Architecture

Authors: Dua Azhar, Alexander MacKenzie, Sophie Caron. Mentors: Sophie Caron. Insitution: University of Utah. The mushroom body of the Drosophila melanogaster is a structure in the brain that is necessary for learning, but much of how it functions remains unknown. In this model organism, D. melanogaster’s mushroom body neurons, known as Kenyon cells, and input projection neurons have connections that are random and biased—in which some projection neurons connect with Kenyon cells more than others—allowing the fly to potentially prioritize the learning of particular odors. I investigated the functional consequences and characterizations of these biases in order to understand the biological role they play for the fly using a theoretical and experimental approach. With a computational model of the D. melanogaster olfactory system, how biased connectivity to the mushroom body influences its ability to form associations with various odors and distinguish between similar odors was explored. Experimentally, the morphological features of olfactory circuits were characterized by low to high connectivity rates to the mushroom body, allowing us to see the unique features in these circuits that are beyond the different connectivity rates. Through a combination of immunohistochemistry and confocal microscopy, high-quality images were generated of these different neuronal olfactory circuits and their morphological qualities, such as the number and volume of boutons they project to the mushroom body. Altogether, these findings demonstrate how neural connectivities behind learning shape the representation space in D. melanogaster and impact its learning outcomes.

Authors: Alexa N Gormick, Adam M Zahm, Justin G English. Mentors: Justin G English. Insitution: University of Utah. Recent advancements in gene therapy have pushed towards the prevention and treatment of a diverse spectrum of disorders and diseases that are caused by misregulation of gene expression programs and their transcriptional regulators. However, the profoundness of the field means that much of the mechanisms and effects of regulation are unknown and understudied. Here, we explore the limits of flexible exogenous gene expression and its potential use in optimizing efficacy and specificity in gene therapy interventions while minimizing the possible associated risks. This is made possible by exploiting the Tet-On system of inducible transcriptional regulation, which allows the expression of any target gene to be reversibly, specifically, and differentially controlled. In this system, the tetracycline repressor (TetR) binds the tetracycline operator (TetO), impeding transcription of any downstream gene embedded by the researcher; tetracycline dosing causes TetR to adopt a new conformation that removes it from TetO, inducing gene expression on command (Das et al., 2016). Because of the diverse utility of this system, we are in pursuit of developing novel TetR-TetO orthologous pairs that do not interfere with this wild-type circuit and can be used to regulate gene expression in parallel. As a first step to generating TetR-TetO orthologs, we mapped the usage of TetO by TetR in a massively parallel reporter assay (MPRA) by engineering an extensive library of mutant TetOs and quantified the resulting range of TetR regulation through reporter gene expression. From this screen, we identified candidate TetO mutants to direct the evolution of the wild-type TetR towards complementary states to those TetO mutant sequences. Our preliminary findings indicate that the engineering of distinct synthetic expression cassettes based on the TetR-TetO operon is feasible. These novel tools may ultimately allow us to build a synthetic genetic circuit to model regulatory feedback loops that can help discover malfunctions in cell growth, reproduction, and cycling that can arise from genetic disorders and can lead to disease.1. Das, A. T., Tenenbaum, L., & Berkhout, B. (2016). Tet-On Systems For Doxycycline-inducible Gene Expression. Current Gene Therapy, 16(3), 156–167. https://doi.org/10.2174/1566523216666160524144041

Authors: Soren Pearce. Mentors: Jacob Hickman. Insitution: Brigham Young University. Conversations about conspiracy theories have become prevalent in contemporary Western society, reaching through all levels of private, academic, and governmental discourse. Part of this discourse revolves around the question of what exactly conspiracy theories are and how they occur within a population; much of the recent academic treatment of conspiracy theories identifies them as a kind of propaganda whose purpose is to promote particular political agendas, especially those with apocalyptic concerns (Cassam 2019). While conspiracy theories certainly have been and continue to be used to further certain political aims, this understanding of them as totally propaganda provides only a narrow insight that fails to capture the scope of how conspiracy theories occur in the real world and how they are experienced by the people who believe in them. Philosophy and political theory can only be so informative, and they lack an ethnographic perspective to instruct on the lived reality of conspiracy theories (Hickman & Webster 2018). During my fieldwork in Belfast, Northern Ireland, I conducted ethnographic research with a group of people who could easily and accurately be labeled conspiracy theorists; my experiences with them provide insight into how conspiracy theories actually operate in the lives of living people. Contrary to popular claims, conspiracy theories—especially those that deal with the end of the world as we know it—are not experienced as primarily political phenomena. Instead, they are experienced as religious truths, and the millenarian activism that often surrounds them is enacted because of a conviction of personal obligation to the truth. Framing conspiracy theories as mere propaganda or dismissing them as the effects of cognitive dissonance incorrectly discounts the empirical reality of these beliefs for the people who have them.

