Fine Arts
Bloom's and SOLO: A Comparison of Educational Taxonomies
Authors: Spenser A Clark. Mentors: Acacia Overono. Insitution: Utah Valley University. It is not uncommon for a college student to see a list of learning objectives when skimming through a syllabus for a program or course. The goal of learning objectives is to set reasonable expectations for student learning and guide their study, as well as providing a framework for the development of teaching practices and assessment. Part of the inception of learning objectives as a means of organizing teaching and assessment in the classroom may be attributable to the Taxonomy of Educational Objectives, more commonly referred to as Bloom's Taxonomy. Another taxonomy similar to Bloom's, but much less well known, is the Structure of Observed Learning Outcome (SOLO) taxonomy. Bloom’s taxonomy organizes learning objectives into six categories: Remember, Understand, Apply, Analyze, Evaluate, and Create. The categories are structured as a cumulative hierarchy in which mastery of each level is assumed necessary for progressing to the next. The structure of Bloom’s is not derived from any specific learning theory, but a categorization of pre-existing learning objectives. Bloom’s therefore suffers from a lack of a strong theoretical foundation and may not accurately reflect how learning actually occurs. Additionally, although Bloom’s has been widely employed in the context of educational assessment, research has shown that it suffers from low interrater reliability and is inconsistent between educational contexts such as courses and topics. Unlike Bloom’s, SOLO is based upon Piaget’s Stage Development theory and categorizes learning into five distinct stages: Prestructural, Unistructural, Multistructrual, Relational, and Extended Abstract. SOLO does not suggest that learning is unidirectional or hierarchical. It also acknowledges internal cognitive processes rather than focusing solely on observable behaviors. Although very little research has investigated its reliability, it could be an attractive alternative to Bloom’s because it may more accurately reflect how learning occurs. The present work reviews the development and implementation of these two models and compares them.
Constant pressure untethered soft robotics: an adaptable solution to the limitations of soft robots
Authors: James Wade, Chris Paul. Mentors: Nathan Usevitch. Insitution: Brigham Young University. Soft Robotics offer significant advantages when completing certain tasks compared to other robots and methods. Compliance, adaptability, and energy efficiency are a few of the major advantages. On the moon, where safety, volume and versatility are of high importance, soft robotics may find an innovative niche. NASA’s BIG Idea Challenge for 2024 incentivizes creating new innovative soft robot designs. Our research group is building our facility mentor, Nathan Usevitch’s, work at Stanford University. Doctor Usevitch and his cohort developed an octahedral, inflated robot composed of multiple tubes folded into triangular shapes in a truss-like structure. Each triangle consisted of a long inflatable tube and 3 motorized modules at the nodes of the triangle. The motorized nodes (consisting of a DC motor and rollers) roll along the length of the tube, lengthening one edge of the triangle while shortening the other. By attaching multiple triangles to each other in geometric shapes, flexible structures are created that can adapt their shape to the desired need. Because this system has a constant inflated volume, no external air compressor is necessary, allowing for untethered movement. The bulk of the mechanical work is performed by electric motors, providing a higher energy efficiency than a system of repeated inflation. Furthermore, this design is compactly stored when deflated, optimal for transport into space.To build on this design and optimize it for use on the moon, our research group will make the following changes and improvements:- Developing the physical prototype. This will enable robust and dynamic movement and the support of large loads- Develop a simulation tool that allows us to explore different configurations of the robot for different tasks- Develop a joint system that allows an astronaut to quickly reconfigure the triangles into different structures based on the required task - Develop a control approach that accounts for the underdamped dynamics of large inflatable structuresThrough our research, we hope to expand the possibilities of soft robotics. We are synthesizing the advantages of traditional robotics (robustness, untethered motion) with the unique strengths of soft robotics (flexibility, adaptability, cost efficiency).
Genetic Mutations in the Genomes of Mother-Offspring Pairs Shows Link Towards Nausea and Vomiting in pregnancy
Authors: Dallin Oyler, Ana Alfaro, Kailee Myxter, Ben Brooks, Amanda Brooks. Mentors: Jessica Pullan. Insitution: Southern Utah University. Nausea and vomiting are common complications that occur in 70% of pregnancies. Hyperemesis Gravidarum (HG) is the most severe form of these symptoms and is estimated to be prevalent in 0.3-2% of pregnancies. Due to the fetal and maternal morbidity associated with HG, identifying the cause and treatment options for these women is a critical task in obstetrics. Research regarding the etiology of HG has been fairly recent and is still ongoing, however, evidence had directed to a positive correlation between increased levels of the serum protein GDF15 and HG symptoms. We hypothesize that polymorphisms in both maternal and fetal DNA plays a role in the upregulated GDF-15 seen in mothers experiencing symptoms of HG during pregnancy. The DNA of 2 mothers and their corresponding children were sequenced and analyzed. The DNA was obtained through buccal swabs from the epithelial cells of the inner cheek, and then purified and ran through PCR. We employed 3 distinct primers that correspond to mutations in the genome that account for the elevated levels of circulating GDF-15 in the mother. As of current, the mother-daughter DNA is still under analysis for single-nucleotide polymorphisms, however recently published literature has suggested results similar to our hypothesis. M. Fejzo et al. shows that upregulated serum GDF-15 is primarily of fetal origin, and that maternal sensitivity to GDF15 increases the risk for developing HG. Additionally, the DNA coding variant GDF15 C211G was shown to elevate the risk of HG
Lighting for Different Land Uses: A Case Study in Cedar City
Authors: Sebastian Partida. Mentors: Jamie Spinney. Insitution: Southern Utah University. Lighting levels have an important role in influencing the ambiance and functionality of various land uses. To achieve specified goals while optimizing energy efficiency and sustainability, lighting intensity must be balanced. The purpose of this study was to compare light intensity for different land uses (e.g., residential, commercial, industrial, and recreational). This study measured light intensity (i.e., brightness) for a random sample of different land uses using a digital light meter within Cedar City, UT. GPS coordinates were also acquired in order to map the brightness data. As expected, the results revealed that residential land uses were the darkest, whereas commercial and industrial land uses were the brightest. The findings indicate communities have to maintain a balance between creating a warm and pleasant atmosphere and ensuring appropriate illumination for safety and security purposes. Energy-efficient LED fixtures and smart lighting systems, for example, can provide adjustable and programmable illumination settings that meet both aesthetic and safety requirements.
Reconstructing seasonality in African bovids using dental microwear
Authors: Auriana Dunn. Mentors: Kathryn Sokolowski. Insitution: University of Utah. Reconstructing the diet of extinct animals can help us understand how living species are suited to their environments, which can inform paleoecological and zooarchaeological research as well as modern species conservation. Seasonal variation in animals’ diets can further be used to reconstruct seasonality patterns in the past and understand how animals may vary their diet under future climate change. However, determining the diet of extinct species is challenging, and detecting seasonal changes in diet is even more so. Dental microwear texture analysis (DMTA) can be a tool to solve this problem. DMTA analyzes dental microwear by measuring the pits and scratches on teeth to determine what an animal consumed in the days and weeks before it died. This project examines the DMTA of modern African Bovidae species to determine if seasonal dietary changes can be observed. If a difference can be found in the dental microwear of specimens that died during different seasons, seasonal changes in diet can be inferred. Here, I gathered dental microwear data from 407 specimens across five modern studies and matched the data to the museum specimens’ date of death to determine whether it died in a wet or dry season. The analysis found that four of the Bovidae species examined in our study showed evidence of seasonal diet shifts in their DMTA data. Dental microwear can be useful in determining seasonal diets and season of death for specimens. This method can be applied to extinct Bovidae species to understand ancient ecosystems and the evolution of Bovidae dietary strategies.
Nonequilibrium Thermodynamics of Voltage-Gated Ion Channels
Authors: Ada Cottam Allen, Mikhael T Semaan. Mentors: Mikhael T Semaan. Insitution: University of Utah. Regularly buoyed from thermodynamic equilibrium by complex and fluctuating environments, living systems must continually respond and adapt to external stimuli. Recent tools from stochastic thermodynamics place concrete energetic and entropic bounds on these processes, for systems arbitrarily far from equilibrium both in and out of steady-state conditions, and thus reveal mechanisms by which these systems absorb and dissipate energy to function. Here, we leverage these tools to simulate and calculate the thermodynamic signatures of several models of sodium and potassium ion channels---channels crucial to propagating action potentials in mammalian neurons---as driven by biologically-realistic action potential spiking protocols. Thus uncovering their detailed energetic responses to such complex environmental conditions, these results enable detailed comparison between the thermodynamic functionality of each channel type with driving one would expect in-vivo. When applied to competing models of the same channel, these tools also provide additional criteria for model selection; to this end, we close by calculating expected ionic currents, directly facilitating comparison with dynamically-driven patch-clamp experiments.
