Fine Arts

Authors: McKayla Ridenour. Mentors: Alex Giannell. Insitution: Utah Valley University. "DID" is a painting that delves into the concept of duality within myself. The painting explores my vulnerability as its subject matter. As someone with Dissociative Identity Disorder (DID), I am displaying myself and another personality in the artwork. I aim to shed light on those suffering from DID and other mental conditions. I used a lot of glazing and subtractive methods to achieve the desired effect during the painting process, such as complex darks and layering of paints.

Authors: Rebekah Victoria Still. Mentors: Alexandra Giannell. Insitution: Utah Valley University. We all experience panic. For many people it is a rare experience, while for those diagnosed with panic disorders, it can be a regular and debilitating occurrence. Oftentimes, it’s embarrassing and difficult for those living with such a disorder to explain to friends, family, coworkers, supervisors, and peers what they’re feeling and why it affects their lives so thoroughly. In this project, I approached various strangers to ask them about their experiences with panic in an effort to develop a unique and universal language, which would enable viewers to better understand panic and open an empathetic dialogue between those with such a disorder and their loved ones.Based on the answers I received, I was able to sort the data and create multiple visual recipes which I used to develop a series of preliminary works. With each rendition, I asked for feedback from those with and without panic disorders, so as to assess the effectiveness of my color palette, symbology, and mark making techniques. Through this process of creation and criticism, I arrived at a composition which successfully encapsulates the feelings, sounds, and appearance of panic.As someone who lives with PTSD, I believe that it’s important to foster empathy for those around us and earn how to effectively communicate our feelings. My objective is that through this work, people who previously didn’t have the words to discuss their mental health will be able to use this piece to start an open and honest conversation with their loved ones. Furthermore, by using a universal, visual language, those who don’t have panic disorders will be able to begin the process of opening their minds and hearts to understand the people who do. In this sense, my final painting is not an answer, but a question meant to inspire further research and exploration.

Authors: Rayne Beau Vanderpool. Mentors: Alexandra Giannell. Insitution: Utah Valley University. For this upcoming UCUR art presentation, I will be showcasing two paintings that I created during a previous painting class under the guidance of my mentor. Both artworks are landscape portraits inspired by the breathtaking Utah mountains. Through these paintings, I experimented with new techniques and aimed to express myself uniquely. I had a lot of fun experimenting with my color palette and visual mixing techniques while creating both of these paintings. Through this presentation, I aim to demonstrate how you can find purpose in your artwork while also enjoying the creative process.

Authors: Nawres Al Saud. Mentors: Alexandra Giannell. Insitution: Utah Valley University. My work beautifully embodies the concept of oneness in diversity by seamlessly blending various elements, perspectives, and voices into a harmonious whole. Like a symphony of colors, my art celebrates the rich tapestry of human experience and the interconnectedness of all things. It serves as a powerful reminder that despite our differences, we share a common humanity. My work is a testament to the idea that diversity is not a source of division but rather a source of strength, resilience, and creativity. It encourages us to embrace the uniqueness of each individual and culture while recognizing the threads that unite us, ultimately emphasizing that we are all part of a larger, interconnected whole.

Authors: Kessley Durrant. Mentors: Alexandra Giannell. Insitution: Utah Valley University. I am doing research on Our Lady of Guadalupe, her significance to Mexican culture, and the Aztec goddess she was transformed from. As a Mexican who grew up Catholic, Guadalupe is an important symbol to me, and such an integral part to Mexican culture. Before she was Guadalupe she was known as Tonantzin. She presented herself to Juan Diego when he was lost in the desert and hopeless. She told him that she would change to save her people. Tonantzin means Our Mother, Mother Earth. The giver of life and she changed in order to save her people. She became Guadalupe. She told Juan Diego that her robe would be the night sky and she would protect all her children from the misdeeds that were being forced on them. So, her symbol is a sign of safety, where people would go when they had nowhere else to turn. It was a way for the Aztec culture to live on in secret and for our culture to grow in the only way it could. I want to be able to represent her as a Goddess before she transformed into Our Lady Guadalupe. I want to open up the conversation with my fellow Mexicans and start getting closer to our roots and understanding our culture better before the conquistadors. I also want to be able to teach others of our culture and the changes that occurred.

Authors: Silvia Medina. Mentors: Alexandra Giannell. Insitution: Utah Valley University. Often times growing up we tend to go through different phases or versions of ourselves until we find one that we truly resonate with. We always retain the older versions, as they still tend to peek out from time to time in different aspects of ourselves. With this piece, I wanted to demonstrate my growth and progress, and how it takes all versions of myself and all my experiences when it comes to being who I am today.

Authors: Jessica DeWeese. Mentors: Alexandra Giannell. Insitution: Utah Valley University. I have made it my goal to try as many mediums as I can, both because it's exciting, and to improve and find my artistic passion. As I have started this journey with the few mediums I have tried, I have learned some things about failing. You always fail in the beginning, but the faster you fail, the faster you learn a better way. I will be sharing failures and successes in various mediums.

Authors: Brittany Cowley. Mentors: Meaghan Gates. Insitution: Utah Tech University. Art, to me, is an experience, one in which an object, sound, or movement has the ability to evoke an emotion in the viewer, taking them from spectator to participant. Since the first time I laid hold of a ball of clay, I could feel its life and ability to be transformed. This organic material has the potential to become whatever someone can dream up. For the true meaning behind the art piece to come forth and pass to the viewers, a sculptor must fully understand what they are trying to convey and how to best accomplish that. Through sculpting and directing the clay, a form takes place. This is just the first step on the path of creating a sculpture that can evoke emotion in the onlooker. Gestures, textures, and glazes are all added to enhance the feelings of the creator.Franz Xaver Messerschmidt created a series of “Character Heads”. I first came across his work at the Getty Museum when I came face to face with The Vexed Man. Mesmerized by this face, I became fully aware that I had become a participant in his sculpture. The bust of this man is elegantly carved with great care yet reveals the most unusual expression. The nose is scrunched up, eyes tightly shut, and mouth drown into an almost pouty frown. On display at this museum of elite, prestigious sculptures, is a piece that at first glance seemed unsuited to occupy the space, yet through the dichotomy displayed it evoked lasting emotions within me. I have discovered a joy in portraying dichotomous relationships in my own work. This relationship is the marriage of two opposing concepts in one piece. A brightly colored, playful child in the process of self-harm or two decomposing hands embraced in a tender touch can speak emotional volumes to the viewer. The thought-provoking questions that run through their minds allow viewers to start participating in the sculptures. Working alongside my mentor, an expert in the field of emotional sculptures, Professor Gates, I seek to more fully explore the world of conflicting emotions in my sculptures. I will be looking into what dichotomies in different forms produce strong emotions when placed alongside one another. Additionally, I am exploring what glazes and textures can be added to enhance the emotional exchange between the creator and the participant. Within the world of ceramics, glazes are used to add texture, color, sheen, and durability to the fired clay. I believe they can also enhance emotions as well. Through creating sculptures that demand the viewer to stop, take a second look, and question, I hope to enable people to reflect on what they are viewing and see their reality more clearly.

Authors: James Blood, Nathan Sheets, Chase Seiter, Lydia Hawley, Erin Taylor, Eliza White, Hillary Wadsworth, Jason Hansen, Jordan Yorgason. Mentors: Jordan Yorgason. Insitution: Brigham Young University. Microglia are the immune cells of the brain and are activated by many drugs of abuse. One drug of abuse of interest is methamphetamine, which is known to increase reactive oxygen species (ROS). Microglia are sensitive to ROS. Methamphetamine changes microglia morphology. To determine if the effects of methamphetamine on microglia are through ROS, glucose oxidase, which reacts with glucose to form hydrogen peroxide, was applied. Glucose oxidase increased ROS production and decreased dopamine release but had little-to-no effect on ATP release. Glucose oxidase has similar effects on microglia morphology compared to methamphetamine. This suggests that methamphetamine effects on microglia are due to ROS production. Methamphetamine locomotor sensitization behavioral experiments were run to mimic repeated methamphetamine exposure. Along with voltammetry experiments to measure dopamine and ATP release, methamphetamine treated animals were used to detect microglial morphology changes using confocal microscopy. Our methamphetamine treatment was able to change microglial morphology compared to saline treated controls. Methamphetamine injected animals also had attenuated glucose oxidase effects on dopamine release. By understanding how neuronal outputs affect microglia activity in the context of psychostimulant use we can better parse out how the mechanisms of addiction are connected to immune system function.

