Life Sciences
Environmental Correlates of Valley Fever Fungus, Coccidioides, in Soil in Southern Utah
Author(s): Evie Adams, Ammon Miles, Katrina Derieg, Eric Rickart
Naturally Derived Antimicrobial Compounds as a Potential Means to Combat Milk Spoilage
Author(s): Joseph Yanchar
Does Lactic Acid Bacteria Inhibit Biofilm Formation of Methicillin Resistant Staphylococcus aureus?
Author(s): Caden Wheeler, Ethan Carter, Aidan Nielsen
Measuring the Hydraulic Permeability of Bovine and Human Spinal Vertebral Bony Endplates
Author(s): Dallin Dodds, Ethan Ence
Comparing Quercetin Antiviral Delivery Vehicle Preparation for CMV-Infected Cells.
Author(s): Keira Lentz, Madelyn Friel
Chilling Insights: A Comparative Study of Cancer Tissue Preservation
Author(s): Paige Nelson, Rebecca Bascom,Jacob Harris, Jack Davis, Mackenzie Burr, Jeffrey Okojie
How Metabolic Differences in T Cells from CD5 Deficiency Impacts Anxiety
Author(s): Sophie Daines
Species Comparison of Hemoparasites in Lizards in Southern Utah
Author(s): Karli Nielson, Evie Adams
Role of Perineuronal Nets in Androgen-Induced Masculinization of Female Vocal Pathways of African Clawed Frogs
Author(s): Anuhya Yalavarty, Logan Klar, Cooper Gangi, Tayla Chiang, Berlyn Prue
Validation of the Zebrafish Wolfram Syndrome 2 Model
Author(s): Ashton Gardner, Corbin Arnold
Medically Relevant Bacterial Growth Capacities Influenced by a Variety of Sugar Substitute Solutions
Author(s): Jessica Oram, Tom Vo
Clinician Derived Phenotypic Risk Scores (PheRS): Improving diagnosis timelines for Multiple Sclerosis patients
Author(s): Hailey Whittier, Quinn Beames
Golden Genes: Harnessing Biolistics and RNA Sequencing to Cultivate Drought-Resilient Tomatoes
Author(s): Aubrilin Johnson
GCSF Involvement in Ethanol Dopamine Adaptations
Author(s): Zachary Valentine, Chase Seiter
Role of the Immune System on Ethanol-Associated Cytokine Release and D2R Expression in Mice
Author(s): Alina Svitlana Rodriguez Bezruchko
What Happens When Flies Eat Their Greens? Exploring Diet-Driven Variation in Fly Life History Traits and Microbiota Composition
Author(s): L'Amat Rosales, Sarah J. Gottfredson Morgan, Brittany S. Burnside
Perceived Effectiveness of Study Practices: A Multi-Semester Analysis of Undergraduate Anatomy Students.
Author(s): Samuel Villicana, Mary Nieves
Effects of the Receptor for Advanced Glycation End Products on Successful Arteriovenous Fistula Maturation
Author(s): River Tobias, Yuxia He, Brayden Fairbourn, Amani Oumar, Marina Knysheva
Decoding Spider Identities: An Venom RNA Analysis Using RNA-to-DNA Barcoding Pipeline
Author(s): Alexander Rich
Investigating the effects of MS-222 on cardiovascular function in leopard frogs
Author(s): Tia Dudley, Ty Erickson
Identifying neurons that express dArc1 in Drosophila melanogaster brain
Author(s): Kylie DeNiro
PonixPros: A Novel Greywater Hydroponics System
Author(s): Myshela Todd, Ryan Jamison, Schuyler Baer
Mechanism of Histidine Ammonia Lyase (HAL)
Author(s): Romina Peralta, Isabel Amaro, Jessica Munro
Applying chimeric antigen receptor (CAR) T cell therapy as a potential cure for the B cell-mediated autoimmune disease, Graves’ Disease
Author(s): Kimball Demars, Abigail Cheever, Hunter Lindsay, Chloe Kang
Nicotinic Acetylcholine Receptors
Author(s): Brennan Motes, Benjamin Lewis, Jonny McEntire, Baird Reynolds, Carter Ulrich, Matthew Anderson, Talon Anderson, James Brume, Tanner Carter, Kelton Couperus, Eliza Crossman, Russell Cutler, Tate Giles, Lizzie Goss, Lola Heninger, Alexa Jones, Donald Palmer, Brian Powell, Brandt Stratton, Melissa Terry
Effects of prolactin on β-cell Nr4a1 expression and downstream gene expression
Author(s): Jonathan Hanson
Are you my mother? Investigating genetic relationships among Common murres at the Oregon Coast Aquarium
Author(s): Audrey Domyan, Mathew Harris
Hearing Without Understanding: A Lesion Network Mapping Analysis of Auditory Agnosia
Author(s): Caleb Gardner, Nathan Bastian
Enhancing rangeland restoration with native, early seral Asteraceae species
Author(s): Samuel Leigh
Forb Species Selection for Improved Mine Reclamation
Author(s): Joanna Pincock, Mallory Hinton
Methylation Changes in Blood Following COVID-19 Based on Previously Described Sperm DMRs
Author(s): Alexandra DiLiberto, Ethan McQuhae
