2020 Abstracts

Trumble, Tanner; Jensen, Francine (Utah Valley University)
Faculty Advisor: Jensen, Robert (Utah Valley University, Nursing)

Background: Individuals who experience homelessness lack the necessary components needed receive end of life care (EOL). However, due to personal and structural barriers such as cost of care, lack of insurance, addiction, and many who experience mental health and intellectual disabilities, homeless individuals are unable to receive palliative or hospice care. Because homeless individuals lack the necessary components of basic living such as food, water and shelter, their quality of life is significantly lower than that of the general population, and this affects their EOL experiences.

Purpose: To explore the factors that affect the homeless population and the barriers they face when accessing health care, including their needs at the EOL, and to provide recommendations for better EOL care.

Methods: A focused literature review was performed using the databases PubMed, Google Scholar and Science Direct using the keywords homeless, end of life, and palliative care covering the years 1985 to 2018.

Findings: Homeless individuals want to experience a "good death". Unfortunately, homeless individuals who seek medical treatment feel deterred due to unfair treatment and belittlement from previous health care experiences and the social stigma surrounding homelessness. This can delay their treatment of chronic or acute conditions and lead to long-term health consequences. One effort to aid in EOL care for homeless individuals is the Social Model Hospice, which provides holistic EOL care in home like setting. Social model hospice overcomes barriers to lack of insurance, social support and a location where EOL care can be delivered for homeless individuals.

Significance: Many barriers are limiting medical care for the homeless that should be available to them at the EOL. It is evident that healthcare providers need to be more aware of the needs of this population to help improve and provide the EOL care homeless individuals deserve.

Backman, Natalia; Ogden, Heath (Utah Valley University)
Faculty Advisor: Ogden, Heath (Utah Valley University, Biology)

The Family Baetidae, is in the order Ephemeroptera, also commonly known as Mayflies. The first baetids were described around 1815 by Leach, and since there are more than 900 species have been described. The family Baetidae is an important group of mayflies because of their position on the mayfly tree of life in that they are a key to understanding evolutionary trends, such as the origin of wings and flight. Taxon sampling for this study consisted of over 100 taxa, representing ??? genera, from lineages distributed geographically worldwide, except Antarctica. Two main datasets were constructed. The genes 12s, 16s, H3, 18s, 28s and CO1 were used as part of a traditional dataset. Targeted capture sequencing was used to generate a phylogenomic dataset, consisting of over 400 loci. Trees were reconstructed from the aligned datasets, and the results were compared. The phylogenomic data resulted in a much more resolved topology.

Daines, Savannah (Utah State University)
Faculty Advisor: Adams, Brett (College of Science, Biology Department)

Traumatic brain injury (TBI) occurs when external forces cause the brain to move rapidly within the skull, resulting in an alteration of brain function. Following the initial injury, a cascade of cellular events known as the secondary injury reduces cerebral energy production and exacerbates pathological consequences. Conditions that close the mitochondrial permeability transition pore (mPTP) provide effective treatment for TBI by restoring ionic balance and coupling of mitochondrial oxidative phosphorylation to ATP production. mPTP closure can be achieved during ketosis when the body metabolizes ketone bodies over glucose as a primary fuel source. Administration of exogenous ketones achieves therapeutic levels of ketosis more quickly and more effectively than fasting or ketogenic diets. No studies to date have evaluated the effectiveness of exogenous ketones in treating TBI in humans. This project will evaluate current scientific literature regarding the role of ketones in TBIs and identify potential future approaches to using ketones as a therapy for TBI.

Perriton, Kiersten; Eppley, Sydnie; Young, Colleen (Utah Valley University)
Faculty Advisor: Jensen, Francine (Utah Valley University, Nursing)

Purpose: To determine the preparedness of new graduate nurses to practice after completion of nurse residency programs.