Information Anatomy Over Partition Space
Authors: Nathan Jackson, Ryan James, James Crutchfield. Mentors: Mikhael Semaan. Insitution: University of Utah. Symbolic dynamics allows for modeling---and designing for---the effects of imperfectly measuring a time series of data, by partitioning into a finite number of possibilities. The resulting time series of discrete symbols is then made especially amenable to information-theoretic methods for understanding its temporal structure and correlation. In particular, as long as the partitioning scheme is generating, the resulting estimations for entropy rate---the rate at which the process creates information---converge to a measure of chaos in the underlying system, a dynamical invariant.However, the entropy rate is not sensitive to what kind of generating partition: colloquially, an instrument must be at least accurate enough, but can be more fine-grained as desired. In contrast, its breakdown into a piece which affects future measurements (“bound”) and a piece which does not (“ephemeral”) depends quite dramatically on the choice of generating partition. We ask, then: is there a canonical partitioning scheme for which the full suite of information measures relate to dynamical invariants?To tackle this, we simulate the well-known tent and logistic maps, sweeping over all two-boundary partitions, calculating the full information anatomies for each. We find that ephemeral and bound information are extremized by the single-boundary coarsest generating partition, suggesting a canonical role for the simplest “good enough” instrument. The remaining multivariate measures, meanwhile, reveal hitherto-unseen structure in the process of imperfect measurement.
Unveiling Cryptic Avifauna Diversity Using Nanopore DNA Sequencing: A Case Study in the Passerine Genus Emberiza
Authors: Ainsley E Parkins, Sylvia Lee, Elizabeth J Heath, Thomas Petitjean, Kyle Cink, Kyle Kittelberger, Cagan Sekercioglou, Rodolfo S Probst. Mentors: Rodolfo S Probst. Insitution: University of Utah. Biodiversity loss poses a significant threat, requiring accurate species assessment and conservation strategies. Non-invasive and cost-effective techniques should be prioritized, especially when dealing with threatened vertebrate fauna. By focusing on cryptic Eastern European species within the genus Emberiza (Passeriformes: Emberizidae), we designed an affordable molecular pipeline (including DNA primers and bioinformatics) integrating DNA barcoding with Nanopore sequencing to address species boundaries and provide conservation information for avifauna diversity. We conducted non-invasive DNA extractions from individual feathers of 192 specimens collected in the Aras River Riparian Corridor (ARRC), an important ecological hotspot in Turkey. By targeting the cytochrome oxidase subunit I (CO1) region, our goal was to differentiate Emberiza taxa and identify potential cryptic lineages while using cutting-edge next-generation sequencing (NGS) of multiplexed specimens with portable Oxford Nanopore Technologies. Our focal study examined boundaries in Emberiza subspecies (E. shoeniclus shoeniclus and E. shoeniclus caspia) with subtle morphological differences, utilizing DNA barcoding and Nanopore sequencing. We obtained 182 Emberiza DNA barcodes. Clustering analysis recovered a paraphyletic assemblage (n=32) and a clade, the latter recovering majority of the barcodes (n=150), separated by at least 8% genetic difference. In both cases, we observed a mixture of barcodes from the nominal subspecies and Caspian subspecies, suggesting that cryptic morphological characteristics are not reflected in genetic separation. Our results also suggest putative cryptic Emberiza species, highlighting the importance of the ARRC for conserving avian diversity. We demonstrate that our pipeline, integrating real-time Nanopore sequencing with non-invasive DNA barcoding, can be used for conservation initiatives (particularly aiding cryptic species identification). This study expands our knowledge of avian diversity and highlights the potential of NGS DNA barcodes as a powerful tool for aiding conservation efforts amidst biodiversity loss.
Internalized HIV stigma among women giving birth in Tanzania: A mixed-methods study
Authors: Anya Weglarz. Mentors: Melissa Watt. Insitution: University of Utah. AbstractBackgroundWomen living with HIV (WLHIV) commonly experience internalized HIV stigma, which refers to how they feel about themselves as a person living with HIV. Internalized stigma interferes with HIV care seeking behavior and may be particularly heightened during the pregnancy and postpartum periods. This thesis aimed to describe internalized HIV stigma among WLHIV giving birth, identify factors associated with internalized HIV stigma, and examine qualitatively the impacts of internalized HIV stigma on the childbirth experience.MethodsPostpartum WLHIV (n=103) were enrolled in the study between March and July 2022 at six clinics in the Kilimanjaro Region, Tanzania. Participants completed a survey within 48 hours after birth, prior to being discharged. The survey included a 13-item measure of HIV-related shame, which assessed levels of internalized HIV stigma (Range: 0-52). Univariable and multivariable regression models examined factors associated with internalized HIV stigma. Qualitative in-depth interviews were conducted with pregnant WLHIV (n=12) and postpartum WLHIV (n=12). Thematic analysis, including memo writing, coding, and synthesis, was employed to analyze the qualitative data.ResultsThe survey sample had a mean age of 29.1 (SD = 5.7), and 52% were diagnosed with HIV during the current pregnancy. Nearly all participants (98%) endorsed at least one item reflecting internalized HIV stigma, with an average endorsement of 9 items (IQR = 6). The most commonly endorsed items were: “I hide my HIV status from others” (87%), “When others find out I have HIV, I expect them to reject me” (78%), and “When I tell others I have HIV, I expect them to think less of me” (75%). In the univariable model, internalized stigma was associated with two demographic characteristics: being Muslim vs. Christian (ß = 7.123; 95%CI: 1.435, 12.811), and being in the poorest/middle national wealth quintiles (ß = 5.266; 95%CI: -0.437, 10.969). Internalized stigma was associated with two birth characteristics: having first birth vs. having had previous births (ß = 4.742; 95%CI: -0.609, 10.093), and attending less than four antenatal care appointments (ß = 5.113; 95%CI: -0.573, 10.798). Internalized stigma was associated with two HIV experiences: being diagnosed with HIV during the current pregnancy vs. diagnosis in a prior pregnancy (ß = 5.969; 95%CI: -1.196, 10.742), and reporting experiences of HIV stigma in the health system (ß = 0.582; 95%CI: 0.134, 1.030). In the final multivariable model, internalized stigma was significantly associated with being Muslim vs. Christian (ß = 6.80; 95%CI: 1.51, 12.09), attending less than four antenatal care appointments (ß = 5.30; 95%CI: 0.04, 10.55), and reporting experiences of HIV stigma in the health system (ß = 0.69; 95%CI: 0.27, 1.12). Qualitative discussions revealed three key themes regarding the impact of internalized HIV stigma on the childbirth experience: reluctance to disclose HIV status, suboptimal adherence to care, and the influence on social support networks.ConclusionWLHIV giving birth in this sample experience high rates of internalized HIV stigma. This stigma was significantly associated with being Muslim, as opposed to being Christian, attending less than four ANC appointments, and reporting experiences of HIV stigma in the healthcare setting. Other factors that were correlated to higher levels of internalized stigma were socioeconomic status, parity, and timing of HIV diagnosis, all of which can impact access to and engagement in healthcare services during the intrapartum and postpartum periods. Internalized HIV stigma impacts the childbirth experience for WLHIV, making the labor and delivery setting an important site for intervention and support.
An Investigation into the Effect of Access to Dental Radiology Skill Practice in Virtual Reality on Undergraduate Dental Hygiene Student Competency and Learning Compared with Access to Traditional Study and Practice Methods
Authors: Michaela Lovejoy, Rylee Udom, Lindsey Fry, Hailey Roubidoux, Makayla Dunbar, Kali Hunt, Mandy Gibbs, Lisa Welch. Mentors: Lisa Welch. Insitution: Utah Tech University. Traditional dental radiography education necessitates the exposure of both clinician and patients to radiation to build clinician skill. Virtual reality (VR) may enable practitioners to learn valuable hands on skills without the use of expensive equipment and without patient or operator exposure to radiation. The purpose of the research is to determine if access to practice in virtual reality (VR) using a specifically designed application, builds skill competency in dental radiology compared with traditional practice methods. A convenience sample of 24 first year dental hygiene students at Utah Tech University were recruited and randomly assigned to the test and control groups. Test group participants were given access to a VR headset with a dental radiology skill practice application installed. Control group participants were given access to traditional dental radiography skill practice methods. To encourage participation, an incentive of a $10 Amazon gift card upon completion of the study was offered. Data will be collected via skill competency evaluation at two-months, mid-term grade scores and final grade scores from the participants’ dental radiology laboratory course. To increase internal validity and reliability, investigators responsible for skill competency evaluation will be blinded and undergo both intra and inter-rater reliability testing to 95% agreement. Upon completion of the Fall semester 2023, data will be analyzed using ANOVA repeated measures between factors accounting for the two independent variables of traditional practice and practice in VR and the dependent variables of competency assessment scores, mid-term and final clinical course grades. Alpha will be set at 0.05. Should it be determined that practice in VR contributes to student learning, VR may enable students to practice additional health science skills in a safe, low stakes environment; thus, increasing student experiential learning and contributing to increased student and patient safety.
