Kevin Lawanto, Utah State University
Psychology
Mice are excellent models for studying aggressive behaviors and the neural circuits underlying aggression. They identify their conspecifics through olfactory communication within the animal group (emission scent marking and detection of volatile and nonvolatile chemicals, such as pheromones). Anomalies in the perception and processing of olfactory cues may induce abnormal social behavior, anxiety or aggression. We performed a behavioral assessment of male NrCAM knockout mice and wild-type littermates. We found that NrCAM-deficient male mice exhibit increased aggression towards unknown conspecifics. Using cFos immunostaining, we revealed differences in neuronal activation between NrCAM knockout mice and wildtype littermates in a circuit relevant to processing of olfactory cues and male-specific behaviors (olfactory bulb, amygdala, bed nucleus of the stria terminalis and hypothalamus). These differences may be the result of misrepresentation of olfactory cues due to abnormal neuronal connectivity in the olfactory system. Our studies may be relevant to pathophysiological mechanisms responsible for abnormal social behaviors, aggression and anxiety.