Losing the Egg, Keeping the Tooth: Vestigial Egg-Tooth Retention in a Live-bearing Snake
Author(s): Truman Holt, Scott Barton, Sara Harris, Sarah Heinz
Innovations in Organic Pesticides: Enhancing Neem Oil with Essential Oils
Author(s): Isabel Lykken, Katharina Clegg
Habitat Preference of Ateles geoffroyi at La Selva Biological Station, Costa Rica
Desdames, Chloe; Smith, Mick (Salt Lake Community College)
Faculty Advisor: Seaboch, Melissa (Salt Lake Community College, Anthropology)
Spider monkeys (genus Ateles) is one of the many endangered species in Costa Rica and they can now only be found in very few places due to deforestation. It is important for conservation reasons to know what forest types spider monkeys prefer. According to prior research in Surinam, Mexico, and Bolivia, Ateles prefers primary forests (undisturbed, high canopy) over secondary forests (degraded, lower canopy). Ateles are frugivores and their habitat preference depends highly on fruit availability. Fruit is more abundant in primary over secondary forests. This goal of this study was to determine whether spider monkeys in Costa Rica have a similar habitat preference. I hypothesize that spider monkeys will be found more often in high canopy primary forests compared to secondary forests. This research was conducted at La Selva Biological Station in northeastern Costa Rica. La Selva is a protected lowland tropical rainforest consisting of both primary forest (55%) and secondary forest in various stages of regeneration. I conducted a census of Ateles geoffroyi by walking established trails, with markers every 50 meters, in May 2019. Whenever a spider monkey was spotted, the trail name, nearest meter marker, and forest type were recorded. On a census of 9 trails, five Ateles groups were located, with four of the sightings being in primary forests. My hypothesis, that Ateles geoffroyi would be found in primary over secondary forests, was supported because 80% of the sightings were in primary forests. This is especially significant because, of the 20.5 kilometers censused, only 4.6 km censused (22%) were in primary forests with the remaining 15.9 km (78%) in secondary forests. This preference for primary forests agrees with prior studies on Ateles in other Neotropical forests. This highlights the importance of conserving primary forest for the well-being of spider monkeys.
Faculty Advisor: Seaboch, Melissa (Salt Lake Community College, Anthropology)
Spider monkeys (genus Ateles) is one of the many endangered species in Costa Rica and they can now only be found in very few places due to deforestation. It is important for conservation reasons to know what forest types spider monkeys prefer. According to prior research in Surinam, Mexico, and Bolivia, Ateles prefers primary forests (undisturbed, high canopy) over secondary forests (degraded, lower canopy). Ateles are frugivores and their habitat preference depends highly on fruit availability. Fruit is more abundant in primary over secondary forests. This goal of this study was to determine whether spider monkeys in Costa Rica have a similar habitat preference. I hypothesize that spider monkeys will be found more often in high canopy primary forests compared to secondary forests. This research was conducted at La Selva Biological Station in northeastern Costa Rica. La Selva is a protected lowland tropical rainforest consisting of both primary forest (55%) and secondary forest in various stages of regeneration. I conducted a census of Ateles geoffroyi by walking established trails, with markers every 50 meters, in May 2019. Whenever a spider monkey was spotted, the trail name, nearest meter marker, and forest type were recorded. On a census of 9 trails, five Ateles groups were located, with four of the sightings being in primary forests. My hypothesis, that Ateles geoffroyi would be found in primary over secondary forests, was supported because 80% of the sightings were in primary forests. This is especially significant because, of the 20.5 kilometers censused, only 4.6 km censused (22%) were in primary forests with the remaining 15.9 km (78%) in secondary forests. This preference for primary forests agrees with prior studies on Ateles in other Neotropical forests. This highlights the importance of conserving primary forest for the well-being of spider monkeys.
