2020 Abstracts

Gaona-Partida, Paul; Chan, Julian; Aguilar-Alvarez, David (Weber State University)
Faculty Advisor: Chan, Julian (Weber State University, Mathematics); Aguilar-Alvarez, David (Weber State University, Exercise and Nutrition Sciences)

PURPOSE/HYPOTHESIS:
Low hemoglobin (HB) levels are used to indicate anemia, which increases your risk for contracting infectious diseases and overall mortality. The rate of iron deficiency anemia in Ghana is more than triple the world average, making this condition a main health concern for the country. In this study, we sought to identify the influence of location and iron consumption on HB levels of Ghanaians.

METHODOLOGY:
Food frequency questionnaire was given to 140 participants in 5 different locations of Ghana (Jamestown, King Tower, Mole, Larabanga, University of Ghana). All food was classified as low, medium, or high iron content according to the USDA food database. Participants were categorized as adequate or inadequate iron consumers according to this classification. ANOVA and t-test analysis was conducted to determine the differences in hemoglobin level means. P-value was set at µ0.05 and HSD was used as the post-hoc test.

RESULTS/PREDICTED RESULTS:
Mole National Park population had higher HB (µ=13.3 ± 2.51) compared to Jamestown (µ=12.1 ± 1.97) (p=0.034) and Larabanga (µ=12.0 ± 1.97) (p =.032). Individuals classified as high iron consumers had significantly higher HB that their low iron consumers counterparts (µ=13.8 ± 2.42 vs µ=12.1 ± 1.97, p=0.001).

CONCLUSION:
We were able to identify foods associated with increased Ghanaians HB. Mole had higher access to iron-rich foods such as game meat, which was reflected in their HB levels. This study illustrates the importance of promoting consumption of indigenous iron-rich foods in the current Ghanaian diet to prevent iron deficiency anemia in this population.

Taylor, Sarah; Fawver, Bradley; DeCouto, Brady; Lohse, Keith R.; Williams, A. Mark� (University of Utah)
Faculty Advisor: Lohse, Keith (University of Utah; Health, Kinesiology, and Recreation); Williams, Mark (University of Utah; Health, Kinesiology, and Recreation)

Achieving elite status in sport often requires athletes to overcome significant physical injuries. However, to date, there has been a paucity of studies exploring how hours engaged in practice and early developmental milestones influence injury rates in "high-risk" winter sports, such as alpine skiing. Moreover, despite numerous published reports on injury epidemiology, a lack of objective measures of performance has been a notable oversight. The purpose of this study was to assess how previous sport engagement and performance are related to injury in a sample of sub-elite youth alpine skiers. Adolescent skiers enrolled in U.S. academies (N = 169, males = 81) were given questionnaires assessing practice/injury history and sport-specific milestones, while performance in speed and technical disciplines were derived from participants' National points (i.e., ranking) for each year available. Simple correlations, MANOVAs, and linear mixed-effect regressions were used to assess relationships between predictors: age, gender, sport-specific milestones (e.g., age of first competition), practice hours, ranking; and the outcomes of interest: injury incidence (i.e., proportion of seasons an athlete sustained injuries causing them to miss > 4 weeks) and injury impact (i.e., average weeks missed due to injury each year). Results revealed that while older athletes had accumulated more injury weeks across their career (p = .020), female skiers reported greater injury incidence (p = .049). Neither injury incidence nor injury impact was associated with performance trends (all p's > .05), but they were negatively associated with time spent in group and individual practice (both p's < .05). Finally, the age of first competition was positively correlated with injury impact (p = .014). These and other findings are discussed in relation to previous studies of sport-injury, as well as applied implications for working with developmental athlete populations in high-risk domains.

Winters, Blaine; Dustin, Tracy; Escobar, Jeana; Ostlund, Megan (Brigham Young University)
Faculty Advisor: Blaine, Winters (Brigham Young University, Biology)

Background:
Evaluation of patients who have fallen varies significantly between nurses as well as health care facilities. In many cases, injuries go unrecognized or their identification is delayed due to poor or incomplete assessments and follow-up.