Authors: Samuel Stearman, Benjamin Crapo, Antonio Trujillo. Mentors: Jeff Hill. Insitution: Brigham Young University. Our goal at BYU SMASH IT lab is to improve patient’s mobility in rehabilitative settings. For this purpose, we’re modeling the human arm to aid in our design of wearable rehabilitative sleeves. We are investigating methods for manipulating elbow flexion and extension using an assistive elbow brace, such as through cable-driven movement and the less used concept of tensegrity. The appeal of these methods is their flexibility, lightweight, and multiple degrees of freedom in movement. In the prototyping stage we’ve created a test stand resembling a human arm that we use to evaluate how our elbow brace would interact with the wearer and measure the forces between the arm and the brace. Measurements from these tests will aid in our design of a future elbow brace. Knowledge gained from this work has the potential to apply to other joints, each with their own rehabilitative and other uses.

Authors: Jessica Crook, Brooke Parker, Michael C Rotter. Mentors: Michael C Rotter. Insitution: Utah Valley University. Fremont cottonwoods are a foundation species throughout the Wasatch front. Cottonwoods face a competitive threat from the invasive tamarisk, which grows very easily in the same habitats. Tamarisk can have a negative impact on cottonwoods, displacing them. The loss of cottonwoods could have negative impacts on ecosystems. This study will examine phytochemical compounds in cottonwoods, and how they are affected by growing in competition with tamarisk. We hypothesize that cottonwoods growing in competition with non-native tamarisk will be stressed and produce higher levels of phytochemical compounds. To test our hypothesis, cottonwoods were grown in pots from cuttings either in competition with a tamarisk cutting, or alone. We then tested total phenolics using a ferric chloride solution, and tannin content using a radial diffusion method. It’s predicted that due to the stress of competition, cottonwoods that grew with tamarisk will have higher overall phenolics and tannins than cottonwoods that were grown on their own. The results of this trial could be important in influencing beaver foraging patterns. Since beavers prefer trees with elevated levels of phenolics and other phytochemicals, this could imply an important mechanism allowing tamarisk to invade an area by stressing cottonwoods and encouraging beaver foraging on these plants.

Authors: Dean Peterson. Mentors: John Chaston. Insitution: Brigham Young University. The microbiota of Drosophila melanogaster fruit flies can be observed to study their effects on fly phenotypes. This paper will focus on the microbiota’s effects on fruit fly dietary preference for yeast (DPY), to determine if specific nutritional molecules produced by the microbiota control DPY. Previous studies have unsuccessfully sought to identify such small molecules by testing for roles of essential amino acids (Leitao-Goncalves 2017). A study completed in our lab suggested that bacterial thiamine biosynthesis/metabolism genes influence fly DPY because mutations shifted the preference from a diet with less yeast to a diet with more yeast (Call 2022). In our first efforts we found that raising flies on thiamine supplemented diet influenced their DPY. I want to determine if supplementing thiamine specifically causes this shift, and if the shift observed in the mutants is seen due to a lack of dietary thiamine. Here, I will perform the same tests with flies given diet supplemented with other B vitamins to test specificity. I will then confirm the role of bacterial thiamine on these phenotypes by rearing flies colonized with bacterial thiamine biosynthesis/metabolism mutants on thiamine supplemented diets. If these flies raised with increased dietary thiamine prefer a diet with less yeast, and the experiment with other B vitamins does not show a similar shift as thiamine, then the specificity of thiamine as the small molecule involved in yeast preference is confirmed.

Authors: Porter Bischoff, Kody Garrett, Clayton Rawson. Mentors: Britt Wyatt, Josh Premo. Insitution: Utah Valley University. This research delves into the underexplored territory of medical experiences and their potential impact on undergraduate students' motivation in STEM courses. While prior studies have focused on factors like gender and ethnicity in STEM, little attention has been given to the influence of medical experiences and chronic conditions on STEM students, despite evidence suggesting that students with medical conditions face unique challenges in completing their degrees.Our study specifically investigates the effects of medical experiences and chronic conditions on students enrolled in science classes at an open enrollment institution. We hypothesize that increased academic interruptions due to medical experiences may lead to decreased science motivation, reduced sense of belonging, self-efficacy, and self-determination.Data was collected from 390 students across 14 biology courses, including non-majors, at a teaching-focused institution, both before and after the courses. Surprisingly, 57% of surveyed students reported having a medical experience, and 22% reported having a chronic condition, highlighting the significance of this identity within the student population.As anticipated, students experiencing more medical interruptions exhibited a notable decrease in their sense of belonging and self-efficacy, albeit with a small effect size. Intriguingly, students with medical experiences who engaged more with science demonstrated significantly higher levels of science immersion and motivation. This suggests that medical experiences can influence student engagement with science, both positively and negatively. The impact of these interruptions on a student's academics is closely linked to their sense of belonging and self-efficacy. However, if medical experiences drive increased engagement with science, students may find themselves more motivated to explore these experiences within the context of scientific inquiry.Understanding how medical experiences can shape students' motivation is essential as science instructors adapt their course content and pedagogy to be more inclusive, embracing the diverse identities within their student population.

Authors: Jakob Lenker, Trevor Kendrick. Mentors: Jeff Tessem. Insitution: Brigham Young University. Diabetes is characterized by a loss in beta cell function within the pancreas and the subsequent inability to produce sufficient insulin to regulate blood glucose. While current diabetes treatments focus on delivering pharmaceutical insulin to diabetic individuals, such treatments are temporary solutions and do not address the root of the issue. Instead, our research focuses on potential mechanisms for inducing greater insulin secretion within the pancreas of the individual. NK6 Homeobox 1 (Nkx6.1) is a major transcription factor in beta cells and its overexpression in beta cells is associated with higher insulin secretion. We have shown that Syntaxin 1A (Stx1A) interacts with Nkx6.1; Stx1A is of particular interest due to its role in mediating insulin granule fusion at the beta cell plasma membrane, directly impacting insulin secretion. We hypothesize that the interaction between Nkx6.1 and Stx1A may play an important yet understudied role in insulin secretion. Here, we present the results of Stx1A overexpression on glucose-stimulated insulin secretion within pancreatic beta cells, as well as the effect on the Nkx6.1 interaction. Understanding more about the role of Stx1A in beta cells could provide therapeutic targets to induce greater insulin secretion, which could aid in the effort toward finding a cure to diabetes.

