Physical Sciences
The Stability of Isolated Bovine Milk Derived Extracellular Vesicles
Author(s): Elley Colledge, McCoy Smith, Ian Cutler
From Ancient Cyanobacteria to Future Tech: The Chemistry of Dipyrroles
Author(s): Jaren Meikle, Samuel Archer
Modifying the Light-Harvesting Capabilities of Phycocyanin using Rhodamine-B
Author(s): Brecken Shakespeare, Colton Koch
Photophysical and Photochemical Investigation of Dipyrrinone Bilin Subunits
Author(s): Cauy Williams, Danielle Newbold
Stratigraphic Insights into the Tectonic Evolution of the Rio Grande Rift
Author(s): Levi Hawks
Uncovering Mixture Interactions through Excess Heat Capacity
Author(s): Calvin Crawford
Strain-Driven Metal-to-Insulator Transition and Ferroelectricity in WTe₂
Author(s): Ross Richins
Encapsulation of Chemotherapeutic Temozolomide in Bovine-Milk Derived Extracellular Vesicles
Author(s): Charlee Cannon, Torrance Johnson, Caleb Weaver
The study of urea on protein biomarker detection by quantum dots
Author(s): Daniel Jensen, Caitlin West
Optimization of Cannabinoid Permeation Agents for Transdermal Delivery Applications
Author(s): Madison Bulloch, Alexia Casillas
Testing of an Acousto-Optic Modulator for Implementation as a Laser Q-Switch
Author(s): Micah Laing, Benjamin Holt
Increased Efficiency in Nonlinear Wireless Power Transfer
Author(s): Zachary Butler, Kendall Rosenkrantz, Yoonji Yo
Student's perceptions on the use of Virtual Reality in organic and inorganic chemistry
Author(s): Isabelle Smith, Alexandra Routsis, Laryssa Larson, Josie Wright, Kaden Jensen
Fluoride Speciation Analysis of the Great Salt Lake Utah
Author(s): Danielle Kemmer, Dillon Reynolds, Alyssa Brown, Benjamin Judd, Dean V. Smith, Tyler Jenkins, Asha Ahmed, Amber Thornton Miller, Dylan Jenkins, Nashly Cruz-Guzman
Synthesis and Characterization of Novel Pterostilbene Derivatives for Potential use as Therapeutics
Author(s): Austin Lamoreaux
Exploring Urban Wildlife Management Plans: A Case Study in Cedar City
Author(s): Jhen Allison Seguiwan
Insights into hydrogen storage utilizing cyclic amino-borane complexes
Author(s): Jordan Colmenero
Optimizing Continuous-wave Nd:YVO4 Laser Performance for Longwave Infrared Generation
Author(s): Benjamin Holt, Alex Gibb, MicahLaing
Lensless High-Resolution Imaging with Laser Interference
Author(s): Ulises Thornock, Brian Weaver, Jackson Phippen
Synthesis of Chiral ɑ-Amino Boronates via a 3-Component Coupling Reaction
Author(s): Anna Page
Quantitation of Trace Oxygen in Anoxic Water Implementing a Microfluidic Device
Author(s): Corban Kerr, Kason Stinson
Tectonic History of the Rio Grande Rift Through a Study of Sediment Provenance
Author(s): Brian Angell
A Pilot Study Investigating Virtual Reality for Chemical Education
Author(s): Kaden Jensen
Creating a New Distance Ladder with Surface Brightness Fluctuations
Author(s): Mikaela Cowles
Seven potential double star systems in the stellar association WSD 05205+3654
Author(s): Stryder Wiese
Optical Scattering for Rapid UTI Detection
Author(s): Feng Guo, Elise Bauer, Kimball Henstrom, Caroline Torgersen, Hannah Thrupp, Isaac Zabriskie, Alex Martinez, Keaton Fuller, Clint Flinders
Comparative study of humic acids from extracted soils and leaves
Holden, Maliea; Richardson, Spencer; Chilom, Gabriela (Dixie State University)
Faculty Advisor: Chilom, Gabriela (Dixie State University, Physical Sciences)
Humic acids are a key component of the terrestrial ecosystem as they are responsible for many physical and chemical properties of soils; buffering capacity, metal-binding capacity, transport and fate of contaminants, stability of aggregates of soil particles and water-holding capacity all depend on the amount and nature of humic substances in a soil.
