2024 Abstracts
Forest Fire Detection Using Deep Learning Techniques
Authors: Mason Davis. Mentors: Mohammad Shekaramiz. Insitution: Utah Valley University. Forest fires are disasters that devastate our local communities here in Utah and communities abroad. Characterized as uncontrolled and unpredictable fires in areas with combustible vegetation, these phenomena cause ecological and economic harm. With global warming driving temperature increases and variability in weather patterns, these fires are becoming more severe and frequent. Calls from local and national leaders for solutions are ever-growing. An important factor in fighting these fires includes early detection and monitoring. With advances in artificial intelligence and computer vision, the accuracy and speed of detection can be greatly improved. In this research, two new deep learning approaches making use of transfer learning are developed and investigated for fire detection. To compare performance further, existing architectures are also deployed for analysis on the fire detection problem, including ResNet-50, Xception, MobileViT, and Support Vector Machine. To train and evaluate the performance of the above models, the popular forest fire dataset known as DeepFire was utilized. This dataset consists of a symmetrical split of fire and no-fire images consisting of 1900 total images in varying forest environments. Each architecture was tuned through hyperparameter searches and trails to seek ideal combinations for optimal performance. A comparison was drawn with the most recent literature making use of this dataset. Here, our modified Xception architecture leveraging transfer learning topped all recent publications on the DeepFire dataset by achieving 99.211% accuracy. With wildfires increasing in frequency and severity, the early detection of these disasters is paramount to controlling their spread. We have seen that deep learning can provide an increasingly accurate way to autonomously survey and detect these disasters. This is a promising step toward autonomous detection and early elimination of these disasters as they start. Future work will include the investigation of real-time processing techniques for fire detection, allowing for real-time data acquisition, inference, and transmission of geo-information to emergency and forest management teams.
fr10 Evolution
Authors: Reagan McKee, Vicente Fernández Lara, Jeremy Bakelar, Randy Klabacka, Dustin Kolste. Mentors: Randy Klabacka. Insitution: Utah Tech University. The capability to survive freezing temperatures is of crucial importance to ectothermic organisms inhabiting cold climates. The mechanisms that have evolved to minimalize the cellular damage incurred by freezing are of interest due to their applications in agriculture and medicine. fr10 is a gene identified in the wood frog (Rana sylvatica)that has been shown to reduce the cellular damage sustained in freezing temperatures. To date, fr10 has not been identified in any taxa beyond R. sylvatica and as such, the evolution of this novel gene remains ambiguous. Furthermore, the exact mechanism by which fr10 reduces freezing related damage has yet to be determined. We use bioinformatics scripts to scan 38 frog genomes to identify orthologs in divergent frog lineages across varying elevational and latitudinal gradients and examine the evolution of this novel gene. Understanding the evolutionary and ecological context of this gene can elucidate its function and may inform commercial and medical applications.
Fremont Red-on-Gray Pottery
Authors: Talia Berglund. Mentors: Michael T. Searcy. Insitution: Brigham Young University. Fremont Red-on-Gray Pottery Specific to the Northern Macro-Region of inhabitance, there has yet to be a comprehensive cataloging of Fremont red-on-gray ceramics. As such, I will be asking the following research questions in regard to this type of ceramic: What designs were painted on Great Salt Lake red-on-gray? And how do these designs compare to other Fremont ceramic types? In order to effectively answer these questions, I will look at Great Salt Lake Fremont ceramic vessels and sherds with traces of red paint on the surface, with a particular emphasis on the artifacts found at Hinckley mounds but comparing them to Wolf Village specimens as well. The research will include recording the shapes and designs that are painted on the vessels, as well as measuring width and length of these lines and shapes. I will also investigate what the red pigment is made out of–using either PXRF or microscopic analysis. These methods will generate a catalog of designs found on red-on-gray ceramics, as well as a data set that will allow me to look for patterns among the painted designs. I plan to develop a general typology of red-on-gray Fremont pottery based on the sample investigated.In carrying out this research, we should be able to assess whether or not the Fremont in the Northern Macro-Region shared painting practices with other Fremont in different areas, and thus possibly determine how they viewed themselves as belonging to or different from other nearby groups of people. If a pattern emerges and red-on-gray designs are shared between groups, then perhaps they interacted with and associated with those groups. If there is a lack of shared practices and designs, the opposite could be potentially true.
