Architecture

Authors: Rafael Deo. Mentors: Matthew Wilcox. Insitution: Brigham Young University. A listening test is an important method used to assess language proficiency. It can be used as placement tests, pre and post-tests, research purposes, classroom evaluations, and many more. Comparison of results of such tests can also be used to assess language gain throughout a period of time. However, to create such listening tests that can genuinely evaluate an individual's ability, audio quality plays an important role, too. This factor should be addressed because it seems trivial, even though it can affect test-takers results. Through this presentation, I will provide general guidelines and practical tools for finding, evaluating and capturing listening passages for proficiency tests.

Authors: Maggie Wu, Ashley Littlefield, Bryant Jones. Mentors: Bryant Jones. Insitution: Snow College. A novel method of predictive thermodynamic property mining using AIMD simulations of molten salts for use in molten salt nuclear reactorsSolving the worlds energy crisis has been a heavily debated and researched topic for many years. One proposed solution to this problem is the micro molten salt nuclear reactor (MMSR). The MMSR is a small portable nuclear powerplant that can provide an affordable source of energy that is completely safe, readily available, and passively controlled. The waste products from this reactor are also heavily sought medically important isotopes. One final hurdle for MMSR development is the mining of the thermodynamic properties for previously unstudied eutectic mixtures of molten salts. Due to the hygroscopic nature of molten salt eutectics, experimental techniques for measuring thermodynamic properties are time and cost prohibitive. Modern supercomputing techniques provide a solution for property mining. However, computational methods have been historically limited to previously experimentally studied salts. There has always been a need for experimentally measured values to be determined first to provide tuning for the computational techniques. This group has developed a novel technique for tuning the values for previously unstudied salts. This greatly enhances the predictive capabilities of computation methods. This technique was then employed to successfully measure the density, Heat capacity, and coefficient of thermal expansion for two promising uranium salt eutectics. These studies provided the data to also study the molecular structure of these salts. This study showed interesting new aggregation of the uranium atoms that will be presented.

Authors: Jaren Meikle, Samuel Archer. Mentors: Jacob Dean. Insitution: Southern Utah University. Dipyrroles are bicyclic, heterocyclic compounds ubiquitous in nature. Dipyrroles form subunits in commonly-occurring photoactive biological subunits such as bilins, and are thus remarkable in their ability to absorb visible light despite their chemical simplicity. In this work, the photochemistry of a model dipyrrole serving as an analogue to the core subunit found in bilins was investigated and found to show a proclivity to undergo pH-dependent reactions. When the acidic and basic variants were irradiated with blue light and the time-resolved UV-vis spectra were recorded, we found stark differences in reactivity between the two variants. The protonated variant is highly photostable and resistant to photoxidation with photonic energy being channeled into rapid internal conversion. The basic variant, however, undergoes consistent oxygen-dependent photooxidation, forming hydroxy and methoxy adducts. Our research is currently focused on elucidating the structure of these photoproducts, identifying the mechanism of photooxidation, as well as modeling the kinetics of the reaction.

Authors: Samuel Andersen. Mentors: Jianlong Han. Insitution: Southern Utah University. We study a Gray-Scott model arising from chemistry. Using nondimensionalization, we reduce the number of parameters, we also analyze the stability of the steady state solutions of the system.

Authors: Elizabeth Jenkins. Mentors: Jerry Johnson. Insitution: Brigham Young University. There is convincing data on the potential relationship between predator-prey environments and cognitive abilities. There is often an increase in cognition found in species living among predators. Culum Brown and Victoria A. Braithwaite (2005) conducted an experiment to test this hypothesis on Brachyraphis episcopi. While they anticipated their results would support this hypothesis, the populations under non-predator conditions solved the cognitive tests more quickly. In this study, I replicate their experiment with a different species, named Brachyraphis rhabdophora, to determine if their results are repeatable. Populations of Brachyrhaphis rhabdophora are found in northwestern Costa Rica and are distinctly segregated into different river drainages. In each drainage, the populations are isolated into predator and non-predator populations. These populations experience a parallel separation of social environment to the populations used by Brown and Braithwaite. Using their same methodology, we measured cognition in Brachyrhaphis rhabdophora by presenting them with the task of locating a hidden food patch. I expected that that the predatory-prey population would complete this task more efficiently, although it’s possible that this species could produce the same contradictory results. Once the data are all collected, I will present the results and publish a paper on my findings.