Exploring the Ability of 6 Novel Phages in Reducing and Inhibiting MRSA Biofilms
MacLachlan, Aileen; Berges, Bradford (Brigham Young University)
Faculty Advisor: Berges, Bradford (Life Sciences, Microbiology and Molecular Biology)
Staphylococcus Aureus (SA) is a well-known human pathogen causing infection in hospital settings world-wide. Given that SA is becoming increasingly resistant to antibiotics, the need to discover alternative treatments is urgent. One path that SA uses to combat antibiotics is by forming biofilms. Biofilms are microbial cell communities that form on surfaces and employ a complex extracellular polysaccharide matrix to protect the bacteria. In the past, bacteriophage (phage) has been investigated as a potential alternative to treat methicillin-resistant SA (MRSA) and break down its biofilm. Recently, students from Dr. Berges' laboratory isolated 6 novel strains of phage. In a recently published paper from Dr. Berges' lab, these phages demonstrated significant reduction of planktonic strains of SA and MRSA.
In this project, we further explore the ability of these 6 phages in breaking down biofilms from hospital associated SA strains. We plan to measure the reduction of SA biofilms caused by these novel phages against a control. The reduction results will be analyzed with previous research results to detect the presence of a polysaccharide degrading enzyme for the purpose of future research. In addition, we also plan on measuring the ability of the phage in preventing biofilm formation.
Faculty Advisor: Berges, Bradford (Life Sciences, Microbiology and Molecular Biology)
Staphylococcus Aureus (SA) is a well-known human pathogen causing infection in hospital settings world-wide. Given that SA is becoming increasingly resistant to antibiotics, the need to discover alternative treatments is urgent. One path that SA uses to combat antibiotics is by forming biofilms. Biofilms are microbial cell communities that form on surfaces and employ a complex extracellular polysaccharide matrix to protect the bacteria. In the past, bacteriophage (phage) has been investigated as a potential alternative to treat methicillin-resistant SA (MRSA) and break down its biofilm. Recently, students from Dr. Berges' laboratory isolated 6 novel strains of phage. In a recently published paper from Dr. Berges' lab, these phages demonstrated significant reduction of planktonic strains of SA and MRSA.
In this project, we further explore the ability of these 6 phages in breaking down biofilms from hospital associated SA strains. We plan to measure the reduction of SA biofilms caused by these novel phages against a control. The reduction results will be analyzed with previous research results to detect the presence of a polysaccharide degrading enzyme for the purpose of future research. In addition, we also plan on measuring the ability of the phage in preventing biofilm formation.
Genomic Analyses Between Neofelis nebulosa and Neofelis diardi Aid in Conservation Efforts for Clouded Leopards
Bursell, Madeline; Dikow, Rebecca; Johnson, Warren; Koepfli, Klaus-Peter; Frandsen, Paul (Brigham Young University)
Faculty Advisor: Frandsen, Paul (Life Sciences, Plant and Wildlife Sciences)
Due to decreasing costs in genome sequencing, conservation genomics is a field that has experienced immense growth over the last few years. By comparing whole genome data within threatened and endangered populations, we can estimate important elements in conservation such as levels of homozygosity and demographic histories that reveal the level of endangerment of a species. This information informs conservation priorities and captive breeding programs. In the present study, we focus on two species of clouded leopards: Neofelis nebulosa and Neofelis diardi. N. nebulosa is a species of clouded leopard that lives in mainland southeast Asia. N.diardi inhabits the islands of Sumatra and Borneo in Indonesia. While these two species were initially thought to be a single species, evidence, such as differences in fur color and sizes of cloud markings, hint that they have diverged into two species. To shed more light on the genomic differences between them, we sequenced, assembled, and annotated whole genomes from both species. With genomes, we will explore differences in demographic histories, variation in blocks of homozygosity, and generate a whole genome phylogeny with other large cat species. Using these analyses, we share insights that will inform the conservation status of the two species.