Frim Patron To Partner: Accomplishments of Museum-Armature Archaeology Relationships
Authors: James Hall. Mentors: Paul Stavast. Insitution: Brigham Young University. As of November 2023 the Utah Statewide Archaeological Society's social media pages have close to 4 thousand followers, which shows that interest in Archaeology. From 1955 to around the mid-90s USAS members contributed greatly to the archaeological research and the protection of archaeological sites and the materials created by those people that had called what is now Utah home. Through the partnership of Universities and Museums they had great success and this poster aims to highlight some of those successes and push for Museums to continue facilitating these opportunities.
From Pixels to Passion: How Mindfulness Reshapes the Landscape of Love and Intimacy as Counterbalance to Media Consumption
Authors: Hadley Avila, Chelom Leavitt. Mentors: Chelom Leavitt. Insitution: Brigham Young University. The association between media consumption and relationship satisfaction has been a growing area of interest within the past several years; however, little research has looked into how different areas of media entertainment might affect specific factors that contribute to relationship satisfaction: relationship flourishing and sexual harmony. We analyzed the association between individual partners media consumption through television viewing, video game playing, and social media, to their level of relationship flourishing and sexual harmony. Additionally, past research has yet to explore possible solutions to the potential negative associations between media and romantic relationships. We analyzed individual partner mindfulness to see if it acted as a moderator against declines in relationship flourishing and sexual growth due to media distractions. We found that while women’s video game use and social media use were both negatively associated with sexual harmony and relationship flourishing, mindfulness only acted as a moderator against the relationship between social media use and relationship flourishing. For men, television viewing and social media use were negatively associated with relationship flourishing and sexual harmony, however, mindfulness did not act as a moderator.
From Self-Critique to Self-Care: Examining the Links Between Perfectionism and Self-Compassion
Authors: Peg Bird, Maria Balaceanu, Grace Carsey, Tiffanee Suhaka, Hunter Mitchell, Ives Hong, Tara Caplin, Ed Wu, John T Jones, Dannelle Larsen-Rife. Mentors: John T Jones. Insitution: Utah Tech University. This study examines the relationship between perfectionism and self-compassion. Perfectionism may be beneficial, but often promotes unrealistically high self-imposed standards, a preoccupation with making mistakes, and a compulsivity toward order, leading to self-criticism and self-loathing. Perfectionism results in persistent feelings of failure, indecision, procrastination, and shame, which negatively impact relationships, work-life satisfaction, and overall well-being (Enns et al., 2001; Frost et al., 1993). Self-compassion is directing warmth and care toward oneself during times of suffering and comprises three core components: self-kindness (offering oneself warmth during adversity), common humanity (acknowledging shared suffering), and mindfulness (approaching the experience of pain with presence and curiosity) (Neff, 2003). Self-compassion is associated with mental health and well-being, including a stable sense of self-worth, increased resilience, life satisfaction, and perspective-taking. Furthermore, self-compassion negatively correlates with anxiety and depression, reduced fear of failure, perfectionism, and self-criticism (Barnard et al., 2011; Neff, 2003; Neff et al., 2006). This correlational study will recruit approximately 100 adult participants to evaluate associations between perfectionism and self-compassion. Participants will complete the Frost Multidimensional Perfectionism Scale and the Self-Compassion Scale (Frost et al., 1990; Neff, 2003). We anticipate a negative correlation between self-compassion and perfectionism, with higher levels of self-compassion corresponding with lower levels of perfectionism. If this prediction is supported by the data, the study’s outcomes will extend existing research on the potentially deleterious effects of perfectionism and pave the way for the development of interventions aimed at improving mental health outcomes among individuals adversely impacted by this trait.