Background: New graduate nurses often feel anxious, concerned or ill prepared to practice as nurses on their own. New graduate nurses worry if the residency program has prepared them for their first nursing job sufficiently for them to gain enough confidence and skill to be on their own. Studies on nurse residency programs show that nurses who complete one-year nurse residency programs had remarkable increases in communicating with family, patients and team members, confidence in skills, and ability to prioritize and organize work. There is a need for continued education, such as nurse residency programs and an active interest in new graduate nurses, such as involved mentors or preceptors to help strengthen clinical reasoning and preparedness of new graduate nurses. Stress in new graduate nurses can impede patient safety and can result in the new nurse quitting the position. When new graduates have designated mentors, fit well with unit socialization, and are oriented to multiple areas, it has been identified that it can build their confidence levels and improve retention rates of new graduate nurses. Nurse residency programs need to provide high quality orientation to help them master their careers.

Significance: This research can give insight into whether the implementation of nurse residency programs helps new nurses feel ready to practice on their own. This information may help provide increased safety and quality of care to patients due to new graduate nurses feeling competent and confident to carry out the patient's health care plan. This can help healthcare companies determine if current programs are effective and what needs to be changed. New nurse graduates may gain confidence, practice with increased patient safety, and corporations may retain the new nurses they have just trained.

Boatright, Greggory; Medrano, Braxton; Goeckeritz, Joel (Brigham Young University)
Faculty Advisor: Roeder, Beverly (Brigham Young University, Life Sciences)

Schwann cells play a major role in helping heal injured nerves. They help clear debris, produce neurotrophins, upregulate neurotrophin receptors, and form bands of Büngner to guide the healing nerve. But nerves do not always produce enough neurotrophins and neurotrophin receptors to repair themselves. Nerve growth factor (NGF) is an important neurotrophin for promoting nerve healing and lysophosphatidylcholine (LPC) has been shown to stimulate NGF receptors (NGFR). This study tested the administration of a single intraneural injection of LPC (1 mg/mL for single LPC injection and 10 mg/mL for multiple LPC injections) at day 0 and one (day 7), two (days 5 and 7), or three (days 5, 7, and 9) injections of NGF (160 ng/mL for single injections and 80 ng/mL for multiple injections) to determine baseline effects on crushed sciatic nerves in rats. The rats were randomly divided into four groups: control, crush, crush-NGF, and crush-LPC-NGF. The healing of the nerves was measured weekly by monitoring gait; electrophysiological parameters: compound muscle action potential (CMAP) amplitudes; and morphological parameters: total fascicle areas, myelinated fiber counts, fiber densities, fiber packing, and mean g-ratio values at weeks 3 and 6. The crush, crush-NGF, and crush-LPC-NGF groups statistically differed from the control group for all six weeks for the electrophysiological parameters but only differed from the control group at week 3 for the morphological parameters. The crush, crush-NGF, and crush LPC-NGF groups did not differ from each other over the course of the study. Single injections of LPC and NGF one week apart or multiple treatments of NGF at 5, 7 and 9 days post-injury did not alter the healing rate of the sciatic nerves during weeks 1-6 of the study. These findings are important to define the baseline effects of NGF and LPC injections, as part of a larger effort to determine the minimal dose regimen of NGF to regenerate peripheral nerves.

Hyman, Rachel; Light, Tim; Montague, Angela; Lucero, Jessica (Utah State University)
Faculty Advisor: Lucero, Jessica (College of Humanities and Social Sciences; Sociology, Social Work and Anthropology Department)

Refugees are recognized as having unique and complex health needs which demand attention upon arrival and throughout the resettlement process (Agrawal & Venkatesh, 2016). Refugee populations are particularly vulnerable to health disparities due to push factors influencing forced migration (Tempany, 2009). These factors include exposure to political violence, natural disasters, and other forms of anthropogenic conflict (UNHCR, 2014). Refugees may arrive in the host country with undiagnosed and untreated health issues, such as infectious diseases, mental distress due to prior traumas, undiagnosed chronic illness, and nutritional deficiencies (Deen & Bridges, 2011). Refugee populations represent high rates of mental and physical health problems compared with the host population (Kirmayer, Gomez-Carrillo, & Veissi�re, 2017). Additional dynamics compound health disparities facing refugees. These include: language barriers, unfamiliarity with a complex health care system, limited health literacy, and inadequate alignment of medical treatments with religious and cultural beliefs (Bowen, 2001; Brown, Carroll, Fogarty, & Holt, 2010). Though there is robust scholarship in the literature and analysis of prevalent health disparities and needs of refugees post-resettlement, few studies address the specific health care concerns of refugees resettled in northern Utah. This study seeks to expand previous findings related to the most salient health care issues facing the refugee community and develop community response to address health disparity. A secondary aim of the research is to determine best practices for the provision of appropriate and effective health services.