Authors: Brett Pickett, Lincoln Sutherland, Jacob Lang. Mentors: Brett Pickett. Insitution: Brigham Young University. Introduction: Breast cancer is one of the most prevalent types of cancer present in society today, and is the second leading cause of cancer death for women. Approximately 13% (1 in 8) of women will develop invasive breast cancer, with 3% of women (1 in 39) dying from this type of cancer. Three important classifications used when formulating a treatment plan for breast cancer are the presence or absence of Estrogen Receptor (ER), Progesterone Receptor (PR), or Hormone Receptor (HR). Treating Estrogen Receptor Positive (ER+) breast cancer with aromatase inhibitors, such as Letrozole, is the current standard treatment for all postmenopausal women. A prior study by Lee et. al. identified PRR11 as the only gene that was significantly overexpressed in resistant vs non-resistant cancers among the 51 genes in chromosome arm 17q23. The goal of the current study is to perform a secondary analysis of this valuable dataset to identify genes, signaling pathways, and biomarkers across the whole human transcriptome that are significantly associated with treatment resistance in ER+ patients.Methods: We retrieved, preprocessed and analyzed 58 ER+ breast cancer samples from patients who had been treated with Letrozole, which are publicly available in the NCBI Gene Expression Omnibus (GEO) database. The Automated Reproducible MOdular Workflow for Preprocessing and Differential Analysis of RNA-seq Data (ARMOR) was used to process our data downloaded from NCBI. This workflow trimmed low quality reads from the RNA-sequence reads, mapped and quantified our data to generate a DEG list. Gene ontology enrichment with camera was also performed. Next, the genes were mapped to common gene identifiers and input to the signaling pathway impact analysis (SPIA) algorithm to identify intracellular signaling pathways that were enhanced by our DEGs. With that information, Pathway2Target was used to identify known drug targets within our identified pathways. Finally, a decision tree-based machine learning approach was used to predict features/expressed genes that could be used to most accurately classify responders vs nonresponders to Letrozole. Results: Our comparison of 36 responders versus 22 non-responders detected a total of 18,735 genes and identified 105 that were statistically significant (p-value < 0.05) after applying a false-discovery rate (FDR) correction, including SOX11, S100A8/S100A8, and IGLV3-25. We then used the Signaling Pathway Impact Analysis (SPIA) algorithm to determine whether any known intracellular signaling pathways were significantly enriched in DEGs (Bonferroni-adjusted p-value < 0.05). This analysis identified 4 pathways that were statistically significant in Non-Responders to Letrozole Treatment. We then used the pathway results to predict 60 existing therapeutic targets that could be repurposed to treat the resistance phenotype. Notably, the predicted targets for the non-response phenotype included VEGFA, a current target for solid tumors as well as ESR1, an Estrogen Receptor. We next wanted to determine whether we could predict transcriptional biomarkers that could aid with identifying patients that do not respond to treatment. To do so, we used the read counts for all samples as the input for this analysis and identified 278 transcriptional biomarkers. Performance metrics for all biomarkers identified yielded an area under the receiver-operator characteristic (AUROC) curve of 0.972 (Figure 2), indicating an exceptional ability to classify Letrozole responders vs non-responders by the transcriptional profile. Sensitivity for all transcriptional biomarkers was measured at 100%, and specificity at 94%. We used the top two biomarkers from our first analysis as input for a second analysis to determine the performance of a smaller subset. Our second analysis determined that PRDX4 and E2F8 together yielded an AUROC of 0.823 and an overall accuracy of 88.2%. Discussion:Our results identify additional DEGs, pathways, targets and biomarkers for further exploration in the treatment and categorization of ER+ breast cancer.

Authors: Eden Beazer, Aubree Bench, Ethan Jones, Jared Carter. Mentors: Jeffrey Tessem. Insitution: Brigham Young University. Incidence of diabetes worldwide has grown from 108 million people in 1980 to 422 million people in 2014, nearly tripling in just thirty-four years. Type 2 diabetes (T2D) is characterized by the loss of pancreatic beta cell mass and the failure of the remaining beta cells to provide adequate insulin. Contributing to the development of T2D is glucolipotoxicity (GLT), a condition characterized by the harmful elevation of glucose and fatty acid levels within beta cells. While there are existing treatments for symptoms of diabetes, much remains to be understood about its underlying causes and effective preventative measures. Flavonoids are naturally occurring phenolic compounds found in many fruits and vegetables that have various anti-inflammatory health benefits. Previous studies suggest that epicatechin, a flavonoid present in cocoa, can reduce the effects of diabetes by diminishing insulin desensitization and increasing glucose stimulated insulin secretion (GSIS). Interestingly, the bioavailability of epicatechin is poor, while its metabolites are more easily absorbed in the small intestine. Further studies demonstrated that under non-stressed conditions in beta-cells, hippuric acid, homovanillic acid, and 5-phenylvaleric acid, metabolites of epicatechin, stimulate insulin secretion at concentrations more realistically found in the body. However, the effects of these metabolites in glucolipotoxic conditions are unknown. Here, we present the effects of epicatechin and its metabolites hippuric acid, homovanillic acid, and 5-phenylvaleric acid on beta cell insulin secretion and mitochondrial respiration under GLT culture conditions. This study aimed to contribute to the limited body of knowledge on the bioactivity of flavonoid metabolites on beta cell function under damaging conditions observed with T2D, offering crucial insights for developing effective strategies to harness the health benefits associated with flavonoids.

Authors: Evelyn Fuentes, Thomas Keate, Christian Riordan. Mentors: Aaron Davis. Insitution: Utah Tech University. Studies predict that extreme weather events, due to climate change, are expected to increase in frequency and magnitude. Specifically, the flooding impacts from a hurricane may lead to the loss of necessary infrastructure, such as water treatment plants, leading to the loss of drinkable water. In response we, as a multidisciplinary team, have developed a purification device that is able to effectively filter water to allow communities and families, without available infrastructure, to receive drinkable water. We are testing different processes of filtration to find the most efficient and cheapest method. This process of filtration would be possible due to a foldable solar array that would power a pump to push water through a filtration system. The solar array would supplement other disaster relief options due to its ability to be used without constant supervision, and it would be capable of continuous, reliable use. This device would allow for the production of drinkable water in the event that water purification infrastructure was down, but grey water was available. The solar array and water purification device would be portable for fast deployment, with options of building a larger device, as part of a disaster relief preparedness package. If successful, this device has the potential to increase disaster preparedness and save lives through providing clean water.

Authors: Owen Damitz. Mentors: Jeffrey Tessem. Insitution: Brigham Young University. Type one and two diabetes affect the everyday lives of millions of people worldwide. These diseases are characterized by decreased functional beta cell mass. Functional beta cell mass is defined by the beta cell’s ability to proliferate, secrete insulin, and resist apoptosis. Wehave shown that the orphan nuclear receptor Nr4a3 is sufficient to induce beta cell proliferation. We have sought to define compounds that can interact with and modulate Nr4a3 activity. Using AutoDock Vina we have defined a number of compounds that interact with Nr4a3. Here wepresent data demonstrating the ability of these compounds to modulate Nr4a3 mediated proliferation, survival, and insulin secretion in the beta cell. Furthermore, we demonstrate the effect of these compounds to modulate Nr4a3 transcriptional control. These findings are the basis for developing interventions to increase functional beta cell mass as a treatment for type 1 and type 2 diabetes.

Authors: Rob Patterson, Nate Graham. Mentors: Sally Rocks. Insitution: Utah Valley University. The pervasive use of pesticides in agricultural practices has raised environmental concerns due to their potential to contaminate water bodies and affect aquatic ecosystems. This study focuses on the identification and quantification of three common pesticides—atrazine, 2,4-dichlorophenoxyacetic acid (2,4-D), and dichlorodiphenyltrichloroethane (DDT) in Utah Lake.. Utilizing advanced chromatographic and spectroscopic techniques, including Gas Chromatography-Mass Spectrometry (GC-MS) and High-Performance Liquid Chromatography (HPLC), we aim to detect the presence and determine the concentration levels of these substances. Water samples were collected from multiple points around the lake to assess the spatial distribution of the pesticides. The method development involves optimization of sample preparation procedures, including solid-phase extraction (SPE) and cleanup, to increase the detection sensitivity and accuracy. This project enhances environmental monitoring and has implications for water quality management, regulatory compliance, and public health in the region. The anticipated results will contribute to a better understanding of pesticide pollution patterns and will aid in formulating strategies to mitigate the contamination of aquatic environments.

Authors: Aubrey Russell, Ben Paepke, Nathan Goldfarb. Mentors: Nathan Goldfarb. Insitution: Utah Valley University. Tuberculosis (TB) remains an insidious scourge of civilization. The causative agent, Mycobacterium tuberculosis (Mtb), is a global health crisis, and TB ranks as the second leading cause of death from an infectious disease worldwide after COVID-19. In 2021, there were approximately 1.6 million deaths reported from TB (including 187,000 people with HIV) and an estimated 10.6 million new infections. Additionally, multidrug resistant TB remains a public health crisis. An initiative of “The Global Plan to End TB” is the development of rapid, point-of-care diagnostic assays for the early diagnosis of TB.2 Here we present our initial efforts towards the goal of the development of a rapid, lateral flow assay (LFA) for the detection of Mtb.