Opioid Use Disorders Treatment Related Disparities in Patients with Psychiatric Illness
Authors: Caroline Nielson, Connor Baird. Mentors: Robert Kagabo. Insitution: Utah Tech University. Opioid Use Disorders Treatment Related Disparities in Patients with Psychiatric IllnessAuthors: Caroline Nielson, Connor Baird, Robert Kagabo, PhD, MSW, MPHAbstractBackgroundThis study is a review of peer-reviewed articles of Opioid Use Disorders (OUD) treatment among individuals with psychiatric illness. OUD is a subset of substance use disorders (SUD) that is chronic and a growing public health concern. There were 47,000 opioid-related deaths in 2018 in the US; OUD is responsible globally for 68% of the drug-related deaths. OUD can result from either prescribed or non-prescribed opioid use. Some populations such as individuals with psychiatric illness have high rates of prescription opioids yet face opioid use treatment and research-related disparities. This review study examines OUD treatment and research-related disparities among patients with psychiatric illness with the goal to improve treatment among this vulnerable population.MethodsUsing PubMed and PsycINFO databases, we performed a search of journal articles regarding OUD treatment which were published between 2010 and 2023. We then completed a review of the journal articles using narrative overview guidelines. All articles reviewed were from randomized controlled trial (RCT) studies. Examples of search terms used include OUD treatment and mental health; OUD and psychiatric illness RCT studies; and opioid use treatment and mental health. Studies included were those of OUD treatment among individuals with psychiatric illness and or with a DSM5 or DSM4 diagnosis. Any studies that did not include OUD treatment and, or a DSM diagnosis, or RCT design were excluded. To avoid duplication, only one journal article from a study was included. ResultsThere were 18 journal articles reviewed that met the inclusion criteria. Treatment periods ranged from 8-24 weeks. Generally, studies excluded individuals with diagnoses such as schizophrenia, schizoaffective disorders, or other serious mental health diagnoses. Several studies included participants with a DSM5 or DSM4 diagnosis of OUD, while excluding individuals with other psychiatric or substance use disorders. Most of the studies used pharmacological treatments and only a few studies had combined pharmacological and behavioral treatments. The common medicines in pharmacological treatments were methadone, buprenorphine, and naltrexone.ConclusionOUD treatment and research related disparities exist among individuals with psychiatric illness, yet this is the population who suffer most from OUD. Additional studies regarding OUD treatment among individuals with psychiatric illness are needed to improve OUD treatments and reduce OUD-related morbidity and mortality rates.
Experimentally determined moments of inertia for a regulation baseball vs. a baseball with redistributed mass
Authors: Dylan Snook, Anthony Cornwall, Travis Ficklin. Mentors: Travis Ficklin. Insitution: Utah Tech University. The purposes of this study were to (a) experimentally measure the moment of inertia of a regulation baseball and (b) use the same method to measure the new moment of inertia of a modified baseball about orthogonal axes. The moment of inertia (I) of a rolling sphere follows the form I = k*m*r2, where m = ball mass, r = ball radius, and k represents a constant specific to the ball. Because baseballs are multi-layered of varying densities, they were not treated as a solid spheres. The balls were rolled multiple times down a plane inclined at 4.55 degrees and acceleration was derived by video tracking the ball using a camera with optical axis perpendicular to the plane of the ball’s motion. Position and velocity were derived during the rolling acceleration, and the slope of velocity was taken to be the rolling acceleration (acc). This was then used in the equation: k = (g sin(theta)/acc) – 1, where g is the acceleration due to gravity and theta is the angle of inclination of the plane. The variable k was calculated based upon average acceleration over many rolling trials and then used to finally calculate I for each ball. Results for the regulation ball and for the modified balls will be presented for multiple axes.
Closely related Enterobacteriaceae species with antibiotic class and subclass resistance
Authors: Coleman Judd, Alexander Beagley. Mentors: Michelle Culumber. Insitution: Weber State University. Due to the overuse of antibiotics in industrial, agricultural, and medical settings, antibiotic-resistant bacteria are becoming more prevalent in various unique settings. We set out with the goal of identifying antibiotic-resistant bacteria from the Great Salt Lake waterfront. After isolating colonies on agar containing the antibiotic Tetracycline, we performed 16S rRNA gene sequencing and identified three separate Enterobacteriaceae species all exhibiting varying levels of antibiotic resistance. We performed an array of biochemical and physiological tests to further distinguish the Enterobacteriaceae species. Full spectrum biochemical tests indicate two near identical species followed by a third, novel species as both a phenotypic and biochemical outlier. Antibiotic resistant bacteria within the Great Salt Lake region present an ever-growing dilemma of clinical and environmental danger that accompanies antibiotic resistant microbes.
Investigating the Potential Toxic Dust Pool Generated by the Shrinking of the Great Salt Lake
Authors: Kirsten Sanders. Mentors: Ruth Kerry. Insitution: Brigham Young University. The Great Salt Lake (GSL) found in the Salt Lake Valley is a remnant of Lake Bonneville. In the 1980s the GSL reached record high water levels. But by 2022, the lake has been drying up and reached record-low water levels. Previous research using seven years of Purple Air Network data has shown that particulate air pollution levels, PM 2.5 and PM 10, are worse within 10km of the Great Salt Lake. Other research investigating the distribution of toxic heavy metals (Copper, Arsenic, Lead, and Zinc) in topsoil samples from throughout the Salt Lake Valley showed that some of the highest levels of Copper and Arsenic pollution were found near Saltair among dried sediments on the shoreline of the Great Salt Lake. This study involved collecting numerous samples from the dried shoreline of the Great Salt Lake and analyzing them for their heavy metal contents using Xray Fluorescence. The heavy metals were then mapped and linked to sediment particle sizes and pH to indicate where the most toxic sediments are located, and where the sediments that are most easily picked up by the wind are located. The maps of heavy metals will be used with our analysis of the Purple Air Network and wind rose data from our previous study to show where toxic dust clouds are most likely to be an issue to the population. Links with 2016 Asthma ER visits and Hospitalizations will also be investigated.
Using Chimeric autoantigen receptor (CAAR) T cells to eliminate autoreactive B cells in autoimmune diseases
Authors: Abigail Cheever, Chloe Kang, Hunter Lindsay, Mackenzie Hansen, Kim O'Neill, K Scott Weber. Mentors: K Scott Weber, Kim O'Neill. Insitution: Brigham Young University. Chimeric Antigen Receptor (CAR) T cell therapy is a modern technology that has become a widely accepted treatment for blood cancers such as lymphoma and leukemia. Recent studies have proven the successful application of CAR T cell therapies in autoimmune diseases as well. Graves’ Disease (GD) is an autoimmune disease that affects approximately 1 in 100 Americans and is the most common cause of hyperthyroidism. GD is mediated by anti-thyroid stimulating hormone receptor (TSHR) antibodies produced by autoreactive B cells. Our hypothesis is that a curative treatment for GD can be created by designing a CAR T cell that specifically targets the autoreactive B cells in GD, by using TSHR as a binding domain to act as bait for the anti-TSHR B cells. We selected TSHR epitopes for the binding domain of the CAAR T cell, and our anti-TSHR antibodies bound significantly to our engineered CAAR T cells. A target B cell line with anti-TSHR B cell receptors was engineered using the Nalm6 B cell line. Using primary human CAAR T cells, activation and cytotoxicity assays against anti-TSHR B cells shows that CAAR T cell therapy is an effective and promising method to treat antibody mediated autoimmune diseases like GD.