Authors: Parker R. Carlquist, Lexi Brady, Seth Dotson, Jeff Glenn. Mentors: Jeff Glenn. Insitution: Brigham Young University. Background: Addressing public health problems requires cooperation from stakeholders who may have wide-ranging political, religious, moral, and societal beliefs. If stakeholders lose trust and mutual understanding between one another, the influence of public health efforts decreases. The COVID-19 pandemic illustrated these complexities as communities became divided in opinions regarding the appropriate response. Without systems and strategies to maintain and increase trust, divisive public health issues may become unsolvable. Objectives: The Campus Conversations project analyzed the effectiveness of reflective structured dialogue (RSD) in helping develop skills and abilities to address difficult conversations and topics. The project hosted conversations among Brigham Young University students of varying demographics and ideologies on divisive topics such as diversity and gender.Methods: Students were recruited to participate in an hour-long conversation with 4-6 others, including a student facilitator who guided the conversation. Conversations began with foundational agreements followed by 3 rounds of questions. Participants were each given an opportunity to speak uninterrupted in each round, followed by group discussion and questions. The structure encourages the sharing of personal experiences and beliefs in an environment that fosters understanding instead of judgement. Pre- and post-conversation surveys were administered to measure the effects of the conversations on skills. Participants were asked to rate how important they believed a skill was and also assess their ability to use it. A collection of 8 different skills and 6 different mindsets/abilities were measured. Results: Survey results found that participation in a conversation using RSD is associated with statistically significant improvements in how students rated the importance of 6 different skills. Additionally, 8 skills and mindsets/abilities saw statistically significant improvements in students’ assessed capability. The skills of “vulnerability” and “suspending judgement” saw the greatest improvements in both rated importance and assessed capabilities. The average change between pre- and post-surveys overall was a 10.5% increase. Conclusions: In order to develop effective public health policies, consensus and understanding must be achieved among stakeholders and communities. The results highlight the potential for RSD conversations to be used as an effective tool to improve students’ belief in the importance of skills required for difficult conversations and potentially improve their ability to use them. Public Health Implications: Public health is currently working to address various divisive problems that require collaboration from stakeholders that range across the political, demographic, and societal spectrums. Utilizing RSD can help promote understanding and the ability to discuss divisive issues in a calm and structured way, forming a foundation whereupon policy can be effectively created, discussed, and advocated.

Authors: Nykitha chomina, Emalee Dias, Mary Roberts. Mentors: Jodi Lopez. Insitution: Utah Valley University. As e-cigarette use has increased in popularity among the general population, especially among adolescents, the demand for research has become evident. E-cigarettes became available in the United States in 2007 and were created as a tobacco cessation tool, even though there is no current research supporting those claims. The wide array of flavors is attributed to the growing popularity of e-cigarettes with known and unknown properties. There is some overlap between the chemicals found in traditional cigarettes and e-cigarettes including nicotine. Some of the most negative effects of these ingredients include carcinogenic effects and negative oral manifestations such as hairy tongue, xerostomia, inflammation, and increased incidence of periodontal disease. For decades dental professionals have been interviewing patients regarding their smoking habits; however, with the rise of e-cigarette use, there is a greater demand for patient education. It is crucial that dental professionals take on an active role when it comes to preaching the truths about the dangers of e-cigarettes and the negative impact on oral health. Keywords: e-cigarette, oral health, ingredients

Authors: Karina Geranios, Madison Mathews, Connor Baird. Mentors: Robert Kagabo. Insitution: Utah Tech University. Abstract: Addressing Teenage Pregnancy and Related Public Health Issues in Rhino Camp Refugee Settlements in UgandaIntroductionWhen individuals cross international borders for fear of persecution due to reasons such as their race, belonging to a particular religion, or political group and seeking safety, they become refugees in the new host country. In most resource deprived countries, these refugees are placed in refugee camps where they receive necessities such as food, water, medical care, or shelter. However, in some cases even in these intended safe refugee camps there are many social and public health challenges mostly due to overcrowding. Teenage pregnancy, which is girls getting pregnant between the ages 10-19 is one of those issues not well investigated within refugee camps. Teenage pregnancy is associated with several adverse outcomes for young mothers including intergenerational cycles of poverty and is the leading cause of death among adolescent girls.MethodsUsing constructs from the community-based participatory research approach, the authors used mixed methods study in June 2023 to collaborate with community members to assess and initiate culturally acceptable teenage pregnancy interventions in Rhino Camp Refugee Settlement. Play and sports activities were used to enhance collaborative efforts between community members and researchers.FindingsMeasures intended to decrease the spread of Covid-19 such as tough lockdowns might have increased risk sexual behaviors and abuse and therefore increased teenage pregnancy. Community leaders are in search of appropriate interventions to reduce teenage pregnancy and provide education to teenage mothers.ConclusionThe study resulted in a collaborative interest between researchers, public health providers, and community leaders to identify culturally acceptable teenage pregnancy measures of intervention. Organized play activities, and menstrual clinics proved to be excellent ways to share teenage pregnancy and related public health challenges information including preventive measures.

