Authors: Alexa Bailey, Sophie Daines, Joshua Bennett, Carlos Moreno, Scott Weber
Mentors: Scott Weber
Insitution: Brigham Young University
As the understanding of cancer pathophysiology continues to increase, there is an increased focus on the role of T cells in targeting cancerous cells and tumor sites. Recently, it was demonstrated that CD5, a transmembrane glycoprotein found on T cells, plays a key role in negatively regulating T cell activity. CD5 also significantly impacts T cell metabolic profiles by increasing oxygen consumption rates (OCR) and extracellular acidification rates (ECAR). We are now investigating the role of CD6, a related membrane protein found on T cells, and its effect on regulating T cell proliferation and metabolism by measuring the proliferation rates and metabolic profile of T cells from a CD5/CD6 double knockout murine model. Because tumor microenvironments are vitally important in determining the immune system’s response to cancer, differences in metabolism may yield new insights for developing immunotherapy techniques.