McQuinn, Sophie; Love, Tiffany (University of Utah)
Faculty Advisor: Love, Tiffany (University of Utah, Psychiatry)

Chronic pain is a major health crisis, and is considered the second major cause of disability in the world. People with chronic pain that lasts 6 months or longer often experience other symptoms as well, including depression. While the causes of chronic pain are often unknown, it has been shown that people with chronic pain exhibit brain structure differences compared to those who do not. It is important to know how chronic pain and brain structure are interconnected so that we can find a better way to treat patients. Gaining more knowledge of this connection can lead to a better understanding of the underlying causes. Brain structure goes hand in hand with neuroplasticity, which plays a key role in normal brain development. While it has been shown that chronic pain can have a significant effect on brain structure, it is unknown whether different symptoms affect different areas of the brain. The effects of chronic pain on the brain have only been looked at in a holistic sense and have not been quantified according to symptoms. Because chronic pain can have a variety of causes, this makes it difficult to determine a good method of treatment for individuals. Our aim was to determine how different symptoms of chronic pain affect the brain individually and evaluate possible overlap. The categories we tested were sensory, affective, unpleasantness, intensity, and depression. We used MRI scans from both healthy individuals and participants experiencing chronic lower back pain. The relative levels of each symptom that the participants were experiencing were determined via the McGill Pain Questionnaire and the Center for Epidemiologic Studies Depression Scale. Having a better understanding of how different symptoms of chronic pain affect the brain can aid in finding more personalized treatment for those experiencing it.

Miles, Leslie; Valentine, Julie (Brigham Young University)
Faculty Advisor: Miles, Leslie (Brigham Young University, College of Nursing); Valentine, Julie (Brigham Young University, College of Nursing)

1 in 10 adolescents (13-18 years old) reported sexual violence in the dating environment with a prevalence rate of 14% among girls and 8% among boys (Wincentak et al., 2017). Additionally, Arliksson-Schmidt et al. (2010) found that adolescent girls with a physical disability or long-term health problem were more likely to experience sexual violence (p=.003). The current literature is limited on describing the characteristics and vulnerabilities of adolescent sexual assault patients. Researchers have found multiple negative sequelae in adolescents who have been sexually assaulted, which includes the following; major depressive disorder, suicide risk, agoraphobia, alcohol abuse & dependence, and substance abuse & dependence (Walt et al., 2014).

To better understand adolescent patients and to guide nursing care, a large (n=5,600) retrospective chart review of SAFEs documentation (2010-2018) examines adolescent descriptors (age 14-18) in a Western state in the United States. Variables include gender, race, age, relationship to suspect, online meeting, pre-existing medical conditions, pre-existing mental illness, previous history of sexual assault, number of non-anogenital injuries, number of anogenital injuries, alcohol and drug use, multiple suspects, and suspect actions (violent physical acts). Comparisons to patients over the age of 18 years will be provided.

The purpose of this podium presentation is to review research findings concerning the demographics and characteristics of adolescents seen for sexual assault forensic examinations to better inform health care professionals. Discussion will include possible medical and nursing interventions to mitigate the potential harmful effects of adolescent sexual assault.