Authors: Matthew Drachman, Caden Weaver, Nicholas Martin. Mentors: Kal Munis. Insitution: Utah Valley University. There has been a lot of public debate in recent years when it comes to the topic of guns in the United States. Scholarship on the subject has shown varying opinions on how people believe on gun ownership, along with the subject of carrying firearms in public. A Pew Research study found 46% of people supported concealed carrying in places, while support among gun owners was 67% (Parker et al., 2017). While research has been conducted on concealed carry, research on open carry support and the factors that contribute to it are rather unknown. Within our study, we attempt to see how support for open carry, which is legal in most places in the U.S., is affected based on who is doing the open carrying of firearms. Particularly controversial political and racial groups. Within our model we randomly assign survey respondents to either our control question to gauge their support for open carry, or one of four vignettes we have designed to see if exposure to the treatment causes a change in how support for open carry will change. Our results have important implications pertaining to attitudinal (in)stability on core civil liberties within the United States.

Authors: David Schloesser. Mentors: B Kal Munis. Insitution: Utah Valley University. How do place-based identities influence American’s attitudes towards perpetrators of politically motivated violence? Through the implementation of a pre-registered conjoint experiment, I seek to answer this question. Ideally, and under normative circumstances, punishment of politically motivated violence should be applied to perpetrators with considerations only towards what/who was targeted in the act and the severity of the violence committed. In the U.S. however, evaluations of guilt are determined through the trial of peers, leaving room for the influence of in-group and out-group biases to appear in the judgement of perpetrators according to the suggestions of Social Identity Theory. As such, biases arise that cloud human judgement based on preconceived attitudes towards various group identities that influence our opinions when judging other individuals. One’s sense of place, or how strongly they identify themselves with their locality and its’ culture, is one of these powerful group social identities that establishes a salient “in-group” persona to other locals, while influencing attitudes towards various “out-groups” of people not from that place. Holding constant other considerations pertinent to acts of politically motivated violence, Americans more harshly evaluate perpetrators of violence from geographic communities other than their own. To judge the relative weight that these place-based identities hold towards the judgement of political violence perpetrators, evaluators were presented with perpetrators with randomly assigned personal characteristics (e.g., where they are from) and varied features of the violent act (e.g., how severe the act was, what/who was targeted), and asked to determine the level of punishment or mercy to be assigned to each perpetrator. I found that perpetrator place characteristics indeed influences the evaluator’s excusal of political violence, however when weighted against the features of the act, the nature of the act matters much more for evaluations on average. These findings can be interpreted as normatively negative, given that an evaluator’s place identity appears to reflect in-group out-group biases that affect the assignment of punishment to a crime. However, the disproportionate effect of the violent act’s target and severity are normatively encouraging.

Authors: Adam Smith, adam@tallsmith.com. Mentors: Kal Munis. Insitution: Utah Valley University. The social desirability bias is a well-documented and well-studied phenomenon in the social sciences, but it has only been in relatively recent literature that experimentalists have begun to study the effects treatments have on the manner in which the social desirability bias is reflected in social behavior. The aim of this study is to test the effects of perceived privacy influences the way people answer this question: "What is the aim of politics?" This study seeks to replicate findings in other research that has delved into the relationship between perceived privacy and social desirability. Another significant area of interest is how neurodivergent identity, especially autism, fits into the relationship. With this study, we can better understand how social desirability affects political discourse as well as provide insights into the neurodivergent mind and how it relates to politics.

Authors: Bryan Jay Frandsen. Mentors: Joseph McMurray. Insitution: Brigham Young University. This paper expands on a citizen-candidate model of electoral competition under both plurality rule and ranked choice voting. The paper finds that ranked choice voting nominally avoids Duverger’s Law by accumulating many identical candidates but yields fewer viable equilibrium policy positions than plurality rule. Additionally, ranked choice voting favors moderate candidates and policies, increasing the probability of their implementation compared to plurality rule. This moderate bias leads to lower polarization in equilibrium than is possible under plurality rule.

