Benjamin Lindsay, Brigham Young University
Engineering
Current treatments for cancer and diseased tissue often cause severe side effects due to drug interactions with healthy cells. In order to minimize these effects, we are developing a nano-scale near-infrared (NIR) light-responsive drug delivery system based on liposome-encapsulated perfluoropentane (PFC5) emulsions with gold nanorods in the PFC5 phase. The nanorods efficiently convert NIR light to heat, vaporizing the liquid PFC5 emulsions, which have boiling points near body temperature. Emulsion vaporization increases the volume inside the liposome enough to burst the phospholipid bilayer and release encapsulated cargo. This system will allow continuous therapeutic drug release localized at the site of NIR laser irradiation with a low-power, portable NIR laser diode. To date, we have successfully loaded PFC5 emulsions with gold nanorods and have loaded liposomes with PFC5 emulsions. Previous work in our lab has shown that a release to the cytosol of cells can be induced by ultrasound using similar liposomes. Experiments designed to demonstrate NIR laser-induced cargo release are currently in progress. We will continue to improve upon this system over the coming months to increase release and decrease the required laser power.