From Struggles to Strength: Strategies, Identity, and Acceptance with the LGBT Community
Authors: Kirsten Graham, Julie Pynn. Mentors: Kirsten Graham. Insitution: Southern Utah University. This study looks at how the LGBT+ population deals with concerns of identity, societal acceptance, and discrimination. The research identifies three primary coping mechanisms that affect resiliency: problem-focused coping, emotional coping, and avoidant coping. The purpose of the study is to determine how coping strategies and resilience relate to obstacles faced by Southern Utah University students. It makes use of qualitative data analysis, the Brief-Scale COPE, and the Brief-Resilience scales. I hypothesize with the quantitative data LGBT individuals who employ strong problem-focused skills are expected to demonstrate higher levels of resilience scoping, LGBT individuals who employ high levels of emotion focused-coping skills are expected to demonstrate low levels of resiliency, and those that demonstrate high levels of avoidant focused-coping are expected to demonstrate low levels of resiliency. Qualitative data analysis will reveal common thematic patterns in the use of problem-focused, emotion-focused, and avoidant coping skills among LGBT+ individuals, providing insights into their coping strategies related to discrimination, social acceptance, and identity. Understanding how the LGBT+ community at Southern Utah University manages to cope with challenges is crucial because it can result in better support and wellbeing. Results are forthcoming
Functional Near-Infrared Spectroscopy and Dementia
Authors: Natalia Rubio, Madison Farrer. Mentors: Christopher Anderson. Insitution: Utah Valley University. Functional Near-Infrared Spectroscopy (fNIRS) is a neuroimaging technique used to monitor brain activity by measuring the changes in blood oxygenation levels, especially when presented with stimuli or given tasks. This is due to the principle that active brain regions require more oxygen, resulting in changes of blood flow and concentrations of hemoglobin. These observable results are achieved by diodes placed on the surface of the scalp that emit near-infrared (NIR) light into the skull. The absorption of this light by the hemoglobin in the brain’s blood vessels is then detected, localizing neural activity. Due to its portability and cost-efficient nature, fNIRS is being widely used across various fields of research and clinical applications whereas other neuroimaging methods might be less feasible or practical. Psychologists and neuroscientists are able to utilize fNIRS to understand how different regions of the brain are involved in various cognitive processes. It has been used in studying conditions like Alzheimer's disease, stroke, traumatic brain injury, autism, schizophrenia, mood disorders, and dementia. In the context of dementia research, fNIRS has emerged as a promising tool . While fNIRS has a low spatial resolution with measurements restricted to the outer cortex of the brain, it enables the study of the progression of dementia by providing real-time data and offering relative tolerance to subject motion. In fact, a neuro-clinic in Provo, Utah (Cognitive FX) has been studying the use of this fNIRS technique on patients with dementia while they perform language tasks. Although no patient data will be used in this study, the use of fNIRS as a technique to learn about the progression of dementia is noteworthy. Therefore, following IRB approval I will perform semi-structured qualitative interviews with two neuro-technicians using fNIRS in this clinic. Items will focus on the strengths and challenges of using fNIRS with dementia patients. Additionally, I will shadow these technicians to gain hands-on experience. Qualitative results will be analyzed and presented. It is anticipated that this research project will raise awareness of the use of fNIRS as a technique in neuroscience as well as its potential to benefit those with dementia.
Gambel Oak Acorns as a Food Resource in the Great Basin, Colorado Plateau, and Southwest
Authors: Sophia Dodge. Mentors: Alex Greenwald. Insitution: University of Utah. This project seeks to address the understudied presence of Gambel Oak acorns in the archaeological record of the Great Basin, Colorado Plateau, and Southwest regions. While ethnographic data and historical records suggest that Native peoples in this area consumed some Gambel Oak acorns, their recognition in archaeological contexts has been limited. This study aims to assess the viability of methodologies for identifying macrobotanical acorn remains, shedding light on their utilization across different time scales, especially as fallback crops during resource shortages, such as climate shifts. Through experimental methods like burning, parching, and midden simulation we will determine how these methods impact the identifiability of acorns. The research holds significance for our understanding of past human responses to climate change and the ongoing struggle for Indigenous food sovereignty, providing valuable insights into sustainable food sources for the future.
