Lauren Miller, Utah State University
Psychology
Affective disorders such as depression, phobias, schizophrenia, and post-traumatic stress disorder impairs the ability to time in the seconds-to-minutes range, i.e., interval timing. We investigated the effect of chronic administration of selective serotonin reuptake inhibitor fluoxetine (FLX) when anxiety-inducing task-irrelevant distracters are presented during an interval timing task. Given that some anti-depressants have beneficial effects on attention and working memory, e.g., decreasing emotional response to negative events, we hypothesized that FLX would decrease activation of amygdala and increase activation of prefrontal cortex. Our results revealed differential activation of amygdala and prefrontal cortex in FLX and vehicle treated rats corresponding to the expected changes in behavior. Results are discussed in relation to the brain circuits involved in interval timing and emotional processing, and the pharmacological management of affective disorders.