Teresa Wilson, Utah Valley University
Health
A critical issue in breast conservation surgery (lumpectomy) for breast cancer treatment is ensuring the tissue surrounding the excised tumor, the margins, are cancer-free. In collaboration with the Huntsman Cancer Institute at the University of Utah, students from Utah Valley University are using high-frequency (HF) ultrasound to test the pathology of lumpectomy surgical margins. This pre-clinical study is a blind study which will involve 80 patients, approximately 320 specimens, and use traditional pathology as the “gold standard” for measuring the HF ultrasound method’s accuracy. Ultrasonic waveforms of margins were acquired at the Huntsman Cancer Hospital in pitch-catch and pulse-echo modes using 50-MHz, 6.35-mm diameter transducers. The data were analyzed to obtain ultrasonic parameters such as wavespeed, attenuation, specimen thickness and spectral peak density (the number of peaks and valleys in a HF ultrasonic spectral band). The objective of this paper is to search for trends in the data acquired to date to provide an assessment of reliability, stability, and robustness of the study.