GAMERS: General Arm Mechatronic Exoskeleton Robot System
Authors: Michael Olson. Mentors: Nathan Usevitch. Insitution: Brigham Young University. Wearable robotic devices are versatile for assisting users in many scenarios. These devices could provide therapy treatments to users recovering from injuries, provide support for factory workers who commonly perform repetitive tasks (in 2021 there were over two million work-related injuries in the US) and aid motion for elderly people with limited mobility. Whereas other assistive devices require external machinery and infrastructure, a wearable device makes it possible to provide aid during activities of daily living, and in normal work scenarios. Wearable tech can reduce metabolic work required to complete a variety of simple tasks, can enable a user to accomplish tasks normally requiring greater strength than they possess, and can help improve motion capabilities of users in cases of limited mobility.At BYU, we are developing a wearable system to assist user's elbow motion. Our design uses a system of motors mounted on a backpack frame. These motors connect to the assistive sleeve through a set of Bowden cables. We are developing a general mechatronic platform that can be used to actuate several different sleeve designs. Developing this platform enables us to quickly experiment with different sleeve designs and cable routings. The system uses three pairs of motors per arm: one pair for arm pronation and supination (wrist rotation), one pair for elbow extension and flexion (like doing a bicep curl), and one pair for medial or lateral rotation (rotation of the arm to the left or right). When one motor tenses to provide force to move the arm in a particular direction, the other motor relaxes, enabling the arm to travel in that direction. The motors are controlled by an Arduino Nano 33 interfaced with a laptop, and the device could be modified to be compatible with an X-Box controller connected to Robot Operating System (ROS), providing wireless control for arm motion. Potential applications may include rehabilitation, mobility assistance, and assistance with repeated tasks.
Geminivirus Resistance in Mustard Plants
Authors: Laureana Lazarte, Adam Hales. Mentors: yu ya liang. Insitution: Utah Valley University. Plant Viruses pose a serious threat to the agricultural industry worldwide, infecting members of the brassica genus, including cabbage, broccoli, and cauliflower. This particular virus is transmitted via the cabbage aphid, which poses a serious problem, as these are extremely common in croplands worldwide (Clafin et al., 2017). The motivation of this project is to expose a variety of Brassica species to a novel DNA virus, which is a putative geminivirus and has recently been discovered in Utah. Then, plants that show signs of disease resistance after being infected with the virus will be identified. Following infection, genetic information from all Brassica species will be obtained and then analyzed to identify possible sources that promote disease resistance. A diverse array of mustard seeds will also be requested from the USDA National Plant Germplasm System. The methods of this study will involve growing a wide variety of plants within the Brassica genus for six to eight weeks in a greenhouse setting, and exposing them to the virus. The plants will then be analyzed on the basis of severity of infection via visible observations using a zero through ten scale that will be developed. DNA from the plants will be extracted and the genomes will then be sequenced. Combining the genome information and disease susceptibility, a Genome-Wide Association Study (GWAS) will be used to look for possible genetic information that could promote disease resistance. The outcomes of this study may also be used for disease resistance breeding.