Purpose:
The purpose of this project was to design a standardized post-fall assessment for geriatric patients residing in long-term care and community settings.

Methods:
A literature review revealed that in the past 10 years, very few studies were conducted on post-fall assessments, and the majority of these studies were conducted outside of the United States. Due to the lack of current literature on the subject, the Advanced Trauma Life Support algorithm was used as a framework for the development of the post-fall assessment.

Outcomes:
A post-fall assessment evaluation was developed which includes the production of a standardized post-fall assessment flowchart, accompanied by a documentation guide. A training video was also produced to illustrate the use of the assessment tools and to allow nurses to practice their new skills.

Implications for Practice:
The standardized post-fall assessment tools will lead to more thorough evaluation and follow-up of patients who have fallen in long-term care or the community setting. This will lead to more rapid treatment of identified injuries as well as fewer missed injuries.

Teaching Methods:
Participants will receive training on the post-fall evaluation method, how it was developed and how it will be implemented.

Contreras, John; Forrest, Rachel T.; Bayles, Madelyn (Westminster College)
Faculty Advisor: Contreras, John (Westminster College, Public Health); Forrest; Rachel T. (Westminster College, Public Health)

Air pollution, much of which results from human activities like transportation, may significantly harm children's health, from worsening asthma to potentially even lowering I.Q. This makes idling near schools a serious concern. In response, the EPA has developed an idle-free schools campaign. This campaign will be implemented during the 2019-2020 school year at a Salt Lake City elementary school. Ground-level ozone and PM2.5 levels will be measured before and after the campaign in order to determine its efficacy. Additionally, during the spring and summer of 2019, parents' perceptions of idling, and, by extension, air pollution, were examined using a focus group and a survey. The resulting data, which was analyzed using R statistical software and Excel, found associations between gender and beliefs about air pollution, as well as between education level and beliefs about air pollution. A better understanding of the effectiveness of the EPA's campaign and of parents' perceptions may be helpful in combating air pollution, leading to improved community health.

Hansen, Riley; Hooper, Victoria; Rawson, Clayton (Utah Valley University)
Faculty Advisor: Gazdik-Stofer, Michaela (Utah Valley University, Biology)

The human microbiome is the community of microbes associated with the human body. Disruption and imbalances in these microbiomes can cause diverse symptoms from depression to eczema. Celiac Disease (CD) is characterized by an immune response in the small intestine that is triggered by the protein gluten, found in wheat. Previous studies have identified microbial dysbiosis in patients with CD. To better understand how these dysbiosis can affect the disease itself we will exam the microbiome diversity and composition in CD patients and healthy individuals on gluten-free diets. This will help identify what microbiome changes are associated with CD compared to those that are caused by the CD patients lack of gluten in their diet. The microbial populations of three different groups will be analyzed: 1. those diagnosed with CD and on a gluten-free diet, 2. those who do not have CD and are on a gluten-free diet, and 3. those who do not have CD and are not on a specific diet. The dietary and disease influences on the microbiome of the gastrointestinal tract will be analyzed via a single stool sample collected from each study subject. Microbial DNA was extracted using the QIAamp PowerFecal DNA kit following manufacturer's specifications (Qiagen) V3/V4 region of 16s rRNA will be sequenced using the 600 cycle v3 MiSeq kit (Illumina) The results of the analysis will be compared to existing microbial genome databases to determine the composition of microbes present in the study groups.

Thompson, Lauren; Ramous, Caroline; Ly, Kellsey; Luu, Kiana; Margetts, Alex; Warren, Tahno; Tippetts, Trevor; Choi, Ran Hee; Symons, JD (University of Utah)
Faculty Advisor: Symons, J. David (University of Utah, Nutrition and Integrative Physiology)

