity of HF ultrasound to breast cancer is due to changes in the microscopic structure of the tissue. With this approach, better diagnosis of breast cancer can be achieved for purposes such as the assessment of surgical margins in lumpectomy procedures. The microscopic structure of the tissue affects HF waves as they pass through the tissue. These structures can therefore be recorded and distinguished by the HF ultrasound. HF ultrasound will show differentiation between healthy tissue, benign pathologies such as hyperplasia, and advanced cancerous formation. With continuing development, variables are being studied which may skew or produce artifacts in the HF ultrasound results.

Alyssa Lark, Brigham Young University Health The purpose of this study is to evaluate the effect of a community-based sexual assault nurse examiner (SANE) program on sexual assault criminal case outcomes in Salt Lake County, Utah.

Tyler Navarro, Utah Valley University Health PURPOSE: An Exercise Science class homework assignment revealed that a significant majority of the Exercise Science majors were Kinesthetic vs. Visual or Auditory learners. The researchers were curious what learning styles other fields of study had and if, like Exercise Science, other fields of study were dominated by one learning style or another. The purpose of this study was to identify the percentage of different learning styles of majors in various fields of study at UVU. Our hypothesis is that each field of study, by its very nature, would be lead by > 50% of the percentage points by one learning style over the others.

Amy A Fairbrother, Utah Valley University Health Research has shown that high-frequency (HF) ultrasound is capable of detecting structural and biomechanical property changes in tissues and cells at the microscopic level. This capability is currently being tested for the real-time identification of breast tissue pathology in surgical margins during lumpectomies. The objective of this study was to determine if structural and property changes arising in tissue from variations in temperature can be detected by using HF ultrasound. Once a tissue sample is excised from the body, the temperature of the sample decreases rapidly from body temperature to that of the surrounding room temperature. Because of the decrease in heat, the tissue can become more rigid and thus less fluid. These alterations in biomechanical properties can affect HF ultrasonic measurements such as wavespeed and attenuation. These biomechanical changes may also affect the ultrasonic signals sensitive to tissue structure such as the number of peaks in the ultrasonic spectra. The methodology of the research was as follows. Fresh samples of bovine tissue were ultrasonically tested at 3 different temperatures: 37º, 24.5º, and 15º C. Each sample was approximately 7.6 mm thick and 3.8 x 2.5 cm in size. To observe the overall effects of temperature on a sample, the tissue was slowly heated from room temperature to body temperature (37º C) and then tested with HF ultrasound. The sample was then cooled back down to room temperature (24.5º C) and tested again using HF ultrasound. Lastly, the sample was cooled further to 15º C and again tested using HF ultrasound. Ultrasonic waveforms were collected using 50-MHz pitch-catch and pulse-echo measurements. The data was then analyzed to determine changes in wavespeed, attenuation, and spectral peak density with temperature. Results from the study will be presented and discussed with respect to the improvement of HF ultrasound procedures for testing tissue samples.

Alexis Holman, Utah Valley University Health

Josh Lee, Dixie State University Health According to the World Health Organization (2012), health care systems in Central America rank in the top 50% of the 190 ranked countries in the world, yet thousands of people are in need of simple medical attention and supplies every day in these areas. Countries such as Honduras lack virtually all access to health services, with 83% of the country’s population without health insurance, and 30% with no health care access at all (Pearson et al., 2012). To address this issue, a 2013 Dixie State University study conducted by the author, an Integrated Studies major with disciplinary emphases in Spanish and Biology, interviewed fifty adult Central American immigrants at a Southern Utah health care facility with the aim to providing student groups embarking on health service projects a researched list of vitally needed medical supplies. Participants in the study were asked to provide information regarding their health care experiences in their countries of origin and draw upon their comparative experiences with health care in the United States in order to determine areas of need. The forty individuals in this study represented a total of seven Central American countries and the interviews were conducted in Spanish and translated into English. The interviews were conducted over an 8-week period of time and results suggested that diabetes, cold, flu, antibiotics, and anti diarrhea medicines and supplies are a few of the needed health care items in these neighboring countries. Although statistical significance was not a feature of this study due to the number of participants, significant consistencies in responses by former residents of a variety of Central American countries suggested that some medical needs are regionally shared and that larger scale follow-up studies may reliably identify these as key resources for student medical delegations traveling to Central America.

Brittni Carr, Brigham Young University Health Purpose/Aims: To examine religiosity and family hardiness in parents raising children with disabilities (CWD) to determine if there are differences according to parent gender and type of disability and if there is a relationship between the variables.