The current project is looking into the properties and ability of humic acids extracted from leaves, to improve the stability and fertility of a mineral soil. The humic acid was extracted from fresh and aerobically incubated leaves by traditional alkali extraction. Three species of trees commonly grown in St George, Utah were selected: Prunus x Cistena, Pyrus Calleryana Bradford, and Chilopsis Linearis. The extracts were characterized by the amount and nature of their carbon content as determined by IR, 1H NMR, and 13C NMR spectroscopy. Their properties showed similarities and differences with humic acid extracted from mineral soil and leonardite.
Faculty Advisor: Chilom, Gabriela (Dixie State University, Physical Sciences)
Humic acids are a key component of the terrestrial ecosystem as they are responsible for many physical and chemical properties of soils; buffering capacity, metal-binding capacity, transport and fate of contaminants, stability of aggregates of soil particles and water-holding capacity all depend on the amount and nature of humic substances in a soil.
The current project is looking into the properties and ability of humic acids extracted from leaves, to improve the stability and fertility of a mineral soil. The humic acid was extracted from fresh and aerobically incubated leaves by traditional alkali extraction. Three species of trees commonly grown in St George, Utah were selected: Prunus x Cistena, Pyrus Calleryana Bradford, and Chilopsis Linearis. The extracts were characterized by the amount and nature of their carbon content as determined by IR, 1H NMR, and 13C NMR spectroscopy. Their properties showed similarities and differences with humic acid extracted from mineral soil and leonardite.
Discovering the causes of sex-ratio distortion in Drosophila pseudoobscura
White, Michelle; Koury, Spencer; Phadnis, Nitin (University of Utah)
Faculty Advisor: Phadnis, Nitin (University of Utah, School of Biological Sciences)
Sex-ratio chromosomes in Drosophila pseudoobscura are of particular interest because they violate not one, but all three of Mendel's laws of genetics. These special X chromosomes distort the ratio of X and Y-bearing sperm, which leads to biased sex-ratios within the offspring. Although such transmission ratio distortions have been observed from as early as 1928, very little is known about the systems of genes responsible for sex-ratio chromosomal drive due to several complications with traditional methods. Here, we perform one part of a three-part experimental series that attempt to dissect and identify not only the genes involved but also its mechanism. Specifically, this approach will use saturation chemical mutagenesis to knock out every gene on sex-ratio (SR) chromosomes. In order to accomplish this task as efficiently and timely as possible, several preliminary experiments were conducted. We provide the natural variability in SR chromosomal drive and the best statistical framework to analyze the actual mutagenesis experiment. Our results further provide an EMS dosage response curve for the D. pseudoobscura species which has only previously existed for D. melanogaster. These findings propose a reconsideration of the traditional methods used for studying SR chromosomal drive and suggest the mechanism behind the genes or systems of genes involved in this process.
With its rich biological history, the field of genetics has truly grown and expanded into all that we know today. With special regard to our very own Nobel Laureate, Dr. Mario Capecchi, The University of Utah has a dynamic relationship with the field of genetics. The Phadnis Lab plays an active role in this remarkable community and has answered several ideas in evolutionary conflict and speciation. Thus, as a student from the University of Utah studying genetics, it would be greatly interesting to be able to present my work at UCUR.