Type II diabetes mellitus (T2DM) is an epidemic worldwide. Cardiovascular complications (e.g. endothelial dysfunction and hypertension) are associated with T2DM. T2DM affects the quality of life for the patient and their caregivers, and the costs for treating cardiovascular complications are unsustainable. An urgent need exists to elucidate new therapeutic targets for intervention. Our laboratory is interested in defining the contribution from the sphingolipid ceramide. We reported earlier that arterial dysfunction and hypertension that otherwise develop in mice that consume an obesogenic diet is attenuated by pharmacological inhibition of ceramide using myriocin and by germline haploinsufficiency for dihydroceramide desaturase (DES1), an enzyme required for ceramide biosynthesis. However, each study had limitations. Myriocin improved systemic glucose homeostasis, and DES1 inhibition elevated dihydroceramides, both of which could impact arterial function. In the present study, we used a novel murine model to inhibit the rate-limiting enzyme responsible for ceramide biosynthesis (serine palmitoyl transferase light chain 2; Sptlc2) specifically in endothelial cells (ECs). We hypothesized that EC specific inhibition of ceramide biosynthesis would preserve arterial function in obese mice. Six-week-old male mice with intact Sptlc2 (wild-type; WT) and EC specific deletion of Sptlc2 (iecSptlc2KO mice) consumed either standard (CON) or high fat diet (HFD) for 14 weeks. qPCR results indicated Sptlc2 was knocked down > 80% in ECs but not media and adventitia from iecSptlc2KO vs. WT mice. In general, results were similar between WT and iecSptlc2KO mice concerning glucose, insulin, and pyruvate tolerance tests (indicating intact glucose homeostasis) and lean mass, fat mass, and fluid mass (indicating body composition was unaltered). Of note, intraluminal flow-mediated vasodilation was greater in femoral arteries from iecSptlc2KO vs. WT mice that consumed high-fat chow. Preventing ceramide biosynthesis specifically in ECs from mice that consume an obesogenic diet might be vasculoprotective.

Bergen, Makenna; Meier, Amanda; Thomas, Victoria; Banna, Jinan; Cluskey, Mary; Stokes, Nathan; Richards, Rickelle (Brigham Young University)
Faculty Advisor: Richards, Rickelle (Life Sciences; Nutrition, Dietetics, and Food Science); Stokes, Nathan (Life Sciences; Nutrition, Dietetics, and Food Science); Banna, Jinan (Tropical Agriculture and Human Resources (University of Hawaii at Manoa), Department of Human Nutrition, Food, and Animal Sciences)

Background: Food insecurity among college students has been reported to be as high as 59%. Most research related to this phenomenon has used quantitative approaches. The purpose of this study was to gain a deeper understanding of college students' perceptions of their own food security using qualitative methodology.
Methods: Researchers interviewed 57 college students at three universities across the western United States. A random sample of transcripts were independently coded in NVivo to determine interrater reliability. Kappa statistics ranged from 0.44-0.99 (food insecure) and from 0.73-0.99 (food secure), indicating moderate to almost perfect agreement. Percent agreement ranged from 92-100% (food insecure) and from 97-100% (food secure). Researchers then divided transcripts for final coding and overarching themes, including differences between food secure and food insecure students under each theme, were discussed.
Results: Three themes emerged to help explain drivers of food insecurity in college students: 1) transition from pre-college life to college life; 2) students' management of finances; and 3) methods and barriers to obtaining food. Differences were identified between food secure and food insecure students. Food insecure students prioritized other living expenses over food and used various strategies when funds were low: purchasing lowest cost campus meal plans, stretching food budget, buying cheaper groceries, and skipping meals. In regards to eating away-from-home, food insecure students prioritized eating at home, using discounts, or waiting to get paid before eating out. Both food secure and food insecure students reported positive aspects of using food assistance programs but believed stigma and embarrassment would deter students from using these programs. A few food insecure students expressed confusion about qualifying for these programs.
Conclusions: This study helps us better understand the context surrounding food insecurity in college students. This understanding could lead to broader solutions to helping college students become more food secure.