Kevin Crockett, Utah Valley University Health Purpose

Erin Horton, Dixie State University Health OPUNTIA FICUS INDICA: RED BLOOD CELL VIABILITY AND AGGLUTINATION PROPERTIES

Sheri Casey, Utah Valley University Health Justification: According to many studies, low socioeconomics is positively correlated to sports participation. Little research explores the economic relationship correlated with youth sports.

Andrea Quiroz, Utah Valley University Health The stimulation and inhibition of tissue vascularization has important applications to tissue engineering and oncology. Approaches to quantitatively evaluate neovascularization in vivo in adult animals with differentiated tissue include both invasive methods that use an implanted or injury-induced matrix in the study organism, or noninvasive small animal imaging methods such as MRI, CT, and PET. The objective of this study was to determine if ultrasonic spectra in the 10-100 MHz range could be used as an in vivo neovascularization assay. Numerical simulations and phantoms were used as model systems to test the feasibility of the approach. The simulations modeled ultrasonic scattering from microscopic vascular networks using randomly oriented cylinders to represent blood vessels and cylindrical wave functions to represent ultrasonic waves. Phantoms were fabricated from a gelatin-soluble fiber mixture and agarose gel. The agarose gel was embedded in the gelatin-fiber in order to simulate vascular tissue. Ultrasonic tests were performed using two broadband ultrasonic transducers centered at 50 MHz. Pitch-catch data were collected and analyzed by calculating the peak density of the ultrasonic frequency spectrum, which is the number of peaks and valleys in the spectrum (a measure of the spectrum’s complexity). Control specimens were tested to determine the differences in the sound wave properties between the gelatin-fiber and the agarose gel. The controls demonstrated the instrument’s ability to differentiate between the two types of material. Measurements of agarose inclusions in the gelatin-fiber showed a significantly higher peak density than those for the control gelatin-fiber. These results indicate that the agarose gel structures are scattering sound to a greater extent than the gelatin-fiber alone. The results thus far have provided a strategy for proceeding with the project in the future. The phantoms will be refined and made more realistic to produce an adequate mimic for vascular tissue.

Kristen Hamblin, Brigham Young University Health Empathy is an essential characteristic in nursing. In fact, the skill of empathy, the ability to understand the feelings or situation of another, is of paramount importance to the nurse-patient relationship. Additionally, empathetic interactions often lead to increased patient satisfaction, compliance, and overall quality of life.

Taylor Colvin, Utah Valley University Health Introduction: There are millions of people in need of prosthetics worldwide and only a very small percentage currently have access to appropriate prosthetic care. As amputees are unable to afford a prosthetic, they are often incapable of maintaining many social interactions and provide for their basic needs. Utah Valley University’s Mobility Mission traveled to Guatemala to manufacture prosthetic limbs for those individuals in need. Our research can also encourage manufacturers to continue developing a better affordable prosthetic that can be donated to those amputees in need to restore quality of life to those individuals.

Stephen Clarkson, Brigham Young University Health While there is an abundance of mobile health apps for weight management on the market today, almost all focus entirely on net caloric intake (exercise minus calories consumed). Recording daily caloric intake can be cumbersome, inefficient and inaccurate. One rising suggestion in the health field for reaching weight goals is objectively recording hand-to-mouth movements (HTMMs) during meals throughout the day. This method focuses entirely on portion control and if any improvements are to be made in this area, an effective method of activity recognition must be developed. In this paper, we report our efforts to classify HTMMs and non-HTMMs in an effort to automate counting the number of HTMMs during meals throughout the day. We also report on the performance of several base-level classifiers such as k-NN, Naive Bayes and Decision Trees as well as meta-level classifiers (Voting, Bagging and Boosting).

Wesley Tietjen, Dixie State University Health High risk sexual behaviors, such as having unprotected sex, are a community health concern because of the heightened susceptibility to sexually transmitted diseases. An estimated 19.7 million people are newly infected with a sexually transmitted disease annually. Young people (ages 15-24) account for nearly half of all new incidences (CDC, 2008). Considering these statistics, the author, a Dixie State University Integrated Studies undergraduate student, conducted an interdisciplinary study to determine the correlation between the degree of self-reported religious devotion of Latter Day Saint (LDS) singles and their likelihood of purchasing or using protection during premarital intercourse. Seventy five students attending Dixie State University in Saint George, Utah participated in this study. Participants completed a 15-item survey consisting of questions inquiring how religious they consider themselves and their feelings towards premarital sex. Of the non-married participants who engage in sex, only 28% (n=4) of LDS respondents reported consistent use of birth control, compared to 84% (n=16) of non-LDS individuals. These results are suggestively significant and are consistent with findings from studies conducted by Douglas Kirby (2007) and others who have demonstrated that teaching abstinence, without providing education about birth control methods other than abstinence, leaves individuals unprepared to practice safe sex if the occasion arises. The relevance of the Dixie State University study to previous more broadly conceived research will be presented along with recommendations for future research.