Gender differences in performance evaluation anxiety in faculty members on the tenure track
Authors: Tatiana Leroy, Jessica C Hill. Mentors: Jessica C. Hill. Insitution: Utah Valley University. The tenure process in higher education is complex and multifaceted. While offering job security, prestige, and academic freedom in research and teaching (Batterbury, 2008), it can also be a source of stress and anxiety due to its competitive nature and demanding evaluation process (Jacobs & Winslow, 2004). Competition can be intense due to a high number of qualified candidates for a limited number of tenure-track positions. Once such a position is secured, tenure-track candidates experience sustained scrutiny of their performance during their probationary period. This stress can impact work-life balance and overall job satisfaction (Hellsten et al., 2011), potentially leading to the loss of high-quality faculty. Our proposed longitudinal study aims to address this issue by identifying factors that increase anxiety and stress during the probationary period of tenure-track faculty. We aim to provide a comprehensive analysis of these trends, with a particular emphasis on gender-based differences. By understanding and addressing the sources of stress during the tenure process, we hope to offer solutions for fostering supportive environments that encourage the retention of a diverse body of high-quality faculty through the award of tenure. This study, as the first of its kind, endeavors to bridge a significant gap in existing research by focusing on the identifying challenges faculty face on their journey toward tenure and generating effective solutions to help retain them. Batterbury, S. (2008). Tenure or Permanent Contracts in North American Higher Education? A Critical Assessment. Policy Futures in Education, 6(3), 286–297. https://doi.org/10.2304/pfie.2008.6.3.286 Hellsten, L.-A., L. Martin, S., J. McIntyre, L., & L. Kinzel, A. (2011). Women on the Academic Tenure Track: An Autoethnographic Inquiry. International Journal for Cross-Disciplinary Subjects in Education, 271–275. https://doi.org/10.20533/ijcdse.2042.6364.2011.0039 Jacobs, J. A., & Winslow, S. E. (2004). Overworked Faculty: Job Stresses and Family Demands. The Annals of the American Academy of Political and Social Science, 596, 104–129. https://www.jstor.org/stable/4127652 Yoon, A. H. (2016). Academic Tenure. Journal of Empirical Legal Studies, 13(3), 428–453. https://doi.org/10.1111/jels.12120
Gender disparities in the pursuit of biology at UVU
Authors: Eden Backman, Britt Wyatt, Kandace Flanary, Jessica Cusick, T Heath Ogden, Joshua Premo. Mentors: Joshua Premo. Insitution: Utah Valley University. Utah Valley University serves a unique student population where ~70% of students are Latter-Day Saints (LDS) and ~30% are non-traditional (over the age of 24) (UVU IR, 2023). Compared to the overall 1.6% of LDS individuals in the United States (Pew Research Center, 2023), the identities of UVU students are vastly underrepresented in education research that has been conducted at other institutions. This is especially important as the LDS religion has been related to one of the most conservative religious groups concerning gender roles (Heaton, Bahr, and Jacobson 2004). Additionally, recent preliminary analysis of public institutional data from Utah universities indicates that UVU is graduating more men than women in biology, drastically contrasting other Utah university and national trends. In Utah, the STEM workforce has seen a significant 20% increase since 2016 (UWLP, 2022). However, it's important to note that during this period of expansion, men have disproportionately reaped the benefits in terms of STEM career opportunities. According to IWPR (2019), men in Utah are 2.5 times more likely to secure a STEM career compared to women. Furthermore, in 2020, STEM careers in Utah boasted median annual wages that were over twice as high as those in other occupations, which has direct implications for individuals' lifetime earnings and social capital. Given this information, we questioned why women were not choosing educational paths that will promote a career in STEM? If they are choosing STEM majors, then what are the factors that promote women to leave STEM during their undergraduate careers? This research project focuses on trying to answer these questions specifically at Utah Valley University (UVU). UVU’s biology program reflects similar patterns that are seen in the STEM workforce in Utah. UVU’s biology program was graduating twice as many men compared to women during the most recent academic year (2022-23)(UVU IR). This was the lowest percentage of women earning a four-year biology degree when compared to all other Utah institutions (USHE, 2023). The following research questions were addressed to help inform our understanding of why inequities in degree attainment by gender are being seen at UVU: 1) Are women less accepting of biological ideas (evolution, vaccines, climate change, etc.) that may be impacting women’s pursuits of biology? 2) Are there differences in how women are relating to science (motivation, immersion, or integration) that may be impacting their pursuit of biology? 3) Are there differences in political orientation or religious affiliation that may be impacting women’s pursuits of biology? To answer these questions, we collected data from 1,455 students (22% were biology majors) enrolled in biology classes at UVU in Fall 2023. Comparisons were made using independent samples t-test (with Bonferroni adjustments) to see the extent to which factors varied between men and women both within and outside of the biology major. In contrast to expectations, results for research question #1 show that women biology majors did not agree with science less than men. In fact, women strongly agreed with several science ideas at a higher rate than did men. These ideas included environmental concern and climate change (women = 66% vs. Men = 41%) and vaccination (women = 63% vs. Men = 48%). This result suggests that differences in acceptance of science ideas may not be driving the differences in degree attainment in biology. If anything, these results suggest that women should be more likely to continue in the biology major compared to men. In addition, when students’ immersion (sense of belonging and science identity) in science was assessed by gender women were slightly higher than men with about 8% more strongly agreeing to being immersed in science. This finding suggested that women are not experiencing lower immersion as a potential factor impacting degree attainment. Further examination of additional factors is underway. This study highlights that there are specific factors that may be contributing to gender disparities in biology bachelor's degree attainment at UVU. We recommend specific interventions targeting areas of differences in the biology program to provide additional scaffolds and supports to promote more equitable career trajectory and lifetime earnings for women pursuing Biology at UVU.