Authors: Ethan Reese. Mentors: Russ Bailey. Insitution: Utah Valley University. Many individuals struggle with oppressively high standards for their character, behavior and environment, know commonly as perfectionism. Perfectionism also carries significant attention in the fields of psychology, at least partially because of its association with higher rates of OCD, depression and anxiety, but also higher performance and goal-achieving (Lunn et al., 2023). The presentation will be synthesized from available literature, and focus on how perfectionism can be positive or negative, and how to effectively adopt beneficial perfectionism. Special emphasis will be placed on the role of perfectionism in academic and workplace settings.There are moderating factors that distinguish adaptive perfectionism from maladaptive perfectionism and various sources of perfectionism, including self-prescribed, socially-prescribed, and other-oriented perfectionism (Benson, 2003). There are diverse explanations of the many ways individuals strive for perfection, or how they impose expectations of it on others, and many of those will be elaborated on. Therapists have both the ability and the professional responsibility to assist in those efforts. The therapeutic modalities specifically suited for working with perfectionism and the consequences of complex relationships between it and certain mental illnesses will be presented for analysis. This discussion will benefit individuals inside and outside of mental health professions alike through exploreing the process of turning perfectionism adaptive, as well as provide direction for future research in on the topic.References:Lunn, J., Greene, D., Callaghan, T., & Egan, S. J. (2023). Associations between perfectionism and symptoms of anxiety, obsessive-compulsive disorder and depression in young people: A meta-analysis. Cognitive Behaviour Therapy, 52(5), 460–487. https://doi.org/10.1080/16506073.2023.2211736Benson, E. S. (2003, November 1). The many faces of perfectionism. Monitor on Psychology, 34(10). https://www.apa.org/monitor/nov03/manyfaces

Authors: Karen Hoggan, Adia Migliori, Jonathan Harr, David Aguilar Alvarez. Mentors: David Aguilar Alvarez. Insitution: Weber State University. BackgroundElevated blood pressure (BP) is a significant risk factor for cardiovascular disease. The effects of high sodium (Na) intake on blood pressure are widely recognized. Of late, potassium (K) intake has gained recognition as a factor in hypertension. Recent studies have shown that the Na/K ratio consumed may be more predictive of hypertension than solely sodium intake. This study examines the association between the Na/K ratio and BP in males and females.MethodsWe utilized a cross-sectional design to evaluate self-reported two-day diet records for 73 male and 183 female students. Sodium and potassium intake were calculated using Diet and Wellness Plus. BP measurements were taken from each participant. Partial correlations were conducted between systolic (SBP) and diastolic blood pressure (DBP), and the following variables: Na, K, and Na/K. SBP means were compared between high sodium consumers and low sodium consumers with the same Na/K ratio using independent samples t-test.ResultsNeither male nor female participants’ SBP or DBP were associated with Na or K intake (p>0.05). However, an increased Na/K ratio was associated with higher DBP in males (r=0.254, p=0.29), but not in females (r=0.04 p=0.79). When the Na/K ratio was paired, participants who consumed over 3000 mg of sodium had a significantly higher SBP (121.1 ± 12.9) than those who consumed less than 3000 mg (115.9 ± 10.7, p=.004).ConclusionsConsumption of Na and K may affect male and female BP differently. In males, the Na/K ratio was predictive of increases in blood pressure. Although Na/K ratio seems to be more predictive of this parameter, within the same Na/K ratio, having lower sodium consumption was associated with lower SBP. This illustrates the complex interaction between BP regulation and nutrition, emphasizing the significance of both lowering sodium intake and maintaining a balanced Na/K ratio for optimal heart health.