Epigenetic Marks of Antiaging Pioglitazone Hydrochloride (PGZ) on Progeny
Authors: Wesley Hendricks. Mentors: Steve Johnson. Insitution: Brigham Young University. Pioglitazone Hydrochloride (PGZ) is a well-accepted treatment of type-II diabetes and has been shown in previous studies to increase lifespan of C. elegans. The agonist has been shown to affect the insulin, IGF-1 signaling pathway (IIS), dietary restriction (DR) and germline signaling pathways. Previous studies have not been able to identify epigenetic marks that are a result of the pathway effects of PGZ (Jia Wenguan et. al). This study seeks to understand how subsequent generations are affected by antiaging compounds and what epigenetic marks are transmitted through the germline of C. elegans from these three pathways. After exposure, through lifespan tracking, we hope to see a change in transgenerational longevity. Using RNAi, we then plan to knockout known genes in each pathway. We hope to see that intestine-germline pathway and maintenance genes that are known to function in each pathway are required for the longevity effect.
Natural Transformation in Staphylococcus aureus biofilms
Authors: Julia Gilpin, Lucy Bowden, Sela Harris, Elisa McRae, Jenny Bean, Brooklyn Jones. Mentors: Bradford Berges. Insitution: Brigham Young University. Staphylococcus aureus (SA) is a significant human pathogen that has acquired antibiotic resistance, posing a global health threat. This bacterium is prevalent in livestock, raw meat, and healthcare settings, leading to infections ranging from mild to life-threatening. The emergence of multi-drug resistant strains, such as Methicillin-Resistant Staphylococcus aureus (MRSA), further complicates treatment. The mechanisms of antibiotic resistance transfer, especially within biofilms, remain poorly understood.This research aims to investigate horizontal gene transfer within biofilms of SA isolated from humans. Leveraging the work of the Berges laboratory and techniques used by other researchers. The experimental design involves the use of heat-killed cells as donors to prevent conjugation, shedding light on how biofilm structure influences transformation efficiency.To address the hypothesis that biofilms serve as hotspots for horizontal gene transfer, the research employs a two-component system for upregulating natural competence genes in SA under biofilm growth conditions. This approach will allow us to detect natural transformation, advancing our understanding of SA infections closely associated with biofilm formation. If successful, this study will provide insights into how SA acquires antibiotic-resistant genes and may lead to the development of preventive measures and treatment strategies to combat drug-resistant strains.
Do Predators Cause Maternal Effects in Livebearing Tropical Fish?
Authors: Nolan Rodeback, Jerald Johnson. Mentors: Jerald Johnson. Insitution: Brigham Young University. The environment plays a crucial role in the development and evolution of organisms. In some cases, the environmental pressures on a mother may result in changes of offspring phenotypes. This phenomenon, called maternal effects, might occur in the tropic fish species Brachyrhaphis rhabdophora. I will conduct an experiment to test if maternal effects can be induced by the presence of a predator. To measure this we will look at maturity age and growth rates in the offspring where mothers are reared in the presence or absence of predators. If predators have an effect, offspring should mature at earlier ages and have faster growth rates than individuals with mothers reared in the absence of predators.
Keystone Species in an Urban Environment: Do Raptors Control the Mexican Gray Squirrel in Mexico City?
Authors: Byron Adams, Elias Johnson, D Alejandro Espinosa-Lucas, R Darío Perez-García, Israel Solano-Zavaleta, J Jaime Zúñiga-Vega, Gonzalo A Ramirez-Cruz. Mentors: Byron Adams. Insitution: Brigham Young University. Urbanization has forced animals to respond to novel environments. One of the challenges of urban ecology is that it is unknown if the ecological processes that take place in wild conditions also occur in urban environments. In natural ecosystems, key predators can limit prey abundance and have a widespread effect on trophic levels. Here, we examine a predator-prey interaction in Mexico City, an urban ecosystem where prey can be evaluated in the presence or absence of apex predators. Nearly all original ecosystems in Mexico City have been converted into man-made structures. Many of the green spaces in the city contain populations of the Mexican gray squirrel. These green spaces are also inhabited by different species of raptors, the most frequent being Harris’s hawk, Cooper’s hawk, and sharp-shinned hawk. Little is known about interactions between raptors and squirrels in terms of demographic parameters. We do know, however, that raptors prey on squirrels. We predicted that in parks where raptors were present, there would be fewer squirrels than in parks where there were no raptors. We studied the relationship between raptors and squirrels using occupancy models to determine the environmental factors that affect the presence of both squirrels and raptors. We then tested if the presence of raptors influenced the occupancy probability of squirrels. Lastly, we estimated the abundance of squirrels in parks, both where raptors are present and where they are absent. Contrary to our predictions, we found no evidence that predators predict squirrel abundance. However, we did find evidence that the presence of raptors can be predicted by the abundance of squirrels. These results suggest that this predator-prey interaction in Mexico City parks could be relatively recent and still not in equilibrium, or that other factors may be affecting the dynamics between these two urban populations.
CICNT surfaces block Staphylococcus aureus biofilm formation on implanted devices in mice
Authors: Brooklyn Jones. Mentors: Bradford Berges. Insitution: Brigham Young University. Staphylococcus aureus (SA) forms biofilms that cause considerable morbidity and mortality in patients who receive implanted devices such as prosthetics or fixator pins. An ideal surface for such medical devices would inhibit biofilm growth. Recently, it was reported that surface modification of stainless-steel materials with carbon-infiltrated carbon nanotubes (CICNT) inhibits the growth of SA biofilms. Through previous research, we investigated this antimicrobial effect on titanium (Ti) materials with CICNT coated surfaces in a variety of surface morphologies and across a broader spectrum of SA isolates. We have in vitro evidence that carbon nanotube-treated materials are effective at preventing SA biofilm formation on Ti, the most common material used in human implanted devices. We now wish to study the effects of carbon nanotube treatments on prevention of SA biofilm formation in vivo which has potential value to improving human health .
The relationship between differential finger force in a squeezing task and spin characteristics of a four-seam fastball thrown by division-I collegiate baseball pitchers
Authors: Anthony Cornwall, Dylan Snook, Travis Ficklin. Mentors: Travis Ficklin. Insitution: Utah Tech University. The purpose of this study was to discover any relationships between individual finger force capabilities of collegiate pitchers and the spin rates and axes of their four-seam fastballs. NCAA Division-I pitchers participated in the study. Using a hand-held dynamometer, multiple trials of a squeezing task were performed by each pitcher. Five trials were made using both index and middle fingers at maximum isometric effort. Then, in counterbalanced order, pitchers also duplicated the isometric squeeze isolating the index and middle fingers in one-fingered squeezes. Pitchers were constrained to make the maximum effort squeezes in a time frame similar to that of delivering a pitch.Spin axis and rate for their four-seam fastballs were taken from previously collected ball flight tracking using a field Trackman system. Analysis was performed for any relationships among axis tilt and relative finger contribution to total force, as well as spin rates with total isometric force. Additional relationships based upon anthropometric measures of the hand and fingers were also explored and the results are to be presented.
Using a Pricking Method for Inoculating Drosophila melanogaster with Wolbachia
Authors: Naavah Craze, crazen@byu.edu . Mentors: John Chaston. Insitution: Brigham Young University. Wolbachia are maternally inherited bacteria found in the reproductive organs of many arthropod species. These parasitic bacteria are influential in the reproductive fitness of the host and can affect a population’s male-to-female ratio. Wolbachia can only be cultured in living cells and current methods for inoculating hosts with this bacteria have low success rates. These factors make these bacteria difficult to study in lab environments. In this project, we test a pricking method for inoculating Drosophila melanogaster with Wolbachia. In this method, axenic, or bacteria-free, female flies will be pricked in the abdomen with a Wolbachia-coated needle. Eggs from these flies will be collected from 3 to 5 days after pricking and will be incubated. The offspring will be tested using gel electrophoresis to see if inoculation was successful. If successful, this method can be used as a simple and efficient way to introduce Wolbachia into Drosophila melanogaster. These inoculated flies can then be used in experiments to study the relationship between the bacteria and the host organism.
