Spencer Ericksen; Annika Warncke; Julio Hidalgo, University of Utah
Environmental enrichment (EE) has been shown to activate wound-healing processes, including glucocorticoid (GC) signaling, and increase the lifespan of colon-tumor-bearing mice. In other studies, glycyrrhetinic acid (GA) treatment enhanced GC signaling, by inhibiting 11-beta-dehydrogenase isozyme 2 (HSD11β2), and consequently reduced lung tumorigenesis. This study will evaluate whether GA treatment in colon-tumor-bearing mice can replace EE conditions and result in similar improvements of overall health and wound repair processes as seen in EE.