Authors: Zach Fiore. Mentors: Jared Nielsen. Insitution: Brigham Young University. Gait apraxia is a type of apraxia that affects lower limb use in walking. It is characterized by difficulty initiating gait, freezing of gait, and other gait disturbances that cannot be attributed to complications affecting sensory, motor, or cerebellar function, psychiatric disease, nor ataxia. Symptoms often present following brain trauma. Previous research has indicated that gait apraxia may be linked to lesions in the frontal lobes, basal ganglia and supplementary motor area. However, the specific cerebral location has been debated with minimal research done on the symptom’s implicated neural circuits. The purpose of this study is to determine the networks in the brain that are involved in the pathophysiology of gait apraxia. To determine this, we used the lesion network mapping method. A systematic literature review was performed, with specific inclusion criteria, to find case studies of patients presenting with gait apraxia stemming from acquired brain injury (n=15). Lesion network mapping analysis (Fox et al., 2018) was performed on 15 cases with a large cohort of healthy control resting-state scans (n=1000). The analysis showed that lesions exhibited functional connectivity to the bilateral medial dorsal and pulvinar nuclei of the thalami (n=15), which supports previous associations of basal ganglia damage contributing to gait apraxia. A novel region, the cingulate cortex (n=15), was also found to be functionally connected to the lesion networks. This region is a part of the cingulo-opercular network, responsible for many functions, including action. This network has recently been found to display strong functional connectivity with the somato-cognitive action network, responsible for coordinating movements with cognitive processes. Further research is necessary to determine the mechanism of how these networks interact in contributing to gait apraxia.

Authors: Joshua Hutchins, Kevin Wong. Mentors: Dario Mizrachi. Insitution: Brigham Young University. Tight junctions (TJ’s) are composed of mainly three types of cell-adhesion molecules (CAMs) that regulate paracellular permeability in epithelial and endothelial cells. These are claudins (CLDNs), occludin (OCLN), and junctional adhesion molecules (JAMs).There are, however, several (27) isoforms of the claudin molecule, all of which are suspected to have different strengths and other properties in cell adhesion. Currently, the comparative strength of the interactions between different CAMs are unknown and no easily replicable model of a TJ has been created. To address this question we resourced to bacterial expression of these mammalian proteins. MG1655 E. coli cells (with flagellum) were transformed to express claudins 1, 2, 3, 5, and 10 as well as occludin and plated on 0.2% agar plates, allowing them to swim overnight. This allowed for a qualitative spectrum of strengths of the CAMs based on how far the cells were able to spread throughout the plate. Cells that interacted strongly swam less. This technique was applied to the case of the Atlantic Salmon. It swims both in fresh and ocean water. As it transitions, the TJs in its skin changes its composition of claudins. We were able to determine that the set of claudins employed during ocean water swimming are capable of stronger strength. This is consistent with the changes in osmolarity dictated by the amount of solute in the ocean water.

Authors: Jacob Adams, Larry Catalasan. Mentors: Tianyi He. Insitution: Utah State University. Soft robotics is a field of robotics involving the controlled movement and manipulation of soft materials to fulfill tasks that standard robots cannot. In this project, we aim to create a soft robotic arm capable of movement by using a machine-learning algorithm to generate its subsequent moves. To fulfill this goal, the robotic arm is contained in a metal frame that has cameras monitoring its position. The camera feed is then processed through a machine-learning algorithm into instructions that can be used to pull various strings attached to the arm which will allow the arm to move. Currently, our team has finished building the frame/arm as well as software that can use cameras to map the position of the arm. The next steps in this project are to research and implement a machine-learning algorithm and write a program that can appropriately adjust stepper motors to pull the strings.

Authors: Melissa Wiggins, Aaron Bigelow, Porter Ellis. Mentors: Ronald Sims. Insitution: Utah State University. Ensuring that the hydrophilic coating of Merit Medical’s Prelude IDeal trans-radial catheter is necessary for its biocompatibility and patient safety. The current method for testing the coating involves a test using Congo Red Dye. The Congo Red Dye does work, but the dye is toxic and all tested catheters must be discarded after testing. The Conge Red Dye test results in wasted catheters. A new method for testing the coating uses fluorescent particles. First, fluorescent particles are added to the hydrophilic coating. These fluorescent particles can be easily visualized on the catheter using UV light. Thus, the uncoated portions of the catheter can be visualized as well. The coated catheters are placed into a black box that ensures only the catheter is being seen. A line scan camera is used to take pictures of every side of the catheter as the catheter spins. Photos of the scanned catheter are then linked together, showing the entire circumference in one picture. The catheter is ultimately tested by analyzing the full picture to find any uncoated regions. By using software to analyze the full picture, the size of uncoated regions is determined with greater accuracy. This new method allows for tested catheters to be used after testing and does not involve any toxic chemicals.

Authors: Chase Mortensen, Juhyeong Lee. Mentors: Juhyeong Lee. Insitution: Utah State University. Foldcore sandwich composites (FSCs) are constructed using multi-layered sheets folded in a desired pattern and placed between two thin face sheets. The choice of material geometric folding pattern provides a large design space to optimize the structural performance of FSCs. These composites are typically made of carbon fiber reinforced polymer (CFRP) composites, offering lightweight and high-energy-absorbing properties. This work aims to characterize the size effects of unit-cell foldcores by analyzing the influence of subscale foldcore models subjected to periodic boundary conditions under quasi-static compression. Three Miura-based unit-cell foldcore models were considered: (1) 1×1, (2) 1×2 (two 1×1 unit-cell foldcores connected in parallel), and (3) 2×1 (two 1×1 unit-cell foldcores connected perpendicularly). Through finite element modeling, three key findings were derived: 1) the finite element model closely replicated experimental results; 2) the application of periodic boundary conditions had an insignificant impact on subscale foldcore models. Third, inconsiderable variations in stress and damage were observed primarily along the foldcore creases when unit-cells were placed in parallel.

Authors: James Walker. Mentors: Pania Newell. Insitution: University of Utah. During the COVID-19 pandemic, the discussion of using fibrous porous materials in the context of face masks has gained significant relevance. These materials consist of networks of fibers that are intertwined through weaving, knitting, or bonding, creating a structure with interconnected pores that facilitate the transport of gasses and liquids. When a face mask is used, it is under tensile stresses that can greatly affect its longevity and behavior, and simulating the behavior of the fibers within the mask under this loading is essential in enhancing its robustness. Numerical analysis involving fibrous porous materials is challenging due to their inherent randomness and anisotropy, however. The models we use need to accurately represent the entire mask, which we achieve using a small cubic cell known as a representative volume element (RVE). In this study, we systematically investigate the role of fiber diameter, fiber cross sectional shape, and RVE size on the mechanical properties of various RVEs using a computational framework built on the finite element method. The RVEs themselves are idealistic, but useful networks of polypropylene fibers that are orthogonally intersected within cubic boundaries. Our results show that once an appropriate RVE size was determined with constant porosity between systems, the stiffness of the samples increases as the cross-sectional shape progresses from a triangle to a square, to a pentagon, etc., largely due to the increases in intersection volume between fibers. We also found that increasing the diameter serves to increase material stiffness. This project not only offers insights into designing more robust face masks but also provides novel tools that can be used for designing other fibrous porous materials.

Authors: Sophia Hessami. Mentors: Elizabeth Vargis. Insitution: Utah State University. Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. During later stages of AMD, immature blood vessels penetrate Bruch’s membrane and release fluid into the subretinal space. This process is referred to as choroidal neovascularization (CNV). Current in vitro models of retinal tissue are limited, so we propose a three-layered microfluidic model of the subretinal tissue, consisting of retinal pigment epithelium (RPE), Bruch’s membrane (BrM), and choroid. We have produced models of BrM using hagfish proteins that are more mimetic to the nonporous, proteinaceous BrM that is seen in vivo. Then, we fabricated a three-layered microfluidic device using the BrM models and polydimethylsiloxane (PDMS). Once the devices were assembled, porcine primary RPE were isolated, cultured, and characterized in the upper channel of the microfluidic device. Going forward, HUVECs will be cultured and characterized in the lower channel of the device. Then, primary RPE and HUVECs will be co-cultured and characterized within the device. The result will be a multilayered microfluidic device containing primary porcine RPE, hagfish protein BrM models, and human umbilical vein endothelial cell (HUVEC) choroid. It is expected that RPE protein secretions will diffuse through the BrM models and initiate interconnected vascular network formation in the endothelial cells. In the future, we will induce chemical hypoxia to turn this model into a diseased model of the subretina. We hypothesize that this in vitro model of the subretinal tissue will lead to a better understanding of the mechanisms of CNV initiation and progression in AMD.