Causal Brain Networks in Insomnia
Authors: Levi Pouwer, Keaton Helquist. Mentors: Jared Nielsen. Insitution: Brigham Young University. OBJECTIVE: To identify brain regions and networks underlying acquired-brain-injury-induced insomnia. BACKGROUND: In patients of tertiary-level mental healthcare facilities, symptoms of chronic insomnia are prevalent in 78.2% of the population. Additionally, among those who suffer from acquired brain injury, few symptoms are as generally pervasive as that of chronic insomnia. Meta-analyses of insomnia patients with fMRI data have failed to identify consistently affected brain regions. Individual studies have suggested several brain regions are involved in insomnia, including the anterior cingulum, orbitofrontal cortex, the insula, caudate nucleus, and the anterior capsula interna. However, few regions have consistently been implicated in the pathophysiology of insomnia. Moreover, little is known regarding the collective brain networks involving insomnia. DESIGN/METHODS: A comprehensive systematic literature review was conducted to identify case studies of individuals afflicted with acquired brain injury-induced insomnia (N=53). The review process was facilitated by employing Cadima, specialized literature review software. To establish a reference baseline for comparison, a substantial cohort of resting-state functional MRI (fMRI) scans from healthy control subjects (N=1000) was meticulously acquired. Subsequently, lesion network mapping analysis, as outlined by Fox et al. in 2018, was applied to the lesions observed in the 53 patients. This method allowed us to assess the impact on functional connectivity and analyze its implications by comparing the patients' lesion networks with the baseline scans obtained from healthy controls. RESULTS: In the context of lesion network mapping analysis, our study revealed that 45 out of 53 patients diagnosed with acquired brain injury-induced insomnia exhibited brain lesions that were functionally connected to both the left amygdala and the left anterior insula. Moreover, in 39 out of 57 patients, the lesion networks also included bilateral anterior insula and the hypothalamus. Comparative analysis of these lesions with a normative database unveiled a substantial disparity in functional connectivity to the left amygdala and left anterior insula in patients suffering from acquired brain injury-induced insomnia. This finding underscores the relevance of tissue within these regions and tissues functionally connected to these areas in relation to the onset of lesion-induced insomnia. CONCLUSION: The observed functional network connectivity among the left amygdala and the left insular region in relation to insomnia introduces a potentially more intricate mechanism underlying the onset of insomnia, in addition to the previously proposed factors such as hyperarousal in cortical regions and subcortical neuropathologies. Our findings highlight the possibility of a deeper connection between the initiation of insomnia and limbic structures, specifically emphasizing their role in emotion and sleep regulation. This suggests that the neural mechanisms influencing anxiety may have interrelated effects on the mechanisms influencing insomnia. It is evident that further investigation, particularly among psychiatric patients afflicted with insomnia, is warranted to delve into the activities occurring in these regions and to elucidate the potential interplay between anxiety and insomnia. This research paves the way for a deeper understanding of the complex relationship between neural pathways and the development of insomnia, ultimately offering valuable insights for future clinical and therapeutic considerations.
A Study of Polymer Bonding and the Restoration of Fragmented Ancient Pottery
Authors: Ellie Martin. Mentors: Cynthia Finlayson. Insitution: Brigham Young University. Pottery reconstruction allows archaeologists to better understand their artifacts and gain a more complete understanding of ancient ceramic techniques. Reconstruction techniques have evolved over time that strive for both better conservation practices and long-lasting results, as well as the use of bonding materials that are reversible rather than permanent. This poster examines the process of utilizing an acetone-based glue consisting of dissolved polymer beads of differing strength solutions. The entire process with be illustrated by step-by-step photos and directions as well as the quality of the final results. Two layers of different solution consistencies are applied to the pottery in different stages before the pieces are joined together. The first layer of glue is a thin coat made of 5% polymer and 95% acetone, and it is applied to any edges that will be refit. This layer fortifies the sherd and ensures that the glue applied is not stronger than the sherd itself. After the first layer has dried, the second coat of glue, made of 12% polymer and 88% acetone, is added to each piece. The sherds are then joined and placed in a secure location to dry, such as a bin of silica beads. Acetone-based polymer glue is strong and flexible, yet also dissolvable. Any mistakes can be unmade with the careful application of small amounts of acetone, and no restoration action is utilized on the pottery fragments that cannot be undone. This method of reconstruction is safe, secure, long-lasting, and meets modern conservation standards.
Antihistamines Blunt the Effect of Localized Vibration on Arterial blood Flow
Authors: Dustin Edmonds, Devin Needs, Riley Fisher. Mentors: Brent Feland. Insitution: Brigham Young University. Research questionHow does localized vibration increase blood flow? We know that localized vibrations increase blood flow. We wanted to know if this is done through the release of hormones, specifically histamines. Relevant research contextResearch on blood flow has been done using whole-body vibration but research on the effects of localized vibration on arterial blood flow is scant. To date, there are only a couple of research articles on massage guns despite their prolific use in the sports industry. No research to date has attempted to assess the mechanism behind the increased blood flow that results from localized vibration.MethodsTwenty-one participants completed this study, 11 males and 10 females, mean age of 22.1 +/- 2.0 years. The mean male height 181.3 +/- 9.6 cm and weight 80.7 +/- 19.0 kg. The mean female height is 169.2 +/- 7.5 cm, and the mean weight is 64.5 +/- 9.3 kg. All subjects were “recreationally active” and exercised at least three times a week for thirty minutes a day. Excessive activity or high-level athletes were not allowed to participate. Each subject received localized vibration to the gastrocnemius (vibration of 47 Hz for 10 minutes) with and without an antihistamine drug by reporting to the lab on 2 separate days. The non-antihistamine trial was performed first, followed at least 24 hours later by ingesting an antihistamine (180 mg of fexofenadine) 1 hour before the trial. Blood flow in the popliteal artery was measured using an ultrasound. Measurements (mean and peak blood velocity, volume flow, popliteal diameter, and heart rate) were taken before localized vibration treatment and then taken at intervals for 19 minutes after the treatment.AnalysisWe used a cell-means mixed model to statistically compare the effect of vibration on blood flow with and without antihistamines. This was done by evaluating the blood flow response immediately post vibration and comparing that to baseline values for both control and antihistamine conditions. Results and ConclusionThere was a significant increase in blood flow without antihistamine while administration of antihistamine blunted the blood flow response and resulted in an insignificant increase in blood flow. In the tests with the antihistamine, we saw an insignificant change in blood flow immediately post vibration, resulting from the localized vibration. From this experiment, we hypothesize that increased blood flow from localized vibration is due to activation of mast cells which release histamines and that this cellular activation is force dependent.
Designing Inducible DNA Constructs for the Chicken
Authors: Lant Jenkins, Dalyn Davis, Caleb Kratt. Mentors: Jeffery Barrow. Insitution: Brigham Young University. Currently, nematodes, fruit flies, and zebrafish are effective models for gene manipulation due to their rapid embryonic development and capacity for producing a large number of offspring. Avians such as the chicken have also served as embryonic models and have proven to be powerful tools for exploring developmental processes such as neural tube or limb development. Because of high chick fecundity, a relatively short period of development, and the accessibility of the chick embryo, the chicken would make an excellent model for gene manipulation that would significantly enhance our study of the relationship between genes and phenotypes in vertebrates. The aim of our research is to develop a line of genetically modified chicken germ cells into which new DNA vectors can be seamlessly introduced via cassette exchange. The design of the germ cells is such that the DNA vectors will be incorporated into the chicken genome at specified safe harbor locations, areas of euchromatin where the introduced DNA will not interfere with other genes. These modified germ cells can then be injected into chicken embryos and contribute to the chick’s germline. We anticipate that this model for modifying the chicken’s genome will significantly enhance our ability to introduce new DNA vectors, making the chicken a more desirable model for studying embryonic development via genetic manipulation.
Isolation of Microcystin-producing Cyanobacteria
Authors: Alix Elliston. Mentors: Lane Law. Insitution: Salt Lake Community College. Cyanobacteria (colloquially known as blue-green algae) are photosynthetic prokaryotes commonly found in water. Several genera of freshwater cyanobacteria, including Microcystis, Planktothrix (Oscillatoria), and Anabaena, produce potent hepatotoxins known as microcystins. Eutrophication and increasing temperatures facilitate an overgrowth of toxin-producing cyanobacteria, referred to as cyanobacterial harmful algal blooms (cyanoHABs). There are several known cyanophages which infect these genera and there has been some research into the role phages play in regulating cyanoHABs. This study aims to isolate microcystin-producing cyanobacteria from Utah Lake, as well as known or novel freshwater cyanophages which can infect the isolates. Any isolated phage will be propagated, have its DNA extracted and sequenced, and studied for use as a CRISPR delivery vehicle to target toxin-producing cyanobacteria, with the aim of knocking out microcystin biosynthesis.
Genetic Modification of Cyanobacteria to Break Down Organic Compounds and Inhibit Toxin Production
Authors: Lonnie Ernst. Mentors: Lane Law. Insitution: Salt Lake Community College. Cyanobacteria are photosynthetic bacteria commonly found in water. Microcystis aeruginosa is one such cyanobacteria that is found within the waters of Utah Lake. M. aeruginosa produces the microcystin toxin which is harmful to the aquatic life and contributes to the ongoing problem of eutrophication and, if ingested, is also harmful to humans. Alongside this toxin producing cyanobacteria, Utah Lake is contaminated with polychlorinated biphenyls (PCBs) which are highly carcinogenic chemical compounds. This study aims to offer a method of bioremediation by engineering M. aeruginosa to carry a BPH gene pathway that breaks down PCBs. Using CRISPR, this gene would remove the microcystin producing gene and replace it with the BPH gene resulting in the engineered M. aeruginosa to breakdown the PCB contaminants and halt further production of the microcystin toxin.