Faculty Advisor: Phadnis, Nitin (University of Utah, School of Biological Sciences)
Sex-ratio chromosomes in Drosophila pseudoobscura are of particular interest because they violate not one, but all three of Mendel's laws of genetics. These special X chromosomes distort the ratio of X and Y-bearing sperm, which leads to biased sex-ratios within the offspring. Although such transmission ratio distortions have been observed from as early as 1928, very little is known about the systems of genes responsible for sex-ratio chromosomal drive due to several complications with traditional methods. Here, we perform one part of a three-part experimental series that attempt to dissect and identify not only the genes involved but also its mechanism. Specifically, this approach will use saturation chemical mutagenesis to knock out every gene on sex-ratio (SR) chromosomes. In order to accomplish this task as efficiently and timely as possible, several preliminary experiments were conducted. We provide the natural variability in SR chromosomal drive and the best statistical framework to analyze the actual mutagenesis experiment. Our results further provide an EMS dosage response curve for the D. pseudoobscura species which has only previously existed for D. melanogaster. These findings propose a reconsideration of the traditional methods used for studying SR chromosomal drive and suggest the mechanism behind the genes or systems of genes involved in this process.
With its rich biological history, the field of genetics has truly grown and expanded into all that we know today. With special regard to our very own Nobel Laureate, Dr. Mario Capecchi, The University of Utah has a dynamic relationship with the field of genetics. The Phadnis Lab plays an active role in this remarkable community and has answered several ideas in evolutionary conflict and speciation. Thus, as a student from the University of Utah studying genetics, it would be greatly interesting to be able to present my work at UCUR.
A Preliminary Paleomagnetic Test for Incremental Pluton Emplacement
Parsons, Travis; Lippert, Peter; Bartley, John (University of Utah)
Faculty Advisor: Lippert, Peter (University of Utah - College of Mines and Earth Science, Geology & Geophysics); Bartley, John (University of Utah - College of Mines and Earth Science, Geology & Geophysics)
Field observations and geochronological measurements of plutons in Yosemite Valley suggest that plutons grow incrementally as a series of stacked sheets of smaller intrusions (i.e., dikes and sills) (Coleman et al., 2004; Glazner et al., 2004; Bartley et al., 2006). This interpretation is in contrast to the traditional view of pluton emplacement through crystallization of a single, massive magma chamber. Most of the observations supporting incremental pluton emplacement use the relationship between zircon U-Pb dating of pluton sections and estimated granitic magma cooling rates to argue that a single magmatic event would crystallize significantly faster than the geochronologic data permit. Incremental pluton emplacement also predicts specific relationships between the age of intruded sheets of magma and the original orientation of these sheets, such that older sheets are expected to be tilted or deformed more than younger sheets. Here we test this prediction of differential tilting by measuring the paleomagnetic inclination preserved in well-dated and structurally characterized sheets of the Tuolumne Intrusive Suite. Magnetic inclination provides a tilt-meter with respect to the Earth's magnetic field direction at the time of pluton emplacement; the reference inclination assuming an untitled pluton is known from independent data sets. We also present rock magnetic data (temperature-dependent magnetic susceptibility, magnetic remanence characteristics) and results from petrographic investigations to characterize the mineralogy and stability of the magnetization. Our results suggest that the low-titanium magnetite remanence carriers are primary and are not biased by secondary magnetizations. The distribution of magnetic inclinations in our sample set — in which older sheets on the periphery of the pluton are shallower than those in younger, more interior sheets, and with respect to the reference inclination — is consistent with predictions from the incremental pluton emplacement hypothesis.