Authors: Danielle Black. Mentors: Chris Anderson. Insitution: Utah Valley University. Attention Deficit Hyperactivity Disorder (ADHD) is a common psychiatric disorder diagnosed in children, characterized by impulsivity, inattention, and hyperactivity. It is frequently co-morbid with eating disorders, primarily bulimia nervosa (BN) and binge-eating disorder (BED). Impulsivity is an important factor in increasing the risk of binge-eating and subsequent feelings of guilt, which may prompt purging behaviors. This often manifests early in childhood as loss of control while eating and can indicate future development of an eating disorder. The current project aimed to assess the link between ADHD symptoms and disordered eating in Utah Valley University alumni. After obtaining IRB approval, 265 alumni responded to an email survey containing nineteen questions regarding ADHD symptoms and three items related to disordered eating. Pearson correlations revealed a significant association between ADHD symptoms and binging (r=.22, p <.01) as well as guilt about eating (r=.17, p <.01). Limitations of the study include the absence of a clinical ADHD diagnoses, relying instead on self-report, and the homogeneous sample, restricting its generalizability. The study was bolstered by its comprehensive coverage of ADHD symptoms and an adequately large sample size to detect statistical significance. This study provides valuable information for those suffering from eating disorders and the clinicians that treat them. Future research could assess the interplay between treating ADHD and reducing the risk of eating disorders. Notably, purging and ADHD symptoms were not significantly correlated, and future research could further explore that relationship. In conclusion, the relationship between binge eating and ADHD symptoms should be acknowledged by clinicians.

Authors: Cari Monson, Julie Pynn. Mentors: Julie Pynn. Insitution: Southern Utah University. Background music refers to music that is played while the listener’s attention is focused on another task (Radocy & Boyle, 1988). Research suggests that the effect of background music on performance during a cognitive task showed improvements in episodic memory. Music activates the limbic system which is involved in controlling memory(e.g., Blood et al., 1999). The purpose of this study is to predict the relationship between music and performance on a cognitive task. It is hypothesized that students who listen to white noise while studying a text will recall more information, than those listening to classical music or pop music. In particular, the lyrics in pop music will be especially distracting(Cheah, 2022). Studying the relationship between music and performance on a cognitive task has implications for understanding memory. Results are forth coming

Authors: Ivelynn Noel. Mentors: Julie Johnson Pynn. Insitution: Southern Utah University. High levels of sexual satisfaction have been correlated with higher levels of marriage satisfaction (Litzinger & Gordon, 2005), relationship satisfaction (Santilla et al., 2008), and mental health and general well-being (Brody & Costa, 2009). While we know that sex frequency and frequency of orgasm affect sexual satisfaction (Barrientos & Paez, 2006), we also need to explore nonsexual factors that affect sexual satisfaction. The existing literature of the effects of religiosity on sexual satisfaction is contradictory, and may have mediating factors such as sex guilt or marital status (Hackathorn et al., 2016). The proposed study aims to examine the effects of religious identity and marital status on sexual satisfaction by measuring sexual-spiritual integration. We predict that unmarried individuals will score higher than married individuals, which indicates a lower sexual-spiritual integration. The findings of this study will add clarity to the convoluted findings in the existing literature , and will help identify nonsexual factors that affect sexual satisfaction. The findings of the study will also provide insight that may help healthcare workers, pastoral counselors , and therapists to better service their clients. Results are forthcoming.

Authors: Vanessa Lozano. Mentors: April Reber. Insitution: Brigham Young University. According to the Center for Immigration Studies, “the total foreign-born or immigrant population in the U.S. hit 47.9 million in September 2022- a record high in American history. When non-English immigrant families arrive in the United States they face the challenges of new customs, rights, and practices in their new home. In the United States various NGOs, government aids, and non-profit organizations are available to immigrants to help them navigate these challenges. Evaluations about the efficacy of these resources should be considered with the increasing number of immigrants in the United States. In this research, we focus on one of these resources, a mental well-being support group geared to immigrants but attended mostly by Latina women. The support group is currently held at a non-profit community center the South Franklin Community Center (SFCC) in Provo, UT, and sponsored by the organization Inciativa Latina para el Bienestar Emocional [Latino Initiative for Emotional Well-being]. To consider the efficacy of this support group in this research we explore the following questions 1) How does support get produced in the context of this support group at the SFCC? 2) Does (and if so, how does) participating in these support groups expand the agency of participants? (By agency, I refer to the capacity or condition of someone to have control or power to act).