Gene analysis of gut microbiota that improves chill coma recovery rates in Drosophila Melanogaster
Authors: Lauren Heath, John Chaston. Mentors: John Chaston. Insitution: Brigham Young University. Mounting evidence shows that gut microbiota disruption is related to several physiological processes and disease development in mammals; however, the mechanisms by which these processes take place are not fully understood due to the complexity of the mammalian gut microbiome. Studying the fruit fly, Drosophila Melanogaster proves to be a valuable model for understanding the gut microbiome on a smaller scale. Previous research has identified microbiota disruption alters the fly’s ability to cope with thermal stress and causes slower chill coma recovery times. Chill coma recovery is an important survival trait and stress response in Drosophila flies. Microbiota may affect the ability of hosts to tolerate stressful situations. The purpose of this project is to determine the effect of different bacterial strains on the mechanisms of chill coma recovery through a metagenome analysis of different bacterial strains. I hypothesize that certain microbe genes will increase chill coma recovery times. To test this assumption, I will mono-associate by flooding different groups of eggs with a microbe wash and infusing their food with the same bacteria strain. After cultivation, a chill coma will be induced by placing mature adult flies in empty vials on ice for three hours, and then the time for each individual to stand up after their transfer to room temperature will be recorded. Subsequently, I will assess cold tolerance, and evaluate the rates of recovery. With this, we can further identify the mechanisms of the chill coma recovery process by pinpointing specific proteins necessary for this process through a metagenome-wide association approach (MGWA) and gene analysis. If I observe no effect of the bacterial strains on chill coma recovery times, I can test different mixes of microbes to determine if improved recovery rates are a side effect of global metabolic changes caused by decreased biodiversity in the gut of drosophila flies. Studying the metabolic processes of Drosophila allows us to unravel further the mechanisms by which gut microbes affect the fitness and health of their host. My findings may be extrapolated to further understand the human gut microbiome.
Generative AI and Image Manipulation
Authors: Tayler Fearn, Caroline Torgensen, Vern Hart. Mentors: Vern Hart. Insitution: Utah Valley University. Coherent diffraction imaging (CDI) is a newly developed modality used to measure phase shifts introduced by fine-scale structures in cells. These phase shifts can be used to distinguish healthy and malignant cells, providing a diagnostic marker for early cancer detection. However, this process, in which diffracted light interferes with incident light, requires collecting scattered photons at large angles, representing high spatial frequencies and short wavelengths. The highest frequencies, needed to reconstruct small details in cells for improved image quality, occur at distances of several centimeters from the central bright fringe. As such, these signals are faint and difficult to collect experimentally. We propose the use of deep learning to synthetically extrapolate diffraction patterns at large distances, where measurements are difficult. In prototyping this method, we will present results produced by a generative adversarial network (GAN), trained using existing data of watercolor paintings to preform style transfer and image extrapolation. This will be an essential step in working towards the larger goal of developing GAN’s that can accurately extrapolate diffraction images.