DID
Authors: McKayla Ridenour. Mentors: Alex Giannell. Insitution: Utah Valley University. "DID" is a painting that delves into the concept of duality within myself. The painting explores my vulnerability as its subject matter. As someone with Dissociative Identity Disorder (DID), I am displaying myself and another personality in the artwork. I aim to shed light on those suffering from DID and other mental conditions. I used a lot of glazing and subtractive methods to achieve the desired effect during the painting process, such as complex darks and layering of paints.
Oneness in diversity
Authors: Nawres Al Saud. Mentors: Alexandra Giannell. Insitution: Utah Valley University. My work beautifully embodies the concept of oneness in diversity by seamlessly blending various elements, perspectives, and voices into a harmonious whole. Like a symphony of colors, my art celebrates the rich tapestry of human experience and the interconnectedness of all things. It serves as a powerful reminder that despite our differences, we share a common humanity. My work is a testament to the idea that diversity is not a source of division but rather a source of strength, resilience, and creativity. It encourages us to embrace the uniqueness of each individual and culture while recognizing the threads that unite us, ultimately emphasizing that we are all part of a larger, interconnected whole.
Spatiotemporal Continuity Capture through Cyanotyping
Authors: Brittney Weiland. Mentors: Alexandra Giannell. Insitution: Utah Valley University. The cyanotype process is a slow time-based method that uses a chemical mixture, water, and UV light to capture instances of spacetime. Cyanotype translations of the body, whether by directly laying a body down on fabric or through the use of translated photographs inherently capture slices of spatiotemporal continuity by nature of its time-based development. Directly placing one's body on chemically treated fabric undergoes only one translation of form: body to image. However, this direct method fails to capture figural resemblance, but rather captures movement through time, leaving traces of 4th dimensional worms. This method draws a closer comparison to temporal continuity but not to recognizable figure. Photographs, long past captured, undergo a process of camera translation, digital translation, printed negative translation, and then finally cyanotype translation but more directly relates to figural recognizability than a direct capture method. However, this photographic process fails to capture more than a few spatiotemporal moments, less in tune with temporal imagery. Through a series of works, Brittney Weiland explores identity through a perdurantist view by capturing moments of body degeneration and drastic physical form changes over the last year as she has battled nearly life-ending illness through the use of cyanotype and photography.
Contrasting elements in visual art
Authors: Ripjaw lemus. Mentors: Alexandra Giannell. Insitution: Utah Valley University. This presentation will explore a selection of artworks which exemplify varying aspects of visual contrast, honing in on the implementation of the principles and elements of art and design. The presentation will include chosen works to show my personal understanding and exploration of these image-making strategies, including the juxtaposition of realism and abstraction, positive and negative space, 2 dimensional and three dimensional, large and small scale, light and dark value, complementary hues, and oposing painting techniques.As an artist and researcher, I am continuing to study how these elements operate in my work and am building an awareness of how a deep investigation of contrasting elements creates a more stimulating experience for the viewer. The three paintings that will be displayed in conjunction with my poster will allow the viewer to experience the work physically as well as participate in discussion with me around artistic decision making and image possibilities.
Desert Water
Authors: Maddalena Willis. Mentors: Alexandra Giannell. Insitution: Utah Valley University. Water is the most essential ingredient for life. In the desert, it is much more valuable. As Utah’s population rises, its high desert climate that provides beautiful scenery and fun recreational activities is running on a limited amount of water. Therefore it is vital that our reservoirs, lakes, streams and groundwater supply are in good condition, but this is impossible without our own efforts to help. As such, it is imperative that we avoid water contamination and negligent overconsumption. Displayed are the two paintings titled Churned and Drought. They are commentaries on the observable effects humans have had on the water condition in Wasatch and Utah County. The painting titled Churned uses the imagery of a boat prop agitating the picture plane of the painting. The serene blues and greens have been mangled and torn apart. The painting titled Drought uses the imagery of abstracted storm drains, pipes and fishing lures to illustrate the alterations humans have made on the waterways. It is very grid-like and inorganic. Combined, these two paintings are a reflection on the current state of our marine desert ecosystem.
Music and Emotion: Using Music as an Apparatus for Connection
Authors: Kimberly Lewin. Mentors: Anne Francis Bayless. Insitution: Utah State University. I have been exploring the relationship between connection, disconnection, and control, and I presented my research on these topics to three composers who wrote a piece based off of their interpretation. At URCO, I will perform one of these compositions.
Sonata in G Minor for Piano
Authors: George Wells. Mentors: Timothy Francis. Insitution: Utah Tech University. Cast in the form of a first-movement, 17th century Sonata, this is an original composition that explores different chord progressions out of dissonance to resolution. This solo piece for piano is structured similar to works typical of the classical time period. Piano repertoire from the classical era feature repeated patterns, simple melodies, and contrasting moods. Atypical of piano repertoire from the classical era are characteristics such as chromaticism, common-tone and augmented chords, polyrhythms, and hemiolas. From a framework of the sonata form with simple patterns and melodies, I explored the mood and color each method of resolution brings to music composition, classical and contemporary. From this work we can come away with a better understanding of the abstract emotion and character naturally found in musical resolutions that have been codified through music theory.
What's That Building? Exploring Public Perceptions of Architectural Functionality Based on Form.
Authors: Sean Donner. Mentors: Brandon Ro. Insitution: Utah Valley University. A building’s function has historically been tied to its form. We see this in civic buildings, schools, churches, and homes. Many of those recognizable forms were abandoned with the modernist movement in the early twentieth century. Are these new forms still related to their functionality and can average people perceive a building’s functionality based on its form. Learning the opinions of the general public will enhance the architect’s ability to design for the people who will live and work in and around the buildings they design.This study aims to answer those questions by means of an online survey. To gain a wider demographic of survey takers, the survey is largely spread through social media where I have access to a wide variety of people across the globe and of differing generations and backgrounds. The survey has two types of questions. The first presents two pictures of buildings and asks the survey taker to tell which holds a specific function. The second question type presents a single building and four choices of building function. In both question types, all signage or other markings of building type were digitally removed from the photographs. The survey includes fourteen architectural functions ranging from single family homes to State Capitols. Each category includes traditional and modern examples. This variety in style will help to analyze whether there is a difference in the general public’s ability to perceive a building’s function if the building is traditionally designed or if it takes a more modern approach in design. Although this survey is still active, the expected results are as follows: Traditional forms are generally more easily discernable than modern designs. Some building forms are equally recognizable regardless of form. The stand outs from this list are schools and stores/shoppes.
Architectural Contextualism: How Context Shapes Building Perception
Authors: Kevin Hart. Mentors: Brandon Ro. Insitution: Utah Valley University. Context, in the realm of contemporary architecture, holds a significant role. It encompasses the information that conveys an understanding of ideas, scenes, or objects. In a world marked by increasing individualism, the consideration of contextual elements in architectural design often takes a back seat. The Royal Ontario Museum serves as a notable case study. The addition of the Michael Lee-Chin Crystal, contrasting with the traditional backdrop, has ignited debates regarding its compatibility with the existing context. This brings forth a critical question: How does altering the contextual surroundings impact people's perceptions?Furthermore, would the public's perceptions differ if the Crystal were the original building, with the traditional structure serving as the addition? This study delves into the role of contextual factors in shaping the architectural experience. Through a comprehensive survey featuring diverse architectural styles situated in various contexts, my aim is to discern preferences: whether individuals lean toward statement buildings or designs that naturally integrate with their surroundings. My research hypothesis suggests that people derive greater enjoyment from buildings that seamlessly integrate with their contextual environment.The implications of these findings are of significant value to architects and designers. They provide insights to facilitate informed design decisions that not only promote community cohesion but also elevate the public's appreciation of architectural structures.
Neurological Links to Home Design Preferences: A Comparative Study using Eye-Emulation Software.