Authors: Beckham Trigo. Mentors: Johnathan Chidester. Insitution: Southern Utah University. The lack of resources, funding, and federal recognition is leading to the deficit in K-12 Education around the United States compared to other first world countries with developed education systems. For years the United States has been hammered on the fact that the country doesn't provide every child with bilingual study opportunities. European countries such as Spain, Italy, Germany, and France all offer bilingual studies and are making them required for students to take. These are key elements in a successful education system and offer so many more opportunities and benefits than the standard single language system we have placed in our K-12 Schools. Statistically the change to a new bilingual research would greatly benefit our country and would help decrease political divisiveness and bring an extent of unity among several ethnic groups in the country. The country continues to grow through immigration where the United States is projected to become the top Spanish speaking country in the world with 140 million speakers. However, the United States is not preparing for this and investing in its future students and citizens. Research has proven time and time again that there are so many benefits to a bilingual education, some of these including an increase in brain activity, and power in children, an academic advantage, and competition in the job market. The United States has deeply oppressed this system due to systematic racism, and political motivation. However, the United States has no established language in which it defines itself even though the majority speak English. The United States is also a world power with a lot of interaction with foreign countries. This in itself is going to be very problematic for the future of the United States as the world climate changes. It needs leaders to represent itself in many other languages, not just in the English language. The contrary to this research is that the language is ineffective to learning, makes it harder for students to assimilate into the United States culture, and spend too much time learning the second language. However, none of these statements can be statistically backed and solely based on a few percent of people's personal experience. Overall the research time and time again directs the United States to the bilingual education system, but when will it be adopted?

Authors: Allie Baumgartner. Mentors: Chizu Matsubara. Insitution: Utah Tech University. • ABSTRACT: A student’s understanding and comprehension of content specific vocabulary is essential for their learning. However, Multilingual Learners (MLs) can struggle to understand what they are learning when they do not have knowledge of content specific vocabulary. This research focuses on the implementation of strategies into a small group reading lesson. These strategies will work towards increasing students’ understanding of content specific vocabulary words, in the areas of social studies and science. By using the methodology of action research, the research will implement research-based strategies for strengthening vocabulary for students learning English as a target language. This research will be conducted over a six-week time frame, with two focus students that are multilingual learners. The research-based word-learning strategies will be incorporated into the small group consisting of four students, to support their learning. Word-learning strategies are strategies that assist students to ascertain the meanings of words that are unfamiliar to them. Students can then apply these strategies to learning of unfamiliar words that are included in the content reading that they do in another small group. The word-learning strategies will support the students in learning, and understanding the meaning of content specific vocabulary words.

Authors: Christopher Galbraith, Derek Langford, Hillary Wadsworth, Eliza White, Erin Taylor, Lauren Ford. Mentors: Jordan Yorgason. Insitution: Brigham Young University. Microglia are monocyte derived immune cells and exhibit complex signaling behavior that include phagocytic activity to threats and prolonged neuronal activity. ATP (adenosine triphosphate) is a known chemoattractant for microglia, but how chemoattraction is modulated by other transmitters is not well understood. ATP is co-packaged and released with dopamine, thus the present work examines microglia morphology and motility in the context of these two transmitters. Microelectroiontophoresis and multiphoton microscopy were used in brain slices from transgenic mice to examine effects of dopamine and ATP signaling on microglia. Lipopolysaccharide (LPS) transitioned the microglia from ramified to amoeboid morphology over a period of 4 hours. LPS also increased both dopamine and ATP release, as measured by fast scan cyclic voltammetry on a similar time course. Surprisingly, dopamine itself did not act as a chemoattractant to microglia, despite increasing after LPS treatment. By examining this relationship between neuronal and microglial activation we can better understand the complex circuitry of the reward pathway and immune system activation.

Authors: Daniel Luke Isemonger, Jacob Cecil, Noah Moffat, Nathaniel Horne, Jordan Yorgason. Mentors: Jordan Yorgason. Insitution: Brigham Young University. Anxiety disorders are increasingly prevalent, and can be exacerbated by drug use, which can contribute to further drug seeking behavior. The underlying neural mechanisms of this relationship are not fully understood, but dopamine transmission is thought to play a key role. The goal of this project is to develop innovative tools to elucidate the role of dopamine and drugs of abuse on anxiety-like behavior and its relation to drug seeking in mice. Specifically, dopamine sensors and 2-photon microscopy via implanted endoscopic lenses, will be used to image dopamine dynamics in the NAcc of behaving mice while they are engaging in a virtual environment (VR) mimicking drug exposure and stress conditions. Using the simulation, mice are exposed to fearful stimuli, which will be related to behavioral responses (movement distance, speed, direction) and extracellular release events. By combining these techniques, we will be able to gain a deeper understanding of how dopamine terminal signaling contributes to drug seeking. This research has the potential to shed new light on the neural relationship between drugs of abuse and anxiety. This could help to inform the development of novel drugs and treatments for this disorder.