Genetic Modification of Cyanobacteria to Break Down Organic Compounds and Inhibit Toxin Production
Authors: Lonnie Ernst. Mentors: Lane Law. Insitution: Salt Lake Community College. Cyanobacteria are photosynthetic bacteria commonly found in water. Microcystis aeruginosa is one such cyanobacteria that is found within the waters of Utah Lake. M. aeruginosa produces the microcystin toxin which is harmful to the aquatic life and contributes to the ongoing problem of eutrophication and, if ingested, is also harmful to humans. Alongside this toxin producing cyanobacteria, Utah Lake is contaminated with polychlorinated biphenyls (PCBs) which are highly carcinogenic chemical compounds. This study aims to offer a method of bioremediation by engineering M. aeruginosa to carry a BPH gene pathway that breaks down PCBs. Using CRISPR, this gene would remove the microcystin producing gene and replace it with the BPH gene resulting in the engineered M. aeruginosa to breakdown the PCB contaminants and halt further production of the microcystin toxin.
Genetic Mutations in the Genomes of Mother-Offspring Pairs Shows Link Towards Nausea and Vomiting in pregnancy
Authors: Dallin Oyler, Ana Alfaro, Kailee Myxter, Ben Brooks, Amanda Brooks. Mentors: Jessica Pullan. Insitution: Southern Utah University. Nausea and vomiting are common complications that occur in 70% of pregnancies. Hyperemesis Gravidarum (HG) is the most severe form of these symptoms and is estimated to be prevalent in 0.3-2% of pregnancies. Due to the fetal and maternal morbidity associated with HG, identifying the cause and treatment options for these women is a critical task in obstetrics. Research regarding the etiology of HG has been fairly recent and is still ongoing, however, evidence had directed to a positive correlation between increased levels of the serum protein GDF15 and HG symptoms. We hypothesize that polymorphisms in both maternal and fetal DNA plays a role in the upregulated GDF-15 seen in mothers experiencing symptoms of HG during pregnancy. The DNA of 2 mothers and their corresponding children were sequenced and analyzed. The DNA was obtained through buccal swabs from the epithelial cells of the inner cheek, and then purified and ran through PCR. We employed 3 distinct primers that correspond to mutations in the genome that account for the elevated levels of circulating GDF-15 in the mother. As of current, the mother-daughter DNA is still under analysis for single-nucleotide polymorphisms, however recently published literature has suggested results similar to our hypothesis. M. Fejzo et al. shows that upregulated serum GDF-15 is primarily of fetal origin, and that maternal sensitivity to GDF15 increases the risk for developing HG. Additionally, the DNA coding variant GDF15 C211G was shown to elevate the risk of HG
Genomic Analysis of Male Reproductive Skew in Bornean and Sumatran Orangutans
Authors: Gabriel Hammond, Rebecca Seegraber, Tim Webster. Mentors: Tim Webster. Insitution: University of Utah. Bornean and Sumatran orangutans demonstrate pronounced differences in their social behavior. All orangutans are more solitary than other apes and monkeys, but Bornean orangutans are even less social than their Sumatran counterparts. This contrast is generally attributed to differences in forest productivity between the two islands, as feeding competition is a major cost to social behavior. Variation in sociality between the two species directly impacts male reproductive skew, or the extent to which males can monopolize reproductive success. Sex-biased demographic phenomena such as male reproductive skew can be reconstructed across a lineage’s history by comparing genetic variation across different regions of the genome. Autosomes and the X chromosome are inherited in different proportions, in a population with an equal sex ratio, four autosome copies will be passed down for every three X chromosomes. Deviations in genetic diversity from this expected ratio can be indications of sex biased demographic events. This project is leveraging differential inheritance of chromosomes to explore the role of orangutan socioecology in shaping male reproductive strategies through genomic analysis of reproductive skew across Bornean and Sumatran orangutans.