Micelle Reed, University of Utah Health For patients with medically intractable epilepsy, a neurological disorder characterized by seizures that are unable to be controlled with medication, surgical resection of the seizure generating zone is necessary to obtain seizure freedom. Intracranial electroencephalography (iEEG) is used for determining areas for resection when noninvasive techniques fail to pinpoint a specific area. High frequency oscillations (HFOs), observed through iEEG, are successful biomarkers for the seizure generating zones and are more localized to the source of seizures than areas of propagation. The most common method for determining HFO occurrence lies in expert epileptologist interpretation of the iEEG data, although this method is limited to small data sets and the expertise of the doctor. This study uses the signal processing techniques of spectrogram analysis and continuous waveform transforms to find high frequency content in sampled patient data. Through the use of Friedman’s Tests, statistical difference between channels is determined and subsequent Wilcoxon signed-rank tests are performed to find the channels with statistically greater high frequency content. This allows for an unbiased, automated determination of seizure generating channels. Localization of the seizure generating area can be decided because of the 1-1 correspondence between the channel signal and macroelectrode placement on the brain. If functional mapping reveals the cost of resection of that area of the brain to be less than the benefit of reduction in seizure activity, surgery will be performed. Through the determination of the true seizure generating zone, surgical resection will lead to the best patient outcome of potential seizure freedom and improved quality of life.

Bradley Weaver, University of Utah Health High-grade gliomas, especially glioblastoma (GBMs, WHO Grade IV), are the most common primary brain tumors in humans. Despite recent advances in molecular targeted therapies for cancer, there has been little progress in treatment of GBMs. Median patient survival after diagnosis is dismal: approximately 12 months. Hypoxia is a key clinical marker of GBMs, which contain pockets of necrotic and hypoxic regions within the solid tumor mass. The transcription factors in the Hypoxia Inducible Factor (HIF) family are the master regulators of the cellular response to hypoxia. Their downstream targets include compounds that promote angiogenesis, increase glycolysis, and inhibit apoptosis. Recent research has identified glioma stem cells (GSCs) surviving within the hypoxic microenvironment, and has implicated HIF1α as a potential regulator of the GSC phenotype. GSCs are thought to promote therapeutic resistance and recurrence of GBMs after surgical resection. Clarifying the role of HIF1α in glioma stem cell dynamics is important for targeting both the tumor cells and their environment in new treatment. It is expected that GSC populations with more aggressive phenotypes will express higher levels of HIF1α and have higher proliferation rates under acute hypoxia. In this study, the HIF1α levels and proliferation dynamics of multiple, unique GSC cell lines are investigated. Cell lines used include two GSC lines isolated from primary patient tumors (NSC20/23) and a stem cell enriched high-grade glioma line. Preliminary results suggest that not all populations of GSCs respond the same way to hypoxic stress, and HIF1α may play a central role in stem cell dynamics, but not in the growth of non-stem tumor cells. Probing further into this relationship will increase our understanding of how brain tumors behave, and how to more effectively target them in patients. Further data and conclusions from this project will be available at the time of presentation.

Charity Anne Rowley, Brigham Young University Health In 2010, The Office of the Inspector General of the U.S. Department of Health and Human Services reported that adverse events during hospitalization contribute to the deaths of 180,000 patients each year! The purpose of this study is to improve patient safety in the hospital by understanding the role of the charge nurse(the 24/7 nursing supervisor in hospital units).

Emily Matson, Brigham Young University Health Cancer, despite its common association with old age, is a leading cause of death for children age 1-14, second only to unintentional injuries. Improvements in diagnosis and treatment are increasing childhood cancer survival, and more research is needed on the risk of subsequent cancer following an initial diagnosis, of either the same or another site. Research on associations between childhood and secondary cancers may improve patient follow-up by providing health professionals with information about which subsequent cancers are likely to occur, which screenings to conduct and what symptoms to look for.