Authors: Andrew Call. Mentors: John Chaston. Insitution: Brigham Young University. The main goal for this project is to confirm previous predictions of specific genes that may influence flies’ dietary preference to consume lactic acid bacteria (LAB). The preference of LAB is a normal phenotype that flies have, because the bacteria is essential for their gut microbiota. A previous genome-wide association study (GWAS) by another student in my mentor’s lab predicted genes that lead flies to prefer to consume diets that have live LAB. This genetically determined fly phenotype was measured by calculating the frequency and number of times the flies would choose the LAB inoculated diet over a control diet. My role will be to test if 7 genes have the influence predicted by this previous analysis. The experiment will follow close with the one previously performed by the student who predicted the genes I’m testing. I’ll be using a flyPAD which has a small arena (cage) that will hold one fly. Inside that arena are 2 wells that contain food. These wells have sensors attached to them, so each time the fly takes a sip of food, an electronic signal will be sent to a computer that keeps track of the number of sips from each well, the duration of each sip taken and time in between each sip and graph all the results taken for comparison between a control group and the test groups. I will starve 48 female mutant drosophila melanogaster for 3 hours prior to the experiment and then place them inside the flyPAD where I have previously placed 1 μl of 1:1 yeast-glucose diets in each well, however I will inoculate 0.05 μl of LAB in one of the diets. I will track each sip the flies take from each of the two foods for 1 hour. To measure accurately, there will be 2 controls also being tested. I will use flies that do not contain the genetic mutation and I will also have control arenas where both food wells do not contain LAB.I expect that any mutant that has a reduced preference for LAB-inoculated diet relative to the control diet represents a validated prediction of the previous study. In some cases, there may be no variation in preference for the control or LAB-inoculated diet, indicating a gene that does not contribute to fly preference for LAB in the diet. If none of the mutants tested validate the genome-wide association predictions, I will go back to the gene list and select one additional subset of genes to test if these influence the genetic prediction. We previously focused on genes that had multiple hits in the previous experiment, regardless of how significant the predictions were. In this second round, I will simply select the ten most significant remaining genes. Overall, this project will help confirm the previously selected genes with their association with a diet preference of lactic acid bacteria, improving the gut microbiota of Drosophila melanogaster.

Authors: Hunter Nelson. Mentors: Jamie Jensen. Insitution: Brigham Young University. Burnout is a mental condition resulting from prolonged stress in work or school. The Healthcare workforce experiences burnout much more than other career fields and many students in undergraduate STEM are pursuing a career in this field. The Pre-Health degree is one of the most competitive and demanding majors in STEM and we expect there to be high levels of burnout amongst these students. Our purpose was to gather and analyze data on the goals and burnout of pre-health care undergraduate students. We used surveys to collect data from students ranging from Freshmen to Seniors. The survey asked students questions regarding their goal motivations and feelings of burnout. Our results display a correlation between mastery-avoidance and experiencing burnout. By understanding these relationships, we can better help pre-health students avoid burnout.

Authors: Rebecca Kreutz. Mentors: John Chaston. Insitution: Brigham Young University. Previous studies of the relationship between Drosophila melanogaster and its microbiome have shown that the bacteria in fruit flies can have a large effect on life history strategy. Higher proportions of Acetobacter, a genus of aerobic bacteria, correlate with faster development to reproductive maturity and higher, earlier fecundity. Greater proportions of Lactobacillus, a genus of anaerobic bacteria, correlate with lower initial reproduction but longer lifespan and maintenance of somatic cells. Despite this, the determinants of a Drosophila’s microbiome are still not well understood. This study will explore the relationship between the depth of the food that flies mature in and the proportion of anaerobic bacteria found in the flies. To test this, I will prepare vials with varying amounts of food, place fly eggs in them, inoculate them with a mixture of Acetobacter and Lactobacillus, homogenize the flies that mature, and compare the proportions of bacteria across the different food depths. Greater food depth will mimic food that is more rotten, because as fruit rots it becomes softer and the fly larvae are able to burrow deeper. As the flies gain greater access to the inside of the fruit, there may be an increase in the proportion of anaerobic bacteria in the fly’s gut, due to the reduced access of the bacteria to the air. Because different food depths can simulate different fruit ages, this study may be able to establish a relationship between the season the flies mature and their microbiome.