Hildt, Alyssa; Anderson, Abby; Miles, Leslie; Valentine, Julie (Brigham Young University)
Faculty Advisor: Miles, Leslie (Brigham young University, Nursing); Valentine, Julie (Brigham Young University, Nursing)

Purpose: To describe characteristics that impacted sexual assault (SA) patients' reports of pain and subsequent pain treatment.
Research Question(s) / hypotheses: 1. What percentage of SA patients complaining of pain received any treatment? 2. What associations exist between SA variables and reports of pain and pain treatment?
Methodology: Retrospective chart review (n=1,652) of SA examinations (2017-2018) was conducted in several counties in Utah, representing 80% of the state. 241 variables were entered into SPSS. Approximately 64% of SA cases reported pain. Descriptive statistical analysis of SA patients reporting pain was conducted on the following variables: pain location, pain severity, gender, race, age, relationship to suspect, pre-existing medical conditions, pre-existing mental illness, suspect actions, time between assault and exam, physical injuries, anogenital injuries, and pain treatment (pharmacological and non-pharmacological).
Findings: On a scale of zero to ten, reported pain mean level 5.68 with a median of six. Eight percent of patients who reported pain did not have a documented pain level, signifying an incomplete pain assessment. Three most common pain locations were the genitals (40%), abdomen/pelvis (31%), and head (24%). Those with mental illness, medical problems, or reported history of SA prior to age 14, were more likely to report pain. Despite the prevalence of pain amongst SA patients, a large majority (78%) received no documented pain treatment. However, some patients received the following: 16% NSAIDs or Tylenol; 5% narcotics; and only 0.1% received non-pharmacological treatment.
Implications: All SA patients should be assessed and treated for pain. SA examination forms should include treatment type, including treatment provided by the emergency department. Nurses should take the lead in advocating for pain treatment in SA patients.
Conclusion: This is the largest study of SA patients' pain assessment and treatment and helps create a comprehensive picture to understand patient and variables that impact pain.

Seibold, B. Tanner; Hutchison, Cortland; Preece, J. Caleb; Feland, J. Brent (Brigham Young University)
Faculty Advisor: Feland, J. Brent (Life Sciences, Exercise Science)

BACKGROUND: To date, a few studies have demonstrated shear wave elastography (SWE) values for the gastrocnemius muscles in younger subjects (<30 yrs). However, little info is available on aging muscle. SWE of aging muscle is needed to better understand the intrinsic tensile changes that take place in muscle over time.
PURPOSE: This study aimed to determine how cross-sectional area (CSA) and SWE correlate with each other) in both the medial and lateral gastrocnemius muscles of active older athletes participating in the HuntsmanWorld Senior Games.
METHODS: Data was collected from 116 volunteers (participants in the Huntsman World Senior Games) in St. George, Utah, 2019. Subjects (62 males: mean age = 68.9 ± 7.8 yrs, Ht = 177.4 ± 8.1 cm, Wt = 85.4 ± 20 kg; 54 females: mean age = 66.9 ± 8.5 yrs, Ht = 164.4 ± 7.2 cm, Wt = 69.8 ± 18 kg) signed an approved consent form and then lay prone on a treatment table for ultrasonic measurement of both CSA and SWE of both heads of the gastrocnemius.
ANALYSIS: All data were analyzed using SPSS ver25 with a multivariate analysis utilizing both age, height, and weight as covariates with Pearson correlations calculated on the relationship between CSA and SWE of both heads.
RESULTS & CONCLUSION: We hypothesized that increases in cross-sectional area would positively correlate with increased SWE values since the muscle would be larger and prior studies have found muscle hypertrophy increases muscle pennation angle. Neither Medial gastroc (r=-.100, p=.280) or Lateral gastroc (r=.047, p=.613) CSA was significantly correlated with their respective SWE ratings. Age significantly affected CSA only after the age of 59, but similarities in CSA and SWE between all participants may be the result of the high level of activity of these subjects.