Faculty Advisor: Frandsen, Paul (Life Sciences, Plant and Wildlife Sciences)
Due to decreasing costs in genome sequencing, conservation genomics is a field that has experienced immense growth over the last few years. By comparing whole genome data within threatened and endangered populations, we can estimate important elements in conservation such as levels of homozygosity and demographic histories that reveal the level of endangerment of a species. This information informs conservation priorities and captive breeding programs. In the present study, we focus on two species of clouded leopards: Neofelis nebulosa and Neofelis diardi. N. nebulosa is a species of clouded leopard that lives in mainland southeast Asia. N.diardi inhabits the islands of Sumatra and Borneo in Indonesia. While these two species were initially thought to be a single species, evidence, such as differences in fur color and sizes of cloud markings, hint that they have diverged into two species. To shed more light on the genomic differences between them, we sequenced, assembled, and annotated whole genomes from both species. With genomes, we will explore differences in demographic histories, variation in blocks of homozygosity, and generate a whole genome phylogeny with other large cat species. Using these analyses, we share insights that will inform the conservation status of the two species.
Impaired Glucose Metabolism in Niacin Deficient Transgenic Mice
Allen, Sierra; Meyer-Ficca, Mirella; Wandersee, Miles (Utah State University)
Faculty Advisor: Meyer-Ficca, Mirella (College of Agriculture and Applied Sciences; Animal, Dairy, and Veterinary Sciences Department)
Niacin, a component of vitamin B3, is necessary for the synthesis of nicotinamide adenine dinucleotide (NAD+). NAD+ is an essential coenzyme in several metabolic processes, including those that regulate glucose and fat homeostasis in the body. Niacin is available to humans in its dietary form through foods such as meat, various legumes, nuts and vegetables. Niacin deficiency has been linked to health problems including age-related decline of cognitive abilities, as seen in Alzheimer's disease, and impaired dermal repair. In cases of extreme niacin deficiency, individuals may even develop pellagra, a disease characterized by dermatitis, diarrhea and dementia. Recent studies in niacin deficient mice indicate that niacin deficiency impairs proper glucose metabolism. Compared to mice with adequate niacin levels, niacin deficient mice experience a significant loss of total body weight and body fat and have impaired glucose regulation in response to insulin. We hypothesize that these metabolic defects result from inadequate levels of NAD+ preventing the conversion of lactate to pyruvate in the gluconeogenesis pathway, which in turn results in decreased blood glucose levels. Another potential explanation is that niacin deficiency results in decreased glycogen stores in the liver, also impeding glucose production. To test these hypotheses, we are studying the relationship between dietary niacin and glucose metabolism in a transgenic mouse model with acquired niacin dependency that accurately represents human niacin metabolism. Results of this study will contribute to better understanding of niacin's role in proper glucose metabolism, with important implications for diabetes and other glucose-related diseases, particularly in populations with limited access to quality food.
Faculty Advisor: Meyer-Ficca, Mirella (College of Agriculture and Applied Sciences; Animal, Dairy, and Veterinary Sciences Department)
Niacin, a component of vitamin B3, is necessary for the synthesis of nicotinamide adenine dinucleotide (NAD+). NAD+ is an essential coenzyme in several metabolic processes, including those that regulate glucose and fat homeostasis in the body. Niacin is available to humans in its dietary form through foods such as meat, various legumes, nuts and vegetables. Niacin deficiency has been linked to health problems including age-related decline of cognitive abilities, as seen in Alzheimer's disease, and impaired dermal repair. In cases of extreme niacin deficiency, individuals may even develop pellagra, a disease characterized by dermatitis, diarrhea and dementia. Recent studies in niacin deficient mice indicate that niacin deficiency impairs proper glucose metabolism. Compared to mice with adequate niacin levels, niacin deficient mice experience a significant loss of total body weight and body fat and have impaired glucose regulation in response to insulin. We hypothesize that these metabolic defects result from inadequate levels of NAD+ preventing the conversion of lactate to pyruvate in the gluconeogenesis pathway, which in turn results in decreased blood glucose levels. Another potential explanation is that niacin deficiency results in decreased glycogen stores in the liver, also impeding glucose production. To test these hypotheses, we are studying the relationship between dietary niacin and glucose metabolism in a transgenic mouse model with acquired niacin dependency that accurately represents human niacin metabolism. Results of this study will contribute to better understanding of niacin's role in proper glucose metabolism, with important implications for diabetes and other glucose-related diseases, particularly in populations with limited access to quality food.