Faculty Advisor: Lippert, Peter (University of Utah - College of Mines and Earth Science, Geology & Geophysics); Bartley, John (University of Utah - College of Mines and Earth Science, Geology & Geophysics)
Field observations and geochronological measurements of plutons in Yosemite Valley suggest that plutons grow incrementally as a series of stacked sheets of smaller intrusions (i.e., dikes and sills) (Coleman et al., 2004; Glazner et al., 2004; Bartley et al., 2006). This interpretation is in contrast to the traditional view of pluton emplacement through crystallization of a single, massive magma chamber. Most of the observations supporting incremental pluton emplacement use the relationship between zircon U-Pb dating of pluton sections and estimated granitic magma cooling rates to argue that a single magmatic event would crystallize significantly faster than the geochronologic data permit. Incremental pluton emplacement also predicts specific relationships between the age of intruded sheets of magma and the original orientation of these sheets, such that older sheets are expected to be tilted or deformed more than younger sheets. Here we test this prediction of differential tilting by measuring the paleomagnetic inclination preserved in well-dated and structurally characterized sheets of the Tuolumne Intrusive Suite. Magnetic inclination provides a tilt-meter with respect to the Earth's magnetic field direction at the time of pluton emplacement; the reference inclination assuming an untitled pluton is known from independent data sets. We also present rock magnetic data (temperature-dependent magnetic susceptibility, magnetic remanence characteristics) and results from petrographic investigations to characterize the mineralogy and stability of the magnetization. Our results suggest that the low-titanium magnetite remanence carriers are primary and are not biased by secondary magnetizations. The distribution of magnetic inclinations in our sample set — in which older sheets on the periphery of the pluton are shallower than those in younger, more interior sheets, and with respect to the reference inclination — is consistent with predictions from the incremental pluton emplacement hypothesis.
Binding Trends of simple hosts and guests with CB5, CB6, and Mc5
Dearden, Heravi, Shen, Arslanian, Shrestha, Mismash, Tinsley, Pay (Brigham Young University)
Faculty Advisor: Dearden, David (Brigham Young University, Chemistry)
Using the Spartan and Ion Molecular Spectrometry Suite (IMoS), we use the 3D modeling to predict stability and molecule favorability. Previously in our experimentation we have seen and proper capping of a host molecule with cucurbit[5]uril. This was different than cucurbit[6]uril as the cap in some cases didn't bond to all the upward oxygens because on the molecular symmetry, thus host enclosure was less favorable in cucurbit[6]uril than cucurbit[5]uril. We also observed in our lab the energy differences using the Extensible Computation Chemistry Environment (ECCE) of cucurbit[5]uril host transfer based on cap and host interactions. These studies show that cucurbit[5]uril with methane as a host is more favorable than outside the cavity. It also shows that methane inside cucurbit[5]uril is more favored than in decamethylcucurbit[5]uril. The studies using computational study will be testable using mass spectrometry, and we predict that the same behavior trend will show using other caps and hosts with cucurbit[5]uril and decamethylcucurbit[5]uril.
Faculty Advisor: Dearden, David (Brigham Young University, Chemistry)
Using the Spartan and Ion Molecular Spectrometry Suite (IMoS), we use the 3D modeling to predict stability and molecule favorability. Previously in our experimentation we have seen and proper capping of a host molecule with cucurbit[5]uril. This was different than cucurbit[6]uril as the cap in some cases didn't bond to all the upward oxygens because on the molecular symmetry, thus host enclosure was less favorable in cucurbit[6]uril than cucurbit[5]uril. We also observed in our lab the energy differences using the Extensible Computation Chemistry Environment (ECCE) of cucurbit[5]uril host transfer based on cap and host interactions. These studies show that cucurbit[5]uril with methane as a host is more favorable than outside the cavity. It also shows that methane inside cucurbit[5]uril is more favored than in decamethylcucurbit[5]uril. The studies using computational study will be testable using mass spectrometry, and we predict that the same behavior trend will show using other caps and hosts with cucurbit[5]uril and decamethylcucurbit[5]uril.