Ouzts, Ethan (Brigham Young University)
Faculty Advisor: Matheson, Rebekka (BYU Family, Home, and Social Sciences; Psychology)

Ketamine was recently approved by the U.S. Food and Drug Administration as a therapeutic approach to treat individuals with treatment-resistant depression. This approval opens the door for other hallucinogens to be approved for psychiatric use. This review compares the antidepressant efficacy and safety of ketamine to serotonergic hallucinogens, such as lysergic diethylamide acid (LSD). Ketamine acts as the standard of comparison in this review. Serotonergic hallucinogens demonstrate similar short to mid-term responses in patients with depression and compares well to ketamine's safety. Researchers should conduct additional randomized, controlled experiments to better establish serotonergic hallucinogens' antidepressant potential. Despite this limitation, serotonergic hallucinogens warrant serious consideration for potential antidepressant treatment.

Trumble, Tanner; Jensen, Francine (Utah Valley University)
Faculty Advisor: Jensen, Robert (Utah Valley University, Nursing)

Background: Individuals who experience homelessness lack the necessary components needed receive end of life care (EOL). However, due to personal and structural barriers such as cost of care, lack of insurance, addiction, and many who experience mental health and intellectual disabilities, homeless individuals are unable to receive palliative or hospice care. Because homeless individuals lack the necessary components of basic living such as food, water and shelter, their quality of life is significantly lower than that of the general population, and this affects their EOL experiences.

Purpose: To explore the factors that affect the homeless population and the barriers they face when accessing health care, including their needs at the EOL, and to provide recommendations for better EOL care.

Methods: A focused literature review was performed using the databases PubMed, Google Scholar and Science Direct using the keywords homeless, end of life, and palliative care covering the years 1985 to 2018.

Findings: Homeless individuals want to experience a "good death". Unfortunately, homeless individuals who seek medical treatment feel deterred due to unfair treatment and belittlement from previous health care experiences and the social stigma surrounding homelessness. This can delay their treatment of chronic or acute conditions and lead to long-term health consequences. One effort to aid in EOL care for homeless individuals is the Social Model Hospice, which provides holistic EOL care in home like setting. Social model hospice overcomes barriers to lack of insurance, social support and a location where EOL care can be delivered for homeless individuals.

Significance: Many barriers are limiting medical care for the homeless that should be available to them at the EOL. It is evident that healthcare providers need to be more aware of the needs of this population to help improve and provide the EOL care homeless individuals deserve.

Cromar, Zachary J.; Findlay, Matthew; Turner, Elizabeth; Mills, Ammon (Utah Valley University)
Faculty Advisor: Gazdik-Stofer, Michaela (College of Science - Utah Valley University, Biology); Sylvester, Steven (College of Humanities and Social Sciences - Utah Valley University, Political Science)

The World Health Organization has included vaccine hesitancy in the top ten threats to global health in 2019. Studies done in the United States have shown that the Moral Foundations Theory (MFT) can be used to identify why individuals are more vaccine-hesitant (VH) than others. Counterintuitively, the dichotomous moral foundations (MF) of care vs. harm, traditionally used in pro-vaccine messaging interventions, or fairness vs. cheating, were not found to be the foundations on which VH parents based their decision not to follow the CDC recommended vaccination schedule. It was discovered that the purity vs. degradation and liberty vs. oppression foundations are more important to VH individuals than all other foundations. Highly VH individuals are twice as likely to emphasize purity and liberty. Concerningly, in 2018, Utah ranked in the bottom ten states for child vaccination rates in 11 of the 19 vaccines reported by the Utah Department of Health. We plan on testing a broader messaging intervention than the current, traditional vaccine messages. Our messaging interventions will emphasize the MFs of liberty vs. oppression and purity vs. degradation to see if they will be more effective than our more traditional messaging intervention emphasizing care vs. harm, or an unrelated control message not related to vaccines. We hypothesize that messages emphasizing the purity and liberty foundations will resonate better with the VH and decrease their vaccine-hesitancy relative to the other groups. If our data supports that the MFs of liberty vs. oppression and purity vs. degradation significantly decrease vaccine-hesitancy than current general vaccine education messaging interventions should be broadened to include these MFs. However, if results do not demonstrate that the liberty vs. oppression MFs are more effective at decreasing vaccine hesitancy, then more research should be performed on the subject.