Authors: Sophia Kramer, Violeta Vasilevska. Mentors: Violeta Vasilevska. Insitution: Utah Valley University. Preliminary literature review showed that studies have been conducted following either elementary or middle/high school students’ after-school math programs. However, this preliminary lit review did not provide any relevant comparison of the data collected from these students’ groups. In this study, we will conduct two after-school meetings with elementary and high school students in the spring semester. During the meetings, students will be working collaboratively on hands-on, discovery math activities. This hands-on learning experience will be adjusted for different grade levels. Both student groups will be given a pre-survey consisting of attitude questions. They will assess perceptions about learning that occurs in after-school (out-of-classroom) learning environments that encourage mathematical thinking and collaboration. At the end of each after-school meeting, students will be given a post-survey (that will contain some questions matching the pre-survey ones). The collected survey data will be compared to examine the different responses resulting from the two different age groups, maturity levels, gender, etc. Survey results will be used to obtain observations about the effect of such after-school programs on student attitude toward math.In this presentation, we present the preliminary data collected during the first after school meeting held at the beginning of the spring semester and provide a comparison of the collected data. Additional meetings and surveys will be conducted later in the semester.

Authors: Eden Backman, Britt Wyatt, Kandace Flanary, Jessica Cusick, T Heath Ogden, Joshua Premo. Mentors: Joshua Premo. Insitution: Utah Valley University. Utah Valley University serves a unique student population where ~70% of students are Latter-Day Saints (LDS) and ~30% are non-traditional (over the age of 24) (UVU IR, 2023). Compared to the overall 1.6% of LDS individuals in the United States (Pew Research Center, 2023), the identities of UVU students are vastly underrepresented in education research that has been conducted at other institutions. This is especially important as the LDS religion has been related to one of the most conservative religious groups concerning gender roles (Heaton, Bahr, and Jacobson 2004). Additionally, recent preliminary analysis of public institutional data from Utah universities indicates that UVU is graduating more men than women in biology, drastically contrasting other Utah university and national trends. In Utah, the STEM workforce has seen a significant 20% increase since 2016 (UWLP, 2022). However, it's important to note that during this period of expansion, men have disproportionately reaped the benefits in terms of STEM career opportunities. According to IWPR (2019), men in Utah are 2.5 times more likely to secure a STEM career compared to women. Furthermore, in 2020, STEM careers in Utah boasted median annual wages that were over twice as high as those in other occupations, which has direct implications for individuals' lifetime earnings and social capital. Given this information, we questioned why women were not choosing educational paths that will promote a career in STEM? If they are choosing STEM majors, then what are the factors that promote women to leave STEM during their undergraduate careers? This research project focuses on trying to answer these questions specifically at Utah Valley University (UVU). UVU’s biology program reflects similar patterns that are seen in the STEM workforce in Utah. UVU’s biology program was graduating twice as many men compared to women during the most recent academic year (2022-23)(UVU IR). This was the lowest percentage of women earning a four-year biology degree when compared to all other Utah institutions (USHE, 2023). The following research questions were addressed to help inform our understanding of why inequities in degree attainment by gender are being seen at UVU: 1) Are women less accepting of biological ideas (evolution, vaccines, climate change, etc.) that may be impacting women’s pursuits of biology? 2) Are there differences in how women are relating to science (motivation, immersion, or integration) that may be impacting their pursuit of biology? 3) Are there differences in political orientation or religious affiliation that may be impacting women’s pursuits of biology? To answer these questions, we collected data from 1,455 students (22% were biology majors) enrolled in biology classes at UVU in Fall 2023. Comparisons were made using independent samples t-test (with Bonferroni adjustments) to see the extent to which factors varied between men and women both within and outside of the biology major. In contrast to expectations, results for research question #1 show that women biology majors did not agree with science less than men. In fact, women strongly agreed with several science ideas at a higher rate than did men. These ideas included environmental concern and climate change (women = 66% vs. Men = 41%) and vaccination (women = 63% vs. Men = 48%). This result suggests that differences in acceptance of science ideas may not be driving the differences in degree attainment in biology. If anything, these results suggest that women should be more likely to continue in the biology major compared to men. In addition, when students’ immersion (sense of belonging and science identity) in science was assessed by gender women were slightly higher than men with about 8% more strongly agreeing to being immersed in science. This finding suggested that women are not experiencing lower immersion as a potential factor impacting degree attainment. Further examination of additional factors is underway. This study highlights that there are specific factors that may be contributing to gender disparities in biology bachelor's degree attainment at UVU. We recommend specific interventions targeting areas of differences in the biology program to provide additional scaffolds and supports to promote more equitable career trajectory and lifetime earnings for women pursuing Biology at UVU.