Authors: Thomas Cryer, Brandon Ro. Mentors: Brandon Ro. Insitution: Utah Valley University. ABSTRACT: This study seeks to understand the visual elements of home design that attract the human eye. Specifically, it aims to compare the visual appeal of traditional homes to modern homes using eye-tracking software. However, this study focuses solely on visual analysis, leaving the exploration of emotional and cultural factors for future research. The purpose is to understand the neurological connections between architectural design and human preferences, shedding light on which elements make homes visually appealing. In the mid-20th century, the architectural landscape shifted towards modernism, characterized by functionalism and minimalism. However, recent research suggests neurological links to architectural preferences that challenge modern design's dominance. This study is relevant today as it explores why people are drawn to traditional homes, considering the current preferences of professional architects. This research contributes to the understanding of how architectural aesthetics impact individuals and communities and offering insights into the neurological aspects that influence architectural preferences. The methodology involves analyzing six homes, three traditional and three modern. The analysis will be conducted using 3M Visual Attention Software individually on each home by tracking participants' eye movements, and then given a numerical ranking of 1-6 based on their visual appeal. Subsequently, a comparative analysis will identify the most and least visually attractive homes. Anticipated results from the software suggest traditional homes will score higher due to the "character," or the details that the eye looks, which are missing in modern architecture. The discussion will explore the idea that contemporary homes, by incorporating traditional elements such as proportion, may achieve higher appeal and last for generations of homeowners. Contemporary designs can evolve into "traditional" homes by aligning with the preferences discovered. By understanding what elements people are naturally drawn to, architects can create more appealing and lasting designs, thereby bridging the gap between modern and traditional aesthetics.
Re-Examining Architectural Design: The Balance Between Simplicity and Complexity
Authors: Joseph Laudie. Mentors: Brandon Ro. Insitution: Utah Valley University. For an architect, choosing how simple and/or complex your designs are can be a difficult effort. It involves balancing various factors, including appearance, function, cost, time, context, etc. While one might state that a certain way is best, it can be difficult to know. For that purpose, this study will examine the question, “How does the perception of a space or structure change as it evolves from a simple to a more complex state?” The difference between these conditions may involve an increased presence of elements, such as motifs, ornaments, etc., gradually becoming more complex. These changes will be analyzed using eye-tracking software.In contemporary architecture, architects grapple with multifaceted considerations. They must combine the varied desires of clients, adapt to evolving technology's possibilities and constraints, prioritize sustainability and efficiency, adhere to budget limitations, stay attuned to cultural and aesthetic trends, meet functional programming requirements, and navigate site-specific constraints. All these factors influence the architect's decision-making process, guiding them toward either simplicity or complexity in their design approach.Because of the difficulty of this cumulative decision, the issue will be thoroughly examined to determine the true effect both simplistic and complex structures have on the everyday individual. This will be done by examining a single, 3-D-modeled room with progressively more complex states, involving more details such as windows, doors, and classical orders and elements. Photos of the respective conditions will be presented side by side and processed through eye-tracking software.It is expected that more complex spaces and conditions will draw attention more consistently. While the analyzed space will present varying states of detail, it is expected that the more complex and expressive setting will consistently demand attention. This conclusion will better inform future design decisions by architects to make spaces more appealing and conducive to the observer.
Thomas S. Monson Center Building Analytique
Authors: Bronwyn Brown. Mentors: Ben Felix. Insitution: Utah Valley University. Architectural Analytique of the Thomas S. Monson Center Building with the Scamozzi Order at University of Utah
Capstone Project
Authors: Roya Adham. Mentors: Kristen Arnold. Insitution: Weber State University. Given the frequency and severity of natural disasters and humanitarian crises, around the globe, the current refuge center at Salt Lake City faces critical challenges in providing sufficient support for its demand.Security and efficiency of indoor space are critical matters in designing a refuge center.the absence of confidentiality can lead to information leakage and compromise the security of the building. (Reinten, et al 2017). The room acoustics will impact the creation of positive communication and interaction for individuals who seek solitude and peace inside the building. Oasis Haven promised to serve as a haven to those in need, helping them to nurture and heal from their past traumas. According to recent research, organizing and laying out spaces, and putting directional signage and informational labels to guide individuals who don't know the language will effectively increase their satisfaction level with the space Jamshidi et al. (2020). Accessibility for all individuals in a space is an ultimate goal of the designers and we must ensure cohesive visual language and consistency throughout the entire design.additionally, it studied and proved the effects of color schemes on employees' task performance due to the healing effects of colors Öztürk, Yilmazer, and Ural (2012). color plays a significant role in creating a space that helps refugees feel more at home and provides a sense of belonging to them. certain colors may symbolize peace, warmth, or security in one culture, while they might have different connotations in another Öztürk, Yilmazer, and Ural (2012) we try to incorporate all those principles and get help from other elements such as natural and artificial light to create space that feels like a true home and provide a sense of stability and comfort to refugees during the times of transition and adjustment.
Venetian Elegance: Harmonizing Heritage and Innovation on the Grand Canal
Authors: Samuel Weisler, Colton Korpi, Josh Lythgoe. Mentors: Aliki Milioti. Insitution: Utah Valley University. The Venice Project addresses the challenge of blending contemporary buildings into the well-established urban environment of Venice, a city well known for its rich architectural heritage. In a city with canals in the place of streets, where motorboats and gondolas are the main mode of transportation, seasonal flooding at high tide continues to become a greater environmental concern. The research centers on the documentation and preservation of these valued characteristics through an analytical and interpretative research approach. The primary focus is on aspects such as perception, harmony of open and enclosed space, and the seamless integration into the urban and environmental fabric.The unique design constraints were taken head on in creating the one of a kind ‘Ca’Meriggiare’, a luxury hotel that enriches Venice’s heritage. In lieu of fighting against them, the design embraces the environmental challenges posed by the periodic flooding of the city and transforms them into an integral part of the design. For instance, the flooding is harnessed to create a charming, arcaded entrance exclusive to hotel guests arriving by boat, providing a unique entry sequence unphased by rising or falling water levels.The expected result of the research is a successful fusion of a contemporary hotel with the rich historical context of the city. The innovative design allowed the periodic flooding to become an integral part of the hotel that added a charm and uniqueness to the guest experience. Ca’Meriggiare stands as a testament to the harmonious integration of historical preservation with environmental adaption that honors Venice’s heritage. This luxury hotel case study offers a holistic perspective on theoretical and design considerations, emphasizing the importance of integration within the environmental dimensions. Rather than viewed as an isolated instance, it provides an overarching framework for innovation that will apply to the evolution of contemporary architecture.
Senior capstone
Authors: Roya Adham. Mentors: Kristen Arnold. Insitution: Weber State University. Given the frequency and severity of natural disasters and humanitarian crises, around the globe, the current refuge center at Salt Lake City faces critical challenges in providing sufficient support for its demand.Security and efficiency of indoor space are critical matters in designing a refuge center.the absence of confidentiality can lead to information leakage and compromise the security of the building. (Reinten, et al 2017). The room acoustics will impact the creation of positive communication and interaction for individuals who seek solitude and peace inside the building. Oasis Haven promised to serve as a haven to those in need, helping them to nurture and heal from their past traumas. According to recent research, organizing and laying out spaces, and putting directional signage and informational labels to guide individuals who don't know the language will effectively increase their satisfaction level with the space Jamshidi et al. (2020). Accessibility for all individuals in a space is an ultimate goal of the designers and we must ensure cohesive visual language and consistency throughout the entire design.additionally, it studied and proved the effects of color schemes on employees' task performance due to the healing effects of colors Öztürk, Yilmazer, and Ural (2012). color plays a significant role in creating a space that helps refugees feel more at home and provides a sense of belonging to them. certain colors may symbolize peace, warmth, or security in one culture, while they might have different connotations in another Öztürk, Yilmazer, and Ural (2012) we try to incorporate all those principles and get help from other elements such as natural and artificial light to create space that feels like a true home and provide a sense of stability and comfort to refugees during the times of transition and adjustment.
Investigating Porosity Defects in Printed Zones of Binder Jet 3D Printing
Authors: Madi Hancock. Mentors: Nathan Crane. Insitution: Brigham Young University. Binder Jetting (BJ), a type of additive manufacturing (3D printing), creates parts through a multi-layered process. Particles are bound together using tiny droplets of liquid binder. Binder jetting has advantages over other additive manufacturing methods including relatively low costs, fast build rates, and a variety of possible printable materials. However, porosity defects commonly seen in BJ printed parts limit the technology's usefulness in demanding industries. There are several proposed causes of these porosity defects, including poor powder compaction in printed areas, residual carbon from the binder, and powder rearrangement due to binder droplet impact. The relative importance of these factors is poorly understood. This study will compare observations of porosity in printed and unprinted regions of Stainless Steel 316 BJ samples to better understand the possible modes of porosity defects.