Morgan Howard, Corinna Trujillo Tanner, Boyd Tanner, Brandon Thatcher, Janelle Macintosh (Brigham Young University)
Faculty Advisor: Trujillo Tanner, Corinna (Nursing, Nursing)

Purpose/Aims: The purpose of this Review of Literature is to present the most current and accurate information about e-cigarette use, or vaping, with recommendations for nursing practice.

Rationale/Conceptual Basis/Background: According to the CDC, to date over 1300 individuals have developed severe lung injury, associated with vaping, including 216 fatalities. Most of these cases involved young people in their teens or twenties. There are concerns that marketing for vaping specifically targets young people and leads potential users to consider the practice relatively safe. On the contrary, vaping is associated with several serious health risks, including lipoid pneumonia, acute respiratory distress syndrome and popcorn lung. Little is known about the effects of the 60+ compounds identified in vaping aerosol, which is inhaled directly into the lungs. Nurses are often the first point of contact for patients in primary care and urgent/emergent settings. Nurses provide valuable patient education, health assessment, and referral. It is important for nurses to have access to the latest information about this developing problem.

Methods: We conducted a review of literature. We reviewed and summarized information from the Food and Drug administration, Centers for Disease Control, American Medical Association, American Academy of Pediatrics, and other reputable sources. All information reviewed had been published within the last six months. Research questions which guided this review sought to identify important considerations for nursing assessment, and nursing interventions.

Findings/Clinical Implications:

Nursing Assessment: An important part of nursing assessment should include documentation of a patient's history of vaping. When a patient presents with respiratory symptoms and has a history of vaping, a detailed vaping history covering the previous 90 days should be obtained. When acute lung injury, caused by vaping is identified, it must be reported to local and state health departments, per the new CDC guidelines.

Nursing interventions should include patient education as follows: 98.7% of "vape juice" assayed by the FDA contained the addictive substance nicotine (even if labeled "nicotine free") Nicotine is highly addictive and damages developing brain tissue in fetuses, infants, children and teens Inhaled "second hand" vape aerosol is dangerous for pregnant women, infants, children and those with lung disease The inhaled solution is not "water vapor" but rather an aerosol created by an electric heating element within the vaping device The inhaled solution contains up to 60 + chemicals including heavy metals

There is no established standard for vaping safety

Flavorings in vape juice, although considered safe for ingestion, have not been approved for inhalation and are not known to be safe

Additional information and recommendations will be forthcoming as our understanding of the risks associated with vaping is rapidly evolving.

Jensen, Afton; Claunch, Kelsie; Verdeja, Marco; Dungan, Matthew; Anderson, Shellie; Clayton, Colter K.; Goates, Michael, Thacker, Evan (Brigham Young University)
Faculty Advisor: Thacker, Evan (Life Sciences, Public Health)

The purpose of this paper is to provide a systematic review of lay perspectives on the meaning of successful aging from older adults across multiple cultures and countries. Furthermore, this article allows for a discussion of the complexity of older adults' perspectives on successful aging and how successful aging may be defined differently across cultures and countries. We conducted a systematic literature review to identify, summarize, and evaluate peer-reviewed studies of qualitative data on lay perspectives of older adults. This review included studies on elderly populations published from 2010 to 2017 that addressed older adults' lay perspectives on successful aging. Such studies involved primary research performed in the United States, Germany, Singapore, Lebanon, Mexico, Canada, and New Zealand. The key concepts that emerged from older adult responses across all studies included physical health, cognitive health, social engagement, attitude/coping, independence/security, and spirituality. The overall emerging themes from our data suggest that older adults were not as concerned with physical health as biomedical previous research of successful aging often suggest. Rather, older adults focused on maintaining positive attitudes in order to cope with life changes, valuing social engagement and contribution as more essential to successful aging. Respondents from Western Europe valued keeping positive attitudes about death and focusing on gratitude instead of worries. Additionally, respondents from the United States and Mexico placed importance on pursuing activities and interests and having strong involvement with family and friends respectively. Noting differences, respondents from the Middle East, Asia, and Oceania Region, as opposed to respondents from North America, moreso prioritized the absence of chronic disease and comfort in one's own environment over keeping active. By providing a more comprehensive organizational framework of older adults' qualitative responses to successful aging, we better understand what successful aging means across cultures.

Backman, Natalia; Ogden, Heath (Utah Valley University)
Faculty Advisor: Ogden, Heath (Utah Valley University, Biology)

The Family Baetidae, is in the order Ephemeroptera, also commonly known as Mayflies. The first baetids were described around 1815 by Leach, and since there are more than 900 species have been described. The family Baetidae is an important group of mayflies because of their position on the mayfly tree of life in that they are a key to understanding evolutionary trends, such as the origin of wings and flight. Taxon sampling for this study consisted of over 100 taxa, representing ??? genera, from lineages distributed geographically worldwide, except Antarctica. Two main datasets were constructed. The genes 12s, 16s, H3, 18s, 28s and CO1 were used as part of a traditional dataset. Targeted capture sequencing was used to generate a phylogenomic dataset, consisting of over 400 loci. Trees were reconstructed from the aligned datasets, and the results were compared. The phylogenomic data resulted in a much more resolved topology.

Durrant, Bianca; Bennion, Sean; Shipp, Dustin (Utah Valley University)
Faculty Advisor: Shipp, Dustin (Utah Valley University, Physics)

determine bacteria is growing the bacteria on agar and then identify the bacteria via the API system (analytical profile index). In some medical cases, 24 hours is too long to wait, especially if a patient needs antibiotics. Raman spectroscopy uses laser light to excite a spectrum specific to each molecule. This molecular specificity enables Raman spectroscopy to identify the species of bacteria without a lengthy growth period. Raman spectroscopy is non invasive and only needs one bacterium for detection. It is therefore faster than growing bacteria and identifying via the API system.

From other research groups we know that Raman spectroscopy is able to classify bacteria, albeit with limited breadth of bacterial types. The next step is to implement imaging techniques to make the identification even faster, so that those techniques can be used in hospitals to determine pathological bacteria, so that the treatment can be given faster. Furthermore, when a hospital is unsure whether the patient has a disease caused by bacteria usually they start treating the patient with antibiotics in case they are infected. If identification only take a few hours instead of two to three days, doctors would only prescribe antibiotics when necessary, thus decrease the risk of multiresistant bacteria.

Gomez, Nathaniel; Blumel, Daniel; Dueñas, Davis; Hazel, Matt; Yu, Ming* (Utah Valley University)
Faculty Advisor: Yu, Ming (Utah Valley University, Chemistry)

Kidney cancer in both men and women is among the top ten most common cancers, where the risk in men is estimated at 1:48, and women at 1:83. The issue with kidney disease is that it is difficult to accurately diagnose early-on. Methods of diagnosis that are currently established are expensive and highly invasive if at all accurate. Our research is focused on developing a fast, reliable and cost-effective method of diagnosing kidney disease by the use of fluorescent quantum dots (QDs). When mixed in a solution that contains protein biomarkers, QDs can act as biosensors because the protein alters their fluorescent properties. With QD biosensing, optimal conditions were discovered for the size of QDs and buffers used for detecting different protein biomarkers. The study provides empirical evidence that the alteration is distinguishable between healthy and cancerous levels of protein.

Lake, Alexander; Soboleva, Tatiana; Berreau, Lisa (Utah State University)
Faculty Advisor: Berreau, Lisa (College of Science, Chemistry and Biochemistry)

Carbon Monoxide (CO) has been found to have a wide range of potential therapeutic effects. For example, low concentrations of CO have been shown to produce anti-inflammatory, anti-hypoxia, anti-proliferative, and anti-apoptotic effects, as well as vasodilation. CO-releasing molecules (CORMs), particularly those which release CO upon triggering with light in the visible range (photoCORMs), are of significant current interest for targeted CO delivery. Our laboratory is developing extended flavonols as highly tunable tunable photoCORMs. In this presentation, the synthesis, characterization, and CO release reactivity studies exploring the use of flavonol esters as CO delivery molecules will be presented.