Authors: Alisa Dabb, David Britt, Elizabeth Vargis. Mentors: David Britt. Insitution: Utah State University. Cytomegalovirus (CMV) is the leading infectious cause of birth defects in the United States. CMV is typically treated with ganciclovir, an antiviral medicine that inhibits the virus. However, ganciclovir also inhibits the growth of neutrophils, a type of immune cell, which leaves the patient vulnerable to other viruses and diseases. To combat the toxic effects of ganciclovir, a subtherapeutic dose of ganciclovir can be used with the combinatorial treatment of quercetin and poloxamer 188 (P188) while maintaining the same level of antiviral activity. Quercetin is a hydrophobic natural flavonoid with antiviral properties that is found in many fruits and vegetables. P188 acts as the delivery vehicle for quercetin and is an FDA-approved polymer that targets the mitochondria in a cell. This study examines two delivery vehicles—P188 and Dimethyl Sulfoxide (DMSO) to optimize the combinatorial treatment of quercetin and ganciclovir.DMSO is a solvent for both polar and nonpolar compounds. DMSO is beneficial for cell growth at low concentrations. Additionally, DMSO successfully delivers hydrophobic quercetin to infected cells, although it does not target quercetin delivery like P188. Targeting the mitochondria, like P188, could be valuable because one mechanism of CMV infection occurs when the virus attacks the mitochondria in an infected cell. This study aims to understand if mitochondrial targeted delivery of quercetin better protects cells against CMV infection compared to non-targeted quercetin delivery.

Authors: Alberto Miranda, Samannoy Ghosh, Yong Lin Kong. Mentors: Yong Lin Kong. Insitution: University of Utah. Microscale robots can impart a broad range of functionalities in the biomedical domain that can be leveraged to address unmet clinical needs, including noninvasive surgery and targeted therapies. Conventional robot navigation methods typically involve specific gaits suited for certain environmental conditions. However, implementing the same conventional methods inside a human body is highly challenging. As the human body is a complex and dynamic environment, a microrobot must adapt to these complex and challenging environments to perform targeted studies. Previous research demonstrated an integration of an untethered, 3D-printed three-linked-sphere crawler with a model-free reinforcement algorithm. The work done with the theoretical Najafi–Golestanian three-linked-sphere mechanism was its first experimental integration with a reinforcement learning algorithm as a relatively simple and highly scalable self-learning robot that can navigate in unconfined and confined spaces. The progress presented in the current research is a direct continuation of the previous work on the 3-linked-sphere crawler. While the previous work focused on developing a proof of concept for adaptive gait learning for the crawler, the current work focuses more on the challenges of implementing the robot in a low Reynolds number fluid medium. Our current research hypothesizes that a self-learning autonomous system could demonstrate successful gait adaptation in a low Reynold’s flow environment. The design of our robot has been significantly improved to make it sustainable for extended use under viscous fluids. The research presented outlines the work that has been done to transition the robot from a crawler into a swimmer, the challenges that have been faced, and how they have been addressed. Successful implementation of this 3-sphere-swimmer will be a step forward in integrating machine learning tools into microswimmers for autonomous gait adaptation inside the human body.

Authors: Ethan Layne, Tareq Hassan. Mentors: Juhyeong Lee. Insitution: Utah State University. A key design criterion for aerospace structural applications is specific mechanical property (i.e., mechanical property divided by the density of a material). Honeycomb sandwich panels which are commonly used in aerospace/aviation structural applications provide lightweight performance, however they have several drawbacks. They include (1) limited alteration of core geometric parameters, (2) few core material selections, and (3) a closed-cell core network. These limitations may be bypassed with 3D-printed lattice-core sandwich panels to provide customizable structural performance. This study investigates impact resistance of architectured sandwich panels designed with various core designs and infill densities. A series of 5~20J low-velocity impact (LVI) tests will be performed on 3D-printed ABS sandwich panels with honeycomb, gyroid, and triangle cores; with infill density varying from 5% to 15%. In this work, the effects of core geometry and corresponding infill density on LVI resistances will be studied to optimize the structural performance of 3D-printed ABS sandwich panels. The primary objective of this study is to characterize these novel sandwich structures with highly customizable 3D-printed complex cores, offering tailorable structure performance.

Authors: Josh D Gubler, Connor D Olsen, Fredi R Mino, Mingchuan Cheng, Jacob A George. Mentors: Connor Olsen. Insitution: University of Utah. The long-term goal of this research is to investigate how lower sampling rates of electromyographic (EMG) signals affect the performance of classification and regression algorithms. EMG signals measure the electrical activity of muscle contractions. Myoelectric interfaces can classify or regress features generated from the EMG signal to control devices like prostheses, exoskeletons, robotic systems, or human-computer interfaces. Most of the power of the EMG signal is contained between 50 and 500 Hz, and most recording devices sample EMG at 1 kHz with a 5-15 Hz high-pass filter and a 375-500 Hz low-pass filter. As myoelectric devices become wireless and integrated with wearable technology, reducing the sampling rate can substantially reduce battery consumption and processing power. We sampled EMG data at 30 kHz from the forearms of three participants while they performed six gestures. We then downsampled to rates ranging between 50-1000 Hz and calculated various EMG features from the downsampled data. We found significant effects for both EMG feature and sampling rate on regression performance of a modified Kalman Filter (p < 0.05, two-way ANOVA). The mean-absolute-value and waveform-length EMG features performed significantly better at low frequencies (<250 Hz) in contrast to zero-crossing, slope-sign-change, and mean-frequency EMG features (p < .05, multiple pairwise comparisons). Sampling rate also had a significant impact on the classification accuracy of a k-nearest neighbors algorithm (p < 0.05, two-way ANOVA). However, sampling rate had no impact on classification accuracy for a continuous Convolutional Neural Network (CNN) (p > 0.05, two-way ANOVA). Future work will validate the effectiveness of this CNN as a control modality when using downsampled EMG from wearable sensors. If proficient control can be achieved from down sampled EMG, this could substantially improve battery life and make EMG a more practical biosensor for wearable devices.

Authors: Elizabeth M J Allen, Steven P Allen, Henrik C A Odeen. Mentors: Steven P Allen. Insitution: Brigham Young University. BackgroundThe focus of this project was creating phantoms with customizable attenuation and stiffness for visualizing histotripsy lesions created with magnetic resonance guided focused ultrasound surgery (MRgFUS). Having phantoms with varying mechanical and acoustic properties is important because they affect cavitation and allow for testing of different histotripsy mechanisms. Creating a tunable phantom with red blood cells (RBCs) spread throughout it is valuable because it allows us to visualize High Intensity Focused Ultrasound (HIFU) lesions from MRgFUS in three dimensions throughout the gel.Materials and MethodsWe produced gels with tunable acoustic and mechanical properties by mixing 5 different ratios of evaporated milk and deionized water with 5 different ratios of agarose powder to create 25 different gels.Gel attenuation was measured using a through transmission setup and Young’s Modulus was obtained using a tensile tester in compression. The MR properties, including T1, T2, and T2* of each gel were also measured prior to creating histotripsy lesions.ResultsIn general, the agarose gels had an increase in attenuation as the amount of evaporated milk increased, and an increase in mechanical stiffness as the amount of agarose powder increased. They also provided excellent lesioning contrast for visualizing MRgFUS lesions.ConclusionsWe successfully created a series of tunable gels for visualizing MRgFUS lesions. These gels are also useful for characterizing ultrasound transducers and can be used to test emerging MRgFUS technology as it becomes more widely used and is further developed.