Greaves, Aspen ; Allison, Jim (Brigham Young University)
Faculty Advisor: Allison, Jim (Family, Home, and Social Sciences; Anthropology)

Portable x-ray fluorescence (PXRF) analysis is a quantitative measure of the presence of an element. Elements from painted red ware sherds from the San Juan region were measured on painted and non-painted portions of the sherds, demonstrating the presence of elements in the paint as opposed to the paste. In particular, manganese, lead, and copper, along with a more ubiquitous iron, were found in the paint. The presences of manganese indicates the intention for the paint to be black when fired, a useful tool in identifying sherds. At Site 13 (42sa13) for example, which was burned, the sherds can appear to be Abajo red-on-orange when they may better be described as Bluff black-on-red. Lead and copper are a bit less straight-forward. Lead appears rarely, and may have no purpose, or could be an intentional sourcing choice. Another question comes from the presence of copper, which may have created a turquoise paint pre- firing. Turquoise is an important color in Pueblo color theory, and so if copper does create a turquoise paint, the presence of copper may be deliberate. Variation in paint, particularly crossed with neutron activation data, leads to a firmer understanding of decisions inherent in the ceramic creation process.

Christensen, Kate L.; Hinkson Jr, Kent D.; Brooks Malisa M.; Bryan, Craig J.� (Utah Valley University)
Faculty Advisor: Hinkson Jr, Kent (Utah Valley University and University of Utah, Psychology); Brooks, Malisa (University of Utah, Psychology)

Among the staggering rates of sexual assault, little attention has been directed towards the specific risk factors involved with coercive sexual assault. The few studies that have been conducted focus solely on college campuses. Studies have found that the potential risk factors between forced sexual assault and coercive sexual assault are fundamentally different. While forced sexual assault is associated with environmental risk factors such as alcohol, coercive assault risk factors have a stronger relationship with the victim's level of depression and self-esteem. Though depression and low self-esteem can affect people for a variety of different reasons, age tends to be a reliable predictor of both of these risk factors. Depression and low self-esteem have some of the highest rates among teens and young adults. When focusing on the Military, we see depression rates higher than that of the general public, with similar patterns of teenagers and young adults (18 to 25) being the most affected. With the knowledge that depression and low self-esteem are risk factors in coercive sexual assault and knowing an age group that is more likely to be depressed and struggle with esteem, we should expect to see a relationship between age and being a victim of coercive sexual assault. In a survey consisting of veterans, age had a mild relationship with coercive rape, with younger people being more susceptible and their older counterparts holding less risk. When focusing on other distinctions of sexual crimes such as harassment, assault, and rape, age was not found to be a risk factor. Knowledge of the relationship between coercive sexual assault and age carries important implications, particularly in the form of education and support. Leaders armed with this data can inform young people of this potential risk, provide preventative strategies, and recommend therapy or support groups when necessary.

Oram, Kathryn; Griffiths, Alayna (Utah Valley University)
Faculty Advisor: Gazdik-Stofer, Michaela (Utah Valley University, Biology)

The World Health Organization currently estimates that 4,384 individuals die per day due to complications of Mycobacterium Tuberculosis and affects 1.8 million people worldwide as it infects individuals through air droplets from a cough or sneeze. Cyclic adenosine monophosphate (cAMP) is known to be a major component in TB because it acts as a macrophage inhibitor that is responsible for blocking the immune defense allowing the M. Tuberculosis to rapidly replicated within cells. The function of cAMP in TB patients is known but the focal point of our research is why and how the increased levels of cAMP effects patients that are infected with TB. Our team uses mutated M. Smegmatis bacteria due to the comparable levels of cAMP secretion and high pathogenicity of M. Tuberculosis. We are currently screening the cAMP secretion in 1,000 mutated M. Smegmatis colonies to identify secretion differences from the wild-type M. Smegmatis. The mutants samples with high variation from the wild-type will be sequenced to identify the genes and determine the proteins that are present. Finding the genes and proteins can help understand why and what causes the inflation on cAMP secretion in TB patients.

Varghese, Alyssa; Crandall, Hillary; Blaschke, Anne (University of Utah)
Faculty Advisor: Crandall, Hillary (University of Utah, Department of Pediatrics); Blaschke, Anne (University of Utah, Department of pediatrics)

Haemophilus influenzae serotype b (Hib) causes serious bacterial infections in children associated with high morbidity and mortality. The incidence of Hib disease decreased with widespread vaccination in the mid-1980's. However, other H. influenzae serotypes, such as serotype a (Hia), have emerged in specific pediatric populations, including Utah and indigenous populations in Alaska and Canada. Hia appears to cause disease similar to Hib in both severity and disease presentations.