Authors: Jens Watts. Mentors: Brian Harker. Insitution: Brigham Young University. What is a standard at its essence? Wren 2022 suggests that in jazz scholarship, undue emphasis has been placed on the analysis of the standard as a work. Instead, the standard should be understood as an archive: the sum of all relationships between different iterations of the work. I posit that further work in this mode will help to correct an antiquated philosophy of music existing on a page and direct further attention to the act of ‘musicking,’ as promoted by Christopher Small in his 1998 book.This article examines three jazz standards: “On the Sunny Side of the Street,” “Autumn Leaves,” and “On Green Dolphin Street.” These standards were chosen because of their varying interpretations in harmony and melody. My analysis of these standards is threefold: theoretical, historical, and ethnographic. I begin with an analysis of the published sheet music for each of these standards, examining unique features of their pitch content. From there, I depart to a historical analysis, examining changes in the performance of the tune over time.The bulk of my research reports on an ethnography of jazz musicians on the Utah scene. My interlocutors were asked to play the standards in question, which I recorded. I examine common features of their interpretations, as well as salient differences. Some of their thoughts on these standards in particular and the practice of learning standards in general are also presented. The resulting collection of information on my multidisciplinary approach to analyzing standards reveals important aspects of the epistemology of jazz music and the ontology of standards themselves.

Authors: Jessica Anderson. Mentors: Jennifer Kohler. Insitution: Utah Tech University. Social media, television, and Cinema all play key roles in shaping our perception of reality. This study examines stigmas and stereotypes of disabilities that are perpetuated through the media specifically through these three sources. It also examines the presence of inspiration porn and the proper representation of physical disabilities in these media sources.

Authors: Samuel Zenteno. Mentors: Brandon Ro. Insitution: Utah Valley University. Evolution of Elementary School Architecture:Elementary school architecture has evolved significantly, reflecting shifts in educational philosophies, technological advancements, and societal priorities. From humble one-room schoolhouses to technologically advanced, sustainable, and inclusive learning spaces, the architectural form mirrors broader changes in education and society. What architectural form best reflects the ideal elementary school learning environment? Studying the evolution of elementary school architecture offers society several advantages:• Informed Design: By understanding the historical context and design trends, architects and educators can create more effective, engaging, and sustainable learning spaces.• Educational Enhancement: Insights from past designs can lead to environments that support modern teaching methods and foster improved student outcomes.• Equity in Education: Recognizing disparities in school facilities informs efforts to ensure all students have access to high-quality educational spaces.Research Methods:This research employs a comprehensive approach, combining historical analysis, architectural documentation, case studies, and conducting surveys with community members. Comparative studies of architectural styles, education methods, and pedagogical influences will shed light on ideal architectural forms for learning environments.Expected Results:Anticipated outcomes include a nuanced historical narrative of elementary school architecture, identification of pivotal design trends, insights into the societal forces that shaped these changes, and a repository of best practices. Ultimately, this research aims to empower architects, educators, policymakers, and communities to collaboratively shape the future of elementary school architecture, fostering equitable, innovative, and sustainable educational environments.An elementary school is the first public building that a child is called to regularly experience, be educated, find a playground, and socialize. In that sense, it is about to become a second home. By understanding the past, we can better prepare for the future of elementary school design.

Authors: Angela Gomez. Mentors: Chizu Matsubara. Insitution: Utah Tech University. Once students know their letter names and sounds, educators have them begin to learn irregular words, commonly known as sight words. These words are irregular due to them not following common patterns that make up a word. Typically, teaching irregular words is done by having students learn a set number of words through flashcards or reading them off a list. However, students who learn irregular words with flashcards or lists struggle and need help when reading those same words in a text. Action research will be used to study the hypothesis: “Will direct phonics literacy instruction help students learn and retain irregular words?” The research is being conducted in a kindergarten classroom by a preservice teacher in her practicum placement. The focus students for the research will be working with the preservice teacher in a small group setting where they will be reading decodable texts that contain irregular words within the text. The students will be able to decode the regular words they come across using their knowledge of alphabet letters and sounds. Students will be learning the irregular words of the text through direct phonics instruction to help them learn and retain their knowledge of irregular words. By using direct phonics instruction within a text, students can learn how to successfully read the irregular word while simultaneously applying it to a text. The other approach to learning irregular words is reading them on flashcards or a list and then having students transfer their knowledge of these words from a list to reading them in a text, which can become problematic for students as they cannot do so. By having students learn irregular words through direct phonics instruction, the expected result is to have students know around 50 irregular words by the deadline required by the local school district.