Stephanie Lawanto, Utah State University
Psychology
Mice are excellent models for studying social behavior. Anomalies in the perception and processing of social cues may induce abnormal social approach or sexual behaviors. We performed an assessment of social behavior in NrCAM knockout female mice and wild-type littermates. We found that NrCAM knockout mice exhibit social behavioral deficits (reduced interaction with unknown conspecifics). Analysis of neuronal activation in a circuit relevant to processing and response to olfactory cues (olfactory bulb, amygdala, bed nucleus of the stria terminalis, hypothalamus), using cFos immunostaining, revealed differences in neuronal activation between NrCAM knockout mice and wild type littermates exposed to unknown conspecifics. These differences may be the result of anomalies in neuronal connectivity in the olfactory systems in NrCAM knockouts. These studies have the potential to generate a new understanding of pathophysiological mechanisms responsible for abnormal social behaviors, and to identify new treatment strategies to reduce social deficits in autism spectrum disease patients.