Cases of invasive H. influenzae disease in children <18 years were identified via a search of electronic medical records within the Intermountain Healthcare system. Phylogenetic division was determined using sodC PCR. Whole genome sequencing (WGS) was performed on available isolates. Gene presence and absence data from resulting assemblies were utilized to build a relationship tree from all available Hia isolates, as well as select Hib, H. influenzae serotype f (Hif), and non-typeable H. influenzae (NTHi) isolates. Multi-locus sequence type (ST) was extracted from WGS data for each isolate.

118 cases of invasive H. influenzae disease were identified from 2007 to 2017. Fifty-one (43.2%) cases were Hia and 11 (9.3%) were Hib. Twenty-eight of 51 (56%) Hia isolates were available for further molecular analysis. Three STs were identified: ST56, ST62, and ST576. Twenty-one isolates (75%) belonged to ST62, clonal division II. The relationship tree indicates that ST62 Hia isolates are most closely related to each other and more closely related to Hif than to other Hia and Hib.

The molecular epidemiology of invasive Hia disease in Utah is unique, with a predominance of ST62 strains, a ST that has been infrequently reported in other studies of invasive Hia. Further genomic analysis will help us understand genetic determinants of virulence. These analyses will be critical in characterizing the clinical and molecular features of invasive H. influenzae disease in Utah.

Brooksby, Austin; Meyer, Jake; Rentschler, Lucas; Spofford, Robbie (Utah State University)
Faculty Advisor: Rentschler, Lucas (Jon M. Huntsman School of Business, Economics and Finance Department)

The ultimatum game is a common experimental economics game done in pairs in which one person chooses a way of dividing a sum of money, and then proposes that split as an ultimatum to the other: Either accept it, or we both walk away with nothing. In theory, equilibrium play would indicate everyone should accept any split they're offered-regardless of the equity-but the experimental economics literature robustly rejects that theory. Smith and Wilson's 2017 paper "Equilibrium Play in Voluntary Ultimatum Games: Beneficence Cannot Be Extorted" produced results different from the vast literature, by making game participation voluntary within the lab. We attempted to replicate Smith and Wilson's results, but failed to do so. The most notable difference between our experiments was our subject pool, so we ran additional trials of the standard ultimatum game and confirmed our subject pool was not significantly different than the general literature. Our paper provides a great example of the importance of replicating results in the social sciences, in addition to a specific contribution to the ultimatum game literature.

Maw, Madison (Brigham Young University)
Faculty Advisor: Nuckols, Janis (Brigham Young University, Linguistics); Thompson, Gregory (Brigham Young University, Anthropology)

In Ecuadorian Quichua culture people do what they can do to avoid being described as quilla—a behavior encapsulating both laziness and sexual promiscuity. Many of their myths revolve an individual who encapsulates one or both parts of quilla, the tale of Wituk and Manduru included. These behaviors are ones that estrange an individual from their family ties, which is a keystone motor of Quichua society. These myths, being origin stories, always end up with the person transforming into a part of nature, usually an animal or plant.

Wituk and Manduru's tale is one of the longer myths as well as one of the only that demonstrates both aspects of quilla so clearly. However, while it depicts what is considered the worst traits, it also demonstrates how to redeem oneself. At the end of the story the sisters transform themselves into trees that produce pods that when mashed create red or black paint. The girls use this to paint the men who they interacted with in their journey into more productive animals.

This paper will explore the implications this story has in modern life for the Quichua people, women in particular. The paint of these trees is highly important in all realms over which women preside, including pottery, beauty, and maintaining the chagra (in simplistic terms, a garden). The paint is used in a transformative and representative way, making the ritual plant grow stronger and allowing women to harness the power of animals around them, just to name a few. Women are able to use this plant to transform themselves and those around them in order to make a better society overall.