Authors: Cassandra DuBose Corry. Mentors: Elizabeth Vargis. Insitution: Utah State University. Age-related Macular Degeneration (AMD) is characterized by a blurring of the central vision and is one of the leading causes of vision loss in the United States. As a branch of the disease, exudative AMD is distinguished by retinal angiogenesis, when new blood vessels grow into the retina. Understanding retinal conditions that promote or discourage angiogenesis by using mathematical models can lead to improved understanding of disease progression and treatments. This discrete mathematical model presented here uses the theory of reinforced random walks to simulate the biological behavior of endothelial cells (ECs) as they leave a parent blood vessel and travel through the choroid and Bruch’s membrane towards the retinal pigment epithelial (RPE) layer. Cell behavior such as number of divisions and blood vessel coverage are analyzed for comparison to experimental observations. Pigment epithelium-derived factor (PEDF) is included and examined for its effect on the behavior of the ECs and its ability to prevent angiogenesis. This computational model provides novel insights into exudative AMD with parameters that can be adjusted to meet different needs.

Authors: Cassandra L Burdick, Caleb J Thomson, Troy N Tully, Jacob A George. Mentors: Caleb Thomson. Insitution: University of Utah. The long-term goal of this research is to decode fine motor intent from electromyography (EMG) of hemiparetic muscles. Stroke is the leading cause of disability in the United States, with 800,000 individuals experiencing a stroke each year. Eighty percent of stroke survivors experience hemiparesis. Severe hemiparesis immobilizes the arm, making it difficult to assess EMG control and motor function on traditional tasks. Here, we introduce a variant of the clinical Box and Blocks Test (BBT) of hand dexterity in virtual reality (VR) to assess fine motor function of EMG control in hemiparetic stroke patients with immobile arms. Our VR variant of the BBT allows individuals to control a VR hand to transfer VR blocks back and forth between two locations separated by a barrier. The VR hand can grasp, rotate, and translate based on EMG commands or other control signals received at 30 Hz via UDP communication. The forces exerted on the blocks and the location of the blocks and hand are logged to assess grasping precision, force regulation, and transfer rate. Multiple block sizes can also be used to assess dexterity with various grip apertures. The ability to assess EMG control in patients with hemiparesis can support the development of myoelectric orthoses. Practicing dexterous myoelectric control in VR may also help alleviate hemiparesis and expedite qualification for myoelectric orthoses.

Authors: Rui Jin, Lindsay C Rupp, Anna Busatto, Rob S MacLeod. Mentors: Rob S. MacLeod. Insitution: University of Utah. Introduction: The electrocardiogram is the most common tool to diagnose and assess cardiac conditions, such as rhythm abnormalities, myocardial ischemia, and heart failure. However, clinical diagnosis and management of heart disease are challenging due to the remote nature of body-surface electrocardiogram measurements, with a median accuracy of 67% among physicians. One approach to improve the accuracy of electrocardiography is to conduct mapping studies in which 10-100 catheter-based electrodes are inserted within the heart. The recorded signals provide more proximity and thus accuracy, but they also require specialized software to analyze, quantify, and visualize. We developed the Signal Processor for Electrogram and Electroanatomic Data (SPEED), a new, open-source, unified pipeline to facilitate effective signal processing and visualization of such cardiac-mapping signals.Materials and Methods: Our pipeline is based on two existing toolboxes, the Preprocessing Framework for Electrograms Intermittently Fiducialized from Experimental Recordings (PFEIFER) and OpenEP. PFEIFER is a toolset for sophisticated signal-processing of cardiac electrograms that allows the user to select semi-automatically fiducial markers, which are time points and intervals of interest within a heartbeat. OpenEP primarily accepts as input complete electroanatomic data, including both processed cardiac electrograms and spatial geometry; OpenEP also provides built-in functions for analyzing and visualizing cardiac electrograms, such as displaying potentials on the cardiac geometry. Since both software packages provide complementary workflows for managing electrograms, our goal was to integrate the two software packages and present it to the user as a new Graphic User Interface utilizing both applications simultaneously.Results: It was natural to develop SPEED in MATLAB as this is also the language used for both PFEIFER and OpenEP. The primary interface to SPEED incorporates a data-centric design such that the user can provide the electrogram and geometry files to be processed, and the algorithm automatically determines the applicable functions based on the input type. Since both PFEIFER and OpenEP can parse data into more interpretable open-source formats, the user can also export the processed data for further analysis in addition to visualizing and quantifying the data features. Through integrating both software packages, SPEED can support the following main functionalities: (1) in-depth filtering and processing of electrogram signals, (2) visualizing anatomic geometry and electrode locations, and (3) mapping three-dimensional potential and activation of cardiac electrophysiology.Discussion: SPEED offers the user a more thorough and unified workflow in the analysis of cardiac-mapping signals than either of its components. The user can utilize the functionalities of both PFEIFER and OpenEP simultaneously, allowing for a versatile and powerful processing pipeline. For instance, the user can extract key features from the recorded electrograms and visualize the location of the corresponding electrodes, a feature that was previously not possible. In addition, the open-source nature of the software packages allows the user to modify or expand the functions to better suit their individual needs. The software design of SPEED is still in the early stages; thus, as with most software, further development and user testing will follow to make the algorithms compatible with more data types and implement additional features. Conclusion: SPEED processes and displays the complex information in a clear and accessible way, allowing the user to perform subsequent interpretations and analyses more easily. SPEED can be used by research cardiologists to facilitate a more efficient workflow, as well as to improve the efficiency and accuracy of clinical diagnosis of heart diseases.

Authors: Lukas Keller, Jixun Zhan, Zhen Zhang. Mentors: Jixun Zhan. Insitution: Utah State University. Curcumin is a common dietary supplement found naturally in the plant turmeric (Curcuma longa). Native to South Asia, the turmeric plant has been an important component in Indian and Chinese folk medicine. Curcumin has long been known to be an effective antioxidant and possesses anti-inflammatory properties. In today’s world, curcumin is a common nutraceutical and plays a part in the billion-dollar supplement industry. However, production and extraction of this compound is difficult and uses vast amounts of resources to cultivate. One solution to produce natural products like curcumin is the use of metabolic engineering to synthesize the product in another organism. The USU Metabolic Engineering Lab has developed a synthetic metabolic pathway to produce curcumin from an amino acid inside genetically transformed E. coli. The use of metabolic engineering techniques can produce larger quantities of the desired compound in greater quantities and purities while using a fraction of the land, water, and energy. To inform the use of these techniques, a predictive computational pathway was developed and is being validated with experimental results. An effective model can help researchers and businesses by allowing them to accurately predict curcumin yield and concentration during production.

Authors: Abby Hoyal. Mentors: Kristen Arnold. Insitution: Weber State University. The United States is one of the most prominent locations involved in the exchange of children in human trafficking. There are very few outlets that take in recovered children help them receive the proper aftercare and help to gain an education to integrate them back into society. Research has shown that children learn most efficiently in spaces that are modular and flexible. In research conducted for habilitation centers for children, they discovered, “Planning flexibility and variability comfort children and parents, accessibility and emotionality for children visiting [these] centers.” (Kasper, Ilvitskaya, Petrova, Shulginova, 2019). It has also been found that learning levels are highest in spaces that allow the children to learn from their surroundings rather than by just the instruction alone. “An interior shall lead children to learn concepts from working with materials, rather than by direct instruction. [Interiors] should improve cognitive learning, promote independence, curiosity, decision-making, cooperation, persistence, creativity, and problem-solving.” (Manav, 2016). One of the key elements to properly educating children, as listed previously, is to promote independence. One of the ways that research has shown independence to be achieved through design is proper wayfinding elements should be implemented so that occupants do not have to rely on any other occupant to navigate the space. Researchers examined how different colors, light temperatures, and lighting brightness can provide a natural easiness to wayfinding for occupants. Results found, that “the use of cool colors and high brightness levels help people be spatially oriented.” (Hidayetoglu, Yildirim, Akalin, 2012). The Grove will be an Aftercare center that will provide refuge and educate child survivors of human trafficking in a modular environment that educates through the use of space and materials used, with an encouraging push for independence throughout the space due to proper wayfinding elements.