Authors: Grant Hendrickson, Christian Moody, Nellie Bowman, Nick Jeffery, Cairo Ziebarth, Joel Davis, Melissa Reeves, Heather Wilson Ashworth. Mentors: Heather Wilson Ashworth. Insitution: Utah Valley University. Self-competence and effort belief may impact student motivation and success in introductory chemistry courses. Self-competence is the need to feel efficacious and capable3. Effort belief is the concept that working harder at a task produces better results4. Mastery-Based Grading (MBG), a nonconventional grading method, provides multiple opportunities for students to show mastery of the course learning objectives5. This research examines the effect of Mastery-Based Grading (MBG) in an active learning classroom on student's self-competence and effort belief compared to that of a conventional grading (CG) approach in a traditional lecture-based classroom. Hypothesis: MBG leads to increased student self-competence and effort belief compared to CG courses. Self-determination1 and expectancy-value theories2 provide the context for understanding the self-competence and effort belief data. At a private midwestern college, general chemistry students in an active learning, MBG course (53 students) and a lecture course (48 students) with a conventional grading policy were studied using a mixed methods approach. Surveys containing Likert and reflection questions were given during week 3 and 14 of the semester. A coding scheme was developed, and reflection questions were coded to consensus. Coded data had a Pearsons coefficient greater than 0.76. Results: Notably, students with initially low self-competency Likert scores showed significant improvement (p=0.01) in the MBG-active course, but not in the conventional course. No significant improvement was observed in students' effort-belief scores as the scores were high at the beginning and stayed high at the end of the semester. In response to the reflection question, “Do you believe you have the ability to be successful in this course?”, there was a 15.35 percent increase in responses that reflected effort-belief in the MBG active learning course. This theme was absent in CG courses throughout the semester. It is noteworthy that MBG students recognized (14.29% compared to pre-reflections) the specific components of the course structure that helped students succeed. This early explorative data suggests that students in active learning MBG courses may experience an increase in self-competence and perceived effort belief compared to their counterparts in traditional classes. 1Deci, E. L., Vallerand, R.J., Pelletier, L.G. & Ryan, R.M. (1991). Motivation and education: The self-determination perspective. Educational Psychologist, 26, 325-346. 2Eccles (Parsons), J. (1983). Expectancies, values, and academic behavior. in J.T. Spence (Ed.) Achievement and Achievement Motivation. San Francisco: W.H. Freeman. 3Ferrell, Brent and Jack Barbera. (2017). Analysis of students’ self-efficacy, interest, and effort beliefs in chemistry. Chemistry Education Research and Practice, 16; 31-337. 4Skinner, E., Saxton, E., Currie, C., & Shusterman, G. (2017). A motivational account of the undergraduate experience in science: brief measures of students’ self-system appraisals, engagement in coursework, and identity as a scientist. International Journal of Science Education, 39(17), 2433-2459. 5Toledo, S., & Dubas, J. M. (2017). A learner-centered grading method focused on reaching proficiency with course learning outcomes. Journal of Chemical Education, 94(8), 1043-1050.

Authors: Libby Brooks. Mentors: Natasha Pavlova. Insitution: University of Utah. About 90% of cancer deaths are from the development of secondary tumor growths from a process called metastasis. As cancer cells divide uncontrollably nutrients from nearby tissue – specifically the amino acid glutamine – are depleted. Glutamine is one of the most abundant amino acids in the bloodstream, and most cells cannot live without it. Tumors have poor vasculature which further contributes to the depletion of nutrients. Even in nutrient-depleted environments, tumors have found ways to grow.Tumors are comprised of cancer cells as well as non-cancerous stromal cells. Studies have shown stromal cells can synthesize glutamine which they release into the tumor microenvironment feeding cancer cells and allowing them to grow. However, the signaling pathway used between the cancer and stromal cells in this relationship remains unclear.To study the signaling pathway by which stromal cells are synthesizing glutamine I treated cells with a common anti-inflammatory drug, dexamethasone. Mice receiving dexamethasone over a long period of time had increased lung metastases when injected with cancer cells. Dexamethasone binds to the glucocorticoid receptor (GR) which activates the expression of glutamine synthetase (GLUL) enzyme mRNA. The expression of GLUL causes the cell to synthesize glutamine. However, the role of GR, in regulating GLUL expression in tumors, remains insufficiently studied.The experiments done for this project show that dexamethasone induces GLUL expression in stromal cells such that they start releasing glutamine. This may promote growth of cancer cells even when there is a deficit of nutrients around. It is hypothesized that due to this property, dexamethasone increases risk of metastasis. This project will aid in the development of cancer therapeutics to treat metastatic cancers.