Brammer, Brianna; Denham, Steven; Wambaugh, Morgan; Brown, Jessica. (University of Utah)
Faculty Advisor: Brown, Jessica (University of Utah, Pathology)

Cryptococcus neoformans is an opportunistic fungal pathogen, which primarily affects those with compromised immune systems, contributing to 15% of global AIDS-related deaths. Initial human exposure occurs after inhalation of desiccated cryptococcal cells, which undergo morphological changes in the lungs, including altering cell body and polysaccharide capsule size. Fatality occurs after C. neoformans disseminates to extrapulmonary organs, including the brain where it causes cryptococcal meningitis. Preliminary data show that fungal cells decrease in size throughout the course of infection; we hypothesize that this shift increases the ability of fungal cells to exit lung epithelium, either extracellularly or via macrophage, as small cryptococcal cells exhibit enhanced extrapulmonary dissemination. We later determined that this effect was not solely due to fungal cell size by inoculating mice with fluorescent beads corresponding to cryptococcal cell size groups. The beads showed similar dissemination trends, but were significantly less efficient at extrapulmonary dissemination, suggesting the necessity of cell surface factors. By measuring the exposure of various fungal factors relative to size, we have identified mannose as a potential key factor in dissemination, as small cells exhibit higher levels of exposed mannose relative to size. The hypothesized role of mannose in cryptococcal dissemination is investigated throughout this project utilizing a variety of techniques, including the addition of polysaccharides to macrophage-cryptococcal association assays to determine mannose-specific recognition, in vivo co-inoculation with mannose and cryptococcal cells, and identifying differential gene expression between cell sizes using RNA sequencing and gene ontology. These data have contributed to our working model of cryptococcal infection, where cryptococcal cells undergo morphological changes in the lungs, yielding a higher prevalence of small cells. Cell size is an important, but not determinant factor in dissemination, suggesting the role of cell surface factors, such as mannose, that increase virulence by promoting phagocytosis and intracellular survival.

Salas, Norma; Condie, Kali; Cook, Lauralee (Utah Valley University)
Faculty Advisor: Jensen, Francine (Utah Valley University, Nursing)

Problem Statement:

Depending on the provider a woman has during her delivery, the education, interventions, and care she receives will differ. Variations of care under an obstetrician and gynecologist (OB/GYN) compared to a midwife may produce differing satisfactory results for women experiencing labor and delivery.

Purpose:

The purpose of this research study is to discover if women who have delivered with both an obstetrician/gynecologist and a midwife are more satisfied with their birthing experience under the care of one provider compared to the other.

Research Question:

Are women who have experienced labor and delivery with an OB/GYN and a midwife more satisfied with their birthing experiences from one provider compared to the other?

Background:

In a patient-centered world, it should be up to the provider and expecting mother to choose the modality of delivery they would like, including the place, medical interventions, positioning, and methods of delivery. OB/GYNs and Midwives vary in practices, and implementations during gestation and delivery. Dissatisfaction with labor and delivery is an aspect of the current healthcare industry that needs to be addressed in order to improve patient care. Coxon, Sandall, and Fulop highlight this issue by pointing out that many women feel constrained with their decisions regarding labor and delivery and that delivery opportunities may be limited due to influences from cultural and historical associations as practiced by the provider (2014). Patient satisfaction is also influenced by pressures women in labor and delivery experience in order to accommodate their providers wishes.

Hope to accomplish:

We hope to determine if women's satisfaction during their labor and delivery experiences are higher with either a midwife or an obstetrician/gynecologist, as well as to promote better education and patient autonomy to increase patient experience satisfaction.