Authors: Morgan Watson. Mentors: Kristen Arnold. Insitution: Weber State University. In the United States, 1 child in every 26 seconds drops out of high school. Out of the 50 million children in America, that are school age, 15 million are unsupervised after school time. With children being at greatest risk between the hours of 3pm and 6pm, these statistics raise a huge red flag. This project’s purpose is to provide peace of mind to working parents, and success for children throughout their school experience and beyond. Research has proven that afterschool program environments are a successful tool used to positively shape and increase healthy behaviors and practices among children (Huang, 2013). School design can affect student behavior, development, and academic performance (Huang, 2013). A key factor in effective school environments is the appropriate use of color. Careful color application has proven to have positive effects on behavior and cognitive learning (Heliyon, 2022). In addition, children have a better school experience when given autonomy. Autonomy improves intrinsic motivation (Ford, 2016). Research suggests that wherever possible, design for autonomy be implemented as a way to support children’s growth and development (Sorensen, 2013). This can be applied through multi-purpose learning spaces and flexible classroom furnishings. Additional spaces for collaboration and creativity are needed to meet the needs of today’s students and hold their attention. Furthermore, autonomy in the classroom environment is supported by designated areas where children can express themselves and make the space their own. Potential areas for this include cubbies and classroom bulletin boards.

Authors: Hailey Packard. Mentors: Brandon Ro. Insitution: Utah Valley University. In the vast landscape of architectural mediums, the key to capturing clients' attention and ensuring a comprehensive grasp of a proposed project lies in the choice of rendering methods. This research endeavors to pinpoint the most effective communication medium through an experiment employing various rendering techniques. Four renderings of a single exterior façade will be crafted, each utilizing diverse media methodologies. To convert the renderings into quantifiable data an innovative approach involves subjecting the renderings to AI-driven algorithms, predicting where the human eye is drawn to in the images in the first 3-5 seconds superseding the influence of cognitive bias, and aiming to identify which of the images inherently captures the most attention. The research results will be examined and the significance of differences between rendering methods addressed. This research delves into the implications for architects, exploring how these findings may influence presentation strategies, considering potential impact of passing fads, taking into account the alignment of media style with architectural subject matter, and noting whether the experiment requires diverse architectural styles for optimal effectiveness. The current hypothesis regarding these results is that the images with contrast and hierarchy in the composition, such as watercolor renderings, will outperform the other methods. The overarching objective of this research project is to discern the most effective medium for capturing the client's attention when presenting architectural projects. Due to modern advancements that increase our access to an abundance of knowledge and techniques, architects and designers must make informed choices about how they present their ideas. By comparing these mediums and formats through these methods, this research will attempt to identify the most effective strategy for engaging clients and enhancing their comprehension of projects which will also aid in contributing to a clearer understanding of visual communication in the architectural field.

Authors: Desiree Ritchie. Mentors: Brandon Ro. Insitution: Utah Valley University. Both music and classical architecture have a strong foundation in proportion. Further research shows that the same systems of proportions are found in both areas. Common chords found in music can be translated into proportions found in architecture. For example, the octave has the same proportion as a 2:1 ratio. While there is a clear relationship, the question remains: does understanding one help in understanding the other? Does understanding music make one a better architect? Can designers benefit from musical instruction? To answer these questions, a comparative survey was conducted asking participants to determine which visual proportion best matched the sound heard. These questions range from basic chords and rectangles to a more complex comparison of the Fibonacci sequence to the golden ratio. The survey also asks about participants' background in both music and architecture, as well as general demographic questions. The demographics of the current survey are limited to students and faculty attending BYU and Utah Valley University, but further studies will provide a more comprehensive result. To analyze the results, a comparison will be conducted on the percentage of individuals who were correctly able to recognize the same proportions visually and audibly. This will then be cross-examined with the demographics, comparing those who have a background in music and/or architecture to those who do not. The expected result is that those familiar with one of the previously mentioned fields will better recognize proportions in both music and architecture. If this is proven true, it will show that having a background knowledge in multiple fields will help to create a more well-rounded and capable individual. It will provide insight on how to become better in one’s chosen field.

Authors: Alexia Trapier. Mentors: Brandon Ro. Insitution: Utah Valley University. I am studying architectural column orders and how they are interpreted by the average person. I chose this because I want to learn how people are drawn to the orders when looking at them so I may better understand the orders themselves, and how the world perceives them without an in-depth knowledge or understanding of their composition. I will be doing a comparison of three column orders via eye-tracking software. These consist of the doric, ionic, and corinthian orders. First, I will use the eye-tracking software over an image of each column capital on its own, afterwards I will run it again with all three images side-by-side. This process will help us discover which column order is preferred by the human eye, and why. I believe by doing these two comparisons we will learn which column order will draw the eye of its viewers, and how in-depth someone might look at the detailing of the capitals. I anticipate that the corinthian order may draw the most attention due to the higher level of detailing this capital contains. As a designer it is important to learn and understand what the human experience and interaction is with a building's design. To understand what your viewers prefer and how it makes them feel is important in the world of architecture. An architect doesn’t design for themselves, they design for others of the world, and thus, it is important to understand why people enjoy a certain amount of detailing, or proportionality. Although I’ve sampled at a small scale, it shows that there’s room for expansion into other aspects of design. I hope that through this research we can better understand why the classical orders are important to have in the world of design today and how they impact design in our world today.

Authors: Bronwyn Brown. Mentors: Ben Felix. Insitution: Utah Valley University. Architectural Analytique of the Thomas S. Monson Center Building with the Scamozzi Order at University of Utah

Authors: Samuel Weisler, Colton Korpi, Josh Lythgoe. Mentors: Aliki Milioti. Insitution: Utah Valley University. The Venice Project addresses the challenge of blending contemporary buildings into the well-established urban environment of Venice, a city well known for its rich architectural heritage. In a city with canals in the place of streets, where motorboats and gondolas are the main mode of transportation, seasonal flooding at high tide continues to become a greater environmental concern. The research centers on the documentation and preservation of these valued characteristics through an analytical and interpretative research approach. The primary focus is on aspects such as perception, harmony of open and enclosed space, and the seamless integration into the urban and environmental fabric.The unique design constraints were taken head on in creating the one of a kind ‘Ca’Meriggiare’, a luxury hotel that enriches Venice’s heritage. In lieu of fighting against them, the design embraces the environmental challenges posed by the periodic flooding of the city and transforms them into an integral part of the design. For instance, the flooding is harnessed to create a charming, arcaded entrance exclusive to hotel guests arriving by boat, providing a unique entry sequence unphased by rising or falling water levels.The expected result of the research is a successful fusion of a contemporary hotel with the rich historical context of the city. The innovative design allowed the periodic flooding to become an integral part of the hotel that added a charm and uniqueness to the guest experience. Ca’Meriggiare stands as a testament to the harmonious integration of historical preservation with environmental adaption that honors Venice’s heritage. This luxury hotel case study offers a holistic perspective on theoretical and design considerations, emphasizing the importance of integration within the environmental dimensions. Rather than viewed as an isolated instance, it provides an overarching framework for innovation that will apply to the evolution of contemporary architecture.

Authors: Sean Donner. Mentors: Brandon Ro. Insitution: Utah Valley University. A building’s function has historically been tied to its form. We see this in civic buildings, schools, churches, and homes. Many of those recognizable forms were abandoned with the modernist movement in the early twentieth century. Are these new forms still related to their functionality and can average people perceive a building’s functionality based on its form. Learning the opinions of the general public will enhance the architect’s ability to design for the people who will live and work in and around the buildings they design.This study aims to answer those questions by means of an online survey. To gain a wider demographic of survey takers, the survey is largely spread through social media where I have access to a wide variety of people across the globe and of differing generations and backgrounds. The survey has two types of questions. The first presents two pictures of buildings and asks the survey taker to tell which holds a specific function. The second question type presents a single building and four choices of building function. In both question types, all signage or other markings of building type were digitally removed from the photographs. The survey includes fourteen architectural functions ranging from single family homes to State Capitols. Each category includes traditional and modern examples. This variety in style will help to analyze whether there is a difference in the general public’s ability to perceive a building’s function if the building is traditionally designed or if it takes a more modern approach in design. Although this survey is still active, the expected results are as follows: Traditional forms are generally more easily discernable than modern designs. Some building forms are equally recognizable regardless of form. The stand outs from this list are schools and stores/shoppes.

