Keyser, Michael A.; Jiang, David; Timmins, Lucas H. (University of Utah)
Faculty Advisor: Timmins, Lucas (University of Utah, Biomedical Engineering)
Coronary heart disease is one of the leading causes of death in the United States and is caused by a buildup of atherosclerotic plaque blocking blood flow in a coronary artery. Stents are used to restore blood flow to affected regions by reopening the blocked artery. Failure among stents is common, and a 3D reconstruction of a stent can be used to investigate the cause of failure. We have previously established a 3D stent reconstruction technique that utilizes optical coherence tomography (OCT) and micro-computed tomography imaging data to provide a high-spatially resolved stent reconstruction. However, analysis revealed that each OCT image was subjected to a curvature induced rotational drift due to the imaging process. Thus, the purpose of this study was to examine the relationship between vessel curvature and OCT image drift. Four separate channels of constant curvatures, 0, 1/60, 1/30, and 1/20 mm^-1 were drilled out of Delrin using a CNC machine resulting in a 'U' shaped channel. Each channel was imaged, and the rotational drift for the curvature of that channel was determined by calculating the average change in image orientation. The orientation of an image was the angle of the top edge of the 'U' with respect to a horizontal line. Results demonstrated the rotational drift was -0.172, -0.598, -0.927, and -1.124 degrees for curvatures of 0, 1/60, 1/30, and 1/20 mm^-1 .We discovered the relationship between the curvature of the channel and the rotational drift of an image to be _=-19.12_-0.227 where _ is the curvature of the channel _ is the rotational drift of the OCT image in degrees. In conclusion, we demonstrated that there is a linear relationship between curvature and OCT image circumferential drift that can be used to improve the overall accuracy of the reconstruction.