Symons, J. David; Thompson, Lauren; Ramous, Caroline; Cho, JaeMin; Boudina, Sihem; Margetts, Alex; Buzianis, Skye; Park, Seul Ki; Luu, Kiana; Hansen, Michele; Pires, Karla; Whitehead, Kevin; Carter, Kandis; Buffolo, Marcio (University of Utah)
Faculty Advisor: Symones, J. David (University of Utah, Nutrition and Integrative Physiology)

Protein aggregates accumulate and organelles become damaged and / or dysfunctional during the process of healthy aging. A progressive loss of the cellular quality control mechanism autophagy (i.e., "self-eating") contributes to this age-associated decline in cellular function in many organs. Evidence for an age-associated repression in cardiac autophagy is not consistent. We hypothesized that 24-month old (old) male C57Bl6/J mice exhibit repressed autophagosome formation in the heart, an accumulation of cardiac protein aggregates, myocardial dysfunction, and reduced exercise capacity vs. 6-month old (adult) mice. First, cardiac lysates from old mice displayed reduced (p<0.05) accumulation of LC3II / GAPDH and degradation of p62 vs. adult animals (assessed via immunoblotting; n=12 per group). Second, the lysosomal acidification inhibitor chloroquine (CQ) induced accrual (p<0.05) of LC3II / GAPDH and p62 in hearts from adult but not old mice (quantified by immunoblotting; n=7 per group). Third, the number and size of protein aggregates was higher (p<0.05) in hearts from old vs. adult mice (measured via scanning electron microscopy; n=5 per group). Fourth, left ventricular mass / tibial length was greater (p<0.05), and indices of systolic, diastolic, and global left ventricular function (measured via transthoracic echocardiography) were impaired (p<0.05), in old vs. adult animals (n=12 per group). Finally, maximal workload performed during a treadmill-test, and soleus muscle oxidative enzyme capacity (citrate synthase activity assessed via ELISA), were less (p<0.05) in aged (n=11) vs. adult (n=12) mice. To determine whether late-in-life exercise training improves cardiac autophagy to an extent that demonstrates functional relevance, separate cohorts of older male mice completed a progressive-resistance treadmill-running program (old-ETR) or remained sedentary (old-SED) from 21-24 months. Body composition (estimated via nuclear magnetic resonance), exercise performance during a maximal workload test, soleus muscle citrate synthase activity, indices of cardiac antioxidant enzyme activity (quantified via immunoblotting), markers of cardiac autophagy, accumulation of cardiac protein aggregates, and indices of myocardial function, all improved (p<0.05) in old-ETR (n=11) vs. old-SED (n=12) mice. These data are the first to demonstrate that markers of cardiac autophagy are elevated, and indicators of protein aggregate removal and myocardial function are improved, in older mice that complete a treadmill-training regimen that is sufficient to increase skeletal muscle CS activity and maximal exercise capacity. Our results provide strong proof of concept to evaluate cause and effect relationships among exercise-training, myocardial autophagy, and cardiac function using genetic approaches in pre-clinical models and these studies are ongoing in our laboratory.

Hale, Kaysi; Anderson, Chris (Utah Valley University)
Faculty Advisor: Anderson, Chris (Utah Valley University, Psychology)

While there is significant data on adolescent sexual activity, education, and attitudes, there is little research done on adults who choose to stay abstinent, especially in the United States. Religiosity plays a significant role in reducing sexual behaviors before marriage. Many Christian faiths teach that sex should only be engaged in after marriage, so many followers choose to stay abstinent until marriage. Education about sex contributes to individuals choosing to stay abstinent and/or choosing to use safe-sex practices. Gender is not a large factor when considering reasons why individuals choose to stay abstinent; women have slightly lower rates of pre-marital sex at 94%; men at 96%. Sexual health and sexual well-being are difficult to define, but especially challenging when trying to define it for those choosing to stay abstinent into adulthood. The proposed study will sample an anticipated 200 self-reported abstinent undergraduates at Utah Valley University. This university has a high proportion of Christian students who are predominantly members of the Church of Jesus Christ of Latter-Day Saints. Data will be collected about why the students report they are remaining sexually abstinent as well as their sexual attitudes, beliefs, behaviors, and feelings about their own sexuality. Correlations can be drawn between religiosity, gender, age, perceived healthy attitudes towards individual sexuality, feelings about sexual stimulating behavior, among other factors. This paper will contribute to the standing data about religiosity and sexuality. It will enhance the literature about how abstinent adults feel about their own sexuality.