Complement and drug inhibition of Naegleria fowleri lytic activity
Gee, Joshua; Clark, Daniel (Weber State University)
Faculty Advisor: Clark, Daniel (Weber State University, Microbiology)
Naegleria fowleri is a fatal human pathogenic free-living amoeba capable of infecting the human central nervous system. The causative agent of an extremely rare and fatal infection known as primary amoebic meningoencephalitis. N.fowleri is dangerously lethal in the fact that it rapidly deteriorates the brain and is most often diagnosed at death. It is believed that N.fowleri CD59-like complement regulatory protein is important in the infection process. The function of this protein has not been made clear, but is thought to play a protective role in resistance to lytic cell death caused by complement. Consequence of this function results in the amoeba becoming camouflaged by the host's native immune system. Inhibition of this protein is a novel step toward treatment of infection. An established and successful approach to treating infectious organisms is to use antibodies that target and interrupt the function of outer membrane proteins involved in the infection process.The goal of this research is to evaluate the hypothesis that human anti-CD59 antibodies can neutralize the amoeba's CD59-like protein in the presence of complement, which would normally lyse the cells. To do this, we established an experimental infection model using human cells (HeLa cervical cancer cells) grown to confluence in a monolayer, which are susceptible to infection by N. fowleri. This model mimics the natural infection of N. fowleri, and will provide a greater understanding of its pathogenesis.
Faculty Advisor: Clark, Daniel (Weber State University, Microbiology)
Naegleria fowleri is a fatal human pathogenic free-living amoeba capable of infecting the human central nervous system. The causative agent of an extremely rare and fatal infection known as primary amoebic meningoencephalitis. N.fowleri is dangerously lethal in the fact that it rapidly deteriorates the brain and is most often diagnosed at death. It is believed that N.fowleri CD59-like complement regulatory protein is important in the infection process. The function of this protein has not been made clear, but is thought to play a protective role in resistance to lytic cell death caused by complement. Consequence of this function results in the amoeba becoming camouflaged by the host's native immune system. Inhibition of this protein is a novel step toward treatment of infection. An established and successful approach to treating infectious organisms is to use antibodies that target and interrupt the function of outer membrane proteins involved in the infection process.The goal of this research is to evaluate the hypothesis that human anti-CD59 antibodies can neutralize the amoeba's CD59-like protein in the presence of complement, which would normally lyse the cells. To do this, we established an experimental infection model using human cells (HeLa cervical cancer cells) grown to confluence in a monolayer, which are susceptible to infection by N. fowleri. This model mimics the natural infection of N. fowleri, and will provide a greater understanding of its pathogenesis.
Detection of Protein Biomarkers by Quantum Dot Adsorption
Gomez, Nathaniel; Blumel, Daniel; Dueñas, Davis; Hazel, Matt; Yu, Ming* (Utah Valley University)
Faculty Advisor: Yu, Ming (Utah Valley University, Chemistry)
Kidney cancer in both men and women is among the top ten most common cancers, where the risk in men is estimated at 1:48, and women at 1:83. The issue with kidney disease is that it is difficult to accurately diagnose early-on. Methods of diagnosis that are currently established are expensive and highly invasive if at all accurate. Our research is focused on developing a fast, reliable and cost-effective method of diagnosing kidney disease by the use of fluorescent quantum dots (QDs). When mixed in a solution that contains protein biomarkers, QDs can act as biosensors because the protein alters their fluorescent properties. With QD biosensing, optimal conditions were discovered for the size of QDs and buffers used for detecting different protein biomarkers. The study provides empirical evidence that the alteration is distinguishable between healthy and cancerous levels of protein.
Faculty Advisor: Yu, Ming (Utah Valley University, Chemistry)
Kidney cancer in both men and women is among the top ten most common cancers, where the risk in men is estimated at 1:48, and women at 1:83. The issue with kidney disease is that it is difficult to accurately diagnose early-on. Methods of diagnosis that are currently established are expensive and highly invasive if at all accurate. Our research is focused on developing a fast, reliable and cost-effective method of diagnosing kidney disease by the use of fluorescent quantum dots (QDs). When mixed in a solution that contains protein biomarkers, QDs can act as biosensors because the protein alters their fluorescent properties. With QD biosensing, optimal conditions were discovered for the size of QDs and buffers used for detecting different protein biomarkers. The study provides empirical evidence that the alteration is distinguishable between healthy and cancerous levels of protein.