Inertial Energy Storage for Jumping Robots
Authors: Caleb McDougal. Mentors: Nathan Usevitch. Insitution: Brigham Young University. Managing difficult terrain poses a major obstacle for current robotics. Everything from search and rescue to extraterrestrial exploration involves complex controls in unpredictable environments. One potential solution to handling such terrain is a robot that can jump. This could bypass the complex terrain handling and increase the speed at which long distances could be covered. While current robots can jump far, their jump distances decreases quickly with added payload massIn this project we propose a design that stores energy by accelerating a flywheel and converting its rotational energy into linear energy through a string system. Our proposed string system concept is similar to the string systems found in twisted string actuators. The strings slow the flywheel down while accelerating it upwards providing the energy for the jump. The primary energy storage mechanism of the robot is storing energy in the spinning mass of the flywheel. This means if we add payload mass to the flywheel we increase total energy stored. This allows us to increase payload mass without significantly affecting the total energy density of the robot. This would enable robots with heavy payloads to jump large distances.We are developing the system through building both a theoretical model as well as physical prototypes. Through analysis of the system we have determined an optimal rate of transmission as well as an optimal geometry for peak transmission. The models relate the geometry of the string system to the rate of transmission from angular to linear speed. We have created and tested prototypes as proof of concept on a small scale. Prototypes have been created using 3D printing and rapid manufacturing techniques. These have allowed us to explore the effects of different parameters.Jumping robots could traverse complex terrain and help explore rugged environments. The flywheel string system could allow the robot to effectively carry large payloads while maintaining large jump heights. The proposed jumping robot design could lead to important innovations in the fields of robotics and dynamics.
The Effect of the Position of Manually Extruded Nanocomposite Strain Gauges on their Physical Properties
Authors: Jordan Penfold, Cera Gowans, David T Fullwood, Anton E Bowden. Mentors: David T Fullwood. Insitution: Brigham Young University. Wearable nano-composite strain sensors created at Brigham Young University are used for biomechanical studies of human motion, due to their ability to follow and sense skin deformation. The manufacturing process for these sensors involves combining the raw materials that make up the sensors – silicone, nickel nanoparticles and nickel-coated chopped carbon fibers – in a planetary mixer, followed by extrusion of the uncured slurry through a syringe with a specialized tip. After extrusion, the sensor material strips are cut to length and subsequently casted and cured. However, undesirable variability in the final piezoresistive properties of the sensors was discovered. This variability was hypothesized to be attributable to sensor positioning during extrusion process. For example, fiber alignment may change as the extrusion process develops, or internal voids may be more evident in sensors cut from different parts of the extruded slurry. To test this hypothesis, several batches of sensors were created with precise records of each sensor position after extrusion. Some sensors were also set aside for CT scans to analyze their void content and nickel concentrations. The results suggested that the sensors located on the initial and terminal ends of the extruded slurry strips had statistically significant differences in piezoresistive properties when compared to the sensors from the central portion of the material strips. Sensors cut from the ends of extruded strips were more likely to have a lower standard deviation of average resistances while strained and relaxed, and were more likely to pass quality control inspection. As a result of this research, we learned that sensors with more consistent physical properties could be obtained by intentionally shortening the strips of slurry produced during the extrusion process (e.g., creating sensor batches with exclusively “end” sensors). After applying this change in methodology, sensor batches usually had more consistent physical properties when compared to sensors made with previous methods.
Application of Statistical Approaches in Non-Linear Normal Mode Calculations
Authors: Davis Wing. Mentors: Matt Allen. Insitution: Brigham Young University. When thin structures vibrate under large forces, can exhibit geometric nonlinearity, which makes it very hard to compute their motion and the stresses they undergo. This work builds on prior efforts, which used a small number of computations derived from detailed models, together with machine learning techniques, to train a reduced order model (ROM). This ROM could then be simulated efficiently to estimate the dynamic, nonlinear response of the structure in a fraction of the time it takes to compute the full-order model.This reduced order modeling technique is called Gaussian Process ROM or GPR ROM, and was developed by Park et al. [MSSP, vol. 184, p. 109720, 2023]. The GPR-ROM approach works by applying a number of static loads to the detailed model of the thin structure, and then by integrating those loads over time, it produces an understanding of the dynamics. In addition to its speed, this approach also provides confidence bounds on its findings, meaning that researchers can gauge a number of plausible values for the nonlinear responses of the system being measured.This research further develops this approach to computing the dynamics of structures by applying the GRP-ROM to a more complicated structure than previously studied, namely, a gong. The gong as a test structure is significant, as the signature sound of a gong is produced through geometric nonlinearities. In order to capture the behavior of the gong, and thereby its sound, several modes need to be studied simultaneously, and thus more degrees of freedom are required to capture its behavior in a ROM. This work evaluates the GPR-ROM process for the gong by computing various ROMs for different load states, thereby capturing the geometric variability of the gong’s responses. Then, the non-linear normal modes (NNMs) of the system are calculated within 95% confidence, which allows for a reasonable understanding of the dynamics of the system. These will be compared to the NNMs computed, at great expense, from the full-order model to validate the method.
Use of data processing and statistical models to understand large sets of experimental chemistry data
Authors: Isaac Sudweeks, Bradley Adams. Mentors: Bradley Adams. Insitution: Brigham Young University. Isopleths are graphical representation of atmospheric data used to analyze the response of an atmospheric chemical such as Ozone to the change in other chemicals in the atmosphere such as oxides of nitrogen and volatile organic compounds. Isopleths then can be used by researchers and other to decide the best way to reduce pollutants in the atmosphere. I set out to use data processing and statistical models to better understand and interpret large experimental chemistry data through the creation of 3 dimensional isopleths. I started by splitting up the data into 2 figures that were functions of 1 variable to make simpler 2d plots. After exploring several techniques to create models such as smoothing splines, b-splines and least squares to fit a quadratic, and through using tools such as generalized cross validation, analysis of covariance, and general visual inspection, I concluded that the best model to create an isopleth is, in the case of the data I was given, a least squares fit-b spline (LSQ spline) using a small number of knots spread evenly over the range of data.
A portable device for measuring Achilles tendon stresses in dancers
Authors: Joey McConkie, Jackson Wilcox, Eli Smith, David Phair. Mentors: Christopher Dillon, Matthew S Allen. Insitution: Brigham Young University. Elevated strain in the Achilles tendon places ballet dancers at high risk for tendinopathy, which in severe cases can terminate a dancer’s career. Typical methods of measuring in vivo tendon stresses—which could be used to predict and prevent tendinopathy—are invasive, making them impractical for professional dancers. We use a portable, non-invasive, externally mounted system of one transducer and two accelerometers to generate and record vibrational motion within the tendon. The speed of sound waves propagating through the tendon is used to calculate the stresses present. The portability of the system allows it to be worn by a dancer during an actual dance routine instead of requiring measurement to be taken at a fixed location where mobility is limited. This system results in data that can noninvasively quantify tendon stresses regularly experienced by ballet dancers. The improved understanding of in situ stresses measured by this device will have great potential for improving the prediction and prevention of debilitating tendinopathy.
Image segmentation for breast cancer focused ultrasound therapies
Authors: Taylor Forbes, Rachel Harris, Benjamin Jackson, Nicole Peterson, Sydney Tanner, Chloe Nelson. Mentors: Christopher Dillon. Insitution: Brigham Young University. Focused ultrasound (FUS) therapy is a non-invasive therapy for breast cancer. Treatment plans for this therapy are created on a patient-to-patient basis, which requires a significant amount of time from medical professionals. An important and time-consuming part of developing treatment plans is the precise segmentation of the breast magnetic resonance imaging (MRI) scan and subsequent treatment simulation to ensure that the treatment is effective and safe. Segmentation involves dividing the MRI dataset into segments by assigning distinct tissue types that are then assigned properties and used in simulations to help clinicians plan FUS treatments. However, imprecise interfaces between different tissue types in MRI images lead to discrepancies between individual segmentations, thereby introducing variability into the segmentation process. This variability—which is found even among expertly performed segmentations—can lead to differences in treatment plans. Here, analysis was performed in order to quantify interobserver variability in breast MRI segmentation. This study was conducted by providing basic segmentation training to undergraduate research assistants with no prior segmentation experience. Each participant segmented the same breast MRI dataset into different tissue types using the software Seg3D. The different segmentations were then compared using contour similarity metrics (such as the Dice Similarity Coefficient and Jaccard Index) as well as tissue volume differences. The interobserver variability was quantified using the results from these analyses, which will be helpful in determining the level of precision required for the use of a given segmentation in FUS treatment planning.