Authors: Thomas Cryer, Brandon Ro. Mentors: Brandon Ro. Insitution: Utah Valley University. ABSTRACT: This study seeks to understand the visual elements of home design that attract the human eye. Specifically, it aims to compare the visual appeal of traditional homes to modern homes using eye-tracking software. However, this study focuses solely on visual analysis, leaving the exploration of emotional and cultural factors for future research. The purpose is to understand the neurological connections between architectural design and human preferences, shedding light on which elements make homes visually appealing. In the mid-20th century, the architectural landscape shifted towards modernism, characterized by functionalism and minimalism. However, recent research suggests neurological links to architectural preferences that challenge modern design's dominance. This study is relevant today as it explores why people are drawn to traditional homes, considering the current preferences of professional architects. This research contributes to the understanding of how architectural aesthetics impact individuals and communities and offering insights into the neurological aspects that influence architectural preferences. The methodology involves analyzing six homes, three traditional and three modern. The analysis will be conducted using 3M Visual Attention Software individually on each home by tracking participants' eye movements, and then given a numerical ranking of 1-6 based on their visual appeal. Subsequently, a comparative analysis will identify the most and least visually attractive homes. Anticipated results from the software suggest traditional homes will score higher due to the "character," or the details that the eye looks, which are missing in modern architecture. The discussion will explore the idea that contemporary homes, by incorporating traditional elements such as proportion, may achieve higher appeal and last for generations of homeowners. Contemporary designs can evolve into "traditional" homes by aligning with the preferences discovered. By understanding what elements people are naturally drawn to, architects can create more appealing and lasting designs, thereby bridging the gap between modern and traditional aesthetics.

Authors: Roya Adham. Mentors: Kristen Arnold. Insitution: Weber State University. Given the frequency and severity of natural disasters and humanitarian crises, around the globe, the current refuge center at Salt Lake City faces critical challenges in providing sufficient support for its demand.Security and efficiency of indoor space are critical matters in designing a refuge center.the absence of confidentiality can lead to information leakage and compromise the security of the building. (Reinten, et al 2017). The room acoustics will impact the creation of positive communication and interaction for individuals who seek solitude and peace inside the building. Oasis Haven promised to serve as a haven to those in need, helping them to nurture and heal from their past traumas. According to recent research, organizing and laying out spaces, and putting directional signage and informational labels to guide individuals who don't know the language will effectively increase their satisfaction level with the space Jamshidi et al. (2020). Accessibility for all individuals in a space is an ultimate goal of the designers and we must ensure cohesive visual language and consistency throughout the entire design.additionally, it studied and proved the effects of color schemes on employees' task performance due to the healing effects of colors Öztürk, Yilmazer, and Ural (2012). color plays a significant role in creating a space that helps refugees feel more at home and provides a sense of belonging to them. certain colors may symbolize peace, warmth, or security in one culture, while they might have different connotations in another Öztürk, Yilmazer, and Ural (2012) we try to incorporate all those principles and get help from other elements such as natural and artificial light to create space that feels like a true home and provide a sense of stability and comfort to refugees during the times of transition and adjustment.

Authors: Andrea Tyler. Mentors: Kristen Arnold. Insitution: Weber State University. The golden thread that runs through this project is ART. The texture, color, shapes, movement, contrast and emphasis which exists in ART will be carried into the interiors. Through this adaptive reuse project, the interior emphasis will be on the historical architecture and will draw on the textures and details as the backdrop. By tapping into these details, the overall aesthetic will ground the visitor to the experience within the space. The ARTshare Project mission is to uplift artists, gather and unite community, and empower human beings through ART. According to research (Pilegaard, 2023) “exhibitions might be said to produce an atmosphere of its own, neither is detached from the architectural interiors’ existing atmosphere. Indeed, they are dependent on it.” Atmosphere, distance and proximity in museum spaces is how we experience space. Access to light, combined with color, improves alertness and affects the soul and spirit. Combinations of color and natural light by using different types of glass throughout the design will stimulate moods and will be incorporated into this environment. Each loop in the golden thread of this project will represent an area of commercial, hospitality, healthcare and residential. Baniyamin, 2020 says, “Researchers have shown that visual stimulation of nature, natural lighting, artwork, relaxing colours and therapeutic sound can greatly accelerate the therapeutic process”. The art therapy rooms place a high priority on privacy while providing a healing environment with light, biophilia and art. Just like artists rely on nature for inspiration, so will the residential condos. With access to views, air and light, the design will connect the resident with nature. The bistro is the air that the interior breaths, inhaling and exhaling, healing and connecting.

Authors: Mikayla Buckway. Mentors: Kristen Arnold. Insitution: Weber State University. Women represent half of the world’s population, and half of the worlds potential. Many of those women face hardships and issues with nowhere to turn for help. The adaptive reuse design build project was created in response to the non profit organization Haven and their need for a women’s center. The selected area and building are of historic beginnings and are centrally located for the best optimization of the center. The center is needed to have multiple different functions and uses. From safe temporary living spaces to counseling offices the main focus will be to cultivate healing, rejuvenation and learning in the space. Studies show that the built environment we chose to surround ourselves with impacts our wellbeing and can be the catalyst for a hastened or slowed recovery (Sternberg 2020). A range of different design elements will need to be incorporated in the space to ensure the goals of the facility are met. The use of nature, biophilia, color and acoustics in designing the physical environment has been shown to optimize health, wellbeing and performance of tenants. Utilizing these elements in the Haven women’s center will be a crucial part of creating the desired space. Using these positive stimuli will also assist in creating a less institutionalized space and more of a home for healing.

Authors: Tyler Peterson, Anna Jensen, Daniel Orr, Anton E Bowden. Mentors: Anton E Bowden. Insitution: Brigham Young University. Prior to approval for usage, spinal disc replacements undergo rigorous and costly tests to ensure that they will perform as designed once implanted. Wear testing, specifically, is one of the most important tests as any loose foreign particles can cause osteolysis of the surrounding tissue. Due to this, minimizing the wear experienced by a joint replacement is of extreme importance, however, wear testing is often done in latter stages of the design process as a functioning prototype is needed. These tests can be prohibitively expensive and adjustments to the prototype only add to the costs, thus a more accessible test to get an initial estimate of the wear is desirable. There are current methods employed to perform these preliminary test results, including the use of a Tribometer, which tests friction and wear. Benefits of using a tribometer are that it can control environmental factors that parallel the ISO testing standards, however, these devices cost thousands of dollars. In the present work, we designed a cost-effective preliminary testing apparatus that accurately recreates loadings that the implant will experience in flexion and extension, as well as lateral bending. The machine consists of a roller that can be loaded axially by compressing a spring to mimic realistic compressive loading conditions, and a motor that will move the roller to replicate spinal bending. The design incorporates a spring element to ensure that contact between the roller and the implant is preserved. Predictable, repeated motions achieved with this machine can provide early insights into the implant wear modes, which can facilitate iterative design improvements. Such knowledge early in the design process can save costs by reducing the need for major design changes in the late stages of product development.

Authors: Kevin Hart. Mentors: Brandon Ro. Insitution: Utah Valley University. Context, in the realm of contemporary architecture, holds a significant role. It encompasses the information that conveys an understanding of ideas, scenes, or objects. In a world marked by increasing individualism, the consideration of contextual elements in architectural design often takes a back seat. The Royal Ontario Museum serves as a notable case study. The addition of the Michael Lee-Chin Crystal, contrasting with the traditional backdrop, has ignited debates regarding its compatibility with the existing context. This brings forth a critical question: How does altering the contextual surroundings impact people's perceptions?Furthermore, would the public's perceptions differ if the Crystal were the original building, with the traditional structure serving as the addition? This study delves into the role of contextual factors in shaping the architectural experience. Through a comprehensive survey featuring diverse architectural styles situated in various contexts, my aim is to discern preferences: whether individuals lean toward statement buildings or designs that naturally integrate with their surroundings. My research hypothesis suggests that people derive greater enjoyment from buildings that seamlessly integrate with their contextual environment.The implications of these findings are of significant value to architects and designers. They provide insights to facilitate informed design decisions that not only promote community cohesion but also elevate the public's appreciation of architectural structures.