Covey, Tracy; Alsup, Garrett; Kreinbrink, Alexia (Weber State University)
Faculty Advisor: Covey, Tracy (College of Science, Department of Chemistry and Biochemistry)
Certain over-the-counter medications, such as acetaminophen and ibuprofen, are known to have an effect on the bioavailability of warfarin, enhancing its anticoagulant properties. The goal of this project is to study how varying the concentration of ibuprofen or acetaminophen affects the amount of warfarin bound to blood plasma proteins. To better understand how strong these drug-drug interactions are with warfarin, we proposed capillary electrophoresis (CE) as an analytical method to separate and detect these compounds. Acetaminophen, ibuprofen, and warfarin have all been analyzed using CE in the literature, so we sought to develop a CE method to separate and detect all three drugs together. We are currently optimizing this method and will use this method to investigate warfarin displacement from plasma proteins